Names Description YDR407C,TRS120 targeting complex (TRAPP) component involved in ER to Golgi membrane traffic YDR180W,SCC2 Sister chromatid cohesion protein YAR050W,FLO1,FLO2, FLO4 FLO5- and FLO8-determined flocculation are considerably less sensitive to mannose than FLO1-determined flocculation. YKL129C,MYO3 myosin I YOR328W,PDR10 Putative ABC transporter highly similar to Pdr5p YJR138W,IML1 Product of gene unknown YGR217W,CCH1 calcium channel YLR223C,IFH1 Interacts with fork head protein. Protein controlling pre-rRNA processing machinery in conjunction with Fhl1p YML104C,MDM1 Required for nuclear and mitochondrial transmission to daughter buds. YPR164W,MMS1,RTT108 sensitive to methyl methanesulfonate (MMS), diepoxybutane, and mitomycin C YJL080C,SCP160 May be required during cell division for faithful partitioning of the ER-nuclear envelope membranes, involved in control of mitotic chromsome transmission YML100W,TSL1 123 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex; homologous to TPS3 gene product YGR184C,UBR1,PTR1 Ubiquitin-protein ligase YKL105C Hypothetical ORF YDR170C,SEC7 Involved in protein transport at multiple stages of the secretory pathway YOR151C,RPB2,RPB150, RPO22, SIT2, SOH2 second largest subunit of RNA polymerase II YER155C,BEM2,IPL2, SUP9, TSL1 Protein with role in bud emergence YJR041C Protein required for cell viability YLR256W,HAP1,CYP1 Activator of CYC1 and CYP3 transcription; positive regulator of cytochrome C genes CYC1 and CYC7 YJL076W,NET1,ESC5, CFI1 Nucleolar protein involved in exit from mitosis YGL195W,GCN1 translational activator of GCN4 through activation of GCN2 in response to starvation YNL250W,RAD50 coiled-coil protein, contains a purine-binding domain, two heptad repeats and a hydrophobic tail YJR033C,RAV1 Regulator of (H+)-ATPase in vacuolar membrane YGR175C,ERG1 squalene epoxidase; an essential enzyme in the ergosterol-biosynthesis pathway; catalyzes the epoxidation of squalene to 2,3-oxidosqualene and is the specific target of the antifungal drug terbinafine. YPL219W,PCL8 PHO85 cyclin YGL253W,HXK2,HEX1, HKB, SCI2 Glucose phosphorylation YPR104C,FHL1 Putative transcriptional regulator of rRNA-processing genes YFL027C,GYP8 GAP for Ypt protein YJL214W,HXT8 High-affinity hexose transporter YPL030W Hypothetical ORF YER130C Hypothetical ORF YBR055C,PRP6,RNA6, TSM7269 RNA splicing factor YEL042W,GDA1 converts nucleoside diphosphates to nucleoside monophosphates to recycle nucleosides and promote transport of additional nucleotide sugars into golgi YLL004W,ORC3 Third subunit of the origin recognition complex YLL055W Hypothetical ORF YOR352W Hypothetical ORF YNL329C,PEX6,PAS8 Required for peroxisome assembly YPL248C,GAL4,GAL81 Positive regulator of GAL genes YGR225W,AMA1,SPO70 Required for sporulation, highly induced during sporulation; activator of meiotic anaphase promoting complex YLR095C,IOC2 Iswi One Complex YBL051C,PIN4 [PSI+] induction YKL127W,PGM1 phosphoglucomutase, minor isoform YPL208W Hypothetical ORF YCR045C Hypothetical ORF YGL203C,KEX1 Killer toxin and alpha factor precursor processing. Kex1p can cleave lys and arg residues from the C-terminus of peptides and proteins. YMR199W,CLN1 role in cell cycle START YJR093C,FIP1 component of a pre-mRNA polyadenylation factor that interacts with poly(A) polymerase YPL120W,VPS30,APG6, VPT30 Required for sorting and delivery of soluble hydrolases to the vacuole. YLR089C Hypothetical ORF YDR411C Hypothetical ORF YCL036W Great for FULL DEAD box protein activity YKR016W Hypothetical ORF YDL154W,MSH5 dispensable for DNA repair and meiotic intrachromosomal reciprocal recombination, required for full reciprocal recombination between homologs, and spore viability YDR279W Subunit of RNase H2 protein YBR080C,SEC18,ANU4 cytoplasmic protein involved in protein transport between ER and Golgi; ATPase YFL053W,DAK2 dihydroxyacetone kinase YGL212W,VAM7,VPS43 Regulator of vacuolar morphogenesis YNL256W,FOL1 folic acid synthesis YEL013W,VAC8,YEB3 An armadillo repeat-containing protein localized on the vacuolar membrane YKL174C Hypothetical ORF YCL045C Hypothetical ORF YAL036C,FUN11 Function Unknown Now; similar to Xenopus GTP-binding protein DRG YJL059W,YHC3,BTN1 Homolog of human CLN3. vacuolar/lysosomal membrane protein. YBR083W,TEC1,ROC1 transcription factor of the TEA/ATTS DNA-binding domain family, regulator of Ty1 expression YGL012W,ERG4 Sterol C-24 reductase YOL055C,THI20 THI for thiamine metabolism. Transcribed in the presence of low level of thiamine (10-8M) and turned off in the presence of high level (10-6M) of thiamine. Under the positive control of THI2 and THI3. YDR311W,TFB1 Component of transcription initiation factor IIb, 75 kDa subunit YCR084C,TUP1,AAR1, AER2, AMM1, CRT4, CYC9, FLK1, ROX4, SFL2, UMR7 general repressor of transcription (with Cyc8p); mediates glucose repression YMR300C,ADE4 phosphoribosylpyrophosphate amidotransferase YGL243W,TAD1 Deaminates adenosine-37 to inosine in eukaryotic tRNA-Ala. YGL059W Hypothetical ORF YOR269W,PAC1 Required for viability in the absence of the kinesin-related Cin8p mitotic motor. YHR118C,ORC6 origin recognition complex (ORC) component that binds to origins of replication and thereby directs DNA replication and is also involved in transcriptional silencing YKL008C,LAC1 Longevity-assurance gene 1 cognate (LAG1 cognate) YOL125W Hypothetical ORF YJL051W Hypothetical ORF YIL144W,TID3,NDC80, HEC1 Product of gene unknown YDR026C Hypothetical ORF YJR072C Protein required for cell viability YKR076W,ECM4 ExtraCellular Mutant YOR204W,DED1,SPP81 ATP-dependent RNA helicase of DEAD box family; suppressor of a pre-mRNA splicing mutation, prp8-1 YLR023C Hypothetical ORF YLR187W Hypothetical ORF YEL004W,YEA4 Shows sequence similarity to GOG5, a gene involved in vanadate resistance YMR319C,FET4 Putative transmembrane low-affinity Fe(II) transporter YPL091W,GLR1,LPG17 converts oxidized glutathine and NADPH into two glutathiones and NADP+ YMR140W,SIP5 Sip5 facilitates the interaction between the Reg1Glc7 phosphatase and the Snf1 kinase. YPL049C,DIG1,RST1 Down-regulator of Invasive Growth, Regulator of Sterile Twelve, binds Fus3 and Ste12 YFL055W The acronym may be misleading. AGP3 has not been shown to be a general amino acid permease with broad substrate specificity YOL140W,ARG8 Acetylornithine aminotransferase YCR014C,POL4,POLX Probable homolog of mammalian DNA polymerase beta; may function in double-stranded DNA break repair YBR068C,BAP2 contains 12 predicted transmembrane domains YNL206C,RTT106 Regulator of Ty1 Transposition - same phenotype as RTT101 - RTT105, disruption causes increase in Ty1 transposition. Isolated from the same screen as the other named RTT genes. YAL015C,NTG1,FUN33, SCR1 endonuclase III like glycosylase involved in DNA repair YOL058W,ARG1,ARG10 arginosuccinate synthetase YGL065C,ALG2 glycosyltransferase YOR088W - YPL230W Up in StarVation YOR155C,ISN1 Inosine 5'monophosphate Specific Nucleotidase YGL114W Hypothetical ORF YPL190C,NAB3,HMD1 May be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing YHR084W,STE12 Involved in pheromone and pseudohyphal growth signal transduction pathways YBR246W Hypothetical ORF YAL040C,CLN3,DAF1, FUN10, WHI1 role in cell cycle START; involved in G(sub)1 size control YOR251C catalyzes transfer of the sulfane atom of thiosulfate to cyanide to form sulfite and thiocyanate YGR200C,ELP2,TOT2 ELongator Protein 2; 90kD subunit; has WD40 repeats YBL013W,FMT1 Formyl-Methionyl-tRNA Transformylase (consistent with name of bacterial homologs) YIL101C,XBP1 DNA-binding transcriptional repressor YDR477W,SNF1,CAT1, CCR1, GLC2, HAF3, PAS14 Required for release from glucose repression, invertase expression, sporulation, and for expression of catabolite-repressed genes when glucose is limiting. Regulates Adr1-dependent transcription primarily at the level of chromatin binding. YDR294C,DPL1,BST1 dihydrosphingosine phosphate lyase (also known as sphingosine phosphate lyase) YOR317W,FAA1 cellular lipid metabolism and protein N-myristolation YLR135W,SLX4 - YBR284W Hypothetical ORF YJL193W Hypothetical ORF YER184C Hypothetical ORF YGL104C,VPS73 - YBL019W,APN2,ETH1 AP endonuclease 2, homolog of human HAP1 and E. coli exoIII YNL191W Hypothetical ORF YER108C - YOL132W,GAS4 Hypothetical ORF YCR066W,RAD18 Zn finger protein, putative ATPase YMR029C,FAR8 Pheromone Arrest YIL140W,AXL2,BUD10, SRO4 involved in polarity establishment/cellular polarization during budding YGL170C,SPO74 Sporulation YPL128C,TBF1,LPI16 TTAGGG repeat binding factor YJR134C,SGM1 involved in carbohydrate metabolism YDL078C,MDH3 malate dehydrogenase YNL001W,DOM34 an ORF of unknown function located in a centromeric region duplicated between chromosomes III and XIV (DOM34 homologue on chromosome III is a pseudogene) YJR061W Hypothetical ORF YGR186W,TFG1,SSU71, RAP74 transcription factor g -1 YLR045C,STU2 Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment. YER016W,BIM1,YEB1, EB1 Bim1p and Kar9p together make up the cortical microtubule-capture site. delays the exit from mitosis when the spindle is oriented abnormally. YPL045W,VPS16,SVL6, VAM9, VPT16 vacuolar sorting protein YKL062W,MSN4 Transcription factor. Multicopy suppressor of snf1 mutation. Key regulator of stress-responsive gene expression. YHR083W Protein required for cell viability YDR498C,SEC20 membrane glycoprotein, sorted by HDEL retrieval system YMR127C,SAS2 Protein involved in silencing HMR, homologous to acetyltransferases YHR009C Hypothetical ORF YBR186W,PCH2 Pachytene CHeckpoint YLR106C,MDN1,REA1 a large protein with a conserved N-terminal domain, a central AAA ATPase domain (with similarity to dynein) composed of 6 tandem AAA protomers, and a C-terminal M-domain containing MIDAS (Metal Ion Dependent Adhesion Site) sequence motifs. YDR023W,SES1 seryl-tRNA synthetase YBR212W,NGR1,RBP1 negative growth regulatory protein YLL057C similar to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; EC 1.14.11.17 YBR121C,GRS1 Glycyl-tRNA synthase YLR132C Protein required for cell viability YDR131C Hypothetical ORF YDR228C,PCF11 pre-mRNA cleavage and polyadenylation factor I component, interacts with Rna14p and Rna15p YDR085C,AFR1 coordinates regulation of alpha-factor receptor signalling and induction of morphogenesis during conjugation YLR203C,MSS51 Protein required for the maturation and translation of COX1 mRNA YBR279W,PAF1 RNA polymerase II-associated, nuclear protein that may serve as both a positive and negative regulator of a subset of genes, perhaps operating in parallel with Gal11p YNL085W,MKT1 Protein involved in propagation of M2 dsRNA satellite of L-A virus YEL056W,HAT2 subunit of histone acetyltransferase; may regulate activity of Hat1p, the catalytic subunit of histone acetyltransferase YDR522C,SPS2 Middle/late gene of meiosis YDR465C,RMT2 Protein Arginine Methyltransferase; R = arginine; MT = methyltransferase YMR234W,RNH1 ribonuclease H YDR317W Hypothetical ORF YNL181W Protein required for cell viability YGR091W,PRP31 pre-mRNA splicing protein YGR261C,APL6,YKS5 beta3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function YFL022C,FRS2 Phenylalanyl-tRNA synthetase, beta subunit, cytoplasmic YOR022C Hypothetical ORF YFR044C Hypothetical ORF YNR026C,SEC12,SED2 Required for recruitment of Sar1p and vesicle formation at the endoplasmic reticulum. YIL039W Hypothetical ORF YDR108W,GSG1,TRS85 Probably has role late in meiosis following DNA replication YMR201C,RAD14 Involved in nucleotide excision repair YGR109C,CLB6 role in DNA replication during S phase YNL315C,ATP11 essential for assembly of a functional F1-ATPase; binds the beta subunit of F1-ATPase. YDR105C,TMS1 Putative membrane protein, conserved in mammals YKL109W,HAP4 Regulates respiratory functions; encodes divergent overlapping transcripts YDR229W,IVY1 Phospholipid-binding protein that interacts with Vpt7p and Vps33p YMR315W Hypothetical ORF YGR163W,GTR2 (putative) small GTPase, similar to Gtr1 YNR003C,RPC34 34-kDa subunit of RNA polymerase III (C) YDR213W,UPC2,MOX4 involved in sterol uptake YLL012W Hypothetical ORF YDR394W,RPT3,YNT1, YTA2 probable 26S protease subunit and member of the CDC48/PAS1/SEC18 family of ATPases YNL187W Hypothetical ORF YOR211C,MGM1,MNA1 involved in the propagation of functional mitochondria yeast YDR388W,RVS167 The BAR adaptor proteins encoded by RVS167 and RVS161 form a complex that regulates actin, endocytosis, and viability following starvation or osmotic stress. YMR274C,RCE1 Protease involved in ras and a-factor terminal proteolysis YER114C,BOI2,BEB1 Protein which binds Bem1p and contains a proline-rich sequence, an SH3 domain, and a pleckstrin homology domain YOR230W,WTM1 WD repeat containing transcriptional modulator 1 YIL134W,FLX1 Nuclear-encoded mitochondrial protein involved in transport of flavine into mitochondria YOR373W,NUD1 Spindle pole body protein YGR052W Hypothetical ORF YNL126W,SPC98 Involved in microtubule organization by the SBP YHR146W,CRP1 Cruciform DNA Binding Protein 1 YLR277C,YSH1,BRR5 subunit of Polyadenylation factor I (PF I) YPR114W Hypothetical ORF YJL087C,TRL1,LIG1, RLG1 tRNA ligase YOL090W,MSH2,PMS5 Functions with Pms1p and Pms2/Mlh1p in a complex that interacts with Pms3p/Msh6p to repair single-base and insertion-deletion mispairs, or Msh3p to repair insertion-deletion mispairs. YGL001C,ERG26 one of three enzymatic activities required for the conversion of 4,4-dimethylzymosterol to zymosterol. YIL120W,QDR1 Quinidine Resistance YLR386W,VAC14 VACuole morphology and inheritance mutant. Vac14 is essential for the regulated synthesis of PtdIns(3,5)P(2), for control of trafficking of some proteins to the vacuole lumen via the MVB, and for maintenance of vacuole size and acidity. YBL035C,POL12 Required for DNA synthesis and correct progression through S phase; plays an essential role at early stage of chromosomal DNA replication, before the hydroxyurea-sensitive step YJR062C,NTA1,DEA1 Removes amide group from N-terminal asparagine and glutamine, to generate aspartate and glutamate, which are destabilizing terminal residues YOR298W Hypothetical ORF YGR150C Hypothetical ORF YJL176C,SWI3,TYE2 transcription factor YMR016C,SOK2 Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase YBR084W,MIS1 mitochondrial C1-tetrahydroflate synthase YLR085C,ARP6 Actin-related protein. Part of the carboxypeptidase Y pathway. YBL104C Hypothetical ORF YHR003C Hypothetical ORF YKL166C,TPK3 Involved in nutrient control of cell growth and division YMR165C,SMP2 involved in plasmid maintenance YDR297W,SUR2,SYR2 Possibly hydroxylates ceramide-1 at C-4 to give ceramide-2. Or, hydroxylates DHS at C-4 to give PHS, which is acylated to give ceramide-2. Not yet clear whether DHS or ceramide-1 is the preferred substrate. YLR276C,DBP9 Dead-Box Protein 9 YBR234C,ARC40 Arp2/3 complex subunit, 40 kilodalton YHR132C,ECM14 ExtraCellular Mutant YDR052C,DBF4,LSD7 Required for Cdc7 kinase activity YHR103W,SBE22 functionally redundant and similar in structure to SBE2 YMR062C,ECM40,ARG7 ExtraCellular Mutant YPL206C Hypothetical ORF YDR515W,SLF1,SRO99 Associates with translating ribosomes; may function in cytoplasm to modulate mRNA translation; regulates the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in medium containing copper salts YJL187C,SWE1,WEE1 Delays the onset of mitosis by phosphorylation and inactivation of the cyclin-dependent kinase Cdc28, thereby relaying the morphogenetic signal to the cell cycle. S. pombe wee1+ homolog YDR285W,ZIP1 Synaptonemal complex protein, component of the central element YHR190W,ERG9 squalene synthetase YMR167W,MLH1,PMS2 Required for mismatch repair in mitosis and meiosis, low levels of postmeiotic segregation, and high spore viability YAL020C,ATS1,FUN28, KTI13 Protein with similarity to human RCC1 protein YER017C,AFG3,YTA10 ATPase family gene YJR121W,ATP2 F(1)F(0)-ATPase complex beta subunit, mitochondrial YDR331W,GPI8 Protein involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins YKL143W,LTV1,YKL2 Protein required for viability at low temperature YMR297W,PRC1,LBC1 dispensable for haploidization and sporulation, but required for full protein degradation during sporulation YBR042C Hypothetical ORF YFL003C,MSH4 dispensable for DNA repair, required for full levels of reciprocal exchange and spore viability YLR088W,GAA1,END2 ER protein essential for attaching GPI (glycosylphosphatidylinositol) to protein YDR416W,SYF1 SYnthetic lethal with cdcForty YLR188W,MDL1 ATP-binding cassette (ABC) transporter family member YOL030W,GAS5 Hypothetical ORF YBR166C,TYR1 Step of tyrosine biosynthesis pathway YGR130C Hypothetical ORF YLR181C Vps20 associated YMR096W,SNZ1 Snooze: stationary phase-induced gene family; involved in cellular response to nutrient limitation and growth arrest YNL246W,VPS75 - YNL003C,PET8 Member of family of mitochondrial carrier proteins YMR069W Hypothetical ORF YGL020C,MDM39 Spore Wall Formation. Mitochondrial Distribution and Morphology YKR060W - YDL129W Hypothetical ORF YBR147W Hypothetical ORF YOR385W Hypothetical ORF YLR243W Protein required for cell viability YDR384C,ATO3 Ammonium Transport Outwards; member of the TC 9.B.33 YaaH family of putative transporters YDR361C Hypothetical ORF YHR046C,INM1 onophosphatase YCR010C,ADY2,ATO1 Accumulation of DYads; member of the TC 9.B.33 YaaH family of putative transporters YHR192W Hypothetical ORF YAL034W-A,MTW1,DSN3, NSL2 Mis TWelve like (a Schizosaccharomyces pombe kinetochore protein) YNL148C,ALF1 alpha-tubulin foldin; protein implicated in folding of alpha tubulin YBR257W,POP4 Required for normal 5.8S rRNA processing and for tRNA processing; associated with RNase MRP and RNase P YML025C Protein required for cell viability YEL005C,VAB2,VAB31 Vac8p binding protein of 31 kDa YNL032W,SIW14 Synthetic interaction with Whi2 YMR178W Hypothetical ORF YGR132C,PHB1 antiproliferative protein involved in determination of replicative life span YHR090C,YNG2,NBN1 Yeast homolog of mammalian Ing1 YPR016C,TIF6,CDC95 similar to human translation initiation factor 6 (eIF6); however, TIF6 does not act as a true translation initiation factor.The protein may be involved in the biogenesis and or stability of the 60S ribosomal subunits YFL038C,YPT1,YP2 involved in the secretion pathway at the ER-to-Golgi step; required for sporulation YEL072W Required for Meiotic nuclear Division YDL217C,TIM22 Mitochondrial inner membrane protein involved in import of proteins of the ADP/ATP carrier (AAC) family YGR081C Hypothetical ORF YHR147C,MRPL6 Mitochondrial ribosomal protein MRPL6 (YmL6) YLR145W Protein required for cell viability YFR043C Hypothetical ORF YIR024C (putative) involved in cell cycle control YAR028W Hypothetical ORF YHR071W,PCL5 PHO85 cyclin YMR090W Hypothetical ORF YOR064C,YNG1,YOR29-15 Yeast homolog of mammalian Ing1 YKR100C Hypothetical ORF YDR246W,TRS23 Trapp subunit of 23 kDa YDR275W,BSC2 Bypass of Stop Codon transcript encoded by this ORF shows a high level of stop codon bypass YNL036W,NCE103,NCE3 endogenous substrate for nonclassical export (Cleves et al. J Cell Biol 1996 133:1017-26). YIR030C,DCG1 Product of gene unknown YNL107W,YAF9 Yeast homolog of the human leukemogenic protein AF9; member of a yeast chromatin modifying complex YDL166C,FAP7 Nuclear protein involved in oxidative stress response YOL110W,SHR5,ERF4 Involved in RAS localization and palmitoylation YDL169C,UGX2 Product of gene unknown YHR081W Like an rRNA Processing protein. Homolog of mammalian C1D, which is a nuclear matrix protein involved in regulation of DNA repair and recombination. YIR017C,MET28 Transcriptional activator of sulfur amino acid metabolism YML098W,TAF13,FUN81, TAF19 TFIID subunit (TBP-associated factor) with predicted molecular weight of 19 kD. YDR178W,SDH4,ACN18 Yeast succinate dehydrogenase (SDH) is a tetramer of non-equivalent subunits--Sdh1p, Sdh2p, Sdh3p, Sdh4p--that couples the oxidation of succinate to the transfer of electrons to ubiquinone. YOR253W,NAT5,ARD2, ROG2 - YGL183C,MND1 needed for Meiotic Nuclear Divisions YHR093W,AHT1 the AHT1 DNA sequence is upstream of HXT4 and contains an HXT4 regulatory element which is a multicopy suppressor of glucose transport defects; probable non-functional ORF YML022W,APT1 Adenine phosphoribosyltransferase YGR273C Hypothetical ORF YDR441C,APT2 similar to adenine phosphoribosyltransferase; appears to be a nonfunctional pseudogene YLL059C Hypothetical ORF YMR042W,ARG80,ARGR1 Regulator of arginine-responsive genes with ARG81 and ARG82 YHR100C Hypothetical ORF YER112W,LSM4,SDB23, USS1 Like Sm-D3 protein YGR133W,PEX4,PAS2, UBC10 Involved in peroxisome biogenesis YJL104W Hypothetical ORF YDR512C Early Meiotic Induction YFR054C Hypothetical ORF YOR148C,SPP2 Required for final stages of splicesome maturation; promotes step 1 of splicing YJL160C Hypothetical ORF YGR131W Hypothetical ORF YML055W,SPC2,SPY1 subunit of signal peptidase complex, homologous to mammalian protein SPC25 YER084W Hypothetical ORF YKL049C,CSE4,CSL2 Required for proper kinetochore function; may be involved in assembly of a CEN-specific chromatin structure YOL109W Overexpression causes resistance to Zeocin YBL018C,POP8 Processing Of Precursors - a group of proteins that appear to be components of both RNase P and RNase MRP YBR013C Hypothetical ORF YDR015C Hypothetical ORF YKL031W Hypothetical ORF YMR057C Hypothetical ORF YGL015C Hypothetical ORF YML122C Hypothetical ORF YER057C,HMF1 Homologous Mmf1p factor YGR045C Hypothetical ORF YKL115C Hypothetical ORF YDR045C,RPC11 TFIIS-like small Pol III subunit C11 YLR255C Hypothetical ORF YBL044W Hypothetical ORF YGL121C,GPG1 G protein gamma. Gpg1 interacts with Gpa2, Gpb1 (YOR371c), and Gpb2 (YAL056w) in yeast two hybrid assays. The interaction between Gpa2 and Gpg1 is indirect and requires Gpb1 OR Gpb2. YEL033W Hypothetical ORF YFL034C-A,RPL22B,YFL035C-B Homology to rat L22 YLR297W Hypothetical ORF YDR157W Hypothetical ORF YDL242W Hypothetical ORF YHR162W Hypothetical ORF YMR273C,ZDS1,CES1, CKM1, NRC1, OSS1 Negative regulator of cell polarity YML010W,SPT5 transcription factor YOR168W,GLN4 glutaminyl-tRNA synthetase YGR187C,HGH1 HMG1/2 homolog YBL007C,SLA1 Involved in assembly of cortical actin cytoskeleton, contains 3 SH3 domains, interacts with Bee1p YFR055W Hypothetical ORF YDR466W Hypothetical ORF YDR444W Hypothetical ORF YIL159W,BNR1 Bni1p-related protein, helps regulate reorganization of the actin cytoskeleton, potential target of Rho4p YNL169C,PSD1 Converts phosphatidylserine to phosphatidylethanolamine. Mitochondrial Psd1p provides ~90% of total cellular phosphatidylserine decarboxylase activity. YDL220C,CDC13,EST4 Regulator of telomere replication. Recruits telomerase to the telomere. Required for G2/M transition in mitosis, synaptonemal complexes, recombination, meiosis I, meiosis II, and spores. Dispensable for premeiotic DNA synthesis. YFL023W,BUD27 Function required for yeast viability on toxin exposure YBL076C,ILS1 cytoplasmic isoleucyl-tRNA synthetase YGR177C,ATF2 Alcohol acetyltransferase YOR365C Hypothetical ORF YJL141C,YAK1 Serine-threonine protein kinase YLR425W,TUS1,SOP10 TOR Unique function Suppressor; exchange factor for RHO1 YDR145W,TAF12,TAF61, TAF68 TFIID subunit (TBP-associated factor) with predicted molecular weight of 61 kD. YMR172W,HOT1 high osmolarity induced transcription YFL042C Due to a sequence change (deletion of G at 46151), YFL043C is now part of YFL042C. YIL151C Hypothetical ORF YCR048W,ARE1,SAT2 Acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) YOR378W Hypothetical ORF YLL019C,KNS1,L124 protein kinase homolog YMR306W,FKS3 Protein with similarity to Gls1p and Gls2p (GB:Z49212) YER190W,YRF1-2,YRF1 Y'-helicase protein 1 YFL066C Hypothetical ORF YCL073C Hypothetical ORF YFL002W-A TyB Gag-Pol protein YBR093C,PHO5 Acid phosphatase, repressible YDL244W,THI13 Product of gene unknown YCL020W TyA Gag protein YFR024C-A,LSB3,YFR024C LAs17 Binding protein YDR012W,RPL4B Highly similar to ribosomal protein L4A YCL069W Hypothetical ORF YMR323W Hypothetical ORF YPR080W,TEF1 translational elongation factor EF-1 alpha YAL005C,SSA1,YG100 Stress-seventy subfamily A YLR432W,IMD3 IMP dehydrogenase homolog YNL336W,COS1 Protein with similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p. might specify receptor of the Cdc1 (and Mn2+?)-dependent growth process. YPL281C,ERR2 enolase-related subtelomeric sequence (ERR1 and ERR2 code for identical proteins) YBL113C Hypothetical ORF YNL209W,SSB2 stress-seventy subfamily B YNL018C Hypothetical ORF YGR295C,COS6 Protein with strong similarity to other subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p YFL058W,THI5 proposed biosynthetic enzyme involved in pyrimidine biosynthesis pathway above the hydroxymethyl-pyrimidine precursor leading to the thiaminemoiety YGR034W,RPL26B Homology to rat L26 YLR162W- - YJR037W Hypothetical ORF YMR325W Hypothetical ORF YGL217C Hypothetical ORF YER131W,RPS26B Homology to rat S26 YKR040C Hypothetical ORF YKL223W Hypothetical ORF YDR426C Hypothetical ORF YHL045W Hypothetical ORF YPR177C Protein required for cell viability YDR542W Hypothetical ORF YLR367W,RPS22B Homology to rat S15a YKL053W Hypothetical ORF YOR169C Protein required for cell viability YMR153C-A Hypothetical ORF YCL065W Hypothetical ORF YLR217W Hypothetical ORF YPL136W Hypothetical ORF YDR442W Hypothetical ORF YLL047W Hypothetical ORF YMR075C-A Hypothetical ORF YGL109W Hypothetical ORF YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YMR317W Hypothetical ORF YNL192W,CHS1,USA4 disrupts mating and sporulation efficiently YPR117W Hypothetical ORF YNL102W,POL1,CDC17, CRT5, HPR3 Required for mitotic DNA synthesis, premeiotic DNA synthesis, recombination, and full sporulation YNR016C,ACC1,ABP2, FAS3 acetyl-CoA carboxylase YMR229C,RRP5 Part of small ribosomal subunit (SSU) processosome (contains U3 snoRNA). Rrp5p is the only ribosomal RNA processing trans-acting factor that is required for the synthesis of both 18S and 5.8S rRNAs. YDR038C,ENA5 Na(+) ATPase YFR016C Hypothetical ORF YGL131C Hypothetical ORF YHR119W,SET1,YTX1 Gene has a 'SET' or 'TROMO' domain at its carboxyterminus like the trithorax gene family from human and Drosophila with postulated function in chromatin-mediated gene regulation. YLR278C Hypothetical ORF YER111C,SWI4,ART1 Involved in cell cycle dependent gene expression YOL081W,IRA2,CCS1, GLC4 Negatively regulates cAPK by antagonizing CDC25 YOR124C,UBP2 Ubiquitin-specific protease YML103C,NUP188 Localized at both the cytoplasmic and nucleoplasmic faces of the nuclear pore complex (NPC); may form the octagonal core structure of NPC YBL101W-B TyB Gag-Pol protein YAL001C,TFC3,FUN24, TSV115 transcription factor tau (TFIIIC) subunit 138 YBR140C,IRA1,GLC1, PPD1 Inhibitory regulator of the RAS-cAMP pathway, negatively regulates cAPK by antagonizing CDC25 YIL026C,IRR1,SCC3 Irregular; involved in sister chromatid cohesion YGR218W,CRM1,KAP124, XPO1 Involved in nuclear export YNL087W Hypothetical ORF; has similarity to YOR086c YJR027W TyB Gag-Pol protein YOR128C,ADE2 phosphoribosylamino-imidazole-carboxylase YHR131C Hypothetical ORF YGL234W,ADE5,7 glycinamide ribotide synthetase and aminoimidazole ribotide synthetase YKL019W,RAM2 CAAX farnesyltransferase alpha subunit YAR014C,BUD14 - YDR080W,VPS41,CVT8, FET2, SVL2, VAM2, VPL20 vacuolar protein sorting YLR142W,PUT1 proline oxidase YLL007C Hypothetical ORF YGR274C,TAF1,TAF130, TAF145 TAFII complex component required for activated transcription YOR018W,ROD1 Resistance to o-dinitrobenzene, calcium, and zinc YJR052W,RAD7 Nucleotide excision repair protein involved in G(sub)2 repair of inactive genes YGL245W Protein required for cell viability YNL240C,NAR1 Nuclear architecture related protein with homology to human Narf (Nuclear prelamin A Recognition Factor) YNR033W,ABZ1 para-AminoBenZoic acid (PABA) biosynthesis; contains regions of homology to both the pabA and pabB genes of E. coli YLR258W,GSY2 Highly similar to GSY1. GSY2 is the predominantly expressed glycogen synthase. Activity is probably regulated by cAMP-dependent and SNF1 protein kinases and type 1 phosphatase YDR171W,HSP42 Similar to HSP26; expression is regulated by stress conditions YPR008W,HAA1 Homolog of Ace1 Activator YMR015C,ERG5 cytochrome P450 involved in C-22 denaturation of the ergosterol side-chain YOR375C,GDH1,URE1, GDH-A, GDHA NADP-specific glutamate dehydrogenase YBL098W,BNA4 Biosynthesis of Nicotinic Acid YDR044W,HEM13 Oxygen-repressed, sixth step in heme biosynthetic pathway YGL083W,SCY1 Suppressor of GTPase mutant YLR440C Protein required for cell viability YAL054C,ACS1,FUN44 one of 2 acetyl-coA synthetases in yeast YML130C,ERO1 essential, FAD-dependent oxidase of protein disulfide isomerase YIL146C,ECM37 ExtraCellular Mutant YJR124C Hypothetical ORF YIR027C,DAL1 allantoinase YDL178W,DLD2,AIP2 D-lactate dehydrogenase, located in mitochondrial matrix YOL091W,SPO21,MPC70 sporulation defective YLR082C,SRL2 Suppressor of Rad53 null Lethality YMR213W,CEF1 homolog of S. pombe cdc5+. c-Myb DNA binding motif at amino terminus is required for cellular growth but not for interaction of Cef1p with Prp19p. YLR116W,MSL5,BBP branchpoint bridging protein -- component of the splicing commitment complex YDR074W,TPS2,HOG2, PFK3 Trehalose-6-phosphate phosphatase YLR244C,MAP1 methionine aminopeptidase YOR190W,SPR1,SSG1 Sporulation regulated genes YMR244W Hypothetical ORF YPR133C,IWS1,SPN1 Interacts with Spt6 YMR164C,MSS11 Multicopy Suppressor of STA10 - 11 YHR168W Hypothetical ORF YOR359W,VTS1 uppressor YPL254W,HFI1,ADA1, SUP110 Transcription factor involved in global regulation of gene expression YNL118C,DCP2,PSU1 Mrna Decapping. essential suppressor of the respiratory deficiency of a pet mutant YDR505C,PSP1,GIN5 high-copy suppressor of cdc17 DNA polymerase alpha mutations YNL025C,SSN8,GIG3, NUT9, SRB11, UME3, RYE2 Component of RNA polymerase II holoenzyme, involved in RNA pol II carboxy-terminal domain phosphorylation. Activity of the kinase (SSN3)/cyclin (SSN8) pair required, along with SSN6 & TUP1, for transcriptional repression of a-specific genes YJL054W,TIM54 Translocase Inner Membrane, 54kD YKL113C,RAD27,ERC11, RTH1 DNA repair protein that belongs to the RAD2(pombe)/FEN1 subfamily YKR063C,LAS1 May regulate expression of genes involved in bud formation and morphogenesis YLL026W,HSP104 plays a major role in the acquisition of tolerance to a variety of stresses such as heat, ethanol, and sodium arsenite, inheritance of [PSI+], and reactivation of mRNA splicing after heat shock. YBR215W,HPC2 Protein required for normal cell-cycle regulation of histone gene transcription YOR320C GlcNAc transferase YML119W Hypothetical ORF YNL261W,ORC5 May be subunit of origin recognition complex (ORC) that mediates the ATP-dependent binding to origins; the ORC binds to origins of replication and thereby directs DNA replication and is also involved in transcriptional silencing YNL041C,COG6,COD2 Complexed with Cog8p; interacts with Cog2p YGR087C,PDC6 Third, minor isozyme of pyruvate decarboxylase YDR088C,SLU7,SLT17 Involved in 3' splice site choices and acts in concert with Prp18 during the 2nd step of splicing. YPR003C Hypothetical ORF YOL018C,TLG2 member of the syntaxin family of t-SNAREs YOR254C,SEC63,PTL1 Protein involved in protein import into ER YOR370C,MRS6,MSI4 protein of the TCD/MRS6 family of GDP dissociation inhibitors (Rab escort protein) YHR017W,YSC83 similar to S. douglasii YSD83 YDR524C,AGE1,SAT1 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector YDR181C,SAS4 Involved in silencing at telomeres, HML and HMR YPR135W,CTF4,CHL15, POB1 Has a role in regulating DNA