0% elimination level, q=0
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00057951517
MAD:

0.03339005591

MSD:

0.00027098425
MAD:

0.02292219033

MSD:

0.00013977484
MAD:

0.01662265564

MSD:

0.00006596252
MAD:

0.01143022191

MSD:

0.00001362988
MAD:

0.00516797870

MSD:

0.00000483477
MAD:

0.00309999205

MSD:

0.00000249704
MAD:

0.00220171740

MSD vs # aa's MAD vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's

5% elimination level, q=0
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00060090312
MAD:

0.03367039240

MSD:

0.00025083569
MAD:

0.02211526612

MSD:

0.00013818280
MAD:

0.01638719062

MSD:

0.00006934112
MAD:

0.01177666545

MSD:

0.00001323493
MAD:

0.00507771205

MSD:

0.00000489252
MAD:

0.00308235704

MSD:

0.00000254701
MAD:

0.00219694969

difference plots

True Positives:
2000
True Negatives:
5
False Positives:
87
False Negatives:
98
Sensitivity:
95.33
PPV:
95.83
Accuracy:
91.55

True Positives:
2003
True Negatives:
7
False Positives:
80
False Negatives:
100
Sensitivity:
95.25
PPV:
96.16
Accuracy:
91.78

True Positives:
2004
True Negatives:
10
False Positives:
76
False Negatives:
100
Sensitivity:
95.25
PPV:
96.35
Accuracy:
91.96

True Positives:
2008
True Negatives:
14
False Positives:
75
False Negatives:
93
Sensitivity:
95.57
PPV:
96.40
Accuracy:
92.33

True Positives:
2027
True Negatives:
32
False Positives:
63
False Negatives:
68
Sensitivity:
96.75
PPV:
96.99
Accuracy:
94.02

True Positives:
2063
True Negatives:
50
False Positives:
38
False Negatives:
39
Sensitivity:
98.14
PPV:
98.19
Accuracy:
96.48

True Positives:
2063
True Negatives:
72
False Positives:
22
False Negatives:
33
Sensitivity:
98.43
PPV:
98.94
Accuracy:
97.49

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

10% elimination level, q=0
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00056277413
MAD:

0.03279074956

MSD:

0.00028466063
MAD:

0.02348405467

MSD:

0.00012988936
MAD:

0.01576457158

MSD:

0.00006709714
MAD:

0.01135622283

MSD:

0.00001412971
MAD:

0.00524666661

MSD:

0.00000490486
MAD:

0.00298928471

MSD:

0.00000257178
MAD:

0.00210361792

difference plots

True Positives:
1818
True Negatives:
25
False Positives:
157
False Negatives:
190
Sensitivity:
90.54
PPV:
92.05
Accuracy:
84.16

True Positives:
1829
True Negatives:
39
False Positives:
139
False Negatives:
183
Sensitivity:
90.91
PPV:
92.94
Accuracy:
85.30

True Positives:
1869
True Negatives:
50
False Positives:
126
False Negatives:
145
Sensitivity:
92.80
PPV:
93.68
Accuracy:
87.63

True Positives:
1868
True Negatives:
50
False Positives:
131
False Negatives:
141
Sensitivity:
92.98
PPV:
93.45
Accuracy:
87.58

True Positives:
1913
True Negatives:
102
False Positives:
72
False Negatives:
103
Sensitivity:
94.89
PPV:
96.37
Accuracy:
92.01

True Positives:
1953
True Negatives:
138
False Positives:
43
False Negatives:
56
Sensitivity:
97.21
PPV:
97.85
Accuracy:
95.48

True Positives:
1978
True Negatives:
174
False Positives:
16
False Negatives:
22
Sensitivity:
98.90
PPV:
99.20
Accuracy:
98.27

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

15% elimination level, q=0
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00054458667
MAD:

0.03307799846

MSD:

0.00024510753
MAD:

0.02171340094

MSD:

0.00013275709
MAD:

0.01596284403

MSD:

0.00007090143
MAD:

0.01155233516

MSD:

0.00001534077
MAD:

0.00522744465

MSD:

0.00000501183
MAD:

0.00291984087

MSD:

0.00000238717
MAD:

0.00199474265

difference plots

True Positives:
1652
True Negatives:
67
False Positives:
218
False Negatives:
253
Sensitivity:
86.72
PPV:
88.34
Accuracy:
78.49

