Maxwell W Libbrecht


Education and Employment


Research interests


  1. Maxwell W. Libbrecht*, Oscar Rodgriguez* (*contributed equally), Jeffrey A. Bilmes, Zhiping Weng, William S. Noble. “A unified encyclopedia of human functional elements through fully automated annotation of 164 human cell types.” Submitted. Preprint at
  2. Maxwell W. Libbrecht, Jeffrey A. Bilmes, William S. Noble. “Eliminating redundancy among protein sequences using submodular optimization.” Submitted. Preprint at
  3. Kai Wei*, Maxwell W. Libbrecht* (*contributed equally), Jeffrey A Bilmes, William S. Noble. “Choosing panels of genomics assays using submodular optimization.” Genome Biology, In press. Preprint at
  4. Owen K. Smith, RyanGuk Kim, Haiqing Fu, Melvenia Martin, Chii-Mei Lin, Koichi Utani, Marc Lalande, Stormy Chamberlaine, Maxwell W. Libbrecht, Eric E Bouhassira, Michael C Ryan, William S. Noble, Mirit I. Aladjem. “Distinct epigenetic features of differentiation-Regulated Replication Origins.” Epigenetics Chromatin, 2016; 9: 18.
  5. Maxwell W. Libbrecht, William S. Noble. “Machine learning applications in genetics and genomics.” Nature Reviews Genetics, 16: 321-332, 2015. 48 citations (Google Scholar). 14,841 downloads. Cover article.
  6. Maxwell W. Libbrecht, Michael Hoffman, Jeff Bilmes, William Stafford Noble. “Entropic graph-based posterior regularization.” Proceedings of the International Conference on Machine Learning (ICML) 2015.
  7. Maxwell W. Libbrecht, Ferhat Ay, Michael M. Hoffman, David M. Gilbert, Jeffrey A. Bilmes, and William S. Noble “Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell-type-specific expression.” Genome Research, 25: 544-557, 2015. Named one of ISCB’s Top 10 Regulatory and Systems Genomics papers of 2015 (
  8. Ho et al (Maxwell W. Libbrecht author #49). “Comparative analysis of metazoan chromatin architecture.” Nature, 512, 449-452, 2014.
  9. Michael M. Hoffman*, Jason Ernst* (*contributed equally), Steven P. Wilder, Anshul Kundaje, Robert S. Harris, Maxwell W. Libbrecht, Belinda Giardine, Jeffrey A. Bilmes, Ewan Birney, Ross C. Hardison, Ian Dunham, Manolis Kellis, and William Stafford Noble. “Integrative annotation of chromatin elements from ENCODE data.” Nucleic Acids Research, 41(2):827–841, 2013. Featured article. 179 citations (Google Scholar).
  10. Anshul Kundaje*, Sofia Kyriazopoulou-Panagiotopoulou*, Maxwell W. Libbrecht* (*contributed equally), Serafim Batzoglou, Arend Sidow “Ubiquitous heterogeneity and asymmetry of the chromatin landscape at transcription regulatory elements.” Genome Research, 22(9):1735-1747, 2012. 95 citations (Google Scholar).
  11. ENCODE Project Consortium. “An integrated encyclopedia of DNA elements in the human genome.” Nature, 489(7414):57-74, 2012. 4403 citations (Google Scholar) Cover article..
  12. The ENCODE Project Consortium. “A Users Guide to the Encyclopedia of DNA Elements (ENCODE) Functional Genomic Data.” PLoS Biology, vol. 9, issue 4, e1001046, 2011.
  13. Kenneth Libbrecht, Maxwell W. Libbrecht. “Interferometric measurement of the resonant absorption and refractive index in rubidium gases.” American Journal of Physics, 74:1055, 2006.


Professional activities

Invited talks

Student mentoring

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