replication complexes. YBR039W,ATP3 participates in catalysis of ATP hydrolysis/synthesis and in the assembly/stability of F1 YPR148C Hypothetical ORF YHR207C,SET5 - YGR077C,PEX8,PAS6 Required for peroxisome assembly YFR013W,IOC3 Iswi One Complex YER156C Hypothetical ORF YDR198C Hypothetical ORF YOL020W,TAT2,LTG3, SAB2, SCM2, TAP2 Tryptophan permease, high affinity YLR352W Hypothetical ORF YLR173W Hypothetical ORF YDR249C Hypothetical ORF YHR033W Hypothetical ORF YDR299W,BFR2 involved in protein transport step at the Brefeldin A blocks YOR237W,HES1,OSH5 Protein implicated in ergosterol biosynthesis YMR276W,DSK2 Required with RAD23 for duplication of the spindle pole body YMR061W,RNA14 Protein with a role in mRNA stability and/or poly(A) tail length YHL002W,HSE1 Has Symptoms of class E vps mutant YJL056C,ZAP1,ZRG10 Zinc-regulated DNA binding protein involved in zinc ion homeostasis YDR380W,ARO10 - YPL104W,MSD1,LPG5 Aspartyl-tRNA synthetase, mitochondrial YKL204W,EAP1 Translation initiation factor eIF-4E associated protein YKR010C,TOF2 topoisomerase I interacting factor 2 YIL142W,CCT2,BIN3, TCP2 cytoplasmic chaperonin of the Cct ring complex related to Tcp1p; subunit beta YBR179C,FZO1 may be involved in mitochondrial fusion YPL269W,KAR9 cortical protein required for cytoplasmic microtubule orientation; Bim1p and Kar9p make up the cortical microtubule-capture site. localizes to shmoo tips and the tips of budding cells in a cell-cycle dependent manner. YOR132W,VPS17,PEP21 Peripheral membrane protein required for vacuolar protein sorting YMR303C,ADH2,ADR2 Glucose-repressible alcohol dehydrogenase II catalyzes activities for the production of certain carboxylate esters. YPL017C Hypothetical ORF YOR271C Hypothetical ORF YLR027C,AAT2,ASP5 aspartate aminotransferase, cytosolic YHR101C,BIG1 bad in glucose or big cells YBL045C,COR1,QCR1 44 kDa core protein of yeast coenzyme QH2 cytochrome c reductase YHR109W,CTM1 cytochrome c trimethylase YDL126C,CDC48 Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; full length homology to mammalian protein VCP; involved in secretion, peroxisome formation and gene expression YOR351C,MEK1,MRE4 Disp. for chr. pairing & chr. condensation seen by in situ hybrid. Required for full double strand breaks, normal length synaptonemal complexes, meiotic recomb. & spore viability. mek1 is rescued by spo13 & in early recomb. function YML032C,RAD52 Required for X-ray damage repair & various types of intra- and interchr. mitotic recombination, including HO switching & plasmid exchange. Disp. for premeiotic DNA synthesis, double strand breaks & heteroduplex formation. YKL146W,AVT3 related to the neuronal gamma -ransporters YBR053C Hypothetical ORF YLR097C - YDR421W,ARO80 - YPR163C,TIF3,RBL3, STM1 Suppressor of translation mutants YLR183C,TOS4 Target of SBF YDL057W Hypothetical ORF YML050W Hypothetical ORF YGR040W,KSS1 Recovery from alpha factor arrest YDL106C,PHO2,BAS2, GRF10 Regulation of phosphate metabolism YBR038W,CHS2 chitin synthase 2 YMR026C,PEX12,PAS11 Pex2p, Pex10p, and Pex12p together make up the RING finger complex of the peroxisomal import machinery. YDL176W Hypothetical ORF YMR028W,TAP42 Two A phosphatase Associated Protein, apparant MW of 42 kDA YBR141C Hypothetical ORF YLR172C,DPH5 diphthamide biosynthesis YEL011W,GLC3,GHA1 Glycogen branching enzyme YAL013W,DEP1,FUN54 Regulator of phospholipid metabolism YGR266W probably contains a single transmembrane span YOL044W,PEX15,PAS21 44 kDa phosphorylated integral peroxisomal membrane protein YDR194C,MSS116 Mitochondrial RNA helicase of the DEAD box family necessary for splicing of several mt introns. YLR328W,NMA1 NAD(+) salvage pathway YGL111W,NSA1 Nop seven associated YBR057C,MUM2,SPOT8 Muddled Meiosis YJR010W,MET3 one of three genes essential for assimilatory reduction of sulfate to sulfide w/sulfite as an intermediate product. catalyzes the reaction of inorganic sulfate w/ATP to form adenosine-5'-phosphosulfate (APS) and pyrophosphate (PPi). YPR120C,CLB5 role in DNA replication during S phase; additional functional role in formation of mitotic spindles along with Clb3 and Clb4 YER037W,PHM8 involved in phosphate metabolism YNL035C Hypothetical ORF YJR004C,SAG1,AG alpha-agglutinin YCL018W,LEU2 leucine biosynthesis YLR139C,SLS1 Protein involved in mitochondrial gene expression, may facilitate translation by delivering mRNAs to membrane-bound translational activation complexes YCR037C,PHO87 May collaborate with Pho86p and Pho84p in inorganic phosphate uptake; protein contains 12 predicted transmembrane domains YFR005C,SAD1 Product of gene unknown YPR018W,RLF2,CAC1 Chromatin Assembly Complex, subunit 1: largest (p90) subunit of three-subunit protein complex (yeast CAF-I) involved in DNA-replication-linked nucleosome assembly. Homol. to p150 subunit human Chromatin Assembly Factor-I (CAF-I) YKL108W,SLD2,DRC1 Synthetically lethal with dpb11-1; required for DNA replication YDL234C,GYP7 GTPase-activating protein YLR312C Hypothetical ORF YDR072C,IPT1,SYR4 necessary for synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C) YBR155W,CNS1 cyclophilin seven suppressor YIR031C,DAL7,MLS2, MSL2 allantoin pathway YOR221C,MCT1 malonyl-CoA:ACP transferase YIR007W Hypothetical ORF YPL179W,PPQ1,SAL6 May play role in regulation of translation YKL183W,LOT5 LOw Temperature responsive YPL026C,SKS1,SHA3 multicopy suppressor of snf3 and grr1 mutants YKL221W,MCH2 monocarboxylate permease homologue YBR130C,SHE3 cytoplasmic protein involved in mother-specific HO expression YJL213W Hypothetical ORF YGL060W Peroxide Stress Control YLR090W,XDJ1 Homolog of E. coli DnaJ, closely related to Ydj1p YPL151C,PRP46 protein required for pre-mRNA splicing in vivo, WD-protein homologous to Arabidopsis thaliana pleiotropic regulators PRL1 and PRL2 YLR433C,CNA1,CMP1 calmodulin binding protein homologous to mammalian calcineurin YCR015C Hypothetical ORF YKL051W,SFK1 Suppressor of PI Four Kinase YGL134W,PCL10 PHO85 cyclin YML019W,OST6 Putative new 37kDa subunit of N-oligosaccharyltransferase complex YBR276C,PPS1 Protein Phosphatase S phase YML127W,RSC9 Remodels the Structure of Chromatin YDR206W,EBS1 EST1-like bcy1 Suppressor YLR318W,EST2 ever shorter telomeres YNR006W,VPS27,GRD11, SSV17, VPL23, VPL27, VPT27, DID7 hydrophilic protein; has cysteine rich putative zinc finger esential for function YBR198C,TAF5,TAF90 TAF(II) complex (TBP-associated protein complex) component required for activated transcription by RNA polymerase II YKR072C,SIS2,HAL3 Involved in cell cycle control and ion homeostasis YOR324C Hypothetical ORF YGL146C Hypothetical ORF YOR019W Hypothetical ORF YCR053W,THR4 threonine synthase YLR060W,FRS1 Phenylalanyl-tRNA synthetase, alpha subunit, cytoplasmic YPL174C,NIP100,PAC13 Nuclear import protein YGR007W,MUQ1,ECT1 choline phosphate cytidylyltransferase (also called phosphoethanolamine cytidylyltransferase or phosphocholine cytidylyltransferase) YBL058W,SHP1 isolated as a suppressor of the lethality caused by overexpression of the phosphoprotein phosphatase 1 catalytic subuniut encoded by GLC7 YOR141C,ARP8 actin-related protein YDL210W,UGA4 GABA-specific transport protein YLR447C,VMA6 vacuolar ATPase V0 domain subunit d (36 kDa) YPL207W Hypothetical ORF YCR077C,PAT1,MRT1 Necessary for accurate chromosome transmission during cell; Involved in mRNA turnover YPL070W Hypothetical ORF YDR234W,LYS4,LYS3 homoaconitase YMR019W,STB4 binds Sin3p in two-hybrid assay YPR105C,COG4,SEC38, COD1 Complexed with Cog8p YHR031C,RRM3,RTT104 involved in rDNA replication and Ty1 transposition YDR036C,EHD3,MRP5 3-hydroxyisobutyryl-CoA hydrolase with similarity to enzymes involved in fatty a cid beta-oxidation YMR318C,ADH6,ADHVI NADPH-dependent alcohol dehydrogenase YPL168W Hypothetical ORF YDL052C,SLC1 fatty acyltransferase homologous to E. coli plsC gene; functionally complements plsC mutants YGL044C,RNA15 Protein with a role in mRNA stability and/or poly(A) tail length YPR192W,AQY1 Aquaporin YOL056W,GPM3 converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis YNL071W,LAT1,ODP2, PDA2 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex YLR257W Hypothetical ORF YMR055C,BUB2,PAC7 Protein required for cell cycle arrest in response to loss of microtubule function YNL063W - YGR104C,SRB5 subunit of RNA polymerase II holoenzyme/mediator complex YNL166C,BNI5 bud neck involved; localizes to mother-bud neck in a septin-dependent manner; bni5 shows synthetic enhancement of septin Ts- mutant phenotypes. YOL094C,RFC4 RFC is a DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA YGL081W Hypothetical ORF YCL016C,DCC1 Defective in sister Chromatid Cohesion YDR151C,CTH1 putative transcription factor YNR034W,SOL1 Multicopy Suppressor Of los1 YOL059W,GPD2,GPD3 Involved in glycerol production via conversion of glyerol-3-phosphate and NAD+ to glycerol phosphate and NADH YHR195W,NVJ1,VAB36 Vac8p binding protein; nucleus-vacuole junction YBR002C,RER2 cis-prenyltransferase involved in dolichol synthesis YLR146C,SPE4 Spermine Synthase YML125C Protein required for cell viability YGL136C,MRM2 Mitochondrial rRNA Methyltransferase; methylates the 21S (mitochondrial) rRNA at position U2791 YPL163C,SVS1 involved in vanadate resistance YJL035C,TAD2 tRNA-specific adenosine-34 deaminase subunit Tad2p YLR298C,YHC1 U1 snRNP protein required for pre-mRNA splicing YGR280C,PXR1,PINX1, GNO1 PinX1-Related gene G-patch NucleOlar protein YAL049C Hypothetical ORF YGL046W - YML014W tRNA methyltransferase YDR162C,NBP2 interacts with Nap1, which is involved in histone assembly YDL043C,PRP11,RNA11 snRNA-associated protein YGL174W,BUD13,CWC26 - YJR024C Hypothetical ORF YMR193W,MRPL24,YML14, YML24 Mitochondrial ribosomal protein MRPL24 (YmL24) YEL018W Esa1p-Associated Factor-5 YLR046C Hypothetical ORF YJR116W Hypothetical ORF YOL009C,MDM12 Required for normal mitochondrial morphology and distribution YPR167C,MET16 3'phosphoadenylylsulfate reductase YER031C,YPT31,YPT8 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment YKR006C,MRPL13,YK105, YML13 mitochondrial ribosomal protein YmL13 YBR187W Hypothetical ORF YGL154C,LYS5 Converts inactive apo-form of Lys2p (alpha-aminoadipate semialdehyde reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine. (Has been called small subunit of alpha-aminoadipate reductase.) YLR093C,NYV1,MAM2 Synaptobrevin (v-SNARE) homolog involved in vacuolar vesicle fusion YPL199C Hypothetical ORF YER063W,THO1 Suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O) YLR407W Hypothetical ORF YBL102W,SFT2 similar to mammalian syntaxin 5 YNL310C Protein required for cell viability YJL001W,PRE3,CRL21 Responsible for the postacidic activity of the yeast 20S proteasome, and necessary for hydrolysis of peptidylglutamyl-peptide. YDR078C Suppressor of hydroxy-urea sensitivity YJL148W,RPA34 RNA polymerase I subunit, not shared (A34.5) YCR051W Hypothetical ORF YHR057C,CPR2,CYP2 Human cyclophilin B protein YOR016C,ERP4 Emp24p/Erv25p related protein 4 YOR236W,DFR1 dihydrofolate reductase YFL005W,SEC4,SRO6 Secretory vesicle associated Rab GTPase that binds to Sec15p and is essential for exocytosis YJL037W Hypothetical ORF YGR129W,SYF2 SYnthetic lethal with cdcForty YLR356W Hypothetical ORF YER079W Hypothetical ORF YOR131C Hypothetical ORF YLR011W,LOT6 LOw Temperature responsive YLR293C,GSP1,CNR1, CST17 maintenance of nuclear organization; homologous to mammalian Ran, a small nuclear GTPase of the ras superfamily YPR165W,RHO1 Gtp-binding protein of the rho subfamily of ras-like proteins YFR008W,FAR7 Pheromone Arrest YKL144C,RPC25,YKL1 Subunit of RNA polymerase III YOL008W Hypothetical ORF YML078W,CPR3,CYP3 cyclophilin-3 (cyclosporin-sensitive proline rotamase-3) YPL144W Hypothetical ORF YDL219W,DTD1 D-Tyr-tRNA(Tyr) deacylase YCR099C Hypothetical ORF YCR046C,IMG1 Required for respiration and maintenance of mitochondrial genome YCL001W-A Hypothetical ORF YAL033W,POP5,FUN53 Processing Of Precursors - refer to a group of proteins that appear to be components of both RNase P and RNase MRP YKL016C,ATP7 ATP synthase d subunit YGR174C,CBP4 Essential for the expression and activity of ubiquinol-cytochrome c reductase YDR163W,CWC15 Complexed with Cef1p YER085C Hypothetical ORF YDR064W,RPS13,RPS13B, RPS13C Homology to rat S13 YJL122W Hypothetical ORF YBR047W Hypothetical ORF YLR074C,BUD20 - YEL035C,UTR5 Product of gene unknown YGR030C,POP6 Processing Of Precursors - a group of proteins that appear to be components of both RNase P and RNase MRP YLR010C,TEN1 protein involved in Telomeric pathways in association with Stn1 YKL122C,SRP21 part of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane YDR540C Hypothetical ORF YBR022W Hypothetical ORF YCL033C Hypothetical ORF YGR243W Hypothetical ORF YLR042C Hypothetical ORF YOL160W Hypothetical ORF YDL039C,PRM7 pheromone-regulated membrane protein YCR060W Hypothetical ORF YFL019C Hypothetical ORF YIL054W Hypothetical ORF YLR204W,QRI5 Product of gene unknown YMR193C-A Hypothetical ORF YOL005C,RPB11 RNA polymerase II subunit, homologous to S. pombe Rpb11p subunit YGR164W Hypothetical ORF YJL173C,RFA3 RFA1, RFA2, and RFA3 make up RPA YDR031W Hypothetical ORF YMR141C Hypothetical ORF YLR275W,SMD2 U1 snRNP protein of the Sm class YDR378C,LSM6 Like Sm-F protein YJR108W,ABM1 aberrant microtubules YBR209W Hypothetical ORF YMR103C Hypothetical ORF YPL080C Hypothetical ORF YOL026C Protein required for cell viability YGR069W Hypothetical ORF YMR122C Hypothetical ORF YDR357C Hypothetical ORF YNL111C,CYB5 cytochrome b5 YGR215W,RSM27 mitochondrial ribosome small subunit component YDL159W,STE7 Serine/threonine/tyrosine protein kinase of the pheromone pathway, homologous to MAP kinase kinase family YLR100W,ERG27 3-keto sterol reductase YPL113C Putative dehydrogenase YMR263W,SAP30 - YPL273W,SAM4 AdoMet-homocysteine methyltransferase YGL153W,PEX14 Peroxisomal peripheral membrane protein (peroxin) involved in import of peroxisomal matrix proteins YOR136W,IDH2 NAD+-dependent isocitrate dehydrogenase YJR070C Hypothetical ORF YGR159C,NSR1,SHE5 nuclear localization sequence binding protein YHR022C Hypothetical ORF YDR534C,FIT1 FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylphosphatidylinositol anchors. YMR052W,FAR3 Required for arrest in G1 in response to pheromone YBR205W,KTR3 Putative alpha-1,2-mannosyltransferase YJL023C,PET130 Nuclear gene encoding mitochondrial protein YNL175C,NOP13 Nucleolar Protein 13 YOR281C,PLP2 Phosducin-like protein YJL026W,RNR2,CRT6 small subunit of ribonucleotide reductase YLR357W,RSC2 RSC2 is a member of RSC complex, which Remodels the Structure of Chromatin. Also essential for the 2-micron plasmid to overcome maternal inheritance bias. YOR042W Hypothetical ORF YNL227C Hypothetical ORF YKL052C,ASK1 inetochores YPR078C Hypothetical ORF YJL066C,MPM1 mitochondrial membrane protein YHR174W,ENO2 enolase YJR028W Ty ORF YDL243C,AAD4 high degree of similarity with the AAD of P. chrysosporium YML063W,RPS1B,PLC2, RP10B Homologous to rat ribosomal protein S3A YHL033C,RPL8A,MAK7 Homolgous to human L7a, mouse L7a, and rat L7a YPR202W similar to other subtelomerically-encoded proteins YBR031W,RPL4A Homology to rat L4, Xenopus L1, Drosophila L1 YMR051C TyA Gag protein YOL051W,GAL11,RAR3, SDS4, SPT13 Regulates transcription of a diverse array of genes. Required for mating and sporulation. YPL275W,FDH2 Homologous to FDH1 YIL018W,RPL2B,RPL5A, LOT2 Homology to rat L8 and E. coli L2. Low Temperature-responsive. YLR462W Hypothetical ORF YNR073C Hypothetical ORF YNL333W,SNZ2 Snooze: stationary phase-induced gene family YAR033W Multicopy suppressor of Sec Twenty one YMR322C - YFL060C,SNO3 SNZ3 proximal ORF, stationary phase induced gene family YJL225C Hypothetical ORF YBL101W-A TyA Gag protein YNL019C Hypothetical ORF YNL228W Hypothetical ORF YLR464W Hypothetical ORF YOL046C Hypothetical ORF YOR366W Hypothetical ORF YDL041W Hypothetical ORF YPL249C-A,RPL36B Homology to rat L36 YJL032W Protein required for cell viability YJL119C Hypothetical ORF YMR326C Hypothetical ORF YOR053W Hypothetical ORF YDR112W Hypothetical ORF YOR135C Hypothetical ORF YNL030W,HHF2 Histone H4 (HHF1 and HHF2 code for identical proteins) YBR174C Hypothetical ORF YLR444C Hypothetical ORF YBL112C Hypothetical ORF YAR060C Hypothetical ORF YBR206W Hypothetical ORF YKL111C Protein required for cell viability YDL011C Hypothetical ORF YDR203W Hypothetical ORF YJL202C Protein required for cell viability YLR232W Hypothetical ORF YIL171W,HXT12 High level of sequence similarity to HXT1 and HXT9 hexose transporters YCR041W Hypothetical ORF YDR269C Hypothetical ORF YMR321C Hypothetical ORF YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YGL197W,MDS3 Mck1 Dosage Suppressor 3; negative regulator of early meiotic gene expression YKL010C,UFD4 Ubiquitin Fusion Degradation YMR207C,HFA1 Similar to acetyl-coenzyme A carboxylase YFL007W,BLM3 bleomycin resistance YDR464W,SPP41 appears to control expression of spliceosome components PRP4 and PRP3 YHR164C,DNA2,WEB2 DNA replication helicase YNL106C,INP52,SJL2 Synaptojanin-like protein YDR293C,SSD1,CLA1, MCS1, RLT1, SRK1 Product of gene unknown YJL092W,HPR5,RADH, RADH1, SRS2 Required for proper timing of committment to meiotic recombination and the transition from Meiosis I to Meiosis II YPL137C Hypothetical ORF YJR109C,CPA2 carbamyl phosphate synthetase YDR097C,MSH6,PMS3 Required for mismatch repair in mitosis & meiosis, low levels of postmeiotic segregation & high spore viability; forms complex with Msh2p to repair both single-base & insertion-deletion mispairs; redundant with Msh3p in repair of in-dels YMR129W,POM152 May be involved in duplication of nuclear pores and nuclear pore complexes during S-phase YOL138C Hypothetical ORF YDL215C,GDH2,GDH-B, GDHB NAD-dependent glutamate dehydrogenase YJR140C,HIR3,HPC1 Involved in cell-cycle regulation of histone transcription YKR102W,FLO10 Protein with similarity to flocculation protein Flo1p YNL262W,POL2,DUN2 DNA polymerase II YNL339C,YRF1-6,YRF1 Y'-helicase protein 1 YKR103W New Full-length MRP-type Transporter ORFs YKR103W and YKR104W are merged in different strain backgrounds. YBL017C,PEP1,VPS10, VPT1 vacuolar protein sorting receptor for carboxypeptidase Y and proteinase A; related to Sortilin YIL126W,STH1,NPS1 helicase related protein, snf2 homolog YLL015W,BPT1 bile pigment transporter YDL058W,USO1,INT1 involved intracellular protein transport, coiled-coil protein necessary for protein transport from ER to Golgi YOL070C Hypothetical ORF YKR089C Hypothetical ORF YNL220W,ADE12,BRA9 adenylosuccinate synthetase YPR175W,DPB2 DNA polymerase epsilon, subunit B YER022W,SRB4 subunit of RNA polymerase II holoenzyme/mediator complex YKR027W Hypothetical ORF YMR258C Hypothetical ORF YHR047C,AAP1',AAP1 arginine/alanine aminopeptidase YER043C,SAH1 putative S-adenosyl-L-homocysteine hydrolase YDL088C,ASM4,NUP59 Suppressor of thermosensitive mutations in the DNA polymerase delta gene YHR076W,PTC7 - YDR004W,RAD57 Required for X-ray damage repair, meiotic recombination, wild-type levels of sporulation and viable spores YGL122C,NAB2 nuclear polyadenylated RNA binding protein YLR314C,CDC3 involved in proper bud growth YKR023W Hypothetical ORF YLR405W dihydrouridine synthase of tRNA YOL006C,TOP1,MAK1, MAK17 topoisomerase I YDR479C,PEX29 Similar to PEX24 in Yarrowia lipolytica YCL039W Hypothetical ORF YNL008C,ASI3 Amino acid Sensor-Independent (ASI) genes encode membrane proteins Asi1p, Asi2p and Asi3p. Asi1p and Asi3p have conserved ubiquitin ligase-like RING domains at their C-termini YPL139C,UME1,WTM3 Negative regulator of meiosis. Unscheduled Meiotic gene Expression. YPR083W,MDM36 Mitochondrial Distribution and Morphology YGR286C,BIO2 Biotin synthase YDR138W,HPR1 Hyperrecombination protein that suppresses intrachromosomal excision recombination YNL293W,MSB3,GYP3 Multicopy Suppressor of Bud Emergence YKR001C,VPS1,GRD1, LAM1, SPO15, VPL1, VPT26 involved in vacuolar protein sorting and normal organization of intracellular membranes; probably required for membrane-protein retention in a late Golgi compartment YHR161C,YAP1801 Yeast Assembly Polypeptide, member of AP180 protein family, binds Pan1p and clathrin YPL011C,TAF3,TAF47 TAF(II) complex (TBP-associated protein complex) component YKR005C Hypothetical ORF YKR018C Hypothetical ORF YOR262W Protein required for cell viability YLR399C,BDF1 Required for sporulation, possible component of chromatin; affects synthesis of snRNA YKL165C,MCD4,ZRG16, SSU21, FSR2 Required for GPI anchor synthesis YDL027C Hypothetical ORF YMR211W,DML1 Drosophila melanogaster Misato-like YMR294W,JNM1,INS1, PAC3 coiled-coil domain protein required for proper nuclear migration during mitosis (but not during conjugation) YDR190C,RVB1,TIP49A, TIH1 RUVB-like protein, TIP49a Homologue YNR029C Hypothetical ORF YKR002W,PAP1 poly(A) polymerase YGL093W,SPC105 Spindle Pole Component of molecular weight 105kDa YCL061C,MRC1,YCL060C Mediator of the Replication Checkpoint; required for full activation of Rad53p in response to replication stress. YPL043W,NOP4,NOP77 RNA recognition motif-containing protein YGR264C,MES1 methionyl tRNA synthetase YOR117W,RPT5,YTA1 Probable 26S protease subunit and member of the CDC48/PAS1/SEC18 family of ATPases YML083C Hypothetical ORF YAL021C,CCR4,FUN27, NUT21 carbon catabolite repression; transcriptional regulator for some glucose-repressed genes including ADH2 YFR023W,PES4 Suppressor of DNA polymerase epsilon mutation YDR035W,ARO3 DAHP synthase; a.k.a. phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited; phospho-2-keto-3-deoxyheptonate aldolase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-deoxy-D-arabine-heptulosonate-7-phosphate synthase YPR006C,ICL2 2-methylisocitrate lyase YDR165W,TRM82 Transfer RNA methyltransferase YKL197C,PEX1,PAS1 member of the AAA-protein family YDR347W,MRP1 shows allele-specific genetic interactions with pet122 and pet123 YDL183C Hypothetical ORF YDR414C,ERD1 Protein required for retention of luminal ER proteins YBR125C,PTC4,GCT1 Phosphatase type Two C YGL249W,ZIP2 Required for 'ZIPpering' up meiotic chromosomes during chromosome synapsis YKR070W Hypothetical ORF YGL039W Hypothetical ORF YER152C Hypothetical ORF YGR245C,SDA1 Severe Depolymerization of Actin YGL040C,HEM2,SLU1 converts delta-aminolevulinic acid to porphobilinogen, an intermediate in the synthesis of heme YHL019C,APM2 homologous to the medium chain of mammalian clathrin-associated protein complex YLR438W,CAR2 ornithine aminotransferase YGL138C Hypothetical ORF YHR070W,TRM5 tRNA modification enzyme YJL052W,TDH1,GLD3 Glyceraldehyde-3-phosphate dehydrogenase 1 YDL100C,ARR4 provides low levels of resistance to arsenicals YLR006C,SSK1 Two-component signal transducer that with Sln1p regulates osmosensing MAP kinase cascade(suppressor of sensor kinase) YFR015C,GSY1 Highly similar to GSY2. GSY2 is the predominantly expressed glycogen synthase YHR005C,GPA1,CDC70, DAC1, SCG1 Involved in the mating pheromone signal transduction pathway; component of pheromone response pathway common to both a and alpha cells. YCR098C,GIT1 member of the yeast sugar permease family, which consists of 34 proteins. YBL005W,PDR3,AMY2, TPE2 Zinc-finger transcription factor related to Pdr1p YDR345C,HXT3 Low-affinity glucose transporter YLR253W Hypothetical ORF YGR028W,MSP1,YTA4 40 kDa putative membrane-spanning ATPase YIL067C Hypothetical ORF YDR364C,CDC40,PRP17, SLT15, SLU4 Required for proper timing of DNA synthesis at all temperatures and completion of DNA synthesis at a restrictive temperature in both mitosis and meiosis, and for completion of meiotic recombination, meiosis I, meiosis II and spores YBR104W,YMC2 Mitochondrial carrier protein YNL309W,STB1 binds Sin3p in two-hybrid assay and is present in a large protein complex with Sin3p and Stb2p YHR075C,PPE1 carboxyl methyl esterase YJL165C,HAL5 Protein kinase homolog, mutant is salt and pH sensitive YDR484W,SAC2,VPS52 May interact with actin as a component or controller of the assembly or stability of the actin cytoskeleton YCR088W,ABP1 Actin binding protein YER149C,PEA2,DFG9, PPF2 Pea2p is localized with Spa2p to sites of polarized growth and is required for efficient mating and bipolar budding; it is required for pheromone-induced shmoo formation YOL144W,NOP8 Nucleolar protein required for 60S ribosome biogenesis YML051W,GAL80 inhibits transcription activation by Gal4p in the absence of galactose YNL325C,FIG4 FIG4 expression is induced by mating factor. YFR029W,PTR3,SSY3 Regulator of expression of the PTR2, GAP1, and BAP2 genes; involved in the the control of peptide transport YEL007W Hypothetical ORF YJL048C Hypothetical ORF YMR275C,BUL1,DAG1, RDS1, SMM2 Involved in the ubiquination pathway, possibly by functioning with Rsp5 YJL053W,PEP8,GRD6, VPS26, VPT4 Plays a role in delivery of proteins to the vacuole YDL144C Hypothetical ORF YMR006C,PLB2 Phospholipase B 2 YLR072W Hypothetical ORF YFL040W Hypothetical ORF YPL004C hosphorylation YDR362C,TFC6 91 kDa tau91 subunit of transcription factor IIIC (TFIIIC) YNL104C,LEU4 leucine biosynthesis YLR368W,MDM30 F-box protein, loss of mitochondrial function. Mitochondrial Distribution and Morphology YHR082C,KSP1 Serine/threonine kinase similar to casein kinase II and other serine/threonine protein kinases YPL106C,SSE1,LPG3, MSI3 HSP70 family member, highly homologous to Ssa1p and Sse2p YKR064W Hypothetical ORF YDR448W,ADA2,SWI8 transcription factor, member of ADA and SAGA, two transcriptional adaptor/HAT (histone acetyltransferase)complexes YNL234W ORF YNL051W,COG5,API4, COD4 Complexed with Cog8p YJL029C,VPS53 Required for Vacuolar Protein Sorting YPL259C,APM1,YAP54 medium subunit of the clathrin-associated protein complex YLL063C,AYT1 Transacetylase YHR149C Hypothetical ORF YNL327W,EGT2 cell-cycle regulation protein, may be involved in the correct timing of cell separation after cytokinesis YKL042W,SPC42 involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane YGR047C,TFC4,PCF1 transcription factor tau (TFIIIC) subunit 131 YOR175C Hypothetical ORF YGL252C,RTG2 Protein involved in interorganelle communication between mitochondria, peroxisomes, and nucleus. Likely role of Rtg2p is to antagonize Mks1p, a negative regulator of RTG target gene activation. YOR266W,PNT1 Involved in targeting of proteins to the mitochondrial inner membrane; Pentamidine resistance protein YJL062W,LAS21,GPI7 Local Anesthetics Sensitive: involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins. YLR026C,SED5 Sed5p is a t-SNARE (soluble NSF attachment protein receptor) required in ER to Golgi transport. YHR120W,MSH1 mutS homolog involved in mitochondrial DNA repair YAL023C,PMT2,FUN25 Transfers mannosyl residues from dolichyl phosphate-D-mannose to seryl and threonyl residues in proteins; acts in complex with Pmt1p YIL035C,CKA1 alpha subunit of protein kinase CK2 YPL109C Hypothetical ORF YLR401C dihydrouridine synthase of tRNA YMR083W,ADH3 shows a high affinity for alcohols with a double bond conjugated to the alcohol function. YHR184W,SSP1,SPO3 Involved in the control of meiotic nuclear divisions & spore formation; dispensable for mitosis, premeiotic DNA synthesis, recombination, meiosis I, meiosis II, & initiation of prospore walls; required for spore wall elongation YAR019C,CDC15,LYT1 Promotes the exit from mitosis by directly switching on the kinase activity of Dbf2. Required for mitosis and sporulation, cell division cycle blocked at 36 C. YJL061W,NUP82,HRB187 Interacts with nuclear pore complex and participates in nucleocytoplasmic transport; required for poly(A)+ RNA export YAL012W,CYS3,CYI1, FUN35, STR1 catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine YOR033C,EXO1,DHS1 Protein that complements a drug-hypersensitive mutation. EXO1 plays a structural role in MMR and stabilizes multiprotein complexes containing a number of MMR proteins. YNL073W,MSK1 mitochondrial lysine-tRNA synthetase YKL176C,LST4 required for amino acid permease transport from the Golgi to the cell surface. involved in regulated secretion/recycling of nitrogen regulated permeases. YBL074C,AAR2 component of free U5 snRNP and recycling factor for U4/U6.U5 tri-snRNP complex; (originally described as a splicing factor specifically required for splicing pre mRNA of the MATa1 cistron) YOR181W,LAS17,BEE1 Homolog of human WASP, proline-rich protein YJR064W,CCT5,TCP5 Required for assembly of microtubules and actin in vivo YBR018C,GAL7 galactose-1-phosphate uridyl transferase YJL167W,ERG20,BOT3, FDS1, FPP1 May be rate-limiting step in sterol biosynthesis pathway YAL038W,CDC19,PYK1 Required for START A in the cell cycle and sporulation YHL039W Hypothetical ORF YNR012W,URK1 converts ATP and uridine to ADP and UMP YKL077W Hypothetical ORF YDL093W,PMT5 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway YBR247C,ENP1,MEG1 Essential nuclear protein YIL014W,MNT3 MaNnosylTransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans YNR048W Hypothetical ORF YKL211C,TRP3 anthranilate synthase Component II and indole-3-phosphate (multifunctional enzyme) YDR520C Hypothetical ORF YLR266C,PDR8 Pleiotropic Drug Resistance YDL001W Required for Meiotic Division YJL111W,CCT7,TCP7 Required for assembly of microtubules and actin in vivo YOR353C Protein required for cell viability YKR101W,SIR1 repressor of silent mating loci YGL119W,ABC1 multicopy suppressor of a cytochrome b mRNA translation defect, essential for the electron transfer in the bc1 complex YNL249C,MPA43 Overexpression leads to increased levels of the lyase PDC1 YDR006C,SOK1 gene dosage suppressors of the conditional growth defect of several temperature-sensitive A kinase mutants YJR051W,OSM1 osmotic growth protein YBL014C,RRN6 involved in the transcription of 35S rRNA genes by RNA polymerase I YKR008W,RSC4 RSC4 is a member of RSC complex, which remodels the structure of chromatin. YNL164C,IBD2 ivision YFR030W,MET10 subunit of assimilatory sulfite reductase YDL024C,DIA3 involved in invasive and pseudohyphal growth YIL045W,PIG2 Interacts with Gsy2p YLL051C,FRE6 similar to FRE2 YNL199C,GCR2 activates transcription of glycolytic genes; homologous to GCR1; may function in complex with Gcr1p YGL077C,HNM1 choline transport protein; may also control uptake of nitrogen mustard YML096W Hypothetical ORF YDL060W,TSR1 RNA accumulation YJR043C,POL32 Polymerase-associated gene YLR137W Hypothetical ORF YOR142W,LSC1 alpha subunit of succinyl-CoA ligase (synthetase; ATP-forming), a mitochondrial enzyme of the TCA cycle YIL006W Hypothetical ORF YMR289W para-AminoBenZoic acid (PABA) biosynthesis. Third enzymatic step in para-Aminobenzoic acid biosynthesis. YDR069C,DOA4,DOS1, MUT4, NPI2, SSV7, UBP4 deubiquitinating enzyme; vacuole biogenesis gene YLR028C,ADE16 AICAR transformylase/IMP cyclohydrolase YLR151C,PCD1 peroxisomal nudix hydrolase active towards coenzyme A and its derivatives YOR274W,MOD5 transfer RNA isopentenyl transferase YNR019W,ARE2,SAT1 Acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) YDR267C Protein required for cell viability YMR241W,YHM2 Yeast suppressor gene of HM mutant (abf2) YER068W,MOT2,NOT4, SIG1 Negative regulator of gene expression YLR246W,ERF2 Mutation has an Effect on Ras Function. Implicated in signaling pathway. YCR057C,PWP2,YCR055C, YCR058C, UTP1 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Eight WD-repeats with homology with G protein beta subunits flanked by nonhomologous N-terminal and C-terminal extensions YIL066C,RNR3,DIN1, RIR3 Ribonucleotide reductase (ribonucleoside-diphosphate reductase) large subunit YLR380W,CSR1,SFH2 chs5 spa2 rescue; isolated as a multicopy suppressor of the lethality of chs5 spa2 double mutant at 37 