True Positives:
1670
True Negatives:
98
False Positives:
187
False Negatives:
235
Sensitivity:
87.66
PPV:
89.93
Accuracy:
80.73

True Positives:
1713
True Negatives:
102
False Positives:
181
False Negatives:
194
Sensitivity:
89.83
PPV:
90.44
Accuracy:
82.88

True Positives:
1734
True Negatives:
131
False Positives:
160
False Negatives:
165
Sensitivity:
91.31
PPV:
91.55
Accuracy:
85.16

True Positives:
1816
True Negatives:
202
False Positives:
84
False Negatives:
88
Sensitivity:
95.38
PPV:
95.58
Accuracy:
92.15

True Positives:
1866
True Negatives:
262
False Positives:
27
False Negatives:
35
Sensitivity:
98.16
PPV:
98.57
Accuracy:
97.17

True Positives:
1886
True Negatives:
279
False Positives:
11
False Negatives:
14
Sensitivity:
99.26
PPV:
99.42
Accuracy:
98.86

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

20% elimination level, q=0
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00055936478
MAD:

0.03267348019

MSD:

0.00026723467
MAD:

0.02277798237

MSD:

0.00013130455
MAD:

0.01572699224

MSD:

0.00006936259
MAD:

0.01132990656

MSD:

0.00001354481
MAD:

0.00472687801

MSD:

0.00000433245
MAD:

0.00258289525

MSD:

0.00000219743
MAD:

0.00182901524

difference plots

True Positives:
1503
True Negatives:
108
False Positives:
283
False Negatives:
296
Sensitivity:
83.55
PPV:
84.16
Accuracy:
73.56

True Positives:
1522
True Negatives:
127
False Positives:
255
False Negatives:
286
Sensitivity:
84.18
PPV:
85.65
Accuracy:
75.30

True Positives:
1560
True Negatives:
176
False Positives:
216
False Negatives:
238
Sensitivity:
86.76
PPV:
87.84
Accuracy:
79.27

True Positives:
1613
True Negatives:
216
False Positives:
176
False Negatives:
185
Sensitivity:
89.71
PPV:
90.16
Accuracy:
83.52

True Positives:
1719
True Negatives:
326
False Positives:
64
False Negatives:
81
Sensitivity:
95.50
PPV:
96.41
Accuracy:
93.38

True Positives:
1773
True Negatives:
376
False Positives:
13
False Negatives:
28
Sensitivity:
98.44
PPV:
99.27
Accuracy:
98.13

True Positives:
1785
True Negatives:
392
False Positives:
4
False Negatives:
9
Sensitivity:
99.50
PPV:
99.78
Accuracy:
99.41

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

0% elimination level, q=1
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00087184799
MAD:

0.04090117152

MSD:

0.00038096846
MAD:

0.02712523683

MSD:

0.00020303228
MAD:

0.01988030397

MSD:

0.00011085116
MAD:

0.01441558273

MSD:

0.00002288860
MAD:

0.00655083792

MSD:

0.00000772354
MAD:

0.00385972101

MSD:

0.00000421523
MAD:

0.00285068294

MSD vs # aa's MAD vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's

5% elimination level, q=1
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00081130981
MAD:

0.03954781529

MSD:

0.00039653367
MAD:

0.02803839951

MSD:

0.00021574927
MAD:

0.02028177361

MSD:

0.00011334035
MAD:

0.01466505588

MSD:

0.00002289934
MAD:

0.00660644866

MSD:

0.00000784847
MAD:

0.00389155300

MSD:

0.00000399125
MAD:

0.00269457717

difference plots

True Positives:
1999
True Negatives:
8
False Positives:
93
False Negatives:
90
Sensitivity:
95.69
PPV:
95.55
Accuracy:
91.64

True Positives:
2002
True Negatives:
7
False Positives:
89
False Negatives:
92
Sensitivity:
95.61
PPV:
95.74
Accuracy:
91.73

True Positives:
1990
True Negatives:
12
False Positives:
93
False Negatives:
95
Sensitivity:
95.44
PPV:
95.53
Accuracy:
91.42

True Positives:
1996
True Negatives:
15
False Positives:
86
False Negatives:
93
Sensitivity:
95.55
PPV:
95.87
Accuracy:
91.83