degrees. Also Sec14p homolog, putative phosphatidylinositol transfer protein. YGL115W,SNF4,CAT3, SCI1 involved in release from glucose repression, invertase expression, and sporulation YLR309C,IMH1,SYS3 Encodes a protein implicated in protein transport; induced under stress conditions. YOL083W Hypothetical ORF YDL105W,QRI2 Product of gene unknown YIR021W,MRS1,PET157 RNA splicing protein of the mitochondrial carrier (MCF) family YML002W Hypothetical ORF YGR199W,PMT6 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway YLR455W Hypothetical ORF YOR075W,UFE1,YOR29-26 t-SNARE that resides on the endoplasmic reticulum and mediates retrograde traffic from the Golgi complex YDR120C,TRM1 N2,N2-dimethylguanosine-specific tRNA methyltransferase YMR066W Synthesis Of Var YHR091C,MSR1 Nuclear-encoded mitochondrial protein YML070W,DAK1 putative dihydroxyacetone kinase YDR349C,YPS7 Gpi-anchored aspartic protease (Yapsin 7) YJL098W,SAP185 SIT4 associated protein, MW of 185 kDa YMR124W Hypothetical ORF YJR155W,AAD10 high degree of similarity with the AAD of P. chrysosporium YPL076W,GPI2,GCR4 Required for synthesis of N-acetylglucoaminylphosphatidylinositol, the first intermediate in synthesis of glycosylphosphatidylinositol (GPI) anchors YDR319C Hypothetical ORF YJR011C Hypothetical ORF YNL286W,CUS2 cold sensitive U2 snRNA Supressor YLR205C,HMX1 Homology to heme oxygenases YOR157C,PUP1 putative proteasome subunit YHR043C,DOG2 2-deoxyglucose-6-phosphate phosphatase YNL050C Hypothetical ORF YDR050C,TPI1 induced under stress conditions YFL045C,SEC53,ALG4 involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for protein assembly in endoplasmic reticulum YDR313C,PIB1 Phosphatidylinositol(3)-phosphate binding YOR174W,MED4 Member of RNA Polymerase II transcriptional regulation mediator YLR165C,PUS5 - YPL024W Negative regulator of Cts1 Expression YOR280C - YGR248W similar to SOL3 YDR130C,FIN1 Cell cycle-dependent filament between nuclei YGR161C Hypothetical ORF YLR351C,NIT3 Nit protein, nitrilase superfamily member YDL142C,CRD1,CLS1 Cardiolipin synthase YDR087C,RRP1 involved in processing rRNA precursor species to mature rRNAs YIR036C Hypothetical ORF YMR132C Hypothetical ORF YPL065W,VPS28,VPT28 soluble, hydrophilic protein involved in transport of precursors for soluble vauolar hydrolases from the late endosome to the vacuole YDR236C,FMN1 Riboflavin kinase YNL208W Hypothetical ORF YPL002C,SNF8,VPS22 appears to be functionally related to SNF7 YMR161W,HLJ1 Homologous to E coli dnaJ protein YMR314W,PRE5 alpha-type of subunit of 20S proteasome YDR533C Hypothetical ORF YGR235C Hypothetical ORF YMR063W,RIM9 Regulator of IME2 (RIM) required for IME1 expression YLR456W Hypothetical ORF YLR179C Hypothetical ORF YNR017W,MAS6,MIM23, MPI3, TIM23 23 kDa mitochondrial inner membrane protein YOR077W,RTS2,YOR29-28 similar to mouse KIN7 protein YIL152W Hypothetical ORF YJL192C,SOP4 suppressor of pma1-7 YPL130W,SPO19 sporulation-defective; SPO19 was found as a weak high-copy suppressor of the spo1-1 ts mutation. The gene is specifically induced late in meiosis (Primig et al. (2000) Nat Genet 26:415-423) YOR111W Hypothetical ORF YMR095C,SNO1 SNZ1 proximal ORF, stationary phase induced gene YPL166W Hypothetical ORF YLR051C Protein required for cell viability YMR264W,CUE1 Cue1p assembles with Ubc7p. Cue1p recruits Ubc7p to the cytosolic surface of the endoplasmic reticulum. Assembly with Cue1p is a prerequisite for the function of Ubc7p YMR311C,GLC8 Homolog of mammalian protein phosphatase inhibitor 2. YDR136C,VPS61 Vacuolar Protein Sorting YIL009C-A,EST3 ever shorter telomeres YBR164C,ARL1,DLP2 Encodes a regulator of membrane traffic. Hydrolyzes GTP; myristylated; in soluble fraction. Part of the carboxypeptidase Y pathway. YJR115W Hypothetical ORF YPL148C,PPT2 Phosphopantetheine:protein transferase (PPTase) that activates the low molecular weight acyl carrier protein (ACP) of mitochondrial type II fatty acid synthase (FAS). YDR469W,SDC1,CPS25, SAF19 likely involved in chromatin remodelingmember of Set1p complex YCR086W,CSM1 Chromosome segregation in meiosis YBR254C,TRS20 Trapp subunit of 20 kDa YCR101C Hypothetical ORF YCL001W,RER1 Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi, where it may function in returning membrane proteins to the ER YKR007W Hypothetical ORF YBR173C,UMP1 Involved in ubiquitin-mediated proteolysis YHR175W,CTR2 Putative low-affinity copper transport protein YLR254C Hypothetical ORF YNL245C,CWC25 Complexed with Cef1p YER007C-A Hypothetical ORF YDR185C Hypothetical ORF YKL070W Hypothetical ORF YPL025C Hypothetical ORF YGR049W,SCM4 Protein that suppresses ts allele of CDC4 when overexpressed YBL090W,MRP21,MRP50 Mitochondrial Ribosomal Protein YAL055W,PEX22,YAF5 Product of gene unknown YLR050C Hypothetical ORF YJR097W Hypothetical ORF YEL003W,GIM4,PFD2 Prefoldin subunit 2; putative homolog of subunit 2 of bovine prefoldin, a chaperone comprised of six subunits YML101C Hypothetical ORF YEL026W,SNU13 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); RNA binding protein (putative), similar to Nhp2p YHR191C,CTF8 (putative) kinetochore protein YKL138C,MRPL31,YML31 15.5 kDa mitochondrial ribosomal protein YmL31 YNL135C,FPR1,FKB1, RBP1 FK506 binding protein; proline rotamase; rapamycin-binding protein YDR511W,ACN9 - YPL192C,PRM3 pheromone-regulated membrane protein YIL032C Hypothetical ORF YDL071C Hypothetical ORF YER135C Hypothetical ORF YJL215C Hypothetical ORF YKR083C,DAD2,HSK1 Duo1 And Dam1 interacting; Helper of AsK1 YDR286C Hypothetical ORF YMR195W Interacting with the cytoskeleton YOR189W Ino Eighty Subunit 4 YJL179W,PFD1 Prefoldin subunit 1; putative homolog of subunit 1 of bovine prefoldin, a chaperone comprised of six subunits YBR292C Hypothetical ORF YER009W,NTF2 May coordinate the Ran-dependent (GSP1/GSP2) association and disassociation reactions of nuclear import; human homolog complements yeast mutants YDR274C Hypothetical ORF YNL269W,BSC4 Bypass of Stop Codon transcript encoded by this ORF shows a high level of stop codon bypass YGL191W,COX13 Modulates cytochrome c oxidase activity YNL153C,GIM3,PFD4 Prefoldin subunit 4; putative homolog of subunit 4 of bovine prefoldin, a chaperone comprised of six subunits YEL008W Hypothetical ORF YOR009W,TIR4 - YCL024W,KCC4 involved in septin organization YMR075W Hypothetical ORF YDR227W,SIR4,ASD1, STE9, UTH2 Sir4 binding to Rap1 initiates the sequential association of Sir and other proteins, allowing the subsequent spreading of heterochromatin proteins along the chromosome. YGR134W,CAF130 CCR4 Associated Factor 130 kDa YNL318C,HXT14 High-affinity hexose transporter YBL052C,SAS3 SAS3 for Something about silencing, gene 3. Influences silencing at HMR. YJL005W,CYR1,CDC35, HSR1, SRA4, TSM0185, FIL1 Required for START A of cell cycle, and glucose and nitrogen repression of sporulation YIL082W-A Hypothetical ORF YBR220C Hypothetical ORF YKL075C Hypothetical ORF YDR432W,NPL3,MTR13, MTS1, NOP3 involved as a protein carrier in mRNA export, involved in mitochondrial protein targeting YAL058W,CNE1,FUN48 Functions in endoplasmic reticulum protein quality control YNL283C,WSC2 cell wall integrity and stress response component 2 YGL167C,PMR1,BSD1, LDB1 Pmr1p, a member of the SERCA family of CaATPases, plays an important role in the transport of Ca++ into Golgi. YDR200C,VPS64,FAR9 - YBL061C,SKT5,CAL2, CHS4, CSD4 protoplast regeneration and killer toxin resistance gene, may be a post-translational regulator of chitin synthase III activity, interacts with Chs3p YOR201C,PET56 Ribose methyltransferase for mitochondrial 21S rRNA YDR425W,SNX41 sorting nexins Snx4p, Snx41p, and Snx42p mediate distinct retrieval pathways from endosomes. YLR234W,TOP3,EDR1 DNA Topoisomerase III YDR335W,MSN5,KAP142, STE21 Multicopy suppressor of snf1 mutation YPR041W,TIF5 eIF5 mediates hydrolysis of eIF2-GTP (SUI2,SUI3,GCD11) at start codons YMR316W,DIA1 may be involved in invasive growth, pseudohyphal growth YKR059W,TIF1 translation initiation factor eIF4A YLR155C,ASP3-1,ASP3 nitrogen catabolite-regulated cell-wall L-asparaginase II YBL005W-A TyA Gag protein YDL248W,COS7 Protein with strong similarity to other subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p YNL332W,THI12 thiamine regulated gene, homologous to nmt1a in Schizosaccharomyces pombe; putatively involved in pyrimidine biosynthesis YLL066C Hypothetical ORF YJR158W,HXT16 hexose transporter YLR158C,ASP3-3,ASP3 nitrogen catabolite-regulated cell-wall L-asparaginase II YDR170W-A Ty ORF YGR192C,TDH3,GLD1, HSP35, HSP36, SSS2 Glyceraldehyde-3-phosphate dehydrogenase 3 YDR312W,SSF2 high copy suppressor of G beta subunit temperature sensitive mutation YML133C Hypothetical ORF YML132W,COS3 Protein with strong similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p (COS3 and YBR302C code for identical proteins) YAR073W,IMD1 IMP dehydrogenase homolog YHR215W,PHO12 acid phosphotase, nearly identical to Pho11p YFL062W,COS4 Protein with strong similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p YHL050C Hypothetical ORF YDR385W,EFT2 translation elongation factor 2 (EF-2) YJL114W TyA Gag protein YJL221C,FSP2 homology to maltase(alpha-D-glucosidase) YOL156W,HXT11,LGT3 High-affinity hexose transporter YBL111C Hypothetical ORF YNL034W Hypothetical ORF YDR193W Hypothetical ORF YPR059C Hypothetical ORF YPR099C Hypothetical ORF YFL020C,PAU5 member of the seripauperin protein/gene family (see Gene_class PAU) YBR301W,DAN3 delayed anaerobic gene YOL079W Hypothetical ORF YNL149C Protein required for cell viability YGR176W Hypothetical ORF YLR406C,RPL31B Homology to rat L31 YGR228W Hypothetical ORF YGR294W Hypothetical ORF YJR114W Hypothetical ORF YOL161C Hypothetical ORF YDL136W,RPL35B,SOS2 Homology to rat L35 YLR159W Note: YLR156W, YLR159W, and YLR161W are identical. YMR316C-B Hypothetical ORF YJL223C,PAU1 member of the seripauperin protein/gene family (see Gene_class PAU) YIR040C Hypothetical ORF YDR360W Hypothetical ORF YLR458W Protein required for cell viability YNL184C Hypothetical ORF YLL064C Hypothetical ORF YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YIR019C,MUC1,FLO11, STA4 Required for invasion and pseudohyphae formation in response to nitrogen starvation YFR031C,SMC2 Chromosome segregation and condensation YGL150C,INO80 Shows similarity to the Snf2p family of DNA-dependent ATPases YLR384C,IKI3,ELP1, TOT1 RNA polymerase II Elongator subunit YGR116W,SPT6,CRE2, SSN20 may be involved in transcription elongation by mediating interactions between RNA polymerase II and chromatin YOR098C,NUP1 nuclear pore complex protein YCR073C,SSK22 functionally redundant with, and homologous to, SSK2 YLR272C,YCS4,LOC7 loss of cohesion YBR081C,SPT7,GIT2 Transcription factor YER110C,KAP123,YRB4 Karyopherin of predicted MW 122.524 Da. Similar to Kap95p (YLR347C) and Kap104p *YBR017C). Ran binding protein, Homolog of importin-beta YAR009C TyB Gag-Pol protein YDR011W,SNQ2 ABC transporter YOR290C,SNF2,GAM1, HAF1, SWI2, TYE3 involved in the coordinate regulation of phospholipid synthesis YDR127W,ARO1 pentafunctional arom polypeptide (contains: 3-dehydroquinate synthase, 3-dehydroquinate dehydratase (3-dehydroquinase), shikimate 5-dehydrogenase, shikimate kinase, and epsp synthase) YHL035C Hypothetical ORF YLR320W,MMS22 - YJR039W Hypothetical ORF YDR159W,SAC3 involved in processes affecting the actin cytoskeleton and mitosis YGL092W,NUP145,RAT10 Nuclear pore complex protein with GLFG motif YPL082C,MOT1,BUR3, LPF4, BTAF1 involved in TBP (TATA-binding protein) regulation YPR095C,SYT1 Suppressor of Ypt3 YPR189W,SKI3,SKI5 dsRNA virus protection family member, contains 8 copies of the tetratricopeptide (TPR) domain YML049C,RSE1 RNA splicing and ER to Golgi transport YOL158C,ENB1,ARN4 Siderophore transporter for enterobactin; AFT1 regulon YBR229C,ROT2,GLS2 Reversal of tor2 lethality. Involved in Beta-1,6-glucan synthesis. YGL022W,STT3 Required for protein glycosylation YIL112W - YPL169C,MEX67 Involved in nuclear mRNA export, binds both poly(A) YPR181C,SEC23 cytoplasmic GTPase-activating protein YLR231C,BNA5 Biosynthesis of Nicotinic Acid YMR085W Hypothetical ORF YKL085W,MDH1 mitochondrial malate dehydrogenase YLL002W,RTT109,KIM2, REM50 Regulator of Ty1 Transposition; Regulation of mitochondrial network; Killed in Mutagen, sensitive to diepoxybutane and/or mitomycin C YLR336C,SGD1 Suppressor of Glycerol Defect YDL005C,MED2 RNA Polymerase II transcriptional regulation mediator YOR229W,WTM2 WD repeat containing transcriptional modulator 2 YJL101C,GSH1 encodes the first enzyme involved in glutathione biosynthesis YLR207W,HRD3 HMG-CoA Reductase Degradation--the HRD complex is responsible for the endoplasmic reticulum (ER)-associated degradation (ERAD) of numerous ER-resident proteins. YNR056C,BIO5 transmembrane regulator of KAPA/DAPA transport YLR347C,KAP95,RSL1 protein involved in nuclear import; required for the docking of import substrate to the nuclear membrane/pore; identified as an rna1-1 synthetic lethal YBR087W,RFC5 RFC is a multisubunit DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA YCR005C,CIT2 non-mitochondrial citrate synthase YDL113C,CVT20,SNX42 Cytoplasm to vacuole targeting YDR351W,SBE2 Required for bud growth YPR194C,OPT2 oligopeptide transporter YGL025C,PGD1,HRS1, MED3 Probable transcription factor, polyglutamine domain protein YBR236C,ABD1 RNA (guanine-7-)methyltransferase (cap methyltransferase) YDR169C,STB3 binds Sin3p in two-hybrid assay YFL001W,DEG1,PUS3 Similar to rRNA methyltransferase (Caenorhabditis elegans) and hypothetical 28K protein (alkaline endoglucanase gene 5' region) from Bacillus sp. YOR264W,DSE3 Daughter Specific Expression 3 YLR270W trehalase-associated protein; hydrolase in the HIT superfamily. YCR106W,RDS1 Regulator of drug sensitivity YBR046C,ZTA1 Zeta-crystallin homolog, has similarity to E. coli quinone oxidoreductase and human zeta-crystallin which has quinone oxidoreductase activity YIL074C,SER33 catalyzes the first step in serine biosynthesis; isozyme of SER3 YDL161W,ENT1 epsin N-terminal homology-containing protein YMR014W,BUD22 - YER087W Hypothetical ORF YEL037C,RAD23 ubiquitin-like protein YDR223W Hypothetical ORF YML027W,YOX1 Homeodomain protein that binds leu-tRNA gene. acts as a repressor at early cell cycle boxes (ECBs) to restrict their activity to the M/G1 phase of the cell cycle. YGL128C,CWC23 Complexed with Cef1p YPR021C Aspartate glutamate carrier YLR373C,VID22 Vacuole import and degradation YGL139W Hypothetical ORF YIL122W,POG1 Promoter of Growth; weak similarity to human transcription adaptor protein p300 YOL041C,NOP12 Nucleolar Protein; isolated as a mutant exhibiting synthetic lethality with a nop2 ts allele. YML057W,CMP2,CNA2 calmodulin binding protein homologous to mammalian calcineurin YBR184W Hypothetical ORF YDL036C Hypothetical ORF YDL148C,NOP14,UTP2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); NucleOlar Protein 14 YJL157C,FAR1 Factor arrest protein YIL076W,SEC28,ANU2 Part of a heptameric protein complex that regulates retrograde Golgi-to-ER protein traffic in eukaryotic cells; coatomer forms the COP I vesicle coat whose functions are essential YGL141W,HUL5 ubiquitin-protein ligase (E3) YDR111C Hypothetical ORF YEL032W,MCM3 Member of complex that acts at ARS's to initiate replication YDR033W,MRH1 Membrane protein related to Hsp30p; Localized by immunofluorescence to membranes, mainly the plasma membr. punctuate immunofluorescence pattern observed in buds. The nuclear envelope, but not vacuole or mitochondrial membranes also stained YKL104C,GFA1 catalyzes first step in hexosamine pathway required for biosynthesis of cell wall precursors YJR149W Hypothetical ORF YIR039C,YPS6 Gpi-anchored aspartic protease (Yapsin 6) YGR196C,FYV8 Function required for Yeast Viability on toxin exposure YDR310C,SUM1 Suppresor of mar1-1 (sir2) mutation YMR302C,PRP12,RNA12, YME2 Integral membrane mitochondrial protein YLR166C,SEC10 100 kD component of the Exocyst complex; required for exocytosis. The Exocyst complex contains the gene products encoded by SEC3, SEC5, SEC6, SEC8, SEC10, SEC15 and EXO70. YMR094W,CTF13,CBF3C 58 kd component (Cbf3c) of the multisubunit 'Cbf3' kinetochore protein complex, which binds to the CDE III element of centromeres YKL080W,VMA5,CSL5, VAT3 42 kDa subunit of V1 sector YIL155C,GUT2 glycerol-3-phosphate dehydrogenase, mitochondrial YER020W,GPA2,SSP101 homologous to mammalian G proteins; potential role in regulation of cAMP levels YPL176C Hypothetical ORF YNR062C Hypothetical ORF YBL030C,PET9,AAC2, ANC2, OP1 the major mitochondrial ADP/ATP translocator; highly homologous to AAC1 and AAC3 YLR378C,SEC61 membrane component of ER protein translocation apparatus YJL209W,CBP1 Protein required for COB mRNA stability or 5' processing. required for translation of COB RNAs. YDR316W Hypothetical ORF YFR021W,AUT10,NMR1, CVT18 Required for cytoplasm to vacuole targeting of proaminopeptidase I and starvation induced autophagy (AUT10). Needed for pre-Meiotic Replication (NMR1). YPR002W,PDH1 prpD homologue; (62% identical to the prpD genes of , which play an unknown but essential role in propionate catabolism) YNL186W,UBP10,DOT4 involved in telomeric silencing YLL006W,MMM1 Involved in mechanism by which mitochondrial shape is established or maintained YGL145W,TIP20,TIP1 transport protein that interacts with Sec20p; required for protein transport from the endoplasmic reticulum to the golgi apparatus YGR234W,YHB1,YHB4 may play a role in the oxidative stress response YPR140W Hypothetical ORF YOL130W,ALR1,SWC3 aluminium resistance YML017W,PSP2,MRS15 Polymerase suppressor 2; Suppressors of group II intron-splicing defect. YGL256W,ADH4,NRC465, ZRG5 Alcohol dehydrogenase type IV YHR202W Hypothetical ORF YCL040W,GLK1,HOR3 Glucose phosphorylation YPL270W,MDL2 ATP-binding cassette (ABC) transporter family member YBL039C,URA7 Last step in pyrimidine biosynthesis pathway; URA7 is very similar to URA8 CTP synthase YNL078W,NIS1 - YJR016C,ILV3 catalyzes third step in common pathway leading to biosynthesis of branched-chain amino acids YJL163C Hypothetical ORF YDL103C,QRI1,UAP1 UDP-N-acetylglucosamine pyrophosphorylase YBR060C,ORC2,RRR1, SIR5 origin recognition complex subunit 2 YHR019C,DED81 Asparaginyl-tRNA synthetase YER127W,LCP5 Lethal with conditional pap1 allele YDR346C - YMR261C,TPS3 115 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex YER045C,ACA1 contains an ATF/CREB-like bZIP domain; transcriptional activator YOL019W Hypothetical ORF YJL154C,VPS35,GRD9, VPT7 Protein involved in vacuolar sorting YGR140W,CBF2,CBF3A, CEP2, CTF14, NDC10 110 kd component (Cbf3a) of the multisubunit 'Cbf3' kinetochore protein complex, which binds to the CDE III element of centromeres YDR516C Early Meiotic Induction YGL078C,DBP3 ATP-dependent RNA helicase CA3 of the DEAD/DEAH box family YOL155C ORF YMR020W,FMS1 Multicopy suppressor of fenpropimorph resistance (fen2 mutant), shows similarity to Candida albicans corticosteroid-binding protein CBP1 YIL166C Hypothetical ORF, member of the Dal5p subfamily of the major facilitator family YGL017W,ATE1 arginyl-tRNA-protein transferase YOL064C,MET22,HAL2 involved in salt tolerance and methionine biogenesis; converts pAp (adenosine 3',5' bisphosphate), a product of sulfate assimilation, into 5' AMP and Pi. YPL222W Hypothetical ORF YMR105C,PGM2,GAL5 Phosphoglucomutase YJR143C,PMT4 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway YGR193C,PDX1 Plays a structural role in pyruvate dehydrogenase complex YPR081C,GRS2 Possible pseudogene; has similarity to Grs1p glycyl-tRNA synthetase, but expression is very low and GRS2 cannot substitute for GRS1 YGR015C Hypothetical ORF YBR250W Hypothetical ORF YGR100W,MDR1,MIC1, GYP2 Mac1-dependent regulator YAL051W,OAF1,YAF1 Oleate-Activated transcription Factor; activates gene expression in response to oleate; many Oaf1 target genes are involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis YLR397C,AFG2,DRG1 ATPase family gene YDR034C,LYS14 Transcriptional activator of lysine pathway genes with 2-aminoadipate semialdehyde as co-inducer; saccharopine reductase synthesis YML005W Hypothetical ORF YDR430C CYtosolic Metalloprotease YHR210C Hypothetical ORF YCL011C,GBP2,RLF6 G-strand Binding Proteinbinds single-stranded telomeric repeat sequences in vitro; similar to Gbp1p, a single-stranded telomeric DNA-binding protein from Chlamydomonas reinhardtii YMR253C Hypothetical ORF YDR536W,STL1 sugar transporter-like protein YMR048W,CSM3 Chromosome segregation in meiosis YFR037C,RSC8,SWH3 8th largest subunit of RSC. Rsc8p mediates multiple RSC complex interactions, undergoes dimerization via the C-term coiled-coil segment, associates with SWI2/SNF2 ATPase Sth1p, forms a complex with RSC6p. YJL014W,CCT3,BIN2, TCP3 Homolog of mammalian CCT family of chaperonin proteins; required for assembly of microtubules and actin in vivo YDL035C,GPR1 G-protein-coupled receptor at plasma membrane; interactions in two-hybrid system with Gpa2p YOR162C,YRR1 Yeast Reveromycin-A Resistant YER098W,UBP9 similar to Ubp13p YMR189W,GCV2,GSD2 Glycine CleaVage system YGR023W,MTL1 Mid-Two Like 1 YKR024C,DBP7 Dead-box protein YDR107C multispanning membrane protein YPR090W Hypothetical ORF YGL004C Hypothetical ORF YNL323W,LEM3,BRE3, ROS3 plays an important role in phospholipid translocation across the plasma membrane. YGR048W,UFD1 Ubiquitin fusion degradation protein YGL206C,CHC1,SWA5 vesicle coat protein YMR054W,STV1 Stv1p and Vph1p may be equivalent subunits for vacuolar-type H(+)-ATPases located on different organelles YCR072C Protein required for cell viability YMR228W,MTF1 Mitochondrial RNA polymerase specificity factor YDR264C,AKR1 Negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control YMR139W,RIM11,GSK3, MDS1 Required for Ime1p phosphorylation, association of the Ime1p-Ume6p meiotic activator, early meiotic gene expression, and sporulation YGL263W,COS12 Protein with strong similarity to subtelomerically-encoded proteins including Cos2p, Cos4p, Cos8p, YIR040c, Cos5p, Cos9p, and Cos6p YNL023C,FAP1 FKBP12-associated protein YDL203C Hypothetical ORF YOL072W,THP1,BUD29 - YER040W,GLN3 Responsible for nitrogen catabolite repression (NCR)-sensitive transcription. During nitrogen starvation, Gln3 is nuclear. Under excess nitrogen, Gln3 is cytoplasmic. Also regulates glutamine-repressible gene products. YNL201C Platinum Sensitivity YGR168C Hypothetical ORF YNL251C,NRD1 RNA recognition motif-containing protein that participates in sequence-specific regulation of nuclear pre-mRNA abundance YGR125W Hypothetical ORF YOR046C,DBP5,RAT8 Dead-Box protein 5 YFR002W,NIC96 Part of complex at nuclear pore containing in addition NSP1p, NUP49p, and p54 YNR063W Hypothetical ORF YHR036W Protein required for cell viability YNL321W not essential for vegetative growth YHR106W,TRR2 mitochondrial thioredoxin reductase YOR381W,FRE3 similar to FRE2 YIL043C,CBR1,CBR5 cytochrome b reductase YPL087W,YDC1 Yeast dihydro-ceramidase YER103W,SSA4 member of 70 kDa heat shock protein family YMR137C,PSO2,SNM1 DNA cross-link repair protein YBR020W,GAL1 galactokinase YKL121W Hypothetical ORF YDR309C,GIC2 Gtpase-interacting component 2 YBL032W,HEK2,KHD1 Heterogeneous nuclear RNP K-like gene YHR014W,SPO13 Spo13 acts as a transcriptional activator in a one-hybrid assay (see Henninger et al (1996) SPO13 and control of meiotic chromosome segregation in Saccharomyces cerevisiae) YMR266W Overexpression Rescues sro7/sop1 in NaCl. Encodes a membrane protein. YDL066W,IDP1 Mitochondrial form of NADP-specific isocitrate dehydrogenase YMR043W,MCM1,FUN80 Involved in cell-type-specific transcription and pheromone response YGR060W,ERG25 membrane-bound non-heme di-iron oxygenase involved in lipid metabolism. YBR161W Hypothetical ORF YIR025W,MND2 needed for Meiotic Nuclear Division YNL219C,ALG9 catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides YDR488C,PAC11 Protein required in the absence of Cin8p YOR025W,HST3 Homolog of SIR2 YGR128C,UTP8 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YKL057C,NUP120,RAT2 Nucleoporin YOR256C Protein required for cell viability YER141W,COX15 cytochrome oxidase assembly factor YPL029W,SUV3,LPB2 putative ATP-dependent helicase YJR080C Hypothetical ORF YOR137C,SIA1 Suppressor of eIF5A YOR180C,DCI1,ECI2 Delta(3,5)-delta(2,4)-dienoyl-CoA isomerase YBR129C,OPY1 imparts Far- phenotype YAR015W,ADE1 phosphoribosyl amino imidazolesuccinocarbozamide synthetase YCR073W-A,SOL2,YCRX13W multicopy suppressor of los1-1 YOR079C,ATX2,YOR29-30 Multi-copy suppressor of SOD-linked defects YOR216C,RUD3,GRP1 Novel matrix protein that is involved in the structural organization of the cis-Golgi. Relieves uso1-1 transport defect; golgin-160 related protein. YLR284C,ECI1 enoyl-CoA isomerase YOR143C,THI80 Thiamin pyrophosphokinase YJR013W Protein required for cell viability YNL075W,IMP4 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Interacts With Mpp10. Imp4p is a specific component of the U3 snoRNP and is required for pre-18S rRNA processing. YCR016W Hypothetical ORF YOR347C,PYK2 Pyruvate kinase, glucose-repressed isoform YBR151W,APD1 actin patches distal YOR164C Hypothetical ORF YKR080W,MTD1 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase YIL053W,RHR2,GPP1 DL-glycerol-3-phosphatase YPL103C Hypothetical ORF YLR128W Hypothetical ORF YBL050W,SEC17 peripheral membrane protein required for vesicular transport between ER and Golgi required for 'priming' step in homotypic vacuole fusion YBR265W,TSC10 catalyzes the second step in the synthesis of phytosphingosine YDL218W Hypothetical ORF YDR184C,ATC1,LIC4 interacts with AIP3, localized to the nucleus YNR002C,FUN34,ATO2 Highly homologous to Ycr010p and similar to Yarrowia lipolytica glyoxylate pathway regulator GPR1 (see MIPS); member of the TC 9.B.33 YaaH family of putative transporters YEL021W,URA3 orotidine-5'-phosphate decarboxylase YER116C,SLX8 - YGL123W,RPS2,RPS4, SUP38, SUP44, SUP138 Homology to rat S2 and E. coli S5 YBR261C Hypothetical ORF YOL088C,MPD2 protein disulfide isomerase related protein YGL085W Hypothetical ORF YOR062C Hypothetical ORF YLL060C,GTT2 Glutathione Transferase YKL208W,CBT1 Subunit of complex involved in processing of the 3' end of cytochrome b pre-mRNA YLR059C,REX2,YNT20 RNA exonuclease YDR428C Hypothetical ORF YDR152W Genetically Interacts with ribosomal genes YER180C,ISC10 Meiosis-specific protein required for spore formation YDR318W,MCM21,CTF5 Involved in minichromosome maintenance YCL047C Hypothetical ORF YPL159C Hypothetical ORF YGL061C,DUO1 Death Upon Overexpression YGL096W,TOS8 Target of SBF YLR412W Hypothetical ORF YPR134W,MSS18 Protein involved in splicing intron a15beta of COX1 YKL154W,SRP102 Signal recognition particle receptor beta subunit YER139C Hypothetical ORF YMR150C,IMP1,PET-TS2858 Inner membrane protease (mitochondrial protein) YIL007C,NAS2 Protein with similarity to the p27 subunit of mammalian proteasome modulator YIL089W Hypothetical ORF YPL233W,NSL1 Nnf1 Synthetic Lethal 1 YDR002W,YRB1,CST20, HTN1, SFO1 Yeast Ran Binder #1; suppressor of FUS1; homolog of mouse HTF9a and human RanBP1 YDR339C Protein required for cell viability YDR067C Hypothetical ORF YBR072W,HSP26 heat shock protein 26 YPL121C,MEI5,LPH6 Meiotic protein required for synapsis and meiotic recombination YJR123W,RPS5 ribosomal small subunit protein homologous to mammalian S5 (has approx. 70% identity with human, rat and hydrozoan S5). It is the least basic of the non-acidic ribosomal proteins. It is phosphorylated in yeast. YFL056C,AAD6 high degree of similarity with the AAD of P. chrysosporium YLL033W Hypothetical ORF YDL002C,NHP10,HMO2 Non-Histone Protein 10 YAR002C-A,ERP1 Emp24p/Erv25p related protein YER018C,SPC25 Spindle Pole Component of molecular weight 25kDa YIL133C,RPL16A,RPL13 Homology to rat L13a YOR295W,UAF30 Topoisomerase 1 and RAD52 epistasis group Interactions YER094C,PUP3,SCS32 20S proteasome subunit beta3_sc YIL167W Hypothetical ORF YGL047W Protein required for cell viability YBR264C,YPT10 similar to Rab proteins and other small GTP-binding proteins YOL139C,CDC33,TIF45, eIF-4E Required for START A of cell cycle and sporulation YPR089W Hypothetical ORF YGL187C,COX4 subunit IV of cytochrome c oxidase YDR475C Jumonji Interacting Protein YKR091W,SRL3 Suppressor of Rad53 null Lethality YPL225W Hypothetical ORF YMR035W,IMP2 Inner membrane protease (mitochondrial protein) YMR181C Hypothetical ORF YDL110C Hypothetical ORF YMR158W,MRPS8 Mitochondrial Ribosome Protein, Small subunit YOL024W Hypothetical ORF YFR011C Hypothetical ORF YDL064W,UBC9 Conjugates Smt3p to proteins YLR164W YLR164Wp is homologous to TIM18p YOL163W Hypothetical ORF, member of the Dal5p subfamily of the major facilitator family YDL004W,ATP16 ATP synthase delta subunit YOR357C,GRD19,SNX3 Functions in Golgi retention. YIR015W,RPR2 RNase P Ribonucleoprotein - name given to subunits that are unique to RNase P (not subunits of RNase MRP) YKL026C,GPX1 Glutathione peroxidase paralogue YCL058C,FYV5 Function required for Yeast Viability on toxin exposure YDL208W,NHP2 HMG-like nuclear protein YNL157W Hypothetical ORF YGL054C,ERV14 ER-derived vesicles YEL054C,RPL12A Homology to rat L12(a) and E. coli L11 YIL168W,SDL1 L-serine dehydratase YDL075W,RPL31A,RPL34 Homology to rat L31 YLR200W,YKE2,GIM1, PFD6 Yeast nuclear gene encoding a protein showing homology to mouse KE2 and containing a putative leucine-zipper motif YGR020C,VMA7 vacuolar H-ATPase 14 kDa subunit (subunit F) of the catalytic (V1) sector YFR035C Hypothetical ORF YOR050C Hypothetical ORF YNL300W Hypothetical ORF YER092W Ino Eighty Subunit 5 YJL184W Hypothetical ORF YBR253W,SRB6 involved in transcription as part of Srb/Mediator complex YER058W,PET117 Required for assembly of active cytochrome c oxidase YGR029W,ERV1 Protein forms dimers in vivo and in vitro, contains a conserved YPCXXC motif at carboxyl-terminal, binds FAD as a cofactor, and catalyzes the formation of disulfide bonds in protein substrates. YGR050C Hypothetical ORF YKL192C,ACP1 mitochondrial acyl carrier protein YDL241W Hypothetical ORF YIR013C,GAT4 very short and so far mRNA can't be detected YGL177W Hypothetical ORF YJR146W Hypothetical ORF YKL061W Hypothetical ORF YLR037C,DAN2 Delayed anaerobic gene YGL189C,RPS26A,RPS26 Homology to rat S26 YIL015C-A - YNL017C Hypothetical ORF YLL014W Hypothetical ORF YDR527W Protein required for cell viability YER120W,SCS2 Suppressor of Choline SynthesisLikely to be involved in regulating INO1 expression, suppressor of a dominant nuclear mutation that is inositol-dependent in the presence of choline YKL201C,MNN4 Required for the transfer of mannosylphosphate to cell wall mannans. YNL058C Hypothetical ORF YGL073W,HSF1,EXA3, MAS3 heat shock transcription factor YOR310C,NOP58,NOP5 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); 57 kDa nucleolar protein involved in the pre-rRNA processing steps that lead to formation of 18 S rRNA; interacts with Nop1p YDR202C,RAV2 Regulator of (H+)-ATPase in Vacuolar membrane YGL213C,SKI8,REC103 essential for protection against viral cytopathology, dispensable for mitotic but required for meiotic recombination and spore viability YLR025W,SNF7,DID1, VPS32 Involved in derepression of SUC2 in response to glucose limitation YPR075C,OPY2 imparts Far- phenotype YGR017W Hypothetical ORF YLR340W,RPP0,RPL10E Homology to rat P0, human P0, and E. coli L10e YNL014W,HEF3,ZRG7, YEF3B Translational elongation factor EF-3B YDL119C Hypothetical ORF YJL031C,BET4 catalyzes prenylation of Ypt1p (as a subunit of PGGTase-II) YLR348C,DIC1 mitochondrial dicarboxylate transport protein YDR491C Hypothetical ORF YBR049C,REB1,GRF2 DNA binding protein which binds sites found in genes transcribed by both RNA polymerase I and RNA polymerase II. Reb1p is required for termination of RNA polymerase I transcription. YJR019C,TES1,PTE1 Thioesterase YPR129W,SCD6 multicopy suppressor of clathrin deficiency YOR145C,PNO1,RRP20 Partner of Nob1 YOR087W,YVC1,YOR088W vacuolar cation channel YLR040C Hypothetical ORF YLR035C-A Ty ORF YDR443C,SSN2,NUT8, SCA1, SRB9, UME2, RYE3 Required for stable association of Srb10p-Srb11p kinase with RNA polymerase holoenzyme; regulates YGP1 epxression; component of RNA polymerase II holoenzyme and Kornberg's mediator (SRB) subcomplex YJL076W,NET1,ESC5, CFI1 Nucleolar protein involved in exit from mitosis YPL220W,RPL1A,SSM1 Homology to rat L10a, eubacterial L1, and archaebacterial L1; identical to S. cerevisiae L1B (Ssm2p) YCR039C,MATALPHA2,ALPHA2, HMLALPHA2 Homeobox-domain containing protein which, in haploid cells, acts with MCM1 to repress a-specific genes. In diploid cells alpha2 acts together with a1 to repress transcription of haploid-specific genes. YDL247W,MPH2 Maltose Permease Homologue. Maltose transporter family member, able to transport hexoses. Capable of transporting maltose, maltotriose, alpha-methylglucoside and turanose. YEL069C,HXT13 high-affinity hexose transporter YNL172W,APC1 anaphase-promoting complex component YLL045C,RPL8B,KRB1, SCL41 Homology to human L7a, mouse L7a, rat L7a YBL072C,RPS8A Homology to mammalian S8 YAR010C TyA Gag protein YDL246C - YGR115C Protein required for cell viability YJR151C,DAN4 Delayed Anaerobic Gene YKL030W Hypothetical ORF YFL061W Hypothetical ORF YBR012W-A TyA Gag protein YFL035C-A - YIL082W Hypothetical ORF YIR043C Hypothetical ORF YPL280W Hypothetical ORF YNL067W,RPL9B Homology to rat L9 YLR280C Hypothetical ORF YGR018C Hypothetical ORF YLR123C contains characteristic aminoacyl-tRNA motif YJR094W-A,RPL43B Homology to human L37a YPL143W,RPL33A Homology to rat L35a YLR322W,VPS65 - YKL225W Hypothetical ORF YDL068W Hypothetical ORF YBL094C Hypothetical ORF YNL296W Hypothetical ORF YML010C-B - YLR434C Hypothetical ORF YBL109W Hypothetical ORF YFL065C Hypothetical ORF YDL023C Hypothetical ORF YHR141C,RPL42B,MAK18 Homology to rat L36a and human L36a YOR170W Hypothetical ORF YNL043C Hypothetical ORF YLR282C Hypothetical ORF YDR133C Hypothetical ORF YDL130W,RPP1B,RPL44', RPLA3 Homology to rat P1, human P1, and E. coli L12eIIB YPR052C,NHP6A Homologous to mammalian high mobility group proteins 1 and 2; functions redundantly with the highly homologous gene, NHP6B; high-mobility group non-histone chromatin protein YGL024W Hypothetical ORF YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YAL024C,LTE1,MSI2 Gdp/GTP exchange factor required for growth at low temperatures YHR165C,PRP8,DBF3, DNA39, RNA8, SLT21, USA2 protein involved in mRNA splicing; lies at the catalytic center of the spliceosome; makes extensive contacts with the U5 snRNA and with the pre-mRNA YGL062W,PYC1 converts pyruvate to oxaloacetate YGL006W,PMC1 May be involved in depleting cytosol of Ca2+ ions YLL021W,SPA2,FUS6, PEA1 spindle pole antigen YNR065C Yeast SortiliN 1 YML081W Hypothetical ORF YGL133W,ITC1 Imitation switch Two Complex 1 YHR077C,NMD2,IFS1, SUA1, UPF2 Protein involved in decay of mRNA containing nonsense codons YJR029W Ty ORF YJL207C Hypothetical ORF YHR211W,FLO5 FLO5- and FLO8-determined flocculation are considerably less sensitive to mannose than FLO1-determined flocculation. YBR059C,AKL1 Ark-family kinase-like protein. This protein is the third member (After Ark1p and Prk1p) of the Ark-family kinases in S. cerevisiae. YML117W Hypothetical ORF YBR275C,RIF1 RAP1-interacting factor, involved in establishment of repressed chromatin YIL030C,SSM4,DOA10 Protein involved in mRNA turnover YDR217C,RAD9 Required for DNA damage-induced G2 arrest in mitosis, required for ionizing radation-induced G1 arrest, and other cdc13-induced G2 arrest in meiosis YDR216W,ADR1 Controls the expression of ADH2, peroxisomal protein genes, and genes required for ethanol, glycerol, and fatty acid utilization. YDR443C,SSN2,NUT8, SCA1, SRB9, UME2, RYE3 Required for stable association of Srb10p-Srb11p kinase with RNA polymerase holoenzyme; regulates YGP1 epxression; component of RNA polymerase II holoenzyme and Kornberg's mediator (SRB) subcomplex YKR095W,MLP1,MPL1 involved in translocation of macromolecules between the nucleoplasm and the NPC YGR094W,VAS1 mitochondrial and cytoplasmic valyl-tRNA synthetase YMR047C,NUP116,NSP116 Involved in nucleocytoplasmic transport; may be required for biogenesis of tRNA YGR271W,SLH1 SKI2-like helicase YJR091C,JSN1,PUF1 benomyl dependent tubulin mutant YHR016C,YSC84,LSB4 SH3 domain in C-terminus YKR021W Hypothetical ORF YJL069C U3 protein YIL068C,SEC6 cytoplasmic protein involved in fusion of post-Golgi vesicles with the plasma membrane. The Exocyst complex is required for exocytosis. YJL090C,DPB11 Part of the DNA polymerase II complex, acts in a checkpoiint pathway during S-phase YML068W,ITT1 Inhibitor of Translation Termination YJL093C,TOK1,DUK1, YKC1, YORK, YPK1 Target Of K1 Killer Toxin YOR063W,RPL3,MAK8, TCM1, YOR29-14 Homology to rat L3 YML123C,PHO84 inorganic phosphate transporter, transmembrane protein YKL149C,DBR1,PRP26 RNA lariat debranching enzyme YJL201W,ECM25 ExtraCellular Mutant YMR270C,RRN9 Upstream activation factor subunit YNL230C,ELA1 similar to mammalian elongin A, interacts with elongin C YBR263W,SHM1,SHMT1, TMP3 Serine hydroxymethyltransferase, mitochondrial YNL119W Hypothetical ORF YMR277W,FCP1 Encodes a carboxy-terminal domain (CTD) phosphatase essential for dephosphorylation of RNA polymerase II. Transcription by RNA polymerase II in S. cerevisiae generally requires CTD phosphatase. YLR107W,REX3 RNA EXonuclease; member of 3'->5' exonuclease family. See Moser et al. 1997 Nucleic acids Res. 25:5110-5118 YOL097C,WRS1,HRE342 W = IUPAC for tryptophan, RS = convention for aminoacyl-tRNA synthetases YPL014W Hypothetical ORF YIR029W,DAL2,ALC1 allantoicase YDL146W Hypothetical ORF YBR017C,KAP104 Karyopherin of 103,613 Da. Similar to yeast karyopherin beta (Kap95p; YLR347c) YNL029C,KTR5 Putative mannosyltransferase of the KRE2 family YAL016W,TPD3,FUN32 protein phosphatase 2A regulatory subunit A YDR458C Hypothetical ORF YML042W,CAT2,YCAT Carnitine O-acetyltransferase, peroxisomal and mitochondrial YPR023C,EAF3 Esa1p-Associated Factor YBR021W,FUR4 uracil permease YBR133C,HSL7 Histone Synthetic Lethal Negative regulator of Swe1 kinase YDR060W,MAK21,NOC1 essential for 60s ribosome biogenesis; involved in nuclear export of pre-ribosomes YGL255W,ZRT1 High-affinity zinc transport protein YOL098C Hypothetical ORF YBL068W,PRS4 ribose-phosphate pyrophosphokinase 4 YDL099W Hypothetical ORF YCR044C,PER1,COS16 Protein Processing in the ER YFR048W Required for Meiotic nuclear Division YJR117W,STE24,AFC1, PIO2 zinc metallo-protease that catalyzes the first step of N-terminal processing of the yeast a-factor precursor YDR021W,FAL1 Similar to eukaryotic initiation factor eIF4a; required for pre-rRNA processing at sites A0, A1, and A2; may be involved in 18S rRNA maturation YDL020C,RPN4,SON1, UFD5 Involved in ubiquitin degradation pathway. May act as common transcription factor on proteasomal and proteasome-related genes. YGR096W thiamine pyrophosphate carrier YFL039C,ACT1,END7, ABY1 Involved in cell polarization, endocytosis and other cytoskeletal functions YIR028W,DAL4 allantoin transport YML038C,YMD8 similar to vanadate resistance protein Gog5 YER144C,UBP5 Putative Ubiquitin-specific protease YIL002C,INP51,SJL1 Synaptojanin-like protein YHL025W,SNF6 Involved in global regulation of transcription YBL086C Hypothetical ORF YMR100W,MUB1 Homolog of samB gene of Aspergillus nidulans (deletion of samB results in mislocalization of septa YML037C Hypothetical ORF YHL009C,YAP3 bZIP protein; transcription factor YGL137W,SEC27 Involved in endoplasmic-to-Golgi protein trafficking YCR105W,ADH7,ADHVII NADP(H)-dependent alcohol dehydrogenase YDR049W Hypothetical ORF YOR350C,MNE1 similar to Lucilia illustris mitochondria cytochrome oxidase YJL089W,SIP4 Possibly involved in Snf1p regulated transcriptional activation YGR246C,BRF1,PCF4, TDS4 RNA polymerase III transcription factor with homology to TFIIB YER003C,PMI40,PMI catalyzes the interconversion of fructose-6-P and mannose-6-P YHL010C Hypothetical ORF YDL085W,NDE2,NDH2 Hypothetical ORF YOR080W,DIA2,YOR29-31 Digs Into Agar YLR225C Hypothetical ORF YIL095W,PRK1 p53 regulatory kinase. the phosphorylation of the Pan1pSla1pEnd3p complex by Prk1p is one of the important mechanisms by which the organization and functions of the actin cytoskeleton are regulated. YGL164C,YRB30 Competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p); able to form trimeric complexes with RanGTP and some of the karyopherins; inhibits RanGAP1(Rna1p)-mediated GTP hydrolysis on Ran. YIR002C,MPH1 Mutator PHenotype; Similar to ATP-dependent RNA helicases YDR451C,YHP1 acts as a repressor at early cell cycle boxes (ECBs) to restrict their activity to the M/G1 phase of the cell cycle. YOR355W,GDS1 involved in nuclear control of mitochondria YMR126C Defect at Low Temperature YJR136C Hypothetical ORF YGR197C,SNG1 Involved in nitrosoguanidine resistance YBR291C,CTP1 citrate transport protein YMR018W Hypothetical ORF YER076C Hypothetical ORF YMR291W Hypothetical ORF YHR064C,SSZ1,PDR13 DnaK homolog, interacts with Zuo1p (DnaJ homolog) to form a ribosome-associated complex (RAC) that is bound to the ribosome via the Zuo1p subunit YPR045C Hypothetical ORF YCR034W,FEN1,ELO2, GNS1, VBM2 Involved in synthesis of 1,3-beta-glucan, a component of the cell wall, and elongation of fatty acids up to 24 carbons YMR240C,CUS1 cold sensitive U2 snRNA Suppressor YGL201C,MCM6 Member of the MCM/P1 family of proteins involved in DNA replication YNL183C,NPR1 Stablizes several nutrient transporters by antagonizing a ubiquitin-mediated protein degradation pathway. YJR131W,MNS1 specific alpha-mannosidase YPR074C,TKL1 Transketolase 1 YFL009W,CDC4 Init. of DNA synthesis & spindle pole body separation; dispensable for both mitotic and meiotic spindle pole body dupl.; essential for mitotic but not premeiotic DNA synth.; wt levels of synaptonemal complexes and intragenic recombination YNL215W Hypothetical ORF YGR191W,HIP1 histidine permease YOL001W,PHO80,AGS3, TUP7, VAC5 Negative regulator of PHO81 and PHO5 YLR359W,ADE13,BRA1, BRA8 Adenylosuccinate Lyase YPR169W Jumonji Interacting Protein YGL091C,NBP35 NBP35 encodes an essential evolutionary conserved protein with homology to bacterial partitioning ATPases YOR260W,GCD1,TRA3 general control of amino acid biosynthesis and cell cycle initiation YGR257C Hypothetical ORF YOL060C,MAM3 putative hemolysin-like protein with three transmembrane domains YML007W,YAP1,PAR1, SNQ3 bZip transcription factor required for oxidative stress tolerance and localized to the nucleus in response to the presence of oxidants. YDR083W,RRP8 - YLR429W,CRN1 Crn1p associates with the Arp2/3 complex and inhibits WA- and Abp1-activated actin nucleation in the absence of preformed actin filaments, suggesting that Crn1 may restrict Arp2/3 complex activity to the sides of filaments. YGR260W,TNA1 Transporter of Nicotinic Acid YDR211W,GCD6 Guanine nucleotide exchange factor, 81 kDa subunit YOR069W,VPS5,GRD2, PEP10, VPT5, YOR29-20 Vacuolar Protein Sorting. component of the retromer coat that retrieves proteins from late endosomes. YIL116W,HIS5 responsive to control of general amino acid biosynthesis YDR452W,PPN1 Phosphate metabolism; transcription is regulated by PHO system YMR251W Hypothetical ORF YJL068C Hypothetical ORF YER021W,RPN3,SUN2 proteasome subunit YPL066W Hypothetical ORF YJL017W Hypothetical ORF YGL142C,GPI10 Involved in glycosyl phosphatidyl inositol synthesis; could be the target of the GPI synthesis inhibitor, YW3548; Most likely an alpha 1,2 mannosyltransferase utilized for the addition of the third mannose onto the GPI core structure. YNL084C,END3 Required for endocytosis and organization of the cytoskeleton YKL155C,RSM22 mitochondrial ribosome small subunit component YER119C,AVT6 related to the neuronal gamma -ransporters YPL265W,DIP5 dicarboxylic amino acid permease YJR107W Hypothetical ORF YOR091W Hypothetical ORF YMR086W Hypothetical ORF YHR045W Hypothetical ORF YBR280C Hypothetical ORF YLR446W Hypothetical ORF YHL032C,GUT1 Glycerol utilization YOR259C,RPT4,CRL13, PCS1, SUG2 Proteasome Cap Subunit YHL048W,COS8 Protein with similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p YPL194W,DDC1 DNA damage checkpoint gene YJR030C Hypothetical ORF YOR323C,PRO2 second enzyme in proline biosynthesis YHR115C Hypothetical ORF YBR008C,FLR1 Fluconazole Resistance 1 YJL110C,GZF3,DEH1, NIL2 Dal80 homolog YCL008C,STP22,VPS23 Ste pseudorevertant; required for vacuolar targeting of temperature-sensitive plasma membrane proteins; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype. YJR075W,HOC1 Homologous to OCH1, an alpha-1,6-mannosyltransferase; Golgi-localized, type II integral membrane protein YPL053C,KTR6,MNN6 Similar to KRE2, mannosylphosphate transferase which may recognize any oligosaccharides with at least one alpha-1,2-linked mannobiose unit. Required for the transfer of mannosylphosphate to cell wall mannans. YKL015W,PUT3 Positive regulator of PUT (proline utilization) genes YDL077C,VAM6,CVT4, VPL18, VPL22, VPS39 Required for the vacuolar morphogenesis in yeast YKL034W,TUL1 Transmembrane Ubiquitin Ligase YDR051C Hypothetical ORF YLR035C,MLH2 Mutl Homolog YPL202C,AFT2 Activator of Iron (Fe) Transcription YKL172W,EBP2 EBNA1-binding protein homolog YDL199C Hypothetical ORF YLR335W,NUP2 Localizes to discrete spots in the nuclear envelope; probably functions in transport through nuclear pore YDR189W,SLY1 Hydrophilic suppressor of ypt1 involved in vesicle trafficking between ER and GolgiSm like protein YLR289W,GUF1 Similar to E. coli elongation factor-type GTP-binding protein LepA YBR041W,FAT1 Putative membrane-bound long-chain fatty acid transport protein homologous to mouse fatty acid transport protein YPR110C,RPC40,RPC5 RNA polymerase III (C) subunit YIL105C Hypothetical ORF YOL119C,MCH4 monocarboxylate permease homologue YLR004C Hypothetical ORF YBR169C,SSE2 HSP70 family member, highly homologous to Sse1p YJR032W,CPR7 a cyclophilin related to the mammalian CyP-40; physically interacts with RPD3 gene product YCL048W Hypothetical ORF YJL107C Hypothetical ORF YPL145C,KES1,LPI3, OSH4 Homologous to human oxysterol-binding protein; implicated in ergosterol biosynthesis and regulation of Golgi-derived transport vesicle biogenesis YLR260W,LCB5 involved in sphingolipid biosynthesis YDL197C,ASF2 anti-silencing protein that causes depression of silent loci when overexpressed YKL212W,SAC1,RSD1 Inactivation of Sac1p leads to specific increase in cellular levels of phosphatidylinositol 4-phosphate, accompanied by changes in vacuole morphology and accumulation of lipid droplets. YDR118W,APC4 subunit of the Anaphase Promoting Complex; all known APC subunits co-immunoprecipitate with epitope-tagged Apc4p YKR069W,MET1,MET20 Methionine metabolism YBR086C,IST2 Similar to calcium and sodium channel proteins YOR001W,RRP6 Ribosomal RNA Processing YDR501W,PLM2 Plasmid Maintenance YLR319C,BUD6,AIP3 actin interacting rotein YFL002C,SPB4 involved in the maturation of 25S ribosomal RNA YML008C,ERG6,ISE1, LIS1, SED6 ergosterol synthesis YBR271W Hypothetical ORF YPL116W,HOS3 Protein with similarity to Hda1p, Rpd3p, Hos2p, and Hos1p YGL009C,LEU1 LEU1 encodes the second enzyme in leucine biosynthesis. YML093W,UTP14 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YKL039W,PTM1 Putative membrane protein YBR223C,TDP1 Tyrosine-DNA Phosphodiesterase YHR114W,BZZ1 Associated with LAS17p/Bee1p YMR217W,GUA1 GMP synthase YDR146C,SWI5 transcriptional activator YML071C,COG8,DOR1 dependent on RIC1 YLR015W,BRE2,CPS60 putative transcription factor, contains a PHD finger motif; homology to member of Set1p complex YBR260C,RGD1 Related GAP Domain YIL056W Hypothetical ORF YNL212W,VID27 Vacuole import and degradation YDR188W,CCT6,HTR3, TCP6, TCP20 cytoplasmic chaperonin of the Cct ring complex (previously called TCP1 or TRiC), distantly related to Tcp1p and to Hsp60 YML128C,MSC1 Meiotic Sister-Chromatid recombination YDL156W Hypothetical ORF YJL198W,PHO90 Low-affinity phosphate transporter YOL123W,HRP1,NAB4, NAB5 Putative polyadenylated-RNA-binding protein located in nucleus; similar to vertebrate hnRNP A/B protein family YER124C,DSE1 Daughter Specific Expression 1 YNL062C,GCD10 First identified as negative regulator of GCN4 expression YNL061W,NOP2,YNA1 May participate in nucleolar function during the transition from stationary phase to rapid growth YDR161W interacts with PP2C YKR093W,PTR2 Functions in transport of small peptides into the cell YOR057W,SGT1,YOR29-08 G2 allele of skp1 suppressor; subunit of SCF ubiquitin ligase complex; essential regulator of cell cycle; essential component of kinetochore assembly pathway. YGR021W Hypothetical ORF YNR044W,AGA1 anchorage subunit of a-agglutinin YDR075W,PPH3 protein phosphatase type 2A YHR209W Hypothetical ORF YLR064W Hypothetical ORF YJL126W,NIT2 Nit protein, nitrilase superfamily member YGR282C,BGL2 Cell wall endo-beta-1,3-glucanase YKR052C,MRS4 mitochondrial carrier protein, highly homologous to Mrs3p YGR231C,PHB2 Possible role in aging YKR046C Hypothetical ORF YPL064C,CWC27 Complexed with Cef1p YDR492W Hypothetical ORF YDR233C reticulon gene member of the RTNLA (reticulon-like A) subfamily YGL019W,CKB1 beta (38kDa) subunit of protein kinase CK2 YNR064C Hypothetical ORF YKL110C,KTI12,TOT4 Protein involved in resistance to K. lactis killer toxin; RNA polymerase II Elongator associated protein YFR047C,BNA6,QPT1 Biosynthesis of Nicotinic Acid YNL159C,ASI2 Amino acid Sensor-Independent (ASI) genes encode membrane proteins Asi1p, Asi2p and Asi3p. YML110C,COQ5,DBI56 co-enzyme Q deficient YCR100C Hypothetical ORF YOR158W,PET123 May be component of mitochondrial translation appartus and may interact with small subunit of mitochondrial ribosomes or with Pet122p to promote translational initiation of cytochrome c oxidase subunit III mRNA YPL196W,OXR1 OXidation Resistance YOL101C Hypothetical ORF YBR152W,SPP381 Suppressor of Pre-mRNA Processing mutant YGL161C,YIP5 rotein 5 YGR135W,PRE9 proteasome component Y13 YPL127C,HHO1 Histone H1 YGR267C,FOL2 First enzyme in biosynthetic pathway for folic acid and tetrahydrobioptern YIR038C,GTT1 Glutathione Transferase YHR008C,SOD2 Manganese-containing superoxide dismutase YJR135C,MCM22 Required for maintenance of chromosomes and minichromosomes YLR192C,HCR1 High Copy suppressor of RPG1 YPR060C,ARO7,HGS1, OSM2, TYR7 chorismate mutase YLR102C,APC9 required for structural stability and the incorporation of Cdc27p into the APC. YPL124W,SPC29,LPH3, NIP29 spindle pole body component YMR200W,ROT1 Reversal of tor2 lethality YOR074C,CDC21,CRT9, TMP1, YOR29-25 cell division cycle blocked at 36 degree C YLR301W Hypothetical ORF YGL237C,HAP2 Global regulator of respiratory genes YLR376C Platinum Sensitivity YFR020W Hypothetical ORF YLR312W-A,MRPL15 Mitochondrial ribosomal protein MRPL15 (YmL15) YBR242W Hypothetical ORF YBL043W,ECM13 ExtraCellular Mutant YMR156C,TPP1 Three Prime Phosphatase 1 YGL076C,RPL7A Homology to rat L7 and E. coli L30 YML092C,PRE8 proteasome component Y7 YGR095C,RRP46 Ribosomal RNA Processing YOR383C,FIT3 FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylphosphatidylinositol anchors. YFR017C Hypothetical ORF YAL003W,EFB1,TEF5 GDP/GTP exchange factor for Tef1p/Tef2p YAL014C,SYN8,UIP2 SNARE protein releated to mammalian SYNtaxin 8, ULP1 Interacting Protein 2 YLR370C,ARC18 Arp2/3 complex subunit YIL113W,SDP1 Hypothetical ORF YGL002W,ERP6 Emp24p/Erv25p related protein 6 YMR182C,RGM1 Putative transcriptional repressor with proline-rich zinc fingers YDR056C Hypothetical ORF YJL178C,ETF1 type II transmembrane protein YDR032C,PST2 Protoplasts-SecreTed protein; the gene product was detected among the proteins secreted by regenerating protoplasts YOR319W,HSH49 Human SAP Homolog 49. A yeast homolog of a human spliceosome associated protein (SAP) called SAP 49. YBR071W Hypothetical ORF YIL024C Hypothetical ORF YKL117W,SBA1 SBA1p binds to Hsp90 and is important for pp60v-src activity in yeast, shows similarity to the mammalian P-Twenty-Three proteins YMR118C Hypothetical ORF YDL200C,MGT1 6-O-methylguanine-DNA methylase YJR073C,OPI3,PEM2 Second and third steps of methylation pathway for phosphatidylcholine biosynthesis YHR110W,ERP5 Emp24p/Erv25p related protein 5 YJL072C,PSF2,CDC102 Partner of Sld Five 2 YJR112W,NNF1 Involved in nuclear function YBR171W,SEC66,HSS1, SEC71 glycoprotein complexed with Sec62p and Sec63p in the Sec63 complex, an integral endoplasmic reticulum membrane protein complex required for translocation of presecretory proteins YDL072C Hypothetical ORF YMR071C Tlg2-Vesicle Protein of 18 kDa YJR104C,SOD1,CRS4 Cu, Zn superoxide dismutase YML030W Hypothetical ORF YFR003C Yeast phosphatase inhibitor 1 YBR252W,DUT1 dUTP metabolism YCL056C Hypothetical ORF YDR092W,UBC13 ubiquitin-conjugating enzyme YMR059W,SEN15 Trna splicing endonuclease 15kDa subunit YOR339C,UBC11 homolog of ubiquitin carrier protein E2-C YMR040W Hypothetical ORF YDR462W,MRPL28 Mitochondrial ribosomal protein MRPL28 (YmL28) YKR074W Hypothetical ORF YPR062W,FCY1 cytosine deaminase highly homologous to Candida albicans cytosine deaminase YPL234C,TFP3,CLS9, VMA11 vacuolar ATPase V0 domain subunit c' (17 kDa) YLR421C,RPN13 Proteasome subunit YHL006C suppressor of HU sensitivity involved in recombination YNR010W,CSE2,MED9 Protein required for accurate mitotic chromosome segregation YPL071C Hypothetical ORF YBR120C,CBP6 Translational activator of COB mRNA YBR282W,MRPL27,YML27 essential for mitochondrial function YGR230W,BNS1 bypasses need for SPO12 YLR400W Hypothetical ORF YEL028W Hypothetical ORF YLR111W Hypothetical ORF YHR039C-B - YGL118C Hypothetical ORF YAL045C Hypothetical ORF YBR190W Protein required for cell viability YLR147C,SMD3,SLT16 involved in snRNP biogenesis and pre-mRNA splicing YEL014C Hypothetical ORF YHR138C Homologous to PBI2 YKL137W Hypothetical ORF YEL073C Hypothetical ORF YPL047W Hypothetical ORF YLR184W Hypothetical ORF YLR365W Hypothetical ORF YBR091C,MRS5,TIM12 Involved in mitochondrial biogenesis, may share a common function with Mrs11p YAL069W Hypothetical ORF YHR139C-A Hypothetical ORF YHR125W Hypothetical ORF YAR030C Hypothetical ORF YBR027C Hypothetical ORF YDR102C Hypothetical ORF YFL014W,HSP12,GLP1, HOR5 induced by heat shock, entry into stationary phase, depletion of glucose, and addition of lipids (fatty acids) YMR254C Hypothetical ORF YER181C Hypothetical ORF YFL010C,WWM1 WW domain containing protein interacting with Metacaspase (MCA1) YOR247W,SRL1 Suppressor of Rad53 null Lethality YJL016W Hypothetical ORF YDL094C Hypothetical ORF YPR156C,TPO3 Polyamine transport protein YOR300W Hypothetical ORF YEL066W,HPA3 Histone and other Protein Acetyltransferase; Has sequence homology to known HATs and NATs YJR045C,SSC1,ENS1, mtHSP70 Nuclear-encoded mitochondrial protein; member of the heat shock protein 70 (HSP70) family; most similar to E. coli DnaK protein; acts as a chaperone for protein import across the inner membrane; subunit of Endo.SceI endonuclease YGL089C,MF alpha mating factor YBR113W Hypothetical ORF YJL151C,SNA3 Homology to PMP3/SNA1 (Sensitivity to Na+) YDL010W Hypothetical ORF YPR143W Protein required for cell viability YNL108C Hypothetical ORF YDR497C,ITR1 member of sugar transporter superfamily YBL069W,AST1 Protein involved in targeting of plasma membrane [H+]ATPase YCR064C Hypothetical ORF YPL102C Hypothetical ORF YPR037C,ERV2 Essential for Respiration and Vegetative growth 2. Protein forms dimers in vivo/vitro, contains a conserved YPCXXC motif at carboxyl-terminal, binds FAD as cofactor, and catalyzes formation of disulfide bonds in protein substrates. YMR295C Hypothetical ORF YKR034W,DAL80,UGA43 Negative regulator of multiple nitrogen catabolic genes YBR224W Hypothetical ORF YDL221W Protein required for cell viability YBR090C Hypothetical ORF YGL152C Hypothetical ORF YDR537C Hypothetical ORF YBL027W,RPL19B Homology to rat L19 YGR293C Hypothetical ORF YCR040W,MATALPHA1,ALPHA1, HMLALPHA1 transcription factor involved in the regulation of alpha-specific genes YBR082C,UBC4 One of several UBC genes encoding ubiquitin-conjugating enzymes that attach ubiquitin to proteins. YAR066W Hypothetical ORF YFL067W Hypothetical ORF YNL301C,RPL18B,RP28B Homology to rat ribosomal protein L18 YPL079W,RPL21B Homology to rat L21 YAR068W putative membrane protein YAR075W Hypothetical ORF YMR121C,RPL15B Homology to rat L15 YDL151C,BUD30 Function required for yeast viability on toxin exposure; random budding in diploid null mutants YLR358C Hypothetical ORF YOR312C,RPL20B,RPL18A1 Homology to rat L18a YPL252C,YAH1 Yeast Adrenodoxin Homologue 1; This protein is targeted to the mitochondrial matrix as shown by using a specific polyclonal antibody YPL282C Hypothetical ORF YBR089W Hypothetical ORF YKL180W,RPL17A,RPL17 Homology to rat L17, human L17, and E. coli L22 YGL235W Hypothetical ORF YPR150W Hypothetical ORF YKL170W,MRPL38,YML38 mitochondrial ribosomal protein L14 YGR139W Hypothetical ORF YNL015W,PBI2,I2B, LMA1 Proteinase inhibitor that inhibits protease Prb1p (yscB or I) YOR045W,TOM6,ISP6, MOM8B involved in supporting the cooperativity between receptors and the general insertion pore and facilitating the release of preproteins from import components YHR079C-B - YNL235C Hypothetical ORF YER087C-A - YAR061W Hypothetical ORF YMR194C-A Hypothetical ORF YDL061C,RPS29B,YS29B Homology to rat S29 YPR039W Hypothetical ORF YKL158W - YLR264W,RPS28B,RPS33B Homology to mammalian S28 YGR183C,QCR9,UCR9 7.3 kDa subunit 9 of the ubiquinol cytochrome c oxidoreductase complex YLR388W,RPS29A Homology to rat S29 YJL142C Hypothetical ORF YGR039W Hypothetical ORF YML009C,MRPL39,YML39 Mitochondrial ribosomal protein MRPL39 (YmL39) YPR182W,SMX3 Sm or Sm-like snRNP protein YEL017C-A,PMP2 May regulate plasma membrane H(+)-ATPase; nearly identical to PMP1 YKL131W Hypothetical ORF YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YDL195W,SEC31,WEB1 involved in protein transport from endoplasmic reticulum to Golgi YOR227W Hypothetical ORF YAL002W,VPS8,FUN15, VPT8 involved in vacuolar protein sorting; required for localization and trafficking of the CPY sorting receptor YJR127C,ZMS1 Product of gene unknown YBL047C,EDE1,BUD15 EH domain protein involved in endocytosis YOL045W,PSK2 PAS domain-containing Serine/threonine Kinase YPR022C Hypothetical ORF YPL085W,SEC16,LPF1 multidomain vesicle coat protein that interacts with Sec23p YBR150C,TBS1 Probable Zn-finger protein YGR090W U3 protein YHR158C,KEL1 protein contains six kelch repeats, contains leucine zipper patterns, similar to KEL2 and KEL3. Kel1p has been proposed to function as an antagonist of the Pkc1p pathway. YLR436C,ECM30 ExtraCellular Mutant YJR035W,RAD26 May be involved in transcription-coupled DNA repair YNL257C,SIP3 Interacts with SNF1 protein kinase YNL242W,APG2,SPO72, AUT8 Defective in autophagy; required for sporulation YOL051W,GAL11,RAR3, SDS4, SPT13 Regulates transcription of a diverse array of genes. Required for mating and sporulation. YPR122W,AXL1,FUS5, STE22 determinant in axial budding pattern of haploid cells, involved in processing of a-factor YKL203C,TOR2,DRR2 putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiation, distribution of the actin cytoskeleton, and meiosis YER160C TyB Gag-Pol protein YHR102W,KIC1,NRK1 Kinase that interacts with Cdc31p; N-rich kinase 1 YDR457W,TOM1 Temperature dependent Organization in Mitotic nucleus YCR089W,FIG2 Factor-Induced Gene 2: expression is induced by the mating pheromones, a and alpha factor; required for efficient mating YER065C,ICL1 component of glyoxylate cycle YCR019W,MAK32 Protein necessary for structural stability of L-A double-stranded RNA-containing particles YDR173C,ARG82,ARGR3, IPK2 Regulator of arginine-responsive genes with ARG80 and ARG81 YMR101C,SRT1 cis-prenyltransferase involved in dolichol synthesis YOL124C Hypothetical ORF YJL108C,PRM10 pheromone-regulated membrane protein YHR139C,SPS100 involved in spore development YIL001W Hypothetical ORF YHL021C Hypothetical ORF YBR007C Hypothetical ORF YPR106W,ISR1 Inhibition of staurosporine resistance YNL247W Protein required for cell viability YLR392C Hypothetical ORF YMR279C Hypothetical ORF YDR235W,PRP42,MUD16, SNU65 Required for yeast pre-mRNA splicing YDR434W,GPI17 Glycosyl Phosphatidyl Inositol 17 YLR449W,FPR4 Homolog of homolog of the nucleolar FKBP, Fpr3 YOR193W Hypothetical ORF YPR127W Hypothetical ORF YPL072W,UBP16 putative deubiquitinating enzyme YDR483W,KRE2,MNT1 N-glycosylation YKL220C,FRE2 Ferric reductase, similar to Fre1p YBR075W Hypothetical ORF YNL006W,LST8 Required for amino acid permease transport from the Golgi to the cell surface YER169W,RPH1 Regulator of PHR1 YKL017C,HCS1,DIP1 DNA helicase 1 YJL208C,NUC1 mitochondrial nuclease YML062C,MFT1,MFT52 Protein involved in mitochondrial import of fusion proteins YPL075W,GCR1,LPF10 trans-acting positive regulator of the enolase and glyceraldehyde-3-phosphate dehydrogenase gene families YGL013C,PDR1,AMY1, ANT1, BOR2, CYH3, NRA2, SMR2, TIL1, TPE1, TPE3 general positive regulator of permeability genes YJR139C,HOM6 catalyzes third step in common pathway for methionine and threonine biosynthesis YLR034C,SMF3 Putative metal transporter, Nramp homolog, homolog of SMF1 and SMF2 YOL061W,PRS5 Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyrophosphokinase) YOR360C,PDE2,SRA5 low-Km (high-affinity) cAMP phosphodiesterase YPR013C Hypothetical ORF YGL112C,TAF6,TAF60 TATA-binding protein-associated-factor YKL200C Deleted due to sequence correction (3/11/1999) YOL015W Hypothetical ORF YBR298C,MAL31,MAL3T Part of the complex locus MAL3; functional in S288C; highly homologous to MAL61 from S. cerevisiae, MAL61 from S. carlsbergenesis strains JM1901 and CB11, and MAL1T from strain 4059 YDL227C,HO Homothallic switching YGR142W,BTN2 Gene/protein whose expression is elevated in a btn1 minus/Btn1p lacking yeast strain. YGR086C Phosphorylation Inhibited by Long chain base YLR274W,CDC46,BOB1, MCM5 Member of complex that acts at ARS's to initiate replication YAL018C Hypothetical ORF YDL206W Hypothetical ORF YFL024C,EPL1 Enhancer of Polycomb-Like (from , based on analogous functions within other eukaryotes. YPL150W Hypothetical ORF YLR017W,MEU1 Protein that regulates ADH2 gene expression YDL224C,WHI4 whi (Wee) mutants give small cell size YOR177C,MPC54 Meiotic Plaque Component YDL204W reticulon gene member of the RTNLA (reticulon-like A) subfamily YBL066C,SEF1 Suppressor of Essential Function YLR353W,BUD8 marks and directs bud emergence to the distal pole of diploid cells YHR092C,HXT4,LGT1, RAG1 hexose transporter YDR137W,RGP1 Ric1p-Rgp1p is an exchange factor, and peripheral membrane protein complex restricted to the Golgi. YER154W,OXA1,PET-TS1402 Mediates the export of proteins from the mitchondrial matrix to the intermembrane space. YBR290W,BSD2 metal homeostasis protein; putative membrane protein YMR290C,HAS1 Helicase Associated with SET1 YIR023W,DAL81,UGA35 Positive regulator of multiple nitrogen catabolic genes YDR306C Hypothetical ORF YDR061W Hypothetical ORF YHR069C,RRP4 Ribosomal RNA Processing YDL007W,RPT2,YHS4, YTA5 Probable 26S protease subunit and member of CDC48/PAS1/SEC18 family of ATPases YNR039C,ZRG17 zinc-regulated gene YKL048C,ELM1 cell morphology