True Positives:
1996
True Negatives:
25
False Positives:
86
False Negatives:
83
Sensitivity:
96.01
PPV:
95.87
Accuracy:
92.28

True Positives:
2026
True Negatives:
55
False Positives:
56
False Negatives:
53
Sensitivity:
97.45
PPV:
97.31
Accuracy:
95.02

True Positives:
2047
True Negatives:
61
False Positives:
45
False Negatives:
37
Sensitivity:
98.22
PPV:
97.85
Accuracy:
96.26

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

10% elimination level, q=1
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00078788489
MAD:

0.03867745402

MSD:

0.00041912057
MAD:

0.02877901280

MSD:

0.00021625588
MAD:

0.02025525271

MSD:

0.00011102445
MAD:

0.01455906726

MSD:

0.00002411645
MAD:

0.00673594101

MSD:

0.00000781660
MAD:

0.00377896615

MSD:

0.00000396299
MAD:

0.00261783836

difference plots

True Positives:
1792
True Negatives:
25
False Positives:
185
False Negatives:
188
Sensitivity:
90.50
PPV:
90.64
Accuracy:
82.97

True Positives:
1846
True Negatives:
32
False Positives:
161
False Negatives:
151
Sensitivity:
92.44
PPV:
91.98
Accuracy:
85.75

True Positives:
1805
True Negatives:
43
False Positives:
156
False Negatives:
186
Sensitivity:
90.66
PPV:
92.05
Accuracy:
84.38

True Positives:
1833
True Negatives:
60
False Positives:
138
False Negatives:
159
Sensitivity:
92.02
PPV:
93.00
Accuracy:
86.44

True Positives:
1890
True Negatives:
105
False Positives:
112
False Negatives:
83
Sensitivity:
95.79
PPV:
94.41
Accuracy:
91.10

True Positives:
1923
True Negatives:
146
False Positives:
64
False Negatives:
57
Sensitivity:
97.12
PPV:
96.78
Accuracy:
94.47

True Positives:
1956
True Negatives:
168
False Positives:
40
False Negatives:
26
Sensitivity:
98.69
PPV:
98.00
Accuracy:
96.99

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

15% elimination level, q=1
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00085551370
MAD:

0.04006349700

MSD:

0.00040483110
MAD:

0.02808848927

MSD:

0.00021392714
MAD:

0.02048950179

MSD:

0.00011668098
MAD:

0.01482954445

MSD:

0.00002477443
MAD:

0.00675637021

MSD:

0.00000822154
MAD:

0.00373747997

MSD:

0.00000407014
MAD:

0.00259030761

difference plots

True Positives:
1642
True Negatives:
58
False Positives:
237
False Negatives:
253
Sensitivity:
86.65
PPV:
87.39
Accuracy:
77.63

True Positives:
1673
True Negatives:
61
False Positives:
232
False Negatives:
224
Sensitivity:
88.19
PPV:
87.82
Accuracy:
79.18

True Positives:
1653
True Negatives:
67
False Positives:
224
False Negatives:
246
Sensitivity:
87.05
PPV:
88.07
Accuracy:
78.54

True Positives:
1701
True Negatives:
96
False Positives:
199
False Negatives:
194
Sensitivity:
89.76
PPV:
89.53
Accuracy:
82.06

True Positives:
1777
True Negatives:
183
False Positives:
120
False Negatives:
110
Sensitivity:
94.17
PPV:
93.67
Accuracy:
89.50

True Positives:
1857
True Negatives:
248
False Positives:
47
False Negatives:
38
Sensitivity:
98.00
PPV:
97.53
Accuracy:
96.12

True Positives:
1877
True Negatives:
261
False Positives:
26
False Negatives:
26
Sensitivity:
98.63
PPV:
98.63
Accuracy:
97.63

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

20% elimination level, q=1
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00078721936
MAD:

0.03900804180

MSD:

0.00041025115
MAD:

0.02752405941

MSD:

0.00018957841
MAD:

0.01921209574

MSD:

0.00011373349
MAD:

0.01469144036

MSD:

0.00002404711
MAD:

0.00648665512

MSD:

0.00000779136
MAD:

0.00345663318

MSD:

0.00000353627
MAD:

0.00234375691

difference plots

True Positives:
1504
True Negatives:
88
False Positives:
299
False Negatives:
299
Sensitivity:
83.42
PPV:
83.42
Accuracy:
72.69