YGL049C,TIF4632 also called eIF4 (eIF-4) gamma YER001W,MNN1 Adds the terminal mannose to the outer chain branches of N-linked mannan, masking mannosylphosphate. YHR187W,IKI1,HAP2, ELP5, TOT5 RNA polymerase II Elongator associated protein YGL148W,ARO2 Chorismate synthase YDL138W,RGT2 plasma membrane glucose sensor YDL056W,MBP1 transcription factor YIL103W Hypothetical ORF YPR119W,CLB2 Involved in mitotic induction YOR138C Hypothetical ORF YJR002W,MPP10 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YDR436W,PPZ2 serine-threonine phosphatase Z YDL104C,QRI7 similar to H.influenzae sialoglycoprotease YKL059C,MPE1 Protein required for cell viability YBR192W,RIM2 Protein of the mitochondrial carrier (MCF) family that is required for respiration YPL209C,IPL1,PAC15 Regulation of yeast chromosome segregation -- plays a crucial role in regulating kinetochore-microtubule attachments. YLR130C,ZRT2 Low-affinity zinc transport protein YER082C,UTP7 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YDR205W,MSC2 Meiotic Sister-Chromatid recombination; transmembrane protein (putative) showing some protein similarity to Zrc1p and Cot1p YLR403W,SFP1 Inhibits nuclear protein localization when present in multiple copies YFR025C,HIS2 Histidinolphosphatase YPR186C,PZF1,TFC2 Transcription factor IIIA (TFIIIA) with putative Zn-fingers YMR133W,REC114 meiosis-specific recombination gene; dispensable for mitotic recombination and axial elements in meiosis but required for synaptonemal complexes, meiotic recombination, and spore viability; classified as an early recombination gene YGR278W,CWC22 Complexed with Cef1p YDR473C,PRP3,RNA3 snRNP from U4/U6 and U5 snRNPs YMR160W Hypothetical ORF YBL008W,HIR1 Involved in cell-cycle regulation of histone transcription YOR038C,HIR2,SPT1 Involved in cell-cycle regulation of histone transcription YHL017W Hypothetical ORF YNR055C,HOL1 Putative ion transporter similar to the major facilitator superfamily of transporters YMR216C,SKY1 SRPK1-like Kinase in Yeast (SRPK1 is a human serine kinase that specifically phosphoryates arginine-serine rich domains found in the SR family of splicing factors.) YKL175W,ZRT3 - YKR015C Hypothetical ORF YPL086C,ELP3,HPA1, TOT3 elongator protein; histone and other protein acetyltransferase; has sequence homology to known HATs and NATs YHR199C Hypothetical ORF YCL028W,RNQ1,[PIN Rich in asparagine (N) and glutamine (Q) YOL033W,MSE1 Mitochondrial glutamyl-tRNA synthetase YMR313C Triacylglycerol lipase YLR228C,ECM22 involved in cell wall biogenesis (putative) YBR019C,GAL10 UDP-glucose 4-epimerase YIL162W,SUC2 - YDL054C,MCH1 Monocarboxylate Permease Homologue YPL126W,NAN1,UTP17 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Net1-Associated Nucleolar protein 1 YNL144C Hypothetical ORF YMR080C,NAM7,IFS2, MOF4, UPF1 Involved in mRNA degradation YDR005C,MAF1 Mod5 protein sorting. Negative effector of Pol III synthesis. YJL100W,LSB6 LAs17 Binding protein YER179W,DMC1,ISC2 Dispensable for double strand breaks, synaptonemal complexes, gene conversion in return to growth assay. Required for full pairing by in situ hybrid. assay, wt time of appearance of synaptonemal complexes and reciprocal Rec in growth assay YAR002W,NUP60 nuclear pore protein YOL076W,MDM20,DEC1 Mitochondrial distribution and morphology YEL015W Enhancer of DeCapping 3 YNL137C,NAM9,MNA6 putative mitochondrial S4 ribosomal protein YGL067W,NPY1 hydrolyzes the pyrophosphate linkage in NADH and related nucleotides YOR100C,CRC1 carnitine carrier YDR456W,NHX1,VPS44 Required for intracellular sequestration of Na+ YMR283C,RIT1 Modifies initiator methionine tRNA to distinguish it from elongator methionine tRNA YGL021W,ALK1 leucine zipper (putative), membrane protein (putative) YNR027W,BUD17 - YGL248W,PDE1 3',5'-Cyclic-nucleotide phosphodiesterase, low affinity YBR065C,ECM2,SLT11 ExtraCellular Mutant YGL097W,SRM1,MTR1, PRP20 Gdp/GTP exchange factor for Gsp1p/Gsp2p YOL073C Hypothetical ORF YGL143C,MRF1 Mitochondrial polypeptide chain release factor YOR166C Hypothetical ORF YGR185C,TYS1,TTS1, TYRRS tyrosyl-tRNA synthetase, cytoplasmic YBR183W,YPC1 Yeast Phyto-ceramidase YHR068W,DYS1 Deoxyhypusine synthase carries out the first step in hypusine biosynthesis, converting lysine and spermidine into deoxyhypusine. YPR001W,CIT3 Mitochondrial isoform of citrate synthase YHR170W,NMD3,SRC5 putative Upf1p-interacting protein YPL093W,NOG1 Nucleolar G-protein 1; LPG15w (working nomenclature) YHR072W,ERG7 carries out complex cyclization step of squalene to lanosterol in sterol biosynthesis pathway YCL044C Hypothetical ORF YIL038C,NOT3 General negative regulator of transcription; may inhibit RNA polymerase II transcription machinery YPR103W,PRE2,DOA3, PRG1, SRR2 responsible for the chymotryptic activity of the yeast 20S proteasome YOR270C,VPH1 vacuolar ATPase V0 domain subunit a (100 kDa) YGR043C Hypothetical ORF YOR240W - YER080W Hypothetical ORF YNL267W,PIK1,PIK41, PIK120 catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton YCL049C Hypothetical ORF YPL036W,PMA2 plasma membrane ATPase YIL033C,BCY1,SRA1 Involved in heat shock resistance, glycogen accumulation, and sporulation YPL215W,CBP3 Protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex) YER122C,GLO3 Zinc-finger-containing protein with similarity to Gcs1p and Sps18p YOL164W Hypothetical ORF YDR368W,YPR1 homologous to the aldo-keto reductase protein family YPL154C,PEP4,PHO9, PRA1, yscA vacuolar proteinase A YJL181W Hypothetical ORF YPR198W,SGE1,NOR1 multi-copy suppressor of gal11 null; member of drug-resistance protein family YGL036W Mtf1 Two Hybrid Clone 2 YOR090C,PTC5 Phosphatase type Two C YPL272C Hypothetical ORF YKL151C Hypothetical ORF YBR030W Hypothetical ORF YGR067C Hypothetical ORF; has similarity to Adr1p DNA-binding domain YOR205C Hypothetical ORF YDR481C,PHO8 repressible alkaline phosphatase YDR076W,RAD55 Required for X-ray damage repair, full sporulation and viable spores YIL088C,AVT7 related to the neuronal gamma -ransporters YOL010W,RCL1 protein similar to the RNA 3' terminal phosphate cyclase (RNA 3' terminal phosphate Cyclase-Like) YDR027C,LUV1,VPS54 Loss Upsets Vacuole. Isolated in a microtubule complex containing Rbl2p. YIL150C,MCM10,DNA43 Protein required for S-phase (DNA synthesis) initiation or completion YOR243C,PUS7 pseudouridylates U2 snRNA at position 35 YDR182W,CDC1,DSC1, DSR1, ESP2 Protein that affects bud emergence, intrachromosomal recombination, and nuclear division YJL013C,MAD3 checkpoint protein required for cell cycle arrest in response to loss of microtubule function YOR101W,RAS1 ras proto-oncogene homolog YDR103W,STE5,HMD3, NUL3 Protein of the pheromone pathway YJR040W,GEF1,CLC Integral membrane protein highly homologous to voltage-gated chloride channels from humans, mice and fish YPL240C,HSP82,HSP83, HSP90 82 kDa heat shock protein; homolog of mammalian Hsp90 YDR400W,URH1 uridine nucleosidase (uridine ribohydrolase); EC 3.2.2.3 YKR037C,SPC34 Spindle Pole Component of molecular weight 34 kDa YDR255C,RMD5,GID2 Required for Meiotic nuclear Division YKL068W,NUP100,NSP100 Participates in nucleocytoplasmic transport; member of GLFG-containing family of nucleoporins YPR097W Hypothetical ORF YEL063C,CAN1 arginine permease YLR063W Hypothetical ORF YOR307C,SLY41 multicopy suppressor of ypt1 deletion YER025W,GCD11,SUI4 eIF2 is a heterotrimeric GTP-binding protein SUI3 encodes the beta subunit YKR017C Hypothetical ORF YAR018C,KIN3,FUN52, NPK1 protein kinase YIL124W,AYR1 Subcellular location of Ayr1p: lipid particles and endoplasmic reticulum of the yeast YMR281W,GPI12 N-acetylglucosaminylphosphatidylinositol de-N-acetylase YDR489W,SLD5,CDC105 Synthetic Lethality with Dpb11-1 YDL127W,PCL2,CLN4 Interacts with cyclin-dependent kinase PHO85 to form kinase complex with G1-periodic activity involved in cell cycle progression YJR096W Protein with similarity to aldo-keto reductases YLR079W,SIC1,SDB25 P40 inhibitor of Cdc28p-Clb5 protein kinase complex YOL092W Hypothetical ORF YPR183W,DPM1,SED3 dolichol phosphate mannose synthase YPL033C Hypothetical ORF YOR115C,TRS33 Trapp subunit of 33 kDa YIL003W Protein required for cell viability YPR109W Hypothetical ORF YOR040W,GLO4 Mitochondrial glyoxylase-II YHL026C Hypothetical ORF YOR095C,RKI1 Ribose-5-phosphate ketol-isomerase YDR337W,MRPS28 Mitochondrial ribosomal protein MRPS28 (E. coli S15) YPR199C,ARR1,YAP8, ACR1 Similar to transcriptional regulatory elements YAP1 and cad1 YLR091W Hypothetical ORF YJL145W,SFH5 putative phosphatidylinositol transfer protein YDR494W Ribosomal Small subunit Mitochondria YKR025W,RPC37 RNA Polymerase C (III) 37 kDa subunit; interacts with C53 subunit. C37 is an RNA polymerase III specific subunit. YOR010C,TIR2,SRP2 cold-shock induced protein of the Srp1p/Tip1p family of serine-alanine-rich proteins YNL195C Hypothetical ORF YHR140W Hypothetical ORF YOL142W,RRP40 Ribosomal RNA Processing YMR077C,VPS20 vaculolar protein sorting (putative) YPL078C,ATP4,LPF7 ATP synthase F0 sector subunit 4; analogous to the bovine b subunit YER100W,UBC6,DOA2 ubiquitin-conjugating enzyme YCL012W - YKR014C,YPT52 rab5-like GTPase involved in vacuolar protein sorting and endocytosis YBR111C,YSA1,RMA2 Protein with weak homology to D. melanogaster serendipity protein and X. laevis basis fibroblast growth factor YPL107W Hypothetical ORF YGR126W Hypothetical ORF YLR250W,SSP120 secretory protein YIL118W,RHO3 ras homolog--GTP binding protein YEL057C Hypothetical ORF YLR178C,TFS1,DKA1 Carboxypeptidase Y inhibitor YGR158C,MTR3 Involved in mRNA transport YLR391W-A - YPR131C,NAT3 Non-essential gene, growth of null mutants is retarded on both YPD & YPG media. The mating efficiency of MATalpha cells, but not MATa cells, is reduced by nearly three orders of magnitude. YBL038W,MRPL16 Mitochondrial ribosomal protein MRPL16 YBR197C Hypothetical ORF YGR006W,PRP18 Prp18 acts in concert with Slu7 during the second step of yeast pre-mRNA splicing. YLR065C Hypothetical ORF YBR084C-A,RPL19A Homology to rat L19 YDR373W,FRQ1 Product of gene unknown YIL164C,NIT1 nitrilase YHR148W,IMP3 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Interacts With Mpp10; Imp3p is a specific component of the U3 snoRNP and is required for pre-18S rRNA processing. It is not required for U3 snoRNA stability. YKL196C,YKT6 Synaptobrevin (v-SNARE) homolog with similarity to Sec22p, Snc1p, and Snc2p, essential for endoplasmic reticulum-Golgi transport YNL056W Hypothetical ORF YGL211W Hypothetical ORF YHR153C,SPO16 Early meiotic protein required for efficient spore formation YPL218W,SAR1 Secretion-Associated, Ras-related. Component of COPII coat of vesicles; required for ER to Golgi protein transport YLR031W Hypothetical ORF YDR121W,DPB4 DNA Polymerase B (II), 4th subunit YNL222W,SSU72 functionally related to TFIIB, affects start site selection in vivo YML079W Hypothetical ORF YJL218W Hypothetical ORF YPL239W,YAR1 YAR1 encodes a 200-amino-acid protein with two ANK repeat motifs and an acidic C terminus rich in PEST-like sequences YAL008W,FUN14 Product of gene unknown YOL029C Hypothetical ORF YER034W Hypothetical ORF YCL076W Hypothetical ORF YGL247W,BRR6 efrigeration YLL053C Hypothetical ORF; maybe continuous with YLL052C (AQY2) in some strain backgrounds including Sigma1278b; functions as an aquaporin in these strains. YIL004C,BET1,SLY12 Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins YNL179C Hypothetical ORF YLR245C,CDD1 Involved in cytidine and deoxycytidine metabolism YNR022C,MRPL50 Mitochondrial Ribosome Protein, Large Subunit YPR063C Hypothetical ORF YNR036C Hypothetical ORF YFR033C,QCR6,COR3, UCR6 ubiquinol-cytochrome c oxidoreductase subunit 6 (17 kDa) YER044C,ERG28,BUD18 Transmembrane domain containing protein which may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or to tether these enzymes to the ER YHR095W Hypothetical ORF YDL123W,SNA4 Homology to PMP3/SNA1 (Sensitivity to Na+) YGR035C Hypothetical ORF YKR049C Hypothetical ORF YMR298W Protein required for cell viability YER109C,FLO8,YER108C, PHD5 Nuclear protein required for diploid filamentous growth, haploid invasive growth and flocculation; note that S288C strains have a mutation in this gene YJR044C,VPS55 Vacuolar Protein Sorting YDR156W,RPA14 14 kDa subunit of RNA polymerase I YOL108C,INO4 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis YMR292W,GOT1 Golgi Transport YBR258C,SHG1,CPS15 - YLR408C Hypothetical ORF YBR194W Synthetic with Old Yellow Enzyme YOR159C,SME1 Required for pre-mRNA splicing, cap modification and U1, U2, U4 and U5 snRNA stability YOL048C Hypothetical ORF YDR363W-A,SEM1,HOD1, DSS1 Suppressor of Exocyst Mutations; Homolog of DSS1; similar to hypothetical protein from S. pombe YPL056C Hypothetical ORF YIL058W Hypothetical ORF YDL181W,INH1 ATPase inhibitor YAR069C Hypothetical ORF YOR020C,HSP10,CPN10 Homolog of E. coli GroES protein; regulates Hsp60, the yeast mitochondrial chaperonin, and is thereby involved in protein folding and sorting in mitochondria YGR206W Hypothetical ORF YIL025C Hypothetical ORF YPL183W-A Putative mitochondrial ribosomal protein YCR020C-A,MAK31,LSM9, SMX1 Like Sm protein; member of the Sm protein family, though slightly divergent because Mak31/Lsm9p does not contain a glycine or cysteine at amino acid 107. YER048W-A Similar to D. melanogaster protein; weaker homology to C. elegans protein with similarity to human cdk7/cyclin H assembly factor YDR278C Hypothetical ORF YIL086C Hypothetical ORF YAR064W Hypothetical ORF YKL053C-A,MDM35 Mitochondrial Distribution and Morphology YEL020W-A,TIM9 Translocase in inner membrane of mitochondria involved in mitochondrial protein import YJL007C Hypothetical ORF YLR346C Protein of unknown function; expression regulated by PDR1 YDR220C Hypothetical ORF YOL013W-A Similar to probable membrane protein YLR334C and ORF YOL106W YDR525W-A,SNA2 Homology to PMP3/SNA1 (Sensitivity to Na+) YLR327C Hypothetical ORF YJL152W Hypothetical ORF YDR328C,SKP1,MGO1 Involved in kinetochore function and ubiquitin-mediated proteolysis YMR173W,DDR48,FSP DNA damage inducible; implicated in the production or recovery of mutations YGR074W,SMD1,SPP92 Homolog of human core snRNP protein D1, involved in snRNA maturation YDR455C Hypothetical ORF YJL015C Protein required for cell viability YLR428C Hypothetical ORF YFR056C Hypothetical ORF YLR140W Protein required for cell viability YDR445C Hypothetical ORF YDR048C Hypothetical ORF YBR124W Hypothetical ORF YDR290W sick with securin disruption YGL074C Protein required for cell viability YBR116C Hypothetical ORF YJL169W Hypothetical ORF YLR281C Hypothetical ORF YBR100W - YML094W,GIM5,PFD5 Prefoldin subunit 5; putative homolog of subunit 5 of bovine prefoldin, a chaperone comprised of six subunits YGR181W,TIM13 Translocase of the inner membrane; mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins YAR031W,PRM9 pheromone-regulated membrane protein YLR279W Hypothetical ORF YBL073W Protein required for cell viability YPL073C Hypothetical ORF YMR306C-A Hypothetical ORF YJL064W Hypothetical ORF YPR100W,MRPL51 Mitochondrial Ribosome Protein, Large Subunit YMR294W-A Hypothetical ORF YDL050C Hypothetical ORF YDR025W,RPS11A Homology to rat S11, human S11, and E. coli S17 YBR010W,HHT1,BUR5, SIN2 Histone H3 (HHT1 and HHT2 code for identical proteins) YCR049C Hypothetical ORF YJL191W,RPS14B,CRY2 Homology to human S14 and rat S14, E. coli S11 YGL102C Protein required for cell viability YBL053W Hypothetical ORF YER074W,RPS24A,RPS24EA Homology to rat S24 YIL060W Hypothetical ORF YNL266W Hypothetical ORF YOR055W Hypothetical ORF YOR200W Hypothetical ORF YEL075C Hypothetical ORF YOR325W Hypothetical ORF YBR226C Hypothetical ORF YOR139C Hypothetical ORF YDR417C Hypothetical ORF YBL087C,RPL23A Homology to E. coli L14 and rat L23 YPR126C Hypothetical ORF YPR043W,RPL43A Homology to human L37a YKR047W Hypothetical ORF YGR032W,GSC2,FKS2 Highly similar to FKS1 (GSC1). GSC2 and FKS1 encode redundant catalytic components of 1,3-beta-glucan synthase. Deletion of both is lethal YNR025C Hypothetical ORF YML117W-A - YBL108W Hypothetical ORF YDR094W Hypothetical ORF YDR114C Hypothetical ORF YBL107W-A Similar to TyA and TyB proteins YPR051W,MAK3 N-acetyltransferase YLR041W Hypothetical ORF YCL046W Hypothetical ORF YHR021C,RPS27B Homology to mammalian S27 YIR044C Hypothetical ORF YMR158C-B - YBL096C Hypothetical ORF YFL011W-A - YGL260W Hypothetical ORF YLR287C-A,RPS30A Homology to mammalian S30 YDL184C,RPL41A,RPL47A Homology to human L41 YDL026W Hypothetical ORF YJL009W Protein required for cell viability YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YBR235W Hypothetical ORF YJR137C,ECM17,MET5 ExtraCellular Mutant YDR040C,ENA1,HOR6, PMR2 Plasma membrane Na+ pump; P-type ATPase YDR128W Hypothetical ORF YKL205W,LOS1 Nuclear pore protein involved in pre-tRNA splicing YJL039C,NUP192 large yeast nucleoporin YIL048W,NEO1 ATPase that leads to neomycin-resistant protein when overexpressed YOL087C Hypothetical ORF YAL019W,FUN30 Shows homology to SNF2 transcriptional regulator YOR341W,RPA190,RRN1 alpha (190 kDa) subunit of RNA polymerase I YDR093W,DNF2 Drs2 Neo1 Family YLR310C,CDC25,CTN1, CDC25' cell division cycle blocked at 36 degree C YFL033C,RIM15,TAK1 RIM15 is glucose-repressed; RIM15 is required for IME2 expression YCR033W,SNT1 - YGR032W,GSC2,FKS2 Highly similar to FKS1 (GSC1). GSC2 and FKS1 encode redundant catalytic components of 1,3-beta-glucan synthase. Deletion of both is lethal YER164W,CHD1 Sole S. cerevesiae member of CHD gene family containing Chromodomain, Helicase domain, and DNA-binding domain YMR306W,FKS3 Protein with similarity to Gls1p and Gls2p (GB:Z49212) YMR190C,SGS1 Involved in maintaining genome stability. Homologous to E. coli RecQ and human BLM and WRN proteins that are defective in the cancer-prone disorder Bloom's syndrome and the premature aging disorder Werner's syndrome, respectively YDL140C,RPO21,RPB1, RPB220, SUA8 RNA polymerase II large subunit YJR066W,TOR1,DRR1 Involved in cell cycle signaling and meiosis YAL029C,MYO4,FUN22, SHE1 Required for mother-specific HO expression, needed for the accumulation in daughter nuclei of Ash1p YLR422W Hypothetical ORF YNL180C,RHO5 Rho family of small GTPases YER147C,SCC4 a major role for the Scc2p/Scc4p complex appears to be to facilitate the loading of cohesin complexes onto chromosomes. YER167W,BCK2,CTR7 Serine/threonine protein kinase of the protein kinase C pathway YOL021C,DIS3,RRP44 Possible component of RCC1-Ran pathway YDR449C,UTP6 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YBR196C,PGI1,CDC30 Phosphoglucoisomerase YMR288W,HSH155 - YNL121C,TOM70,MAS70, MOM72, OMP1 Translocase of Outer Mitochondrial membrane YIL090W Hypothetical ORF YDR090C Hypothetical ORF YEL040W,UTR2,CRH2 (alias: ypersensitivity) YHR032W Hypothetical ORF YPR065W,ROX1,REO1 The ROX1 gene encodes a heme-induced repressor of hypoxic genes in yeast. YCL057W,PRD1 Saccharolysin (oligopeptidase yscD) YPL005W Hypothetical ORF YEL023C Hypothetical ORF YLR219W,MSC3 Meiotic Sister-Chromatid recombination YJL171C Hypothetical ORF YHR166C,CDC23 Required for mitosis and RNA synthesis YER059W,PCL6 PHO85 cyclin YFL050C,ALR2 aluminium resistance YGR059W,SPR3 a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilament genes; regulated by ABFI YPL147W,PXA1,LPI1, PAL1, PAT2, SSH2 Pxa1p and Pxa2p appear to be subunits of a peroxisomal ATP-binding cassette transporter necessary for transport of long-chain fatty acids into peroxisomes YKL106W,AAT1 aspartate aminotransferase, mitochondrial YMR135C Dose-dependent Cell cycle Regulator YGR155W,CYS4,NHS5, STR4, VMA41 encodes the first enzyme in cysteine biosynthesis. catalyzes the first committed step of transsulfuration. YDR117C Hypothetical ORF YLR148W,PEP3,VAM8, VPS18, VPT18 vacuolar membrane protein YHR179W,OYE2 NAPDH dehydrogenase (old yellow enzyme), isoform 2 YNL082W,PMS1 Required for mismatch repair in mitosis and meiosis, low levels of postmeiotic segregation, and high spore viability, dispensable for homeologous recombination YPR047W,MSF1 alpha subunit of yeast mitochondrial phenylalanyl-tRNA synthetase YLR190W Hypothetical ORF YHR073W,OSH3 Oxysterol Binding Protein YMR113W,FOL3 FOLinic acid requiring YNR060W,FRE4 similar to FRE2 YDR273W,DON1 prospore membrane localizing protein YOL112W,MSB4 Multicopy Suppressor of Bud Emergence YML124C,TUB3 alpha-tubulin YOR037W,CYC2 Involved in import of cytochrome c into mitochondria YKR071C Protein required for cell viability YOR073W Hypothetical ORF YIL063C,YRB2 Ran-GTPase-binding protein involved in nuclear export YNR015W,SMM1,DUS2 Suppressor of Mitochondrial Mutation in the tRNAasp gene; Dihydrouridine synthase 2 YPR171W,BSP1 Binding protein of Synaptojanin Polyphosphoinositide phosphatase domain; may function to link synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton YMR031C Hypothetical ORF YJR006W,HYS2,HUS2, POL31, SDP5 Putative role in DNA replication YER136W,GDI1,SEC19 Regulates vesicle traffic in secretory pathway by regulating dissociation of GDP from Sec4/Ypt/rab family of GTP-binding proteins YPR034W,ARP7,SWP61 involved in transcriptional regulation YMR305C,SCW10 Soluble Cell Wall protein YLR354C,TAL1 Transaldolase, enzyme in the pentose phosphate pathway YHR176W,FMO catalyzes the O2- and NADPH-dependent oxidations of biological thiols, including oxidation of glutathione to glutathione disulfide YKL193C,SDS22,EGP1 Interacts with and may be a positive regulator of GLC7 which encodes type1 protein phosphatase YFL048C,EMP47 47 kDa type I transmembrane protein localized to the Golgi YCL051W,LRE1 involved in laminarase resistance YOR034C,AKR2 Protein involved in constitutive endocytosis of Ste3p YMR091C,NPL6 involved in nuclear protein targeting YJL116C,NCA3 With NCA2, regulates proper expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase YGR143W,SKN1 Involved in (1->6)-beta-glucan biosynthesis YDR195W,REF2 RNA End FormationRNA-binding protein involved in cleavage step of mRNA 3'-end formation, prior to polyadenylation YPL262W,FUM1 Fumarase; converts fumaric acid to L-malic acid in the TCA cycle YPL006W,NCR1 Niemann-Pick Type C homologous gene YLR113W,HOG1,SSK3 Osmoregulation. Hog1p is activated under stress conditions when the cAMP cellular content is low. YLR214W,FRE1 Ferric (and cupric) reductase YER069W,ARG5,6 N-acetyl-gamma-glutamyl-phosphate reductase and acetylglutamate kinase YDL216C,RRI1,CSN5, JAB1 subunit of COP9 signalosome (CSN) YPR157W Hypothetical ORF YOR187W,TUF1 Translation elongation factor Tu, mitochondrial YHL016C,DUR3 Urea active transport protein YBL089W,AVT5 related to the neuronal gamma -ransporters YHL028W,WSC4,YHC8 cell wall integrity and stress response component 4 YPR141C,KAR3,OSR11 kinesin-like nuclear fusion protein YML076C,WAR1 ORF YDL095W,PMT1 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway; acts in complex with Pmt2p YHR004C,NEM1 Nuclear Envelope Morphology YBR270C Hypothetical ORF YJL216C Hypothetical ORF YCR091W,KIN82 Putative serine/threonine protein kinase most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily YMR102C Hypothetical ORF YDR065W Hypothetical ORF YJR078W,BNA2 Biosynthesis of Nicotinic Acid YDR207C,UME6,CAR80, NIM2, RIM16 Regulator of both repression and induction of early meiotic genes. Ume6p requires Ume4 for mitotic repression and interacts with and requires Ime1p and Rim11p for induction of meiosis-specific transcription YKL043W,PHD1 protein similar to StuA of Aspergillus nidulans YER014W,HEM14 converts protoporphyrinogen IX to protoporphyrin IX (in synthesis of heme) YNL193W Hypothetical ORF YDR219C Hypothetical ORF YML016C,PPZ1 may play a role in regulating osmotic stability YDR485C,VPS72 - YML067C,ERV41 ER vesicle protein YGR055W,MUP1 high affinity methionine permease YNL299W,TRF5 TRF4 homolog; TRF4/5 function is required for proper mitosis YEL041W Hypothetical ORF YGR080W,TWF1 Twinfilin A is a member of a conserved family of actin monomer sequestering proteins. TWF1 is comprised almost entirely of two tandem repeats, each having sequence homology with cofilin (COF1). YOR147W,MDM32 Mitochondrial Distribution and Morphology YOR061W,CKA2,YOR29-12 may have a role in regulation and/or execution of the eukaryotic cell cycle YJL134W,LCB3,LBP1, YSR2 Protein involved in incorporation of exogenous long chain bases in sphingolipids YDL089W Hypothetical ORF YML116W,ATR1,SNQ1 aminotriazole resistance YGR178C,PBP1,MRS16 Poly(A)-binding protein binding protein YBR026C,ETR1,MRF1, MRF1' Involved in mitochondrial fatty acid biosynthesis YOR272W,YTM1 microtubule-associated protein YLL016W,SDC25 homologous to cdc25 YDR393W,SHE9,MDM33 Mrna (identified by a library screen) that causes growth arrest when overexpressed. Mitochondrial Distribution and Morphology YMR131C,RRB1 RiboSome Assembly 2 YJL078C,PRY3 Pathogen Related in Sc, contains homology to the plant PR-1 class of pathogen related proteins. The protein sequence is over 60% identical with the Pry2p & Pry3p over 145 resid. PRY1 is >35% identical (50% similar) to tobacco PR-1c protein. YBR172C,SMY2 partial suppressor of myo2-66 YPL212C,PUS1 Involved in tRNA biogenesis YMR049C,ERB1 Eukaryotic Ribosome Biogenesis YGL084C,GUP1 Involved in active glycerol uptake YNL077W,APJ1 HSP40 family chaperone YKL187C Hypothetical ORF YGR111W Hypothetical ORF YNL072W,RNH35 RNase H(35), a 35 kDa ribonuclease H YHR011W,DIA4 protein similar to bacterial seryl-tRNA synthases YNR053C,NOG2 Nuclear/Nucleolar GTP-binding protein 2 YKR044W,UIP5 Ulp1 Interacting Protein 5 YDR325W,YCG1,TIE1, YCS5 Yeast Condensin G YMR145C,NDE1,NDH1 Hypothetical ORF YDR204W,COQ4 Involved in ubiquinone biosynthesis. YNL128W,TEP1 Similar to human tumor suppressor gene known as TEP1, MMAC1 and PTEN1 YBR259W Hypothetical ORF YML006C,GIS4 GIG3 suppressor YER032W,FIR1,PIP1 Factor Interacting with REF2, interacts strongly with REF2 protein in 2-hybrid screen YMR179W,SPT21 involved in trascriptional regulation of Ty1 LTRs YEL017W Hypothetical ORF YNL154C,YCK2 membrane-bound casein kinase I homolog YDL022W,GPD1,DAR1, HOR1, OSG1, OSR5 glycerol-3-phosphate dehydrogenase YNL080C Deletion causes slight growth defect, similar to U. maydis myp1 protein YGL100W,SEH1 Nuclear pore protein, homologous to sec13 YNL278W,CAF120 CCR4 Associated Factor 120 kDa YGL178W,MPT5,PUF5, HTR1, UTH4 Product of gene unknown YNR051C,BRE5 protein of unknown function YDL134C,PPH21,PPH1 serine-threonine protein phosphatase 2A YGL233W,SEC15 Protein involved in vesicle traffic between Golgi and plasma membrane. The Exocyst complex is required for exocytosis. YOR047C,STD1,MSN3, SFS3 interacts with the SNF1 protein kinase and TBP in two-hybrid and in in vitro binding studies YGR279C,SCW4 Soluble Cell Wall protein YOL069W,NUF2 Protein associated with spindle pole body and critical for nuclear division YDR370C Hypothetical ORF YGL116W,CDC20,PAC5 Required for onset of anaphase YMR205C,PFK2 phosphofructokinase beta subunit YGL155W,CDC43,CAL1 may participate in a ras-like C-terminus modification of proteins involved in nuclear division and bud growth YPL164C,MLH3 Mutl Homolog YGR165W,MRPS35,MrpS35 Mitochondrial Ribosome Protein, Small Subunit YNL217W Hypothetical ORF YGR002C Protein required for cell viability YNL263C,YIF1 Yip1-Interacting Factor, shows similarity to NADH dehydrogenases YJL046W Hypothetical ORF YPR040W,TIP41 SDF1 the first obserwed null phenotype was Sporulation DeFiciency YHR024C,MAS2,MIF2 53 kDa subunit of the mitochondrial processing protease YNR043W,MVD1,ERG19 involved in the polyisoprene biosynthesis pathway YGR202C,PCT1,BSR2, CCT1 phosphorylcholine transferase; or cholinephosphate cytidylyltransferase YJR103W,URA8 Last step in pyrimidine biosynthesis pathway YPR191W,QCR2,COR2, UCR2 40 kDa ubiquinol cytochrome-c reductase core protein 2 YIL121W Quinidine resistance 2 YOL022C Protein required for cell viability YIL005W,EPS1 - YNR032W,PPG1 Serine/threonine protein phosphatase involved in glycogen accumulation YKL139W,CTK1 putative kinase subunit of the kinase complex that phosphorylates the RPO21 CTD (carboxy-terminal domain); also called CTDK-I alpha subunit YBL020W,RFT1 encodes a flippase that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane YJL012C,VTC4,PHM3 Phosphate metabolism; transcription is regulated by PHO system YOL126C,MDH2 cytosolic malate dehydrogenase YOR027W,STI1 Heat shock protein also induced by canavanine and entry into stationary phase YDR329C,PEX3,PAS3 48-kDa peroxisomal integral membrane protein YLL054C Hypothetical ORF YOR118W Hypothetical ORF YHR034C protein possibly involved in protein synthesis YOL152W,FRE7 similar to FRE2 YOR081C Hypothetical ORF YDR350C,TCM10,ATP22 functions at a post-translational stage in assembly of F0 ATPase. YLR242C,ARV1 iability 1. similar to Nup120p and C.elegans R05H5.5 protein. YPL032C,SVL3 Styryl dye vacuolar localization YIL091C Protein required for cell viability YOR028C,CIN5,HAL6, YAP4 Protein involved in silencing YPL161C,BEM4,ROM7 Involved in polarity establishment and bud emergence; interacts with the Rho1p small GTP-binding protein YFR053C,HXK1 Glucose phosphorylation YLR459W,CDC91 fifth component of GPI transamidase that may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI. YPL227C,ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase YKL035W,UGP1 EC:2.7.7.9UDP-glucose pyrophosphorylase or UTP-glucose-1-phosphate uridylyltransferase YPL111W,CAR1,LPH15 arginase YPR138C,MEP3 ammonia permease of high capacity and low affinity; shows sequence similarity to Mep1p and Mep2p YGR212W Hypothetical ORF YMR013C,SEC59 catalyzes the CTP-mediated phosphorylation of dolichol, the terminal step in dolichyl monophosphate (Dol-P) biosynthesis. required for viability, normal rates of lipid intermediate synthesis, protein N-glycosylation. YBR200W,BEM1,SRO1 SH3-domain protein that binds Cdc24p, Ste5p and Ste20p, and the Rsr1p/Bud2p/Bup5p GTPase YLR083C,EMP70 identified as a 24 kDa cleavage product in endosome-enriched membrane fractions YBR199W,KTR4 Putative alpha-1,2-mannosyltransferase YMR262W Hypothetical ORF YKL055C,OAR1 3-oxoacyl-[acyl-carrier-protein] reductase YLR307W,CDA1 Required for proper formation of the ascospore wall YML121W,GTR1 Involved in the function of the Pho84 phosphate transporter YOR311C,HSD1 ER membrane protein YHL013C Hypothetical ORF YLR018C,POM34 nuclear pore integral membrane protein YLR308W,CDA2 Required for proper formation of the ascospore wall YJL133W,MRS3 mitochondrial carrier protein YPL132W,COX11,LPI13, PSO7 Mitochondrial membrane protein required for insertion of Cu(B) and magnesium during assembly of cytochrome c oxidase YDR098C,GRX3 Member of a glutaredoxin subfamily in Sc together with GRX4 & GRX5. Sign. sequence diff. with the other glutaredoxin subfamily, formed by the previously described GRX1 & GRX2 glutaredoxins (Luikenhuis MBC 9:1081, 1998) YJR083C Hypothetical ORF YPL266W,DIM1,CDH1 Dimethyladenosine transferase, (rRNA(adenine-N6,N6-)-dimethyltransferase),reponsible for m6[2]Am6[2]A dimethylation in 3'-terminal loop of 18S rRNA YDR374C Hypothetical ORF YOR222W,ODC2 - YNL156C - YLR290C Hypothetical ORF YDR068W,DOS2 Product of gene unknown YBR146W,MRPS9 Probable mitochondrial ribosomal protein S9 YHR029C Hypothetical ORF YKL007W,CAP1 capping - addition of actin subunits YBR160W,CDC28,CDK1, HSL5, SRM5 Catalytic subunit of the main cell cycle cyclin-dependent kinase YHR062C,RPP1 Ribonuclease P protein 1; required for processing of precursor tRNA and 35S precursor rRNA; ortholog of the human scleroderma autoimmune antigen, Rpp30 YDR296W,MHR1,XTC1 Involved in mitochondrial homologous DNA recombination. Binds to activation domains of acidic activators. Presence in RNA pol II holoenzyme may help recruit an Ssn3-active form of the holoenzyme to target promoters. YKL096W,CWP1,YJU1 cell wall protein, involved in O and N glycosylation, acceptor of B1-6 glucan. YDL111C,RRP42 Ribosomal RNA Processing YHR044C,DOG1 2-deoxyglucose-6-phosphate phosphatase YOR152C Hypothetical ORF YLR048W,RPS0B,NAB1B, YST2 Homology to rat Sa; closely related to mammalian p40/laminin receptor precursors (LRPs); required for translation and contributes to the assembly and/or stability of the 40S ribosomal subunit YHR200W,RPN10,MCB1, SUN1 homolog of the mammalian S5a protein, component of 26S proteasome YJR101W,RSM26 mitochondrial ribosome small subunit component YCL034W,LSB5 LAs17 Binding protein YNL129W Hypothetical ORF YGL098W,USE1 Unconventional SNARE in the ER Use1p is a SNARE and forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p. YLR326W Hypothetical ORF YLR194C Hypothetical ORF YPL027W,SMA1 Spore Membrane Assembly YOR358W,HAP5 Regulates respiratory functions; subunit of a heterotrimeric complex required for CCAAT binding YGR232W,NAS6 Interaction with the 19S regulatory particle of the 26S proteasome detected by coimmunoprecipitation. YIR042C Hypothetical ORF YGL210W,YPT32 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment YMR157C Hypothetical ORF YBR035C,PDX3 pyridoxine (pyridoxiamine) phosphate oxidase YOR213C,SAS5 Involved in silencing at telomeres, HML and HMR YBL093C,ROX3,NUT3, SSN7 RNA polymerase II holoenzyme/mediator subunit YAL007C,ERP2 Emp24p/Erv25p related protein 2 YML053C Hypothetical ORF YDR177W,UBC1 ubiquitin-conjugating enzyme YOR294W,RRS1 Regulator for ribosome synthesis YFR012W Hypothetical ORF YGL033W,HOP2 HOmologous Pairing YOR258W,HNT3 histidine triad superfamily, third branch YBL040C,ERD2 ER protein retention YOR021C Hypothetical ORF YDR487C,RIB3 Riboflavin biosynthesis YPL052W Hypothetical ORF YHR121W Hypothetical ORF YER012W,PRE1 Required for mitotic division and sporulation YBR122C,MRPL36,YML36 Mitochondrial ribosomal protein MRPL36 (YmL36) YJL097W Protein required for cell viability YBR106W,PHO88 May be a membrane protein involved in inorganic phosphate transport and regulation of Pho81p function YDR066C Hypothetical ORF YPL099C Hypothetical ORF YER066W Hypothetical ORF YKL214C,YRA2 nnealing protein YKL159C,RCN1 Regulator of calcineurin YFL031W,HAC1,ERN4, IRE15 Transcription factor that is required for the unfolded protein-response pathway; binds to CRE motif; homologous to ATF/CREB 1 YDR179C,CSN9 subunit of Cop9 Signalosome (CSN) YDL125C,HNT1 Hint homolog, member of the histidine triad superfamily of nucleotide-binding proteins YIR037W,HYR1,GPX3 Hydroperoxide resistance conferring gene. Sensor and transducer of the hydroperoxide signal to Yap1. Hydroperoxide receptor and redox-transducer. YOR252W Hypothetical ORF YEL045C Hypothetical ORF YFL012W Hypothetical ORF YIL138C,TPM2 Tropomyosin isoform 2 YEL044W Ino Eighty Subunit 6 YIL051C,MMF1,IBM1 Maintenance of Mitochondrial Function YBR012C Hypothetical ORF YHR217C Hypothetical ORF YER035W,EDC2 Enhancer of mRNA Decapping YLL042C,APG10 Involved in autophagy; protein-conjugating enzyme involved in the Apg12p-Apg5p conjugation pathway YKL067W,YNK1,NDK1 catalyzes the phosphorylation of nucleoside diphosphates into the corresponding triphosphates for nucleic acid biosynthesis. YOR150W,MRPL23 mitochondrial ribosomal protein of the large subunit YBR210W,ERV15 Putative ER vesicle protein with similarity to Erv14p YNL281W,HCH1 high copy Hsp90 supressor YIL098C,FMC1 Formation of Mitochondrial Complexes YEL027W,CUP5,CLS7, GEF2, VMA3 vacuolar ATPase V0 domain subunit c (17 kDa) YLR315W,NKP2 Non-essential Kinetochore Protein YIL111W,COX5B Cytochrome-c oxidase chain Vb YGR076C,MRPL25,YMR26 Mitochondrial ribosomal protein MRPL25 (YmL25) YML033W - YHL041W Hypothetical ORF YDR377W,ATP17 Subunit f of mitochondrial ATP synthase. Homologous to bovine subunit f. YLL030C Hypothetical ORF YML108W defines a new subfamily of the split beta-alpha-beta sandwiches. YNL146W Hypothetical ORF YDL012C Hypothetical ORF YIR020C Hypothetical ORF YLR124W Hypothetical ORF YOR068C [Abnormal]Vacuole Morphology YOR024W Hypothetical ORF YIL008W,URM1 ubiquitin-like protein YPR098C Hypothetical ORF YNL244C,SUI1,MOF2, RFR1 translation initiation factor eIF1 YOL118C Hypothetical ORF YHR087W Hypothetical ORF YJL166W,QCR8,COR5 Ubiquinol cytochrome-c reductase subunit 8 (11 kDa protein) YAL064W Hypothetical ORF YNR037C,RSM19 mitochondrial ribosome small subunit component YLR296W Hypothetical ORF YLR364W Hypothetical ORF YER097W Hypothetical ORF YPR146C Hypothetical ORF YGL182C Hypothetical ORF YMR245W Hypothetical ORF YMR074C Hypothetical ORF YLR416C Hypothetical ORF YLR075W,RPL10,GRC5, QSR1 similar to members of the QM gene family, which is implicated in differentiation in other eukaryotes and tumorigenesis in humans; homology to rat L10; ubiquinol-cytochrome C reductase complex subunit VI requiring protein YKL199C - YHR094C,HXT1,HOR4 High-affinity hexose (glucose) transporter YNL185C,MRPL19 mitochondrial ribosomal protein of the large subunit YLR262C,YPT6 Ras-like GTP binding protein involved in the secretory pathway. Ypt6p is required for fusion of endosome-derived vesicles with the late Golgi. YBR178W Hypothetical ORF YER056C,FCY2,BRA7 purine-cytosine permease YKL147C Hypothetical ORF YOR082C Hypothetical ORF YLR316C,TAD3 tRNA-specific adenosine-34 deaminase subunit Tad3p YDL069C,CBS1 translational activator of cytochrome b YPR053C Hypothetical ORF YJR128W Hypothetical ORF YOR199W Hypothetical ORF YKL219W,COS9 Protein with similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p YPR111W,DBF20 kinase required for late nuclear division YOR120W,GCY1,GCY Galactose-induced transcript YOR332W,VMA4 vacuolar ATPase V1 domain subunit E (27 kDa) YJR048W,CYC1 iso-1-cytochrome c YOL134C Protein required for cell viability YAL004W Hypothetical ORF YML073C,RPL6A,YL16A Homology to rat L6 and human L6 YOR331C Hypothetical ORF YOL099C Hypothetical ORF YDR093W,DNF2 Drs2 Neo1 Family YBR048W,RPS11B Homology to rat S11, human S11, and E. coli S17 YOL120C,RPL18A,RP28A Homology to rat ribosomal protein L18 YKL202W Hypothetical ORF YNL120C Hypothetical ORF YPL276W,FDH2 Homologous to FDH1 YCR087C-A Hypothetical ORF YGR118W,RPS23A Homology to rat S23 and E. coli S12 YMR142C,RPL13B Homology to rat L13 YPR197C Hypothetical ORF YPL044C Protein required for cell viability YDR544C Hypothetical ORF YFL063W Hypothetical ORF YPR132W,RPS23B Homology to rat S23 and E. coli S12 YKR035W-A,DID2,FTI1 Doa4-independent degradation; Rad52 Inhibitor (Fifty Two Inhibitor) YNL140C Hypothetical ORF YLR463C Hypothetical ORF YGL259W,YPS5 Gpi-anchored aspartic protease (Yapsin 5) YJL220W Hypothetical ORF YLL044W Hypothetical ORF YCR001W Hypothetical ORF YOR167C,RPS28A,RPS33A Homology to mammalian S28 YEL059C-A,SOM1 high copy suppressor of imp1 mutation, may be required for the function of the Imp1 peptidase and/or the protein sorting machinery YDR034W-B Similar to probable membrane protein YDR210W and others; Similar to YBR016W YLR395C,COX8 Cytochrome-c oxidase chain VIII YOR210W,RPB10 RNA polymerase II subunit YDR276C,PMP3,SNA1 plasma membrane protein involved in salt tolerance YDR461W,MFA1 a-factor mating pheromone precursor YHR001W-A,QCR10 8.5 kDa subunit of the ubiqunol-cytochrome c oxidoreductase complex YLL009C,COX17 Involved in copper metabolism and assembly of cytochrome oxidase YMR256C,COX7 subunit VII of cytochrome c oxidase YOR302W CPA1 uORF , Arginine attenuator peptide, regulates translation of the CPA1 mRNA YNR032C-A,HUB1 Similar to ubiquitin-like protein 8 of Arabidopsis thaliana and C. elegans YCR102W-A Similar to several yeast probable membrane proteins, including YNR075W and YFL062W YNL070W,TOM7,MOM7, YOK22 Involved in mitochondrial protein import YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YLL048C,YBT1,BAT1 Yeast bile transporter, similar to mammalian bile transporter YMR050C TyB Gag-Pol protein YIR033W,MGA2 Product of gene unknown YPL022W,RAD1,LPB9 UV endonuclease YLR342W,FKS1,CND1, CWH53, ETG1, GSC1, PBR1 Required for viability of calcineurin mutants YOR296W Hypothetical ORF YJR092W,BUD4 co-assembles with Bud3p at bud sites YEL025C SWI/SNF and RSC interacting protein 1 YHL030W,ECM29 ExtraCellular Mutant YKR054C,DYN1,DHC1, PAC6 Dynein YDL112W,TRM3 Trna ribose methylase YER132C,PMD1 Paralog of MDS3 YOR188W,MSB1 Protein that may play a role in polarity establishment and bud formation YDR301W,CFT1,YHH1 Functions in cleavage of 3'-ends of pre-mRNAs, prior to polyadenylation; 23.5% identical to the 160-kDa subunit of mammalian cleavage and polyadenylation specificity factor (CPSF-160) YNR031C,SSK2 Suppressor of Sensor Kinase (SLN1) YMR219W,ESC1 Establishes Silent Chromatin. May be a component of a redundant pathway that functions to localize silencing complexes to the nuclear periphery. YPL012W,RRP12 Required for normal pre-rRNA Processing. Member of a group of seven genes whose expression is repressed during growth on glucose before and during the diauxic shift. YHR080C Hypothetical ORF YIL013C,PDR11 ATP-dependent permease, member of ATP-binding cassette (ABC) transporter family YOR304W,ISW2 has strong homology to Drosophila ISWI YIL173W,VTH1 vps ten homolog YPL217C,BMS1 BMH1 sensitive YGL173C,KEM1,DST2, RAR5, SEP1, SKI1, XRN1 Plays a role in cytoplasmic mRNA degradation. The disparate functions of Kem1p may belie a functionally relevant coupling of microtubule binding to DNA strand exchange, possibly related to its role in chromosome pairing and exchange. YDR104C,SPO71 Product of gene unknown YGL120C,PRP43,JA1 Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA YFL011W,HXT10 high-affinity hexose transporter YPR025C,CCL1 essential for cell proliferation YGR276C,RNH70,REX1 RNase H(70), a 70 kDa ribonuclease H YMR023C,MSS1,PET53 May play a part in mitochondrial translation YER052C,HOM3,BOR1, SIL4 First step in common pathway for methionine and threonine biosynthesis YKL060C,FBA1,LOT1 Low Temperature-responsive YLL005C,SPO75 Sporulation YDL038C Hypothetical ORF YJL156C,SSY5 Product of gene unknown YOL053W Hypothetical ORF YFR034C,PHO4 Transcription factor that activates expression of phosphate pathway YLR389C,STE23 involved in a-factor processing YNL167C,SKO1,ACR1 Suppressor of PKA overexpression; bZIP protein that binds to CRE motifs, interacts with Mig1p YGL157W Hypothetical ORF YKR058W,GLG1 self-glucosylating initiator of glycogen synthesis; similar to mammalian glycogenin YPL268W,PLC1 Encodes homolog of delta isoform of mammalian phosphoinositide-specific phospholipase C. Hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG). YGR005C,TFG2 transcription initiation factor TFIIF middle subunit YOL066C,RIB2 N-terminal part related to RNA:pseudouridine (psi)-synthases C-terminal portion contains the deaminase domain implicated in Riboflavin synthesis YNL311C F-box protein YGR054W yeast homolog of mammalian eIF2A YML023C Protein required for cell viability YBR222C,PCS60,FAT2 Probable AMP-binding protein YKR088C Tlg2-Vesicle Protein of 38 kDa YLR141W,RRN5 involved in transcription of rDNA by RNA polymerase I. UAF interacts directly with an upstream element of the promoter and mediates its stimulatory function. YIL077C Hypothetical ORF YOR134W,BAG7 Structural homolog of SAC7 YDL155W,CLB3 Involved in mitotic induction and perhaps in DNA replication and spindle assembly YGR179C,OKP1 Outer Kinetochore Protein YGR113W,DAM1 Duo1 And Mps1 interacting. Localized to intranuclear spindles and spindle pole bodies. Key Ipl1p target for regulating kinetochore-microtubule attachments. YOR161C Hypothetical ORF YML035C,AMD1,AMD3 putative alpha-mannosidase YDR387C Hypothetical ORF YDR001C,NTH1 hydrolyzes trehalose; may be inolved in growth transition from glucose to glycerol; shows significant sequence similarity to Nth2p YIL119C,RPI1 possesses a transcriptional activation domain and affects the mRNA levels of several cell wall metabolism genes. YLR057W Hypothetical ORF YBR216C Peroxide Stress Control YPL195W,APL5,YKS4 Delta-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function YHR042W,NCP1,CPR1 NADP-cytochrome P450 reductase YFL052W Hypothetical ORF YIL137C Hypothetical ORF YLR321C,SFH1 Involved in chromatin modeling, cell cycle progression YCR054C,CTR86 CTR86 shares a terminator region with THR4. CTR86 contains aGCN4 responsive site suggesting it may also be involved in amino acid biosynthesis. YDR541C Hypothetical ORF YJL084C Hypothetical ORF YIR003W Hypothetical ORF YKL126W,YPK1,SLI2 76.5 kDa Serine/threonine protein kinase with similarity to protein kinase C, is 90% identical to Ypk2p YMR106C,YKU80,HDF2 Exhibits DNA binding activity on its own, associates with Hdf1p to form major DNA end-binding complex YDR532C Hypothetical ORF YOR070C,GYP1,YOR29-21 Gtpase activating protein for Ypt1p YLL008W,DRS1 nucleolar DEAD-box protein required for synthesis of 60S ribosomal subunits YKL079W,SMY1 not believed to act as a kinesin, colocalizes with Myo2p YKR084C,HBS1 Protein related to translation elongation factor EF-1alpha and to Suf12p/Sup2p/Gst1p/Sup35p YJL081C,ARP4,ACT3 54.8 kDa actin-related protein YGL038C,OCH1,NGD29 initiates the polymannose outer chain elongation of N-linked glycans YAL010C,MDM10,FUN37 Mitochondrial outer membrane protein involved in mitochondrial morphology and inheritance YML056C,IMD4 similar to IMP dehydrogenase YLR239C,LIP2 LIPoyl ligase 2 YLR451W,LEU3 Regulates genes involved in branched chain amino acid biosynthesis and in ammonia assimilation. Positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis. YJR059W,PTK2,STK2 Putative serine/threonine protein kinase that enhances spermine uptake YHR037W,PUT2 delta-1-pyrroline-5-carboxylate dehydrogenase YBR003W,COQ1 hexaprenyl diphosphate synthesis YNL117W,MLS1 carbon-catabolite sensitive malate synthase YMR180C,CTL1,CTH1 CET1-Like Gene #1 (CET1 = capping enzyme triphosphatase 1) YOR206W,NOC2 NucleOlar Complex 2; involved in nuclear export of pre-ribosomes YML018C Hypothetical ORF YJL025W,RRN7 involved in the transcription of 35S rRNA genes by RNA polymerase I YEL020C Hypothetical ORF YBL084C,CDC27,APC3, SNB1 Protein required for cell cycle YNR001C,CIT1,CS1, LYS6 citrate synthase. Nuclear encoded mitochondrial protein. YOR301W,RAX1 A rax1 mutation converts the budding pattern of an axl1 null mutant from bipolar to axial. YNL022C Non-essential protein with similarity to S. pombe hypothetical protein E349594 YNL048W,ALG11 Specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-Glycosylation intermediate YEL061C,CIN8,KSL2, SDS15 Kinesin-related protein involved in establishment and maintenance of mitotic spindle YMR296C,LCB1,END8, TSC2 Serine palmitoyltransferase catalyses the committed step in sphingolipid synthesis, the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine. YHR151C Hypothetical ORF YDR054C,CDC34,DNA6, UBC3 ubiquitin-conjugating enzyme, E2 YOL031C homolog of Yarrowia lipolytica SLS1; GrpE-like protein in the ER YKL032C,IXR1,ORD1 intrastrand crosslink recognition protein YNR008W,LRO1 Lecithin cholesterol acyl transferase (LCAT) Related Orf YLR341W,SPO77 Sporulation YDR113C,PDS1 May be an anaphase inhibitor that plays a critical role in control of anaphase by both the anaphase promoting complex (APC) and DNA-damage checkpoints YOR241W,MET7 METhionine requiring YOL011W,PLB3 Phospholipase B YGL227W,VID30,GID1 vacuole import and degradation (VID); TOR inhibitor (TIN) YOR337W,TEA1 Mutants are defective in Ty1 Enhancer-mediated Activation YMR017W,SPO20,DBI9 DBF2 Interacting Protein; SNAP 25 homolog YDR160W,SSY1,SHR10 Ssy1p controls expression of several transporter genes, including BAP2, TAT1, PTR2 and YDR046c YPL235W,RVB2,TIP49B, TIH2 RUVB-like protein, TIP49b Homologue YGR189C,CRH1 congo red hypersensitive YOR363C,PIP2,OAF2 peroxisome induction pathway 2 (PIP2); transcriptional activator of peroxisome proliferation; may form heterodimer with Oaf1 to activate oleate-inducible gene expression YOL023W,IFM1 mitochondrial initiation factor 2 YDR341C Protein required for cell viability YDR256C,CTA1 catalase A YLR092W,SUL2 sulfate uptake is mediated by specific sulfate transporters SUL1 and SUL2, which control the concentration of endogenous activated sulfate intermediates. YGR252W,GCN5,ADA4, SWI9 functions in the Ada and SAGA (Spt/Ada) complexes to acetylate nucleosomal histones YDR474C Hypothetical ORF YBR142W,MAK5 Necessary for maintenance of dsRNA killer plasmids. Is predicted to encode an DEAD-box RNA helicase YMR310C Hypothetical ORF YER027C,GAL83,SPM1 Glucose repression protein YLR263W,RED1 Required for full chr. pairing & chr. condensation seen by in situ hybridization, axial elements, stable localization of Hop1p & synaptonemal complexes; at HIS2 required for normal levels of double strand breaks YGR288W,MAL13 Part of complex locus MAL1; nonfunctional in S288C, shows homology to both functional & nonfunctional MAL-activator proteins in other Sc strains & to other nonfunctional MAL-activator sequences from S288C (i.e. MAL33, YPR196W, & YFL052W) YER118C,SHO1,SSU81 Transmembrane osmosensor (structurally unrelated to SLN1) with four transmembrane segments & a cytoplasmic SH3-domain. The SH3-domain interacts with a proline-rich motif in the N-terminal region of Pbs2p (a MAP kinase kinase homolog) YCL052C,PBN1 Protease B Non-derepressible YNL291C,MID1 N-glycosylated integral plasma membrane protein YGR013W,SNU71 associated with U1 snRNP (no counterpart in mammalian U1 snRNP; contains few SR-, RE- and RD-dipeptides YML088W F-box protein YIL130W Hypothetical ORF YHR135C,YCK1,CKI2 membrane-bound casein kinase I homolog YDR332W Hypothetical ORF YNR052C,POP2,CAF1 Putative transcription factor YGR141W,VPS62 - YNL223W,AUT2,APG4 Involved in autophagy. Interacts with Tub1p and Tub2p and forms a complex with Aut7p. Required for sporulation. YLR080W,EMP46 Evidence suggests that Emp46p and Emp47p are required for the export of specific glycoprotein cargo from the endoplasmic reticulum. YJL153C,INO1,APR1 involved in the rate limiting step of inositol biosynthesis YHL011C,PRS3 ribose-phosphate pyrophosphokinase 3 YPR112C,MRD1 Multiple RNA Binding Domain; essential for synthesis of the small ribosomal subunit YHR172W,SPC97 Spindle Pole Body component with an molecular weight of 97 kDa YBR054W,YRO2 Homolog to HSP30 heat shock protein Yro1p YJL128C,PBS2,HOG4, SFS4, SSK4 Involved in osmoregulation, member of the HOG1 mitogen-activated protein kinase (MAPK) cascade YDL170W,UGA3 Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4) YJL021C Seq change merges YJL021C and YJL020C. YBR015C,MNN2,TTP1, CRV4, LDB8 Probable type II membrane protein involved in mannan synthesis. Catalyzes addition of first mannose to branches on poly l,6-mannose backbone of outer chain of cell wall N-linked mannans. YKL145W,RPT1,CIM5, YTA3 Required for degradation of ubiquitinated substrates and for anaphase chromosome separation YDL167C,NRP1 asparagine-rich protein YLR196W,PWP1 periodic tryptophan proteinProtein with periodic trytophan residues that resembles members of beta-transducin superfamily because of presence of WD-40 repeats YDR018C Hypothetical ORF YJL105W,SET4 - YBR149W,ARA1 D-arabinose dehydrogenase YML074C,FPR3,NPI46 binds the immunosuppressant drugs, FK506 and rapamycin, and is localized to the nucleolus; binds to nuclear localization signal-containing peptides in vitro YDR091C Strong protein homology (68% identical) to human RNase L Inhibitor (RLI). Required for vegetative growth and early sporulation. YMR008C,PLB1 Responsible for the production of the deacylation products of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol YDR254W,CHL4,CTF17, MCM17 Protein necessary for stability of ARS-CEN plasmids; suggested to be required for kinetochore function YKL171W Hypothetical ORF YDL003W,MCD1,PDS3, RHC21, SCC1 Mitotic Chromosome Determinant; similar to S. pombe RAD21; may function in chromosome morphogenesis from S phase through mitosis YMR116C,ASC1,CPC2 WD repeat protein (G-beta like protein) that interacts with the translational machinery YDR365C Protein required for cell viability YNL125C,ESBP6,MCH3 Protein with similarity to mammalian monocarboxylate transporters MCT1 and MCT2 YDR372C,VPS74,API1 - YLR133W,CKI1 choline kinase YDL037C,BSC1 Bypass of Stop Codon transcript encoded by this ORF shows a high level of stop codon bypass YCL037C,SRO9 Associates with translating ribosomes; may function in the cytoplasm to modulate mRNA translation; may be involved in organization of actin filaments YKR056W,TRM2,NUC2, NUD1, RNC1 tRNA methyltransferase YBR098W,MMS4,YBR100W, SLX2 endonuclease YGR188C,BUB1 checkpoint gene involved in permitting entry into mitosis depending upon the assembly state of microtubules YPL101W,ELP4,HAP1, TOT7 ELongator Protein 4; 50kD subunit. Homolog of ATPases, yet with substitutions of amino acids critical for ATP hydrolysis. YGL095C,VPS45,STT10, VPL28 Protein of the Sec1p family essential for vacuolar protein sorting; required for the function of both Pep12p and the early endosome/late Golgi SNARE Tlg2p . YDL209C,CWC2 Complexed with Cef1p YLR014C,PPR1 Positive regulator of URA1 and URA3 YBR156C,SLI15 Mitotic spindle protein involved in chromosome segregation. YJL196C,ELO1 elongation enzyme 1, required for the elongation of the saturated fatty acid tetradecanoic acid (14:0) to that of hexadecanoic acid (16:0) YPL180W Hypothetical ORF YGL194C,HOS2,RTL1 Protein with similarity to Hda1p, Rpd3p, Hos1p, and Hos3p YER054C,GIP2 Glc7-interacting protein; shares homology with PIG2; contains conserved 25 residue motif, called the GVNK motif, also found in GAC1, PIG1, PIG2, and RGI, the mammalian type 1 phosphatase targeting subunit. YML086C,ALO1 D-arabinono-1,4-lactone oxidase YDL084W,SUB2 rr1-1 YKL178C,STE3,DAF2 The a factor receptor encoded by the STE3 gene allows yeast cells of the Alpha mating type to recognize cells of the a mating type YPR121W,THI22 THI for thiamine metabolism. Transcribed in the presence of low level of thiamine (10-8M) and turned off in the presence of high level (10-6M) of thiamine. Under the positive control of THI2 and THI3. YGR250C Hypothetical ORF YFL041W,FET5 ferrous iron transport YNL026W Essential protein with similarity to S. pombe hypothetical protein E241976 YDR247W,VHS1 Gene whose overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation YNL132W,KRE33 Killer toxin REsistant YBL046W Hypothetical ORF YHR112C Hypothetical ORF YER091C,MET6 cobalamin-independent methionine synthase YMR144W Hypothetical ORF YPL083C,SEN54 Trna splicing endonuclease 54kDa subunit YER186C Hypothetical ORF YLL001W,DNM1 Involved in receptor-mediated endocytosis and mitochondrial organization. Required for the cortical distribution of the mitochondrial network. YBR006W,UGA2,UGA5 involved in utilization of GABA as a nitrogen source YGR041W,BUD9 among a group of genes whose products are necessary for bud-site selection; likely involvement in positioning the proximal pole signal YNL068C,FKH2 Fork Head homolog two YPL175W,SPT14,CWH6, GPI3 N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein YGR117C Hypothetical ORF YLR361C Dose-Dependent Cell cycle Regulator YBR058C,UBP14,GID6 Functional homolog of mammalian isopeptidase T; may facilitate proteolysis by preventing unanchored ubiquitin chains from competitively inhibiting polyubiquitin-substrate binding to the 26S proteasome YGR110W Hypothetical ORF YNL160W,YGP1 may be involved in cellular adaptations prior to stationary phase YPR024W,YME1,OSD1, YTA11 Mitochondrial protein of the CDC48/PAS1/SEC18 family of ATPases YHR040W Box C/D snoRNA accumulation YNL134C - YBR182C,SMP1 Second MEF2-like Protein 1Transcription factor of the MADS (Mcm1p, Agamous, Deficiens, SRF) box family; closely related to RLM1 YNL188W,KAR1 involved in spindle pole body duplication and karyogamy, interacts with Cdc31p, localizes to the spindle pole body YCL043C,PDI1,MFP1, TRG1 Catalyzes the formation and isomerization of disulfide bonds during the folding of secretory proteins. YHR107C,CDC12,CLA10, PSL7 involved in proper bud growth YOL122C,SMF1,SBS1 Isolated as high copy suppressor of a cdc1 mutation & involved in high affinity Mn2+ uptake. SMF1 was isolated as a high copy suppressor of a ts mutation in the PEP (mito. matrix protease) gene & may influence PEP-dependent protein import YCR017C,CWH43 - YNL312W,RFA2,BUF1, RPA2 Involved in nucleotide excision repairRFA1, RFA2, and RFA3 make up RPA YOR238W Hypothetical ORF YGR222W,PET54 translational activator of cytochrome c oxidase subunit III; required for splicing of cytochrome c oxidase subunit I mRNA YDR446W,ECM11 ExtraCellular Mutant YKL128C,PMU1 Phospho MUtase homolog. Small region homologous to active site of phospho-mutases, these move phosphates via a phospho-histidine intermediate. Homologs include: Sc GPM1, bact. Pgm, Hs Bpgm & rat fructose-2,6-bisphosphatase YGR201C Hypothetical ORF YGL057C Hypothetical ORF YFL028C,CAF16 CCR4 associated factor YOR287C Protein required for cell viability YPR066W,UBA3 Required for activation of RUB1 (ubiquitin-like protein) together with ULA1. Related to UBA2 and to N-terminus of UBA1. Collaborates with UBC12 in conjugation of RUB1 to other proteins. Required for modification of CDC53/cullin with RUB1. YNL010W Hypothetical ORF YML105C,SEC65 signal recognition particle subunit, homologue of mammalian SRP19 YNL194C Hypothetical ORF YOR106W,VAM3,PTH1 Syntaxin-related protein; required for vacuolar assembly; PEP12 homolog YFR032C Hypothetical ORF YCR009C,RVS161,END6, FUS7, SPE161 Protein required for viability after N, C, or S starvation. The BAR adaptor proteins encoded by RVS167 and RVS161 form a complex that regulates actin, endocytosis, and viability following starvation or osmotic stress. YDR099W,BMH2,SCD3 Brain Modulosignalin Homolog YER175C,TMT1,TAM1 Trans-aconitate Methyltransferase 1 YDL114W Hypothetical ORF YPL094C,SEC62,LPG14 membrane component of ER protein translocation apparatus YOR223W Hypothetical ORF YFR052W,RPN12,NIN1 Part of 26S proteasome complex that may activate Cdc28p YML112W,CTK3 CTD kinase-I gamma subunit YLL023C Hypothetical ORF YCR007C Hypothetical ORF YLL027W,ISA1 Iron Sulfur Assembly -- IscA/NifA homolog YBR070C Protein required for cell viability YHR038W,RRF1,KIM4, FIL1 Ribosomal Recycling Factor 1; originally characterized as FIL1, a Factor for Isocitrate Lyase expression YPR071W Hypothetical ORF YNL213C Hypothetical ORF YIL139C,REV7 Protein required for mutagenesis by physical and chemical agents YOL038W,PRE6 alpha-type of subunit of 20S proteasome YLR078C,BOS1,SEC32 necessary for vesicular transport from the ER to the Golgi complex YIR001C,SGN1,RBP1, RBP29 contains one RNA recognition (RRM) domain YDR196C predicted to catalyze the final step in synthesis of Coenzyme A YEL001C Hypothetical ORF YBR107C,IML3,MCM19 Increase Minichromosome Loss YGR075C,PRP38 RNA splicing factor YBR153W,RIB7 Protein involved in the biosynthesis of riboflavin, second step in the riboflavin biosynthesis pathway YMR117C,SPC24 Spindle Pole Component of molecular weight 24kDa YGR247W,CPD1 2',3'-cyclic nucleotide 3'-phosphodiesterase, similar to cyclic phosphodiesterases from Arapidopsis and wheat YGR167W,CLC1,SCD4 Clathrin light chain YGL011C,SCL1,PRC2 Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7) YKL130C,SHE2 Required for mother cell-specific HO expression YGR057C,LST7 Required for amino acid permease transport from the Golgi to the cell surface YKL142W,MRP8,YKL3 mitochondrial ribosomal protein YHR013C,ARD1 subunit of the major N alpha-acetyltransferase; complexes with Nat1p YER174C,GRX4 Member of a glutaredoxin subfamily in Sc together with GRX3 & GRX5. Significant sequence diff. with the other glutaredoxin subfamily, formed by the previously described GRX1 & GRX2 glutaredoxins (Luikenhuis MBC 9:1081, 1998) YKL024C,URA6,SOC8 - YPL051W,ARL3 Similar to ADP-ribosylation factor. Part of the carboxypeptidase Y pathway. YBR014C Hypothetical ORF YDR453C,TSA2,cTPxII thioredoxin peroxidase YPR172W Hypothetical ORF YOR097C Hypothetical ORF YJL177W,RPL17B Homology to rat L17, human L17, and E. coli L22 YJR118C,ILM1 Product of gene unknown YHR193C,EGD2 GAL4 enhancer protein, homolog of human alpha NAC subunit of the nascent-polypeptide-associated complex YIR032C,DAL3 ureidoglycolate hydrolase YPL067C Hypothetical ORF YDR535C Hypothetical ORF YJR102C,VPS25,VPT25 vacuolar protein sorting (putative) YLR066W,SPC3 signal peptidase subunit YMR138W,CIN4,GTP1, UGX1 Protein involved in chromosome segregation and microtubule function; homologue of human Arl2 YGR001C Hypothetical ORF YLL049W Hypothetical ORF YDL120W,YFH1 Yeast Frataxin Homologue YLR073C Hypothetical ORF YGR082W,TOM20,MAS20, MOM19 Translocase of Outer Mitochondrial membrane YKL186C,MTR2 mRNA transport regulator YPL211W,NIP7 Nip7p is required for 60S ribosome subunit biogenesis YEL067C Hypothetical ORF YDL121C Hypothetical ORF YDR437W Protein required for cell viability YBR201W,DER1 Degradation in the Endoplasmic Reticulum YMR151W,YIM2 Product of gene unknown YPL250C Interacting with the cytoskeleton YLR013W,GAT3 The amino acid sequence of this ORF is very homologous to that of GAT4/YIR013C. YDR513W,TTR1,GRX2 Glutaredoxin (thioltransferase) (glutathione reductase) YNL328C,MDJ2 Protein of the mitochondrial inner membrane with similarity to E. coli DnaJ and other DnaJ-like proteins, function partially overlaps that of Mdj1p YBR109C,CMD1 master regulator of calcium mediated signalling YPR064W Hypothetical ORF YLL050C,COF1 yeast cortical cytoskeleton component; mammalian cofilin homolog YJR067C,YAE1 Essential protein of unknown function YJR058C,APS2,YAP17 Related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex YDR100W Tlg2-Vesicle Protein of 15 kDa YHR136C,SPL2 Suppressor of plc1-delta. Isolated as a dosage suppressor of the temperature-sensitive phenotype of a plc1 null mutant. Also suppresses the hyperosmotic-sensitive phenotype of the plc1 null mutant. YDR519W,FPR2,FKB2 binds the immunosuppressant drug FK506 YMR123W,PKR1 Pichia farinosa Killer toxin Resistance YDR095C Hypothetical ORF YPL170W,DAP1 damage response protein related to membrane progesterone receptor YDR252W,BTT1 beta subunit of the nascent-polypeptide-associated complex (NAC); homologous to human BTF3b; Negative effect on expression of several genes transcribed by RNA polymerase II YOR392W Hypothetical ORF YMR269W protein possibly involved in protein synthesis YBL092W,RPL32 Homology to rat L32 and mammalian L32 YNL143C Hypothetical ORF YBL028C Hypothetical ORF YPL046C,ELC1 similar to mammalian elongin C, interacts with elongin A YNL198C Hypothetical ORF YAR053W Hypothetical ORF YIR020W-B - YLR038C,COX12 essential during assembly for full cytochrome c oxidase activity YFL032W Hypothetical ORF YKR032W Hypothetical ORF YKL102C Hypothetical ORF YKL006C-A,SFT1 Required for transport of proteins between an early and a later golgi compartment. possible NSF attachment protein receptor (V-SNARE) YML084W Hypothetical ORF YDL130W-A,STF1,AIS2 ATPase stabilizing factor YMR320W Hypothetical ORF YKR057W,RPS21A,RPS25 Homology to rat S21 YDR241W,BUD26 - YLR438C-A,LSM3,SMX4, USS2 Like Sm-D2 protein; contains Sm-like domain; coprecipitates with U4, U5 and U6 snRNAs. YGL032C,AGA2 adhesion subunit of a-agglutinin YNL211C Hypothetical ORF YDR510W,SMT3 may be involved in function and/or structure of the eukaryotic kinetochore homologous to SUMO-1 YMR007W Hypothetical ORF YER146W,LSM5 Like Sm-E protein YCR085W Hypothetical ORF YGR008C,STF2 ATPase stabilizing factor YNL044W,YIP3 