True Positives:
1495
True Negatives:
134
False Positives:
283
False Negatives:
278
Sensitivity:
84.32
PPV:
84.08
Accuracy:
74.38

True Positives:
1541
True Negatives:
149
False Positives:
234
False Negatives:
266
Sensitivity:
85.28
PPV:
86.82
Accuracy:
77.17

True Positives:
1558
True Negatives:
183
False Positives:
217
False Negatives:
232
Sensitivity:
87.04
PPV:
87.78
Accuracy:
79.50

True Positives:
1702
True Negatives:
277
False Positives:
117
False Negatives:
94
Sensitivity:
94.77
PPV:
93.57
Accuracy:
90.36

True Positives:
1764
True Negatives:
354
False Positives:
41
False Negatives:
31
Sensitivity:
98.27
PPV:
97.73
Accuracy:
96.71

True Positives:
1789
True Negatives:
381
False Positives:
12
False Negatives:
8
Sensitivity:
99.56
PPV:
99.33
Accuracy:
99.09

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

0% elimination level, q=2
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00060273417
MAD:

0.03385907513

MSD:

0.00026776305
MAD:

0.02283728213

MSD:

0.00015430364
MAD:

0.01731205978

MSD:

0.00007460330
MAD:

0.01195491970

MSD:

0.00001436398
MAD:

0.00530043085

MSD:

0.00000525281
MAD:

0.00316962436

MSD:

0.00000253517
MAD:

0.00219049901

MSD vs # aa's MAD vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's

5% elimination level, q=2
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00058551190
MAD:

0.03329787703

MSD:

0.00026658117
MAD:

0.02246322804

MSD:

0.00014844773
MAD:

0.01668949015

MSD:

0.00007573522
MAD:

0.01199642743

MSD:

0.00001571450
MAD:

0.00547925327

MSD:

0.00000494776
MAD:

0.00304764421

MSD:

0.00000262985
MAD:

0.00221137005

difference plots

True Positives:
1958
True Negatives:
14
False Positives:
113
False Negatives:
105
Sensitivity:
94.91
PPV:
94.54
Accuracy:
90.05

True Positives:
1950
True Negatives:
11
False Positives:
126
False Negatives:
103
Sensitivity:
94.98
PPV:
93.93
Accuracy:
89.54

True Positives:
1970
True Negatives:
12
False Positives:
117
False Negatives:
91
Sensitivity:
95.58
PPV:
94.39
Accuracy:
90.50

True Positives:
1981
True Negatives:
26
False Positives:
104
False Negatives:
79
Sensitivity:
96.17
PPV:
95.01
Accuracy:
91.64

True Positives:
2002
True Negatives:
38
False Positives:
76
False Negatives:
74
Sensitivity:
96.44
PPV:
96.34
Accuracy:
93.15

True Positives:
2013
True Negatives:
67
False Positives:
54
False Negatives:
56
Sensitivity:
97.29
PPV:
97.39
Accuracy:
94.98

True Positives:
2036
True Negatives:
83
False Positives:
37
False Negatives:
34
Sensitivity:
98.36
PPV:
98.22
Accuracy:
96.76

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

10% elimination level, q=2
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00057129592
MAD:

0.03339285879

MSD:

0.00027267427
MAD:

0.02290548843

MSD:

0.00014327376
MAD:

0.01651940281

MSD:

0.00008086501
MAD:

0.01238222320

MSD:

0.00001595999
MAD:

0.00539154024

MSD:

0.00000534780
MAD:

0.00304623999

MSD:

0.00000273781
MAD:

0.00217918796

difference plots

True Positives:
1767
True Negatives:
37
False Positives:
211
False Negatives:
175
Sensitivity:
90.99
PPV:
89.33
Accuracy:
82.37

True Positives:
1735
True Negatives:
49
False Positives:
220
False Negatives:
186
Sensitivity:
90.32
PPV:
88.75
Accuracy:
81.46

True Positives:
1763
True Negatives:
54
False Positives:
211
False Negatives:
162
Sensitivity:
91.58
PPV:
89.31
Accuracy:
82.97

True Positives:
1762
True Negatives:
63
False Positives:
198
False Negatives:
167
Sensitivity:
91.34
PPV:
89.90
Accuracy:
83.33