Interacts with YPT proteins YDL152W Protein required for cell viability YLR252W Hypothetical ORF YLR379W Protein required for cell viability YDR412W Protein required for cell viability YDR340W Hypothetical ORF YJR071W Hypothetical ORF YDR187C Protein required for cell viability YDL009C Hypothetical ORF YKL097W-A - YBL065W Hypothetical ORF YJL120W Hypothetical ORF YDR366C Hypothetical ORF YNL205C Hypothetical ORF YLL037W Protein required for cell viability YPR092W Hypothetical ORF YMR159C,APG16,SAP18 autophagy YKL118W Involved in meiotic nuclear division. YKL036C Protein required for cell viability YGL166W,CUP2,ACE1 Upregulates metallothionein (CUP1) expression in response to Cu2+ YGL239C Protein required for cell viability YNL203C Hypothetical ORF YBR278W,DPB3 C and C' subunits of DNA polymerase II YDR526C Hypothetical ORF YIL148W,RPL40A,CEP52A, UBI1, UB11 Homology to rat L40 YDR450W,RPS18A Homology to rat S18 and E. coli S13 YDR225W,HTA1,H2A1, SPT11 Histone H2A (HTA1 and HTA2 code for nearly identical proteins) YLR331C Jumonji Interacting Protein YDL083C,RPS16B Homology to rat S16 YPR123C Hypothetical ORF YIL069C,RPS24B,RPS24EB Homology to rat S24 YDR008C Hypothetical ORF YBR277C Hypothetical ORF YML013C-A - YGR259C Hypothetical ORF YGL103W,RPL28,CYH2 Homology to rat, mouse L27a. May be involved in peptidyl transferase activity. YCR097W-A Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36. (ChrIII) YBR219C Hypothetical ORF YAL058C-A - YGL168W required for hydroxyurea resistance YOL121C,RPS19A Homology to rat S19 YCR031C,RPS14A,CRY1, RPL59 Homology to mammalian S14, E. coli S11 YMR172C-A Hypothetical ORF YNL171C Hypothetical ORF YLR171W Hypothetical ORF YPL278C Hypothetical ORF YBL070C Hypothetical ORF YNL338W Hypothetical ORF YDL187C Hypothetical ORF YGL042C Hypothetical ORF YBL095W Hypothetical ORF YBR090C-A - YNL337W Hypothetical ORF YHR055C,CUP1-2,CUP1 required for cell growth at high copper concentrations. YDR431W Hypothetical ORF YCR063W,BUD31,CWC14 - YDR271C Hypothetical ORF YIL174W Hypothetical ORF YMR324C Hypothetical ORF YGL053W,PRM8 pheromone-regulated membrane protein YDR467C Hypothetical ORF YNL226W Hypothetical ORF YMR290W-A Protein required for cell viability YOL150C Hypothetical ORF YGR122C-A Similar to probable membrane protein YLR334C and ORF YOL106W YKL076C Platinum Sensitivity YCL023C Hypothetical ORF YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YLR032W,RAD5,REV2, SNM2 putative ATPase/DNA helicase YGR014W,MSB2 putative integral membrane protein YKL182W,FAS1 pentafunctional enzyme consisting of the following domains : acetyl transferase, enoyl reductase, dehydratase and malonyl/palmityl transferase YJL109C,UTP10 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YJR031C,GEA1 component of a complex guanine nucleotide exchange activity for the ADP-ribosylation factor ARF YDR507C,GIN4,ERC47 Growth inhibitory gene YER105C,NUP157 yeast nuclear pore complex component YPR010C,RPA135,RPA2, RRN2, SRP3 135 kDa subunit of RNA polymerase I YNL054W,VAC7 Integral 128-kDa vacuolar membrane protein; may function to regulate Fab1 kinase activity. YBL022C,PIM1,LON1, Lon mitochondrial ATP-dependent protease YGL140C Hypothetical ORF YGL151W,NUT1 Negative regulator of URS2 of the HO promoter YNL139C,RLR1,THO2, ZRG13 Required for LacZ RNA expression from certain plasmids; suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O); plays a role in transcription elongation by RNA polymerase II YMR109W,MYO5 contains proline-rich tail homology 2 (TH2) and SH3 domains YBR012W-B TyB Gag-Pol protein YGL094C,PAN2 Required for Pab1p-stimulated poly(A) ribonuclease activity YLR383W,RHC18,SMC6 Protein involved in recombination repair, homologous to S. pombe rad18. Structural maintenance of chromosomes (SMC) protein. YOR086C Hypothetical ORF; has similarity to YNL087w YLR071C,RGR1 affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation YBR218C,PYC2 converts pyruvate to oxaloacetate YOR011W,AUS1 ABC(ATP-binding cassette) protein involved in Uptake of Sterols YPL160W,CDC60 cytosolic leucyl tRNA synthetase YML109W,ZDS2,CES4 multicopy suppressor of a sin4 defect YKL004W,AUR1 involved in phospolipid metabolism YPR031W NuA3 ORF 1 YAR035W,YAT1 Outer carnitine acetyltransferase, mitochondrial YKL046C,DCW1 Defective Cell Wall. N-glycosylated, GPI-anchored membrane protein. YJR036C,HUL4 ubiquitin-protein ligase (E3) YKL081W,TEF4,EFC1 Translation elongation factor EF-1gamma YJL044C,GYP6 GTPase-activating protein for Ypt6 YOR335C,ALA1,CDC64 Cytoplasmic alanyl-tRNA synthetase gene YBR204C Hypothetical ORF YAL056W,GPB2,KRH1 Gpa2 interacting partner; Homolog of GPB1 Gpb2 binds in the two hybrid system with Gpa2 and plays an inhibitory signaling role attributable to interactions with Gpa2 and an unknown target in the PKA pathway. YOL068C,HST1 Homolog of SIR2 YDR258C,HSP78 Similar to E. coli ClpB protein; involved in folding of some mitochondrial proteins YIL009W,FAA3 acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatty acid activator 3), activates endogenous but not imported fatty acids and provides substrates for N-myristoylation YNL112W,DBP2 ATP-dependent RNA helicase of DEAD box family YLR304C,ACO1,GLU1 Aconitase, mitochondrial YHR050W,SMF2 SMF2 was isolated as a high copy suppressor of a temperature sensitive mutation in the PEP ( mitochondrial matrix protease) gene and may influence PEP-dependent protein import YDL070W,BDF2 bromodomain protein, homolog of BDF1 YDR168W,CDC37,SMO1 cell cycle protein necessary for passage through START YDR268W,MSW1 mitochondrial tryptophanyl-tRNA synthetase YJL010C Protein required for cell viability YBR078W,ECM33 ExtraCellular Mutant YMR021C,MAC1,CUA1 metal-binding transcriptional activator YDR463W,STP1,BAP1, SSY2 Involved in pre-tRNA splicing and in uptake of branched-chain amino acids YDL101C,DUN1 Dun1 kinase has complex checkpoint functions including DNA damage-dependent cell cycle arrest in G(2)M, transcriptional induction of repair genes, and regulation of postreplicative DNA repair pathways. YLR163C,MAS1,MIF1 mitochondrial processing protease subunit YDR506C Hypothetical ORF YER036C Hypothetical ORF YBR158W,AMN1,ICS4, CST13 Antagonist of MEN (Mitotic Exit Network)Chromosome STability YKR051W Hypothetical ORF YGR156W,PTI1 Pta1p Interacting protein YPL060W,LPE10 mitochondrial protein with homology to MRS2 YER048C,CAJ1 Homologous to E. coli DnaJ; contains leucine zipper-like motif YLR303W,MET17,MET15, MET25 O-Acetylhomoserine-O-Acetylserine Sulfhydralase YDR192C,NUP42,RIP1, UIP1 interacts specifically with the HIV-1 Rev protein effector domain; Ulp1 Interacting Protein 1 YMR125W,STO1,CBC1, GCR3, CBP80 Large subunit of the nuclear cap-binding protein complex YDR132C Hypothetical ORF YOR006C Hypothetical ORF YEL036C,ANP1,GEM3, MNN8 Mannan 8; Protein of the endoplasmic reticulum with a role in retention of glycosyltransferases in the Golgi, also involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol YDL205C,HEM3 catalyzes the third step in heme biosynthesis YNL009W,IDP3 peroxisomal NADP-dependent isocitrate dehydrogenase YJR153W,PGU1,PGL1, PSM1 Endo-polygalacturonase YHR156C,LIN1 LIN element of a link between sister chromatid cohesion, DNA replicarion and splicing YPL122C,TFB2 Transcription/repair factor TFIIH subunit YIL145C,PAN6 - YKL045W,PRI2 p58 polypeptide of DNA primase YOR014W,RTS1,SCS1 B-type regulatory subunit of protein phosphatase 2A (PP2A) YKL150W,MCR1 NADH-cytochrome b5 reductase YKR090W Paxillin-like protein 1 YDR300C,PRO1 catalyzes first step in proline biosynthesis YLR226W,BUR2,CST4 bypass UAS Requirement YMR010W Hypothetical ORF YOR267C,HRK1 Hygromycin Resistance Kinase YLR070C,XYL2 XYLitol Dehydrogenase YNL241C,ZWF1,MET19, POS10 Glucose-6-phosphate dehydrogenase YER123W,YCK3,CKI3 plasma membrane-bound casein kinase I homolog YLR237W,THI7,THI10 Thiamine Metabolism YOR368W,RAD17 DNA Damage checkpoint control YPL247C Hypothetical ORF YNL161W,CBK1 cell wall biosynthesis kinase. required for efficient apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation. YPR029C,APL4 Gamma-adaptin, large subunit of the clathrin-associated protein (AP) complex YGR210C Hypothetical ORF YPR056W,TFB4 RNA polymerase transcription initiation TFIIH (factor b), 37 kDa subunit YDR288W Protein required for cell viability YDL091C Hypothetical ORF YPL258C,THI21 THI for thiamine metabolism. Transcribed in the presence of low level of thiamine (10-8M) and turned off in the presence of high level (10-6M) of thiamine. Under the positive control of THI2 and THI3. YBR123C,TFC1 transcription factor tau (TFIIIC) subunit 95 YOR076C,SKI7,YOR29-27 Antiviral protein. Ski7p G protein appears to function as a signal-coupling factor between the two multi-complexes operating in the 3'-to-5' mRNA-decay pathway. YHL024W,RIM4 Regulator of IMe2 expression YPL134C,ODC1 Oxodicarboxylate carrier YPR185W,APG13 autophagy YOR233W,KIN4,KIN31, KIN3 protein kinase YGL185C Putative hydroxyacid dehydrogenase YPR180W,AOS1 along with Uba2p forms a heterodimeric activating enzyme for Smt3p YIL078W,THS1 Threonyl-tRNA synthetase, cytoplasmic YDR354W,TRP4 anthranilate phosphoribosyl transferase YBR001C,NTH2 hydrolyzes trehalose; may be inolved in growth transition from glucose to glycerol; shows significant sequence similarity to Nth1p YHL007C,STE20 Involved in pheromone response and pseudohyphal growth pathways YBR283C,SSH1 SEC61 homolog involved in co-translational pathway of protein transport YJL036W,SNX4,CVT13 Sorting NeXin YER081W,SER3 catalyzes the first step in serine biosynthesis; isozyme of SER33 YEL065W,SIT1,ARN3 Siderophore Iron Transport YPR048W,TAH18 Product of gene unknown YMR081C,ISF1,MBR3 May regulate NAM7 function, possibly at level of mRNA turnover YCR023C Hypothetical ORF YKL185W,ASH1 Zinc-finger inhibitor of HO transcription which is asymmetrically localized to the daughter cell nucleus YFL049W Hypothetical ORF YGR149W Hypothetical ORF YCL027W,FUS1 cell-surface protein required for cell fusion YAL034C,FUN19 Function unknown now YER171W,RAD3,REM1 DNA helicase component of transcription factor b (yeast homolog of human TFIIH) YPL055C,LGE1 large cell size mutant YJR110W Gene product shows sequence similarity to conserved myotubularin dual specificity phosphatase [PTP/DSP] gene family [Laporte et al. [1998] Hum Mol Gen 7:1703] YCR067C,SED4 Sed4p is an integral ER membrane protein, which, along along with its close homolog, Sec12p, is involved in vesicle formation at the ER YMR293C protein similar to bacterial glutamyl-tRNA amidotransferases YJL131C Hypothetical ORF YGL184C,STR3 Sulfur TRansfer YBR076W,ECM8 ExtraCellular Mutant YKL132C,RMA1 probable folyl-polyglutamate synthetase YDR017C,KCS1 Converts inositol hexakisphosphate to diphosphoinositol polyphosphates. Contains two leucine heptad repeats. Essential for biogenesis of the yeast vacuole and the cell's responses to certain environmental stresses. YNL165W Hypothetical ORF YKL021C,MAK11 essential for cell growth and replication of M dsRNA virus; contains four beta-transducin repeats YGR249W,MGA1 Mga1p shows similarity to heat shock transcription factor YDR153C,ENT5 Epsin N-Terminal homology-containing protein YLR149C Hypothetical ORF YER143W,DDI1,VSM1 DNA Damage Inducible; binds to T- and V- snare complexes YBR069C,TAT1,VAP1 Amino acid transport protein for valine, leucine, isoleucine, and tyrosine YKL073W,LHS1,CER1, SSI1 Lumen HSP Seventy Required for efficient translocation of protein precursors across the ER membrane YIL099W,SGA1 intracellular sporulation-specific glucoamylase involved in glycogen degradation. Induced during starvation of a/a late in sporulation, but dispensable for sporulation YER019W,ISC1 - YMR203W,TOM40,ISP42, MOM38 Translocase of Outer Mitochondrial membrane YHR027C,RPN1,HRD2, NAS1 Subunit of 26S Proteasome (PA700 subunit) YBR237W,PRP5,RNA5 RNA helicase homolog YML046W,PRP39 May function to facilitate or stabilize the interaction between U1 snRNP and the 5' splice site in pre-mRNAs YDR124W Hypothetical ORF YDL042C,SIR2,MAR1 regulator of silencing at HML, HMR, telomeres, and rDNA YLR127C,APC2,RSI1 subunit of the Anaphase Promoting Complex; all known APC subunit co-immunoprecipitate with epitope-tagged Apc2. Apc2 shows similarity to cullins. YBR127C,VMA2,ATPVS, VAT2 vacuolar H-ATPase regulatory subunit (subunit b), 60 kDa subunit of V1 sector YML065W,ORC1 binds to origins of replication and thereby directs DNA replication and is also involved in transcriptional silencing YEL055C,POL5 DNA polymerase V that has motifs typical of DNA polymerase family. Aphidicolin-sensitive; stimulated by yeast proliferating cell nuclear antigen (PCNA). YDR244W,PEX5,PAS10 Essential for import of proteins with SKL-like import signal into peroxisomal matrix YDR324C,UTP4 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YML114C,TAF8,TAF65 TBP Associated Factor 65 KDa YDR122W,KIN1 Serine/threonine protein kinase YNL123W Hypothetical ORF YER158C Hypothetical ORF YDR523C,SPS1 dispensable for mitosis, involved in middle/late stage of meiosis, required for spore wall formation YNL115C Hypothetical ORF YFR038W Hypothetical ORF YNL248C,RPA49 49-kDa alpha subunit of RNA polymerase A YHL020C,OPI1 Negative regulator of phospholipid biosynthesis YHR123W,EPT1 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase YGR046W Protein required for cell viability YOR085W,OST3 Catalyzes the transfer of oligosaccharide from dolichol-oligosaccharide donor to consensus glycosylation acceptor sites (asparagines) in newly synth. proteins - ER lumen; may enhance oligosacch. transfer to subset of acceptor substrates YGL158W,RCK1 Serine/threonine protein kinase YOL153C Hypothetical ORF YJL049W Hypothetical ORF YDR143C,SAN1 (putative) transcriptional regulator YMR210W Hypothetical ORF YGR122W Hypothetical ORF YNL317W,PFS2 Polyadenylation Factor I subunit 2 YDR116C,MRPL1 Mitochondrial Ribosomal Protein, Large Subunit YKR067W,GPT2,GAT1 Encodes a Glycerol-3-phosphate acyltransferase YDR245W,MNN10,BED1, SLC2, REC41 Required for mannan synthesis and for polarized growth and bud emergence YNL136W Hypothetical ORF YHL014C,YLF2,YLF1 Protein with weak similarity to B. subtilis GTP-binding protein and to human glycogen phosphorylases YNR038W,DBP6 Dead Box Protein 6 YDR353W,TRR1 Thioredoxin reductase YLR115W,CFT2,YDH1 cleaves pre-mRNAs prior to polyadenylation; homologous to both the 73- and 100-kDa subunits of mammalian cleavage and polyadenylation specificity factor (CPSF), as well as to YSH1/BRR5 YEL058W,PCM1,AGM1 Phosphoacetylglucosamine Mutase YOR067C,ALG8,YOR29-18 adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein YIL031W,ULP2,SMT4 Peptidase that removes SUMO-conjugates from proteins YOR313C,SPS4 sporulation-specific protein YFR040W,SAP155 155 kDa SIT4 protein phosphatase-associated protein YNL012W,SPO1 dispensable for mitosis, premeiotic DNA synthesis, synaptonemal complexes, and recombination, but required for meiotic spindle pole body duplication/separation, meiosis I, meiosis II, and spore formation YGR065C,VHT1 vitamin H transporter YPR091C Hypothetical ORF YIR011C,STS1,DBF8, SSM5 restores protein transport when overexpressed and rRNA stability to a sec23 mutation YGR237C Hypothetical ORF YNL127W,FAR11 Pheromone Arrest YHR159W Hypothetical ORF YLR382C,NAM2 mitochondrial leucyl tRNA synthetase YPR160W,GPH1 Releases glucose-1-phosphate from glycogen YOR196C,LIP5 Involved in lipoic acid metabolism YGL208W,SIP2,SPM2 Member of a family of proteins, including Sip1p and Gal83p, that interact with Snf1p and Snf4p and are involved in the response to glucose starvation YJL088W,ARG3 Sixth step in arginine biosynthesis YML034W,SRC1,YML033W Spliced mRNA and Cell cycle regulated gene YBR036C,CSG2,CLS2 Required for growth in high (>25mM) calcium, contains 9 or 10 putative membrane spanning regions YKL157W,APE2,YKL158W, LAP1 Removal of intron fused YKL158W and YKL157W (Davis et al.(2000) NAR 28:1700-6) YAL053W Hypothetical ORF YGR213C,RTA1 involved in 7-aminocholesterol resistance YJR126C,VPS70 - YMR079W,SEC14,PIT1 Required for vesicle budding from the Golgi YDR191W,HST4 Homolog of SIR2 YLR267W bypass of PAM1 YBR110W,ALG1 beta-1,4-mannosyltransferase YHR117W,TOM71,TOM72 Translocase of the Outer Mitochondrial membrane, 71.9 kDa YKL188C,PXA2,PAT1 Homolog of the human adrenoleukodystrophy transporter; forms a heterodimer with Pxa1p of two half ATP-binding cassette transporters in the peroxisome membrane YNL116W Hypothetical ORF YFL016C,MDJ1 involved in protection against heat-induced protein aggregation but not necessary for protein import into the mitochondrion YLR423C,APG17 required for activation of Apg1 protein kinase YCR036W,RBK1 ribokinase YIL021W,RPB3 45 kDa subunit of RNA polymerase II YDR055W,PST1 Protoplasts-secreted YHR178W,STB5 binds Sin3p in two-hybrid assay YMR120C,ADE17 AICAR transformylase/IMP cyclohydrolase YPR108W,RPN7 Regulatory Particle Non-ATPase, homolog of mammalian proteasomal subunit S10/p44 YEL064C,AVT2 related to the neuronal gamma -ransporters YJR008W Hypothetical ORF YDR320C,SWA2,AUX1, BUD24 auxilin-like protein YKL012W,PRP40 Splicing component that associates with the yeast U1 small nuclear ribonucleoprotein particle YMR212C,EFR3 PHO _E_ighty _F_ive _R_equiring YBR029C,CDS1,CDG1 CDP-diacylglycerol synthase, CTP-phosphatidic acid cytidylyltransferase, CDP-diglyceride synthetase YER049W Hypothetical ORF YKL162C Hypothetical ORF YDR352W Hypothetical ORF YLR019W,PSR2 Plasma membrane Sodium Response 2 YNL304W,YPT11 acts positively on mitochondrial distribution toward the bud. YBR159W microsomal beta-keto-reductase YGL209W,MIG2,MLZ1 Involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter YLR129W,DIP2,UTP12 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); DOM34 Interacting Protein YDR502C,SAM2,ETH2 methionine biosynthesis regulation YOL062C,APM4,AMP1 Clathrin associated protein, medium subunit YBR238C Hypothetical ORF YHL040C,ARN1 Transporter that specifically recognizes siderophore-iron chelates and is expressed under conditions of iron deprivation. YLR220W,CCC1 Functions in the homeostasis of both calcium and manganese ions YNL055C,POR1,OMP2 Outer mitochondrial membrane porin (voltage-dependent anion channel, or VDAC) YPL156C,PRM4 pheromone-regulated membrane protein YCR047C,BUD23 - YKL095W,YJU2,CWC16 Product of gene unknown YNL252C,MRPL17,YML30 mitochondrial ribosomal protein of the large subunit YDR429C,TIF35 Translation initiation factor 3 p33 subunit YPL232W,SSO1 SSO1 and SSO2 encode syntaxin homologs (post-Golgi t-SNAREs); act in late stages of secretion YOR255W Outer Spore Wall YGR172C,YIP1 Golgi integral membrane protein; binds to the transport GTPases Ypt1p and Ypt31p YPR009W,SUT2 Involved in sterol uptake; homologous to SUT1 YJR150C,DAN1,CCW13 Delayed Anaerobic YBL010C Hypothetical ORF YLR136C,TIS11,CTH2 Zinc finger containing homolog of mammalian TIS11, glucose repressible gene YER023W,PRO3,ORE2 delta 1-pyrroline-5-carboxylate reductase YNL151C,RPC31,ACP2, RPC8 31-kDa subunit of RNA polymerase III (C); HMG1 like protein YGR042W Hypothetical ORF YOR036W,PEP12,VPL6, VPS6, VPT13 integral membrane protein; c-terminal TMD; located in endosome YFR031C-A,RPL2A,RPL5B Homology to rat L8 and E. coli L2 YNR009W Hypothetical ORF YDR284C,DPP1,ZRG1 contains a novel phosphatase sequence motif found in a super family of phosphatases including mammalian PAP2 YIR016W Hypothetical ORF YJR144W,MGM101,MGM9 Involved in mitochondrial genome maintenance YBR256C,RIB5 Riboflavin biosynthesis YJR099W,YUH1 ubiquitin hydrolase YAL059W,ECM1 putative transmembrane domain protein involved in cell wall biogenesis YOL047C Hypothetical ORF YJL140W,RPB4,CTF15 fourth-largest subunit of RNA polymerase II YJR074W,MOG1 Required for nuclear-protein import YMR147W Hypothetical ORF YJR056C Hypothetical ORF YDR140W Hypothetical ORF YGL101W Hypothetical ORF YJR050W,ISY1,UTR3, NTC30 Interacts with Syf1p, Prp39p and Ypl213wp. YOR284W - YDL059C,RAD59 Involved in mitotic recombination YMR188C,MRPS17 - YER002W,NOP16 Nucleolar protein 16 YHL044W Hypothetical ORF YOR089C,VPS21,VPS12, VPT12, YPT21, YPT51 Rab5-like GTPase involved in vacuolar protein sorting and endocytosis post vesicle internalization; geranylgeranylated; geranylgeranylation required for membrane association YLR168C possibly involved in intramitochondrial sorting YJL004C,SYS1 Multicopy suppressor of ypt6 null mutation YOR232W,MGE1,YGE1 involved in protein import into mitochondria YGL037C,PNC1 NAD(+) salvage pathway gene YJL096W,MRPL49 mitochondrial ribosomal protein of the large subunit YKL065C Yeast homolog of human BAP31 protein YOL071W Early Meiotic Induction YDR071C Hypothetical ORF YJL124C,LSM1,SPB8 Like Sm protein; the finding that Lsm1 contains the Sm consensus motifs and most closely resembles Sm-B has been controversial (Fromont-Racine et al, 1997 Nature Genetics 16:277-282, and Bertrand Seraphin, personal communication). YOL159C Hypothetical ORF YFR026C Hypothetical ORF YCR003W,MRPL32,YML32 Mitochondrial ribosomal protein MRPL32 (YmL32) YLR402W Hypothetical ORF YJR055W,HIT1 Protein required for growth at high temperature YNL046W Hypothetical ORF YPL038W,MET31 Involved in methionine metabolism YKL013C,ARC19 Arp complex subunit YGL196W Hypothetical ORF YOR163W,DDP1 Diadenosine and Diphosphoinositol Polyphosphate Phosphohydrolase YCL026C-A,FRM2,YCLX08C Protein involved in the integration of lipid signaling pathways with cellular homeostatis YHR180W Hypothetical ORF YGL222C,EDC1 Enhancer of mRNA Decapping YFL051C Hypothetical ORF YML011C Hypothetical ORF YML036W Hypothetical ORF YGL262W Hypothetical ORF YFL015C Hypothetical ORF YHL037C Hypothetical ORF YOR094W,ARF3,ARL2 GTP-binding ADP-ribosylation factor YER117W,RPL23B Homology to rat L23 and E. coli L14 YNL285W Hypothetical ORF YOR122C,PFY1,PRF1 profilin (actin-binding protein) YIL012W Hypothetical ORF YBR269C Hypothetical ORF YGL034C Hypothetical ORF YOR268C Hypothetical ORF YHR059W,FYV4 Function required for Yeast Viability on toxin exposure YMR082C Hypothetical ORF YFR049W,YMR31 mitochondrial ribosomal protein (precursor) YIL028W Hypothetical ORF YPL062W Hypothetical ORF YDR504C Hypothetical ORF YCL007C,CWH36 calcofluor white hypersensitivity YJR120W Hypothetical ORF YHL015W,RPS20,URP2 Homology to rat S20, human S20, Xenopus S22, and E. coli S10 YLR269C Hypothetical ORF YGL226W Hypothetical ORF YCR083W,TRX3 mitochondrial thioredoxin YGL080W Hypothetical ORF YDR224C,HTB1,SPT12 Histone H2B (HTB1 and HTB2 code for nearly identical proteins) YJR157W Hypothetical ORF YOR171C,LCB4 involved in sphingolipid biosynthesis YOL036W Hypothetical ORF YOL004W,SIN3,CPE1, GAM2, RPD1, SDI1, SDS16, UME4 DNA binding protein involved in transcriptional regulation YKL135C,APL2 Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex YJL019W,MPS3,YJL018W, NEP98 MonoPolar Spindle98 kDa Nuclear Envelope Protein. essential integral membrane protein that localizes to the SPB half-bridge. YJL194W,CDC6 Protein involved in initiation of DNA replication YML099C,ARG81,ARGR2 Regulator of arginine-responsive genes with ARG80 and ARG82 YML013W,SEL1 owering YBR117C,TKL2 transketolase, homologous to tkl1 YDR270W,CCC2 copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes YOR054C,VHS3,YOR29-05 Gene whose overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation YBR225W Hypothetical ORF YMR119W,ASI1 Amino acid Sensor-Independent (ASI) genes encode membrane proteins Asi1p, Asi2p and Asi3p. Asi1p and Asi3p have conserved ubiquitin ligase-like RING domains at their C-termini YLR248W,RCK2,CLK1, CMK3 Serine/threonine protein kinase YLR443W,ECM7,ZRG15 Involved in cell wall maintenance YNL277W,MET2 catalyzes the conversion of homoserine to O-acetyl homoserine which in turn combines with hydrogen sulfide to form homocysteine, the immediate precursor of methionine YBL082C,RHK1,ALG3 Resistance to Hansenula Killer 1, hypothetical F-458 protein YOR299W,BUD7 bud site selection YPR125W Hypothetical ORF YLR175W,CBF5 major low affinity 55 kDa Centromere/microtubule binding protein YJL168C,SET2,EZL1 Contains a 'SET' or 'TROMO' domain at the N-terminus of the protein Methyltransferase activity is important for transcriptional repression activity YAL017W,PSK1,FUN31 contains serine/threonine protein kinase domain and shows homology with the SNF1 serine/threonine protein kinase YIL169C Hypothetical ORF YOL100W,PKH2 Pkb-activating Kinase Homologue YFR024C - YHR054C Hypothetical ORF YMR170C,ALD2 Expression induced in response to high osmotic stress. NAD+ is preferred coenzyme. YJL219W,HXT9 High-affinity hexose transporter YBR118W,TEF2 translational elongation factor EF-1 alpha YLL024C,SSA2 member of 70 kDa heat shock protein family YLL039C,UBI4,SCD2, UB14 UBI4 locus contains five-six tandem, in-frame copies of ubiquitin protein coding sequence (depending on strain background)(PMID:6095120, 3038523)transcription of UBI4 is induced in response to several stress conditions YEL070W Hypothetical ORF YOR393W,ERR1 enolase-related subtelomeric sequence (ERR1 and ERR2 code for identical proteins) YIL170W,HXT12 High level of sequence similarity to HXT1 and HXT9 hexose transporters YDL229W,SSB1,YG101 Stress-Seventy Subfamily B; involved in translation, perhaps by guiding the nascent chain through the ribosome YML117W Hypothetical ORF YLR460C Hypothetical ORF YHR066W,SSF1 putative involvement in mating YBR299W,MAL32,MAL3S Part of the complex locus MAL3; functional in S288C; highly homologous to MAL62 from S. carlsbergenesis strain CB11 YDR545W,YRF1-1,YRF1 Y'-helicase protein 1 YJL138C,TIF2 translation initiation factor eIF4A YHR216W,IMD2,PUR5 inosine monophosphate dehydrogenase, the enzyme that catalyzes the first dedicated step of GMP biosynthesis. YGR254W,ENO1,HSP48 enolase I YJR156C,THI11 thiamine regulated gene, homologous to S. pombe NMT1A. Proposed biosynthetic enzyme involved in pyrimidine biosynth. pathway above the hydroxymethyl-pyrimidine precursor leading to the thiamine moiety. Three copies THI5, THI11 & THI12 YGR292W,MAL12 Part of the complex locus MAL1; functional in S288C YHR010W,RPL27A,RPL27 Homology to mammalian L27 YBL002W,HTB2 Histone H2B (HTB1 and HTB2 code for nearly identical proteins) YOR309C Hypothetical ORF YDL096C Hypothetical ORF YGR011W Hypothetical ORF YLR198C Protein required for cell viability YJR018W Hypothetical ORF YGR073C Protein required for cell viability YIL052C,RPL34B Homology to rat L34 YGR151C Hypothetical ORF YHL046C Hypothetical ORF YGL261C Hypothetical ORF YML035C-A - YLR294C Hypothetical ORF YCR097W,HMRA1,YCR097WB, A1, MATA1 silenced copy of A1, which encodes a homeobox-domain containing protein that, together with alpha2, represses transcription of haploid-specific genes in diploid cells YBR232C Hypothetical ORF YER056C-A,RPL34A Homology to rat L34 YAL068C Hypothetical ORF YPR130C Hypothetical ORF YKL169C Hypothetical ORF YLR062C,BUD28 - YPR076W Hypothetical ORF YLR061W,RPL22A Homology to rat L22 YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YHR079C,IRE1,ERN1 Involved in myo-inositol biosynthesis; implicated as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus YDR291W Hypothetical ORF YMR259C Hypothetical ORF YPR184W,GDB1 Glycogen debranching enzyme; the enzyme that debranches the glycogen having a glucanotranferase + 1-6amyloglucosidase activity YER172C,BRR2,RSS1, SLT22, SNU246, PRP44 RNA helicase-related protein required for pre-mRNA splicing; Snurp 246 kDa protein (Snurp = Small nuclear ribonucleoprotein particle) YJL042W,MHP1 Similar to a 250 kD Drosophila microtubule-associated protein (MAP) (which can rescue MHP1 null mutant) and to mammalian MAP4 proteins YGL016W,KAP122,PDR6 Member of the karyopherin-beta family with possible role in nuclear transport and regulation of pleiotropic drug resistance. YGL156W,AMS1 vacuolar alpha mannosidase YHL023C Required for Meiotic nuclear Division YOR330C,MIP1 catalytic subunit of mitochondrial DNA polymerase YBL063W,KIP1,CIN9 Mitotic spindle assembly YLR024C,UBR2 ubiquitin-protein ligase (E3) YMR012W,CLU1,TIF31 CLU1 is similar to the Dictyostelium cluA gene YIL129C,TAO3,PAG1 Identified in a hunt for mutants that activate OCH1 transcription YJL130C,URA2 First and second steps of pyrimidine biosynthesis YDL231C,BRE4 contains several putative trans-membrane domains YLR247C Hypothetical ORF YER138C TyB Gag-Pol protein YDR283C,GCN2,AAS1 Derepression of GCN4 expression YEL022W,GEA2 Guanine-nucleotide Exchange on ARF YLR430W,SEN1,CIK3, NRD2 component of a nuclear-localized tRNA splicing complex YBR208C,DUR1,2,DUR80 Urea amidolyase (contains urea carboxylase and allophanate hydrolase) YDR150W,NUM1,PAC12 May function in nuclear migration during mitosis and meiosis by affecting astral microtubule functions, perhaps by being involved in polymerization and stabilization of microtubules YML039W TyB Gag-Pol protein YDL230W,PTP1 phosphotyrosine-specific protein phosphatase YJR141W Protein required for cell viability YKL054C,DEF1,VID31 RNA polymerase II DEgradation Factor 1 YGL026C,TRP5 tryptophan synthetase YKL140W,TGL1,YKL5 triglyceride lipase-cholesterol esterase YDR314C Hypothetical ORF YEL050C,RML2 mitochondrial ribosomal protein L2 of the large subunit YLR215C Product of gene unknown YNL280C,ERG24 sterol C-14 reductase YJR060W,CBF1,CEP1, CPF1 centromere binding factor; binds in vivo to CDE I sites in centromeres (and some promoters), and induces DNA bending, required for mitotic segregation and normal growth rate YPL183C Hypothetical ORF YPL264C Hypothetical ORF YLL022C Hat1 Interacting Factor 1 YOR249C,APC5,RMC1 subunit of the Anaphase Promoting Complex; all known APC subunits co-immunoprecipitate with epitope-tagged Apc5 YBL054W Hypothetical ORF YPL061W,ALD6 Utilizes NADP+ as the preferred coenzyme. Activated by Mg2+. YFR028C,CDC14,OAF3 Required for mitosis and sporulation YGL207W,SPT16,CDC68, SSF1 global regulator of transcription YMR231W,PEP5,END1, VAM1, VPL9, VPS11, VPT11 peripheral vaculor membrane protein; putative Zn-finger protein YAL061W putative polyol dehydrogenase YIL073C,SPO22 sporulation-defective; SPO22 contains phospholipase A2 signature sequence (positions 135-143, found by Emotif search). The gene is specifically induced early in meiosis (Primig et al. (2000) Nat Genet 26:415-423) YFR014C,CMK1 Calmodulin-dependent protein kinase YNL275W transporter YFR007W Hypothetical ORF YMR065W,KAR5,FIG3 appears to be required for the completion of nuclear membrane fusion and may play a role in the organization of the membrane fusion complex YJL006C,CTK2 cyclin-related subunit of the kinase complex that phosphorylates the RPO21 CTD (carboxy-terminal domain); also called CTDK-I beta subunit YML054C,CYB2 Expression is repressed by glucose and anaerobic conditions, is induced by L-lactate and is regulated by GRR1, ROX3, HAP1, HXK2 and CYC8 YKR029C,SET3 - YDL238C Hypothetical ORF YJL041W,NSP1 Nucleoskeletal protein found in nuclear pores and spindle pole body YOL107W Hypothetical ORF YMR152W,YIM1 Mitochondrial inner membrane protease, similar to E. coli leader peptidase YNL005C,MRP7 Mitochondrial ribosomal protein MRP7 (YmL2) (E. coli L27) YLR233C,EST1 Ever Shorter Telomeres; mediates enzyme access by bridging the interaction between the catalytic core of telomerase and Cdc13; may act as a positive regulator of telomerase once the enzyme has been brought to the telomere. YGL063W,PUS2 pseudouridine synthase 2 YOR032C,HMS1 High-copy mep2 suppressor YPL084W,BRO1,LPF2 BCK1-like resistance to osmotic shock YNL011C Hypothetical ORF YBR102C,EXO84,USA3 exocyst complex component; homolog in rat brain called rExo84.pre-mRNA splicing factor. YMR204C Hypothetical