True Positives:
1842
True Negatives:
148
False Positives:
101
False Negatives:
99
Sensitivity:
94.90
PPV:
94.80
Accuracy:
90.87

True Positives:
1898
True Negatives:
200
False Positives:
49
False Negatives:
43
Sensitivity:
97.78
PPV:
97.48
Accuracy:
95.80

True Positives:
1917
True Negatives:
219
False Positives:
23
False Negatives:
31
Sensitivity:
98.41
PPV:
98.81
Accuracy:
97.53

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

15% elimination level, q=2
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00062882881
MAD:

0.03452992120

MSD:

0.00026325062
MAD:

0.02257110426

MSD:

0.00013983865
MAD:

0.01623724814

MSD:

0.00007442243
MAD:

0.01174121396

MSD:

0.00001609117
MAD:

0.00527245486

MSD:

0.00000521636
MAD:

0.00283656176

MSD:

0.00000250480
MAD:

0.00197753414

difference plots

True Positives:
1573
True Negatives:
92
False Positives:
288
False Negatives:
237
Sensitivity:
86.91
PPV:
84.52
Accuracy:
76.03

True Positives:
1586
True Negatives:
120
False Positives:
262
False Negatives:
222
Sensitivity:
87.72
PPV:
85.82
Accuracy:
77.90

True Positives:
1596
True Negatives:
143
False Positives:
243
False Negatives:
208
Sensitivity:
88.47
PPV:
86.79
Accuracy:
79.41

True Positives:
1629
True Negatives:
187
False Positives:
187
False Negatives:
187
Sensitivity:
89.70
PPV:
89.70
Accuracy:
82.92

True Positives:
1708
True Negatives:
266
False Positives:
105
False Negatives:
111
Sensitivity:
93.90
PPV:
94.21
Accuracy:
90.14

True Positives:
1779
True Negatives:
342
False Positives:
34
False Negatives:
35
Sensitivity:
98.07
PPV:
98.12
Accuracy:
96.85

True Positives:
1795
True Negatives:
368
False Positives:
15
False Negatives:
12
Sensitivity:
99.34
PPV:
99.17
Accuracy:
98.77

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

20% elimination level, q=2
# synthetic chains 100 250 500 1000 5000 15000 30000
difference plots

MSD:

0.00058089771
MAD:

0.03317963928

MSD:

0.00027753029
MAD:

0.02306642769

MSD:

0.00014692349
MAD:

0.01631356607

MSD:

0.00007562771
MAD:

0.01172184193

MSD:

0.00001508746
MAD:

0.00481382841

MSD:

0.00000449043
MAD:

0.00257740837

MSD:

0.00000238577
MAD:

0.00183330710

difference plots

True Positives:
1371
True Negatives:
172
False Positives:
330
False Negatives:
317
Sensitivity:
81.22
PPV:
80.60
Accuracy:
70.46

True Positives:
1418
True Negatives:
164
False Positives:
317
False Negatives:
291
Sensitivity:
82.97
PPV:
81.73
Accuracy:
72.24

True Positives:
1473
True Negatives:
239
False Positives:
266
False Negatives:
212
Sensitivity:
87.42
PPV:
84.70
Accuracy:
78.17

True Positives:
1504
True Negatives:
266
False Positives:
222
False Negatives:
198
Sensitivity:
88.37
PPV:
87.14
Accuracy:
80.82

True Positives:
1617
True Negatives:
425
False Positives:
71
False Negatives:
77
Sensitivity:
95.45
PPV:
95.79
Accuracy:
93.24

True Positives:
1675
True Negatives:
472
False Positives:
24
False Negatives:
19
Sensitivity:
98.88
PPV:
98.59
Accuracy:
98.04

True Positives:
1690
True Negatives:
481
False Positives:
10
False Negatives:
9
Sensitivity:
99.47
PPV:
99.41
Accuracy:
99.13

MSD vs # aa's MAD vs # aa's Acc vs # aa's Multiple MSD vs # aa's Multiple MAD vs # aa's Multiple Acc vs # aa's

MSD vs # aa's	MAD vs # aa's	Multiple MSD vs # aa's	Multiple MAD vs # aa's

MSD vs # aa's	MAD vs # aa's	Acc vs # aa's	Multiple MSD vs # aa's	Multiple MAD vs # aa's	Multiple Acc vs # aa's