ORF YIR004W,DJP1,ICS1, PAS22 DnaJ-like protein required for Peroxisome biogenesis; Djp1p is located in the cytosol YPL256C,CLN2 role in cell cycle START YDL128W,VCX1,HUM1, MNR1 Similar to sodium/calcium exchangers, including bovine Na+/Ca2+,K+ antiporter; putative vacuolar transmembrane protein YNR059W,MNT4 MaNnosylTransferase YER064C mutation leads to reduction of ERG9, CYC1-LacZ, and GCN4-LacZ expression YOR144C Enhanced Level of Genomic instability, Repressor of Ty1 Transposition YKL005C BYpass Ess1 YKL210W,UBA1 similar to Uba2p YMR005W,TAF4,TAF48, TSG2, MPT1 Protein required for protein synthesis YLR213C,CRR1 CRH-Related YER028C Hypothetical ORF YBR249C,ARO4 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase isoenzyme YPL039W Hypothetical ORF YMR239C,RNT1 Ribonuclease III YNR074C putative reductase YNR035C,ARC35,END9 Arp complex subunit YHR007C,ERG11,CYP51 - YDR265W,PEX10,PAS4 Pex2p, Pex10p, and Pex12p together make up the RING finger complex of the peroxisomal import machinery. YDR123C,INO2,DIE1, SCS1 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis YPL201C Hypothetical ORF YBL016W,FUS3,DAC2 Required for the arrest of cells in G(sub)1 in response to pheromone and cell fusion during conjugation YPL095C Hypothetical ORF YHR099W,TRA1 TRA1 is the homolog of the human protein TRRAP which we have isolated as an essential cofactor of c-Myc. YER125W,RSP5,MDP1, MUT2, NPI1, UBY1, SMM1 involved in ubiquitin-mediated protein degradation YDR239C Hypothetical ORF YBR243C,ALG7,TUR1 ER protein that transfers Glc-Nac-P from UDP-GlcNac to Dol-P YDL031W,DBP10 Dead box protein 10 YPR161C,SGV1,BUR1 CDC28/cdc2 related protein kinase YJL034W,KAR2,BIP, GRP78 Involved in translocation of nascent polypeptides across the ER membrane YGR079W Hypothetical ORF YFR051C,RET2 coatomer (COPI) complex delta subunit YGR166W,KRE11,TRS65 Involved in biosynthetic pathway for cell wall beta-glucans YDR261C,EXG2 Exo-1,3-b-glucanase YOR023C,AHC1 Ada Histone acetyltransferase complex component YML087C Hypothetical ORF YLR177W Hypothetical ORF YER070W,RNR1,CRT7, RIR1, SDS12 ribonucleotide reductase YIL015W,BAR1,SST1 extracellular protease synthesized in a-cells that cleaves and inactivates alpha factor YDR307W Hypothetical ORF YPL050C,MNN9 Protein required for complex glycosylation YNL076W,MKS1,LYS80 Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation YOL117W,RRI2,CSN10 subunit of COP9 Signalosome (CSN) like protein complex that cleaves the ubiquitin-like protein Rub1 from Cdc53 YHR052W,CIC1,NSA3 Core interacting component 1 YJR130C,STR2 Sulfur TRansfer YIL041W Golgi-Vesicle Protein of 36 kDa YPR139C,VPS66 - YPL118W,MRP51 Mitochondrial Ribosomal Protein YOL136C,PFK27 6-phosphofructo-2-kinase YMR198W,CIK1 aryogamy; CIK1 is important for proper organiziation of microtubule arrays and establishment of a spindle; is essential for karyogamy; and expression is regulated by KAR4 and mating YLL058W Hypothetical ORF YJL146W,IDS2 IME2-Dependent Signalling YDR110W,FOB1,HRM1 The gene product is essential for both DNA replication fork blocking and recombinational hotspot activities. YDR062W,LCB2,SCS1, TSC1 Serine palmitoyltransferase catalyses the committed step in sphingolipid synthesis, the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine. YPL263C,KEL3 Kelch-repeat protein, similar to Kel1 and Kel2 YOR084W - YBL081W Hypothetical ORF YOR315W Hypothetical ORF YLR265C,NEJ1,LIF2 Nonhomologous End-Joining regulator 1; Repressed by MAT heterozygosity; Interacts with Lif1p in a yeast two-hybrid assay YJL020C,BBC1,MTI1 shows synthetic fitness defect with bni1 mutants and associates with the Bee1p-Vrp1p-Myo3/5p complex YBR004C Hypothetical ORF YJR089W,BIR1 baculoviral IAP repeat-containing protein YDR101C,ARX1 - YOR362C,PRE10 proteasome component YC1 (protease yscE subunit 1) YPL155C,KIP2 kinesin-related protein YKR011C Hypothetical ORF YBR202W,CDC47,MCM7 Essential for initiation of DNA replication YLR291C,GCD7 translation initiation factor eIF2b, 43 kDa subunit; negative regulator of GCN4 expression YER051W Hypothetical ORF YCL032W,STE50 involved in pheromone signal transduction pathway; interacts with G protein and Ste11p YAL022C,FUN26 predicted membrane protein YLR286C,CTS1 Endochitinase YDL143W,CCT4,TCP4 subunit of the TRiC/CCT complex; cytoplasmic chaperonin subunit required for actin cytoskeleton assembly or function. YMR011W,HXT2 hexose transporter YGR208W,SER2 phosphoserine phosphatase YDR028C,REG1,HEX2, PZF240, SPP43, SRN1 The reg1 locus encodes a gene which is involved in RNA processing and is a negative regulator of glucose-repressible genes. YDL013W,HEX3,SLX5 Protein involved in hexose metabolism YMR186W,HSC82 constitutively expressed heat shock protein YDL239C,ADY3 Accumulation of DYads. Mediates assembly of the Don1p-containing structure at the leading edge of the prospore membrane via interaction with components of the spindle pole body. YNL040W Hypothetical ORF YDL074C,BRE1 putative coiled-coil protein with RING-finger and myosin-like domains YER096W,SHC1 Required for proper maturation of the ascospore through its participation in the synthesis of the chitosan layer. YAR003W,SWD1,FUN16, CPS50, SAF49 likely involved in chromatin remodelingmember of Set1p complex YIL135C,VHS2 Gene whose overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation YOL049W,GSH2 Glutathione Synthetase YEL053C,MAK10 Glucose-repressible protein YLR345W Hypothetical ORF YIL075C,RPN2,SEN3 involved in tRNA processing and degradation of ubiquitinated proteins YBR148W,YSW1 Spore-specific protein YKR061W,KTR2 May be involved in extracellular matrix assembly; involved in N-linked glycosylation of cell wall mannoproteins YBR079C,RPG1,TIF32 Exhibits significant sequence similarity with a subunit of the mammalian translation initiation factor 3 YER099C,PRS2 ribose-phosphate pyrophosphokinase 2 YNL229C,URE2,[URE3] Nitrogen catabolite repression regulator that acts by inhibition of GLN3 in good nitrogen source. Altered form of Ure2p creates [URE3] prion. YJR152W,DAL5,UREP1 allantoate permease YCR065W,HCM1 Dosage-dependent suppressor of cmd1-1 mutation; shows homology to fork head family of DNA-binding proteins YLR273C,PIG1 Putative type 1 phosphatase regulatory subunit; interacts with Gsy2p YDL160C,DHH1 Putative RNA helicase of DEAD box family YGR088W,CTT1 cytoplasmic catalase T YPR152C Hypothetical ORF YLR362W,STE11 involved in the mating signalling pathway YLR324W Hypothetical ORF YDR336W Hypothetical ORF YDR119W Hypothetical ORF YJR007W,SUI2 eIF2 is a heterotrimeric GTP-binding protein GCD11 encodes the gamma subunit YOR292C Hypothetical ORF YKL125W,RRN3 Required for transcription of rDNA by RNA Polymerase I YBR094W Hypothetical ORF YER151C,UBP3 Possible role for UBP3 in controlling the activity or assembly of the SIR protein complex. YLR058C,SHM2,SHMT2 serine hydroxymethyltransferase YPL092W,SSU1,LPG16 putative sulfite pump YLR287C Hypothetical ORF YBR281C Hypothetical ORF YJR015W Hypothetical ORF YGL126W,SCS3 Required for inositol prototrophy YLR259C,HSP60,CPN60, MIF4 60 kDa heat shock protein YBL080C,PET112 May serve important general function in mitochondrial gene expression, probably in translation; required for translation of COX2 mRNA YDL063C Hypothetical ORF YLL062C,MHT1 S-Methylmethionine Homocysteine methylTransferase YGL171W,ROK1 contains domains found in the DEAD protein family of ATP-dependent RNA helicases; high-copy suppressor of kem1 null mutant YMR033W,ARP9,SWP59 involved in transcriptional regulation YCL064C,CHA1 catabolism of hydroxy amino acids YMR064W,AEP1,NCA1 Requried for the translation of OLI1 mRNA. YDR237W,MRPL7 Mitochondrial ribosomal protein MRPL7 (YmL7) YMR104C,YPK2,YKR2 protein kinase YOR002W,ALG6 Required for glucosylation in the N-linked glycosylation pathway YCR021C,HSP30,YRO1 Protein induced by heat shock, ethanol treatment, and entry into stationary phase; located in plasma membrane YLR049C Hypothetical ORF YOR377W,ATF1 Alcohol acetyltransferase YGL229C,SAP4 SAP4 is related to SAP155, SAP185, and SAP190, all of which associate with the SIT4 protein phosphatase YAL067C,SEO1 Suppressor of Sulfoxyde Ethionine resistance YOR140W,SFL1 Transcription factor with domains homologous to myc oncoprotein and yeast Hsf1p required for normal cell surface assembly and flocculence YCR079W Hypothetical ORF YLR206W,ENT2 epsin N-terminal homology-containing protein YPL188W,POS5 involved in oxidative stress YGR072W,UPF3,SUA6 factor stimulating decay of mRNAs containing premature stop codons; acts with Nmd2p and Nam7p YBR145W,ADH5 alcohol dehydrogenase isoenzyme V YOR371C,GPB1,KRH2 Gpa2 interacting partner; Homolog of GPB2 Functions, with Gpb2, in the cAMP-PKA pathway via interactions with Gpa2 and another unknown target. YDR057W,YOS9 Appears to play a direct role in the transport of GPI-anchored proteins to the Golgi apparatus. YLR450W,HMG2 Induces cells to assemble peripheral ER membrane arrays and short nuclear-associated membrane stacks. Rate-limiting enzyme in sterol biosynthesis. YPL228W,CET1,CES5 Interacts with Ceg1p, the mRNA capping enzyme alpha subunit; removes gamma-phosphate from triphosphate-terminated RNA YGR157W,CHO2,PEM1 First step in the methylation pathway for phosphatidylcholine biosynthesis YDL021W,GPM2 Similar to GPM1 (phosphoglycerate mutase); converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis YPL088W Hypothetical ORF YEL052W,AFG1 ATPase family gene YMR114C Hypothetical ORF YPR118W Hypothetical ORF YIR034C,LYS1 saccharopine dehydrogenase YDR096W,GIS1 putative zinc finger protein; repressor of PHR1 transcription YNL042W bypass of PAM1 YPL255W,BBP1 Involved in mitotic cell cycle and meiosis YER106W,MAM1 Monopolar microtubule Attachment during Meiosis I YGR284C,ERV29 ER Vesicle protein of 29 kDa (apparent MW) YGL240W,DOC1,APC10 Doc1p and Cdc26p are associated with the anaphase-promoting complex and are involved in the degradation of Clb2p YDR480W,DIG2,RST2 Down-regulator of Invasive Growth, Regulator of Sterile Twelve YNL098C,RAS2,CTN5, CYR3, GLC5 Ras proto-oncogene homolog. Ras2 is involved in growth on non-fermentable carbon sources, the starvation response, sporulation, pseudohyphal growth and aging. YLR439W,MRPL4,YML4 essential for mitochondrial function and for proper cell growth under non-respiratory conditions YPR061C Hypothetical ORF YPR011C Hypothetical ORF YPL054W,LEE1 Product of gene unknown YIL061C,SNP1 U1snRNP 70K protein homolog YOL016C,CMK2 Calmodulin-dependent protein kinase YBR024W,SCO2 Originally identified as a multicopy suppressor of a respiratory defective mutant; homolog of Sco1p YPR147C Hypothetical ORF YDR058C,TGL2 Triglyceride Lipase YJL159W,HSP150,CCW7, ORE1, PIR2 Heat shock protein, secretory glycoprotein YFL044C Hypothetical ORF YOR123C,LEO1 member of the RNA polymerase II-associated Paf1 complex YOL096C,COQ3 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase YNL232W,CSL4,SKI4 Represses the replication of double-stranded RNA viruses, protecting the host from the otherwise lethal effects of the virus YMR087W Hypothetical ORF YMR226C NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids YLR209C,PNP1 purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides YGR120C,COG2,SEC35 Secretion deficient YML041C,VPS71 - YHR185C,PFS1,ADY1 Prospore Formation at Selected spindle poles YDL087C,LUC7,EXM2, EPE1 Living Under Cap-binding complex expression YGL117W Hypothetical ORF YOR220W Hypothetical ORF YER126C,NSA2 Killer toxin Resistant; Nop seven associated protein 2 YDR503C,LPP1 Lipid phosphate phosphatase YJL174W,KRE9 cell wall beta-glucan assembly YKL040C,NFU1,NUB1 Nifu-like protein YHR012W,VPS29,PEP11 vacuolar protein sorting YMR312W,ELP6,HAP3, TOT6 ELongator Protein 6; 30kD subunit. Homolog of ATPases, yet with substitutions of amino acids critical for ATP hydrolysis. YGR207C Hypothetical ORF YPL162C Hypothetical ORF YIL011W,TIR3,YIB1 TIP1-related YLR285W - YCR075C,ERS1 Suppressor of ERD1 mutation; seven transmembrane domain protein YDR405W,MRP20,MRPL41 Involved in mitochondrial translation YDL086W Hypothetical ORF YAR008W,SEN34,FUN4 tRNA splicing endonuclease 34kDa subunit; homologous to the 42-kDa subunit, SEN2; contains active site for 3' splice site cleavage YLR414C Hypothetical ORF YDL202W,MRPL11 Mitochondrial ribosomal protein MRPL11 (YmL11) YGR153W Hypothetical ORF YCR018C,SRD1 involved in the processing of pre-rRNA to mature rRNA YHR026W,PPA1,VMA16 vacuolar ATPase V0 domain subunit c'' YNL158W Protein required for cell viability YNL038W,GPI15 Glysosyl Phosphatidyl Inositol YDR298C,ATP5,OSC1 Subunit 5 of the mitochondrial ATP synthase complex; homologous to bovine OSCP and E. coli delta. YDR167W,TAF10,TAF23, TAF25 TFIID subunit (TBP-associated factor) with predicted molecular weight of 23 kD. YDR408C,ADE8 glycinamide ribotide transformylase YHR089C,GAR1 small nucleolar RNP proteins YDL212W,SHR3,APF1 Protein required for appearance of amino acid permeases on the cell surface YDR084C Tlg2-Vesicle Protein of 23 kDa YMR222C - YJR014W Hypothetical ORF YLR119W,SRN2,SRN10, VPS37 Suppressor of rna1-1 mutation YIL132C,CSM2 Chromosome segregation in meiosis YER170W,ADK2,AKY3, PAK3 Adenylate kinase (mitochondrial GTP:AMP phosphotransferase) YGR226C - YGR268C - YMR073C Hypothetical ORF YDR183W,PLP1 Phosducin-Like Protein YDR468C,TLG1 member of the syntaxin family of t-SNAREs YNR018W Hypothetical ORF YML001W,YPT7,AST4, VAM4 Gtp-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, and for fusion of endosomes to vacuoles when expressed from high copy plasmid YPR154W,PIN3,LSB2 [PSI+] induction YNL133C,FYV6 Function required for Yeast Viability on toxin exposure YJL011C,RPC17 Specific subunit of Pol III which participates together with C34 in the recruitment of Pol III by the preinitiation complex. YER134C Hypothetical ORF YDL235C,YPD1 Ypd1p is an intermediate protein between Sln1p and Ssk1p in the phosphorelay reaction. YDL177C Hypothetical ORF YHR152W,SPO12 Thought to be a positive regulator of exit from M-phase in mitosis and meiosis; interacts with Dbf2p and Dbf20p protein kinases YPR149W,NCE102,NCE2 involved in secretion of proteins that lack classical secretory signal sequences YHL043W,ECM34 ExtraCellular Mutant YDR404C,RPB7 dissociable subunit of RNA polymerase II YGL106W,MLC1 may stabilize Myo2p by binding to the neck region YGL031C,RPL24A,RPL30A Homology to rat L24 YDL092W,SRP14 Signal recognition particle subunit YIL065C,FIS1,MDV2 Involved in mitochondrial division YKL056C Hypothetical ORF YMR236W,TAF9,TAF17 TFIID subunit (TBP-associated factor) with predicted molecular weight of 17 kD. YMR148W Hypothetical ORF YGL010W Hypothetical ORF YGL058W,RAD6,UBC2 Involved in DNA repair and sporulation. Rad6p interacts with Ubr1 and Rad18p. mRNA is induced early in meiosis and peaks at meiosis I. YFL017C,GNA1,PAT1 involved in UDP-N-acetylglucosamine biosynthesis YKL063C Hypothetical ORF YPL223C,GRE1 Induced by osmotic stress YDR529C,QCR7,COR4, CRO1, UCR7 ubiquinol-cytochrome c oxidoreductase subunit 7 (14 kDa) YHR049C-A Hypothetical ORF YDL196W Protein required for cell viability YBL078C,AUT7,APG8, CVT5 Forms a protein complex with Aut2p to mediate attachment of autophagosomes to microtubules. Defective in maturation of the vacuolar protein, aminopeptidase I YLR311C Hypothetical ORF YLL025W Hypothetical ORF YOL131W Hypothetical ORF YHL018W Hypothetical ORF YOR376W Hypothetical ORF YER121W Hypothetical ORF YDL162C Hypothetical ORF YML058W,SML1 Suppressor of mec lethality. Ribonucleotide reductase inhibitor. YGL007W Hypothetical ORF YKL058W,TOA2 Transcription factor IIA, small chain YDR029W Hypothetical ORF YPL098C Hypothetical ORF YGL029W,CGR1 Coiled-coil growth-regulated. May contribute to compartmentalization of nucleolar constituents. YPR014C Hypothetical ORF YGL220W Hypothetical ORF YGL070C,RPB9,SHI1, SSU73 small subunit of yeast RNA polymerase II participating in elongation and formed of two conserved zinc domains YBL048W Hypothetical ORF YJL199C Hypothetical ORF YML075C,HMG1 Induces cell to assemble stacks of paired nuclear-associated membranes called karmellae. YGL219C,MDM34 Mitochondrial Distribution and Morphology YKR042W,UTH1 Youth, involved in determining yeast longevity YOR202W,HIS3,HIS10 imidazoleglycerol-phosphate dehydratase YLR435W RNA accumulation YLR283W Hypothetical ORF YLL036C,PRP19,PSO4 Required for error prone repair, induced mitotic recombination, and sporulation YLR216C,CPR6 a cyclophilin related to the mammalian CyP-40; physically interacts with RPD3 gene product YGR152C,RSR1,BUD1 Gtp-binding protein of the ras superfamily involved in bud site selection YPL237W,SUI3 eIF2 is a heterotrimeric GTP-binding protein GCD11 encodes the gamma subunit YNL204C,SPS18,SPX18 sporulation-specific protein YPR124W,CTR1 High affinity copper transporter into the cell, probable integral membrane protein YCR012W,PGK1 3-phosphoglycerate kinase YJR088C Hypothetical ORF YLR197W,SIK1,NOP56 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); similar to microtubule binding proteins and to X90565_5.cds YDL186W Hypothetical ORF YBR050C,REG2 Possible regulatory subunit for the PP1 family protein phosphatase Glc7p YLR375W Involved in pre-tRNA splicing and in uptake of branched-chain amino acids YGL043W,DST1,PPR2 Transcription elongation factor S-IIMeiotic DNA recombination factor YNR075W,COS10 Protein with strong similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p YKR013W,PRY2 Pathogen Related in Sc, contains homology to the plant PR-1 class of pathogen related proteins. The protein sequence is over 60% identical with the Pry2p & Pry3p over 145 resid. PRY1 is >35% identical (50% similar) to tobacco PR-1c protein. YDR007W,TRP1 Note that the sequence of TRP1 from strain S228C, which is the sequence stored in SGD, contains an ochre mutation at codon 67. YNL331C,AAD14 aryl-alcohol dehydrogenase located on chromosome 14 YML040W TyA Gag protein YAR071W,PHO11 Acid phosphatase, secreted YPL198W,RPL7B Homolog of mammalian ribosomal protein L7 and E. coli L30 YGL131C Hypothetical ORF YGL218W Hypothetical ORF YLR180W,SAM1,ETH10 S-adenosylmethionine synthetase YPL277C Hypothetical ORF YFL059W,SNZ3 Snooze: stationary phase-induced gene family YDR149C Hypothetical ORF YJL195C Protein required for cell viability YGR160W Hypothetical ORF YIL177C Hypothetical ORF YLR134W,PDC5 pyruvate decarboxylase YJR145C,RPS4A Homology to rat S4 and human S4 YER011W,TIR1,SRP1 Cold-shock induced protein of the Srp1p/Tip1p family of serine-alanine-rich proteins. Encodes a stress-response cell wall mannoprotein and this gene is downregulated at acidic pH. YEL076C-A Hypothetical ORF YNL334C,SNO2 SNZ2 proximal ORF, stationary phase induced gene YHR214C-B TyB Gag-Pol protein YGL008C,PMA1 Major regulator of cytoplasmic pH. Part of the P2 subgroup of cation-transporting ATPases; functions physiologically to pump protons out of the cell. YNL033W Hypothetical ORF YLR441C,RPS1A,RP10A Homologous to rat S3A YGL135W,RPL1B,SSM2 Homology to rat L10a, eubacterial L1, and archaebacterial L1; identical to S. cerevisiae L1A (Ssm1p) YCL067C,HMLALPHA2,ALPHA2, MATALPHA2 Homeobox-domain containing protein which, in haploid cells, acts with MCM1 to repress a-specific genes. In diploid cells alpha2 acts together with a1 to repress transcription of haploid-specific genes. YLR261C,VPS63 - YDL034W Hypothetical ORF YGR219W Hypothetical ORF YBR009C,HHF1 Histone H4 (HHF1 and HHF2 code for identical proteins) YML102C-A - YOL039W,RPP2A,RPL44, RPLA2 Homology to rat P2, human P2, and E.coli L12eIB YOR102W Protein required for cell viability YDR230W Hypothetical ORF YBL100C Sporulation YNL057W Hypothetical ORF YOR105W Hypothetical ORF YLR465C,BSC3 Bypass of Stop Codon transcript encoded by this ORF shows a high level of stop codon bypass YLL065W growth inhibitor YHR212C Hypothetical ORF YDR521W Hypothetical ORF YOL050C Hypothetical ORF YDL163W Protein required for cell viability YOR121C Hypothetical ORF YPR044C Hypothetical ORF YOR345C Hypothetical ORF YJR020W Hypothetical ORF YIL175W Hypothetical ORF YPL142C Protein required for cell viability YPL251W Protein required for cell viability YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YGR270W,YTA7 Member of CDC48/PAS1/SEC18 family of ATPases YOL078W,AVO1 Adheres VOraciously (to TOR2) YAL063C,FLO9 putative cell wall protein involved in flocculation YLR371W,ROM2 Gdp-GTP Exchange Protein (GEP) for the Rho1p Small GTP-binding Protein; high copy suppressor of cik1 and kar3 deletion mutants. YKL038W,RGT1 transcriptional repressor and activator YLR466W,YRF1-4,YRF1 Y'-helicase protein 1 YCR093W,CDC39,NOT1, ROS1, SMD6 Required for Start B in mitosis and spindle pole body separation at meiosis I YIL115C,NUP159,NUP158, RAT7 Located on cytoplasmic side of nuclear pore complex; may be involved in nuclear import or mRNA export; binds to karyopherin beta and a nuclear transport substrate in vitro YER176W,ECM32,HEL1, MTT1 DNA Helicase; identified as an ExtraCellular Mutant; homology exists between ECM32 and two other identified DNA helicases, DNA2 and NAM7 YBL101C,ECM21 ExtraCellular Mutant YFL008W,SMC1,CHL10 coiled-coil protein involved in chromosome structure or segregation YGR296W,YRF1-3,YRF1 Y'-helicase protein 1 YDR141C,DOP1 homolog of Emericella nidulans developmental regulatory gene, dopey (dopA). YDR420W,HKR1 cell surface protein that may regulate cell wall beta-glucan synthesis and bud site selection; Hanenula mrakii killer toxin-resistance protein YER033C,ZRG8 Zinc regulated gene YCR032W,BPH1 beige protein homologue 1 YOL075C Hypothetical ORF YPL283C,YRF1-7,YRF1 Y'-helicase protein 1 YDL102W,CDC2,HPR6, POL3, TEX1 essential for mitotic and meiotic DNA synthesis, dispensable for meiotic spindle pole body duplication, but required for synaptonemal complexes and full intragenic recombination, spindle pole body separation and spindle formation YER166W,DNF1 Drs2 Neo1 Family YCR081W,SRB8,YCR080W, GIG1, NUT6, SSN5 activation mediator subcomplex of RNA polymerase I holoenzyme YGR061C,ADE6 5'-phosphoribosylformyl glycinamidine synthetase YMR247C Hypothetical ORF YFR039C Hypothetical ORF YLR152C Hypothetical ORF YER044C-A,MEI4 Functions in early recombination YDR243C,PRP28 Required for the first step of splicing in vitro YBR105C,VID24,GID4 also involved in vacuolar protein targeting YGL075C,MPS2,MMC1 Monopolar spindle two, encodes a membrane protein localized at the nuclear envelope and the spindle pole body throughout the cell cycle. The protein is approximately 45 kDa, and contains a coiled-coil motif and a hydrophobic domain. YOL116W,MSN1,FUP1, HRB382, MSS10, PHD2 multicopy supressor of snf1 and sta10 mutations YDR459C likely functions in pathway(s) outside Ras YIL154C,IMP2',IMP2 Protein involved in nucleo-mitochondrial control of maltose, galactose and raffinose utilization YHR078W Hypothetical ORF YGL192W,IME4,SPO8 IME4 appears to activate IME1 in response to cell-type and nutritional signals and thereby regulate meiosis YHR194W,MDM31 Mitochondrial Distribution and Morphology YDR303C,RSC3 Zinc cluster protein YBL103C,RTG3 bHLH/Zip transcription factor which regulates CIT2 gene expression YMR092C,AIP1 Protein localizes to actin cortical patches. Probable binding site on actin lies on front surface of subdomain 3 and 4. YKR097W,PCK1,JPM2, PPC1 phosphoenolpyruvate carboxylkinase YOL063C MMS1 Related YPL020C,ULP1 Ubl (ubiquitin-like protein)-specific protease 1; initially processes Smt3; also acts as a deconjugating enzyme for Smt3 YNL231C,PDR16,SFH3 involved in pleiotropic drug resistance by controlling lipids in various cellular compartments; positively regulated by PDR1; putative phosphatidylinositol transfer protein. YEL046C,GLY1 L-threonine aldolase that catalyzes cleavage of L-allo-threonine and L-threonine to glycine YMR208W,ERG12,RAR1 mevalonate catabolism YPR004C Hypothetical ORF YBR248C,HIS7 glutamine amidotransferase:cyclase, also called imidazole glycerol phosphate synthase YPL191C Hypothetical ORF YOR242C,SSP2 Sporulation SPecific YJR125C,ENT3 epsin N-terminal homology-containing protein YHR018C,ARG4 argininosuccinate lyase YOR059C Hypothetical ORF YLR138W,NHA1 Putative Na+/H+ antiporter YJR068W,RFC2 RFC is a DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA YBR044C,TCM62 mitochondrial protein; (putative) chaperone YLL032C Hypothetical ORF YLR191W,PEX13,PAS20 Pas20p may be the component of peroxisomal protein import machinery that binds Pex5p, the mobile receptor for type I peroxisomal targeting sequence (PTS1)-containing proteins YDR144C,MKC7,YPS2 protease involved in protein processing that shares functions with Yap3 and Kex2 YMR067C Hypothetical ORF YKL217W,JEN1 Repressed by glucose, induced by lactic acid; in high copy, weakly suppresses cpr3 null mutant phenotype on lactate medium at 37C YER088C,DOT6 Derepression Of Telomeric silencing YOR348C,PUT4 proline-specific permease (also capable of transporting alanine and glycine) YOL128C,YGK3 Yeast homologue of mammalian Glycogen Synthase Kinase 3 YDR259C,YAP6,HAL7 bZIP protein YNR066C Hypothetical ORF YLR413W Hypothetical ORF YGL176C Hypothetical ORF YDR009W,GAL3 Involved in galactose induction of GAL genes YPL184C Hypothetical ORF YKL179C,COY1 CASP Of Yeast YBR056W Hypothetical ORF YNL066W,SUN4,SCW3 Protein involved in the aging process. Related to glucanases. YJR154W Hypothetical ORF YER005W,YND1,YEJ5 Yeast Nucleoside Diphosphatase YJL123C Hypothetical ORF YDR321W,ASP1 Asparaginase I, intracellular isozyme YCR002C,CDC10 cell division cycle blocked at 36 degree C YDR222W Hypothetical ORF YAL047C,SPC72 Spc72p interacts with Stu2p in the two-hybrid assay; Spc72p localizes to the spindle pole bodies. Molecular weight is 72 kD YGL160W Hypothetical ORF YKL093W,MBR1 Involved in mitochondrial biogenesis YER095W,RAD51,MUT5 Involved in processing ds breaks, synaptonemal complex formation, meiotic gene conversion and reciprocal recombination. YER086W,ILV1,ISO1 threonine deaminase YDR460W,TFB3,RIG2 Transcription/repair factor TFIIH subunit YDR496C,PUF6 member of the PUF protein family YGR171C,MSM1 mitochondrial methionyl-tRNA synthetase YLR182W,SWI6,PSL8, SDS11 Involved in cell cycle dependent gene expression YGL048C,RPT6,CIM3, CRL3, SCB68, SUG1 member of the 26 S proteasome YER157W,COG3,GRD20, SEC34 secretion (golgi retention) deficient YIL079C,AIR1 ING finger protein YHL038C,CBP2 Protein required for splicing of COB aI5 intron YJL047C,RTT101 Regulator of Ty1 Transposition YNL254C Hypothetical ORF YGL169W,SUA5 Protein involved in translation initiation YIL136W,OM45 45-kDa mitochondrial outer membrane protein YKL022C,CDC16 a component of anaphase-promoting complex required for the G2/M transition in mitosis and degradation of mitotic cyclins, required for sporulation YDL214C,PRR2 - YLR222C,UTP13 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YGL055W,OLE1,MDM2 converts saturated fatty acyl-CoAs into cis-Delta-9 unsaturated fatty acids. YHR028C,DAP2,DPP2 Dipeptidyl aminopeptidase B (DPAP B) YDL044C,MTF2,NAM1 Necessary for the stability and/or processing of some large mitochondrial transcripts YBL060W Hypothetical ORF YEL002C,WBP1 wheat germ agglutinin-binding protein YMR097C Hypothetical ORF YGR198W Protein required for cell viability YJL057C probable serine/threonine kinase YDR395W,SXM1,KAP108 Suppressor of mRNA export mutant; Importin-beta like gene YBR288C,APM3,YKS6 Mu3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway YER024W,YAT2 The Yat2p protein shows significant homology with the known carnitine acetyltransferase associated with the outer-mitochondrial membrane, Yat1p, and also functions as a carnitine acetyltransferase. YOL137W,BSC6 Bypass of Stop Codon transcript encoded by this ORF shows a high level of stop codon bypass YKL089W,MIF2 centromere protein required for normal chromosome segregation and spindle integrity YMR093W,UTP15 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YDR514C Hypothetical ORF YDR386W,MUS81,SLX3 Mms and UV Sensitive; Mus81p and Rad54p are found together in a complex from whole-cell extracts YFR010W,UBP6 deubiquitinating enzyme (putative) YOR160W,MTR10,KAP111 Protein involved in mRNA transport from nucleus to cytoplasm YNR050C,LYS9,LYS13 Seventh step in lysine biosynthesis pathway YER047C,SAP1 interacts with Sin1p YKR079C Protein required for cell viability YFL030W - YOR176W,HEM15 Performs last step in heme biosynthesis pathway, inserting ferrous iron into protoporphyrin IX YKL018W,SWD2,CPS35, SAF37 member of Set1p complex YDR358W,GGA1 Golgi-localized, gamma-adaptin homology, Arf-binding. Interacts with Arf1p and Arf2p in a GTP-dependent manner. Effector of Arf that facilitates traffic through the late Golgi. YMR168C,CEP3,CBF3, CBF3B, CSL1 Cbf3 kinetochore complex binds CDE III centromere element; Cep3p contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain and a putative coiled coil dimerization domain YLR240W,VPS34,END12, PEP15, VPL7, VPT29 phosphatidylinositol 3-kinase YGL028C,SCW11 Soluble Cell Wall protein YPL069C,BTS1 Required for membrane attachment of YPT1 and SEC4 YKR050W,TRK2,RPD2 membrane protein; low affinity potassium transport YDR415C Hypothetical ORF YNL218W,MGS1 Maintenance of Genome Stability 1 YML082W Hypothetical ORF YHR208W,BAT1,ECA39, TWT1 BAT1 highly expressed during logarithmic phase and is repressed during stationary phase, whereas BAT2 has the opposite pattern of expression. YPL181W,CTI6,RXT1 Hypothetical ORF YLL031C,GPI13,MPC1 Glycosylphosphatidylinositol (GPI) biosynthesis YER161C,SPT2,SIN1, EXA1 non-specific DNA binding protein (sin1) YNL308C,KRI1 KRRI-Interacting protein 1 YNL124W,NAF1 Nuclear Assembly Factor YJR100C Hypothetical ORF YBL033C,RIB1 First step in the riboflavin biosynthesis pathway YLR067C,PET309 Involved in expression of mitochondrial COX1 by regulating translation of COX1 mRNA and by affecting transcription or stability of COX1 mRNAs YHR206W,SKN7,BRY1, POS9 Protein with similarity to DNA-binding region of heat shock transcription factors YOR349W,CIN1 Protein involved in chromosome segregation, required for microtubule stability YKR077W Hypothetical ORF YHR039C,MSC7 Meiotic Sister-Chromatid recombination YHR061C,GIC1 Gtpase-interacting component 1 YPL096W,PNG1 de-N-glycosylation enzyme YKL218C Pyridoxal-5'phosphate-dependent enzyme homologous to mouse glial serine racemase YLR077W Hypothetical ORF YHR183W,GND1 6-phosphogluconate dehydrogenase, decarboxylating; converts 6-phosphogluconate + NADP to ribulose-5-phosphate + NADPH + CO2 YAL041W,CDC24,CLS4 calcium-binding protein involved in bud emergence and schmooing YJL033W,HCA4,DBP4, ECM24 putative RNA helicase YPL236C Hypothetical ORF YOL013C,HRD1,DER3 Ubiquitin-protein ligase for endoplasmic reticulum-associated degradation. YMR223W,UBP8 putative deubiquitinating enzyme YIL042C Hypothetical ORF YAR044W,OSH1 May be involved in ergosterol synthesis YJL091C,GWT1 GPI-anchored wall protein transfer 1 YBL029W Hypothetical ORF YOR043W,WHI2 Protein involved in growth regulation. Whi2 and its binding partner, Psr1-phosphatase, are required for a full activation of the general stress response, possibly through the dephosphorylation of Msn2. YOR356W Hypothetical ORF YKL116C,PRR1 - YBL106C,SRO77,SNI2 Suppressor of defect in the small GTPase Rho3p YLR105C,SEN2 tRNA splicing endonuclease subunit YCL025C,AGP1,YCC5 broad substrate range permease which transports asparagine and glutamine with intermediate specificity YPL125W,KAP120 karyopherin YJR142W Hypothetical ORF YBR241C Hypothetical ORF YLR099C,ICT1 Increased Copper Tolerance; Similar to Ecm18p YBR180W,DTR1 dityrosine transporter MFS-MDR YHR129C,ARP1,ACT5 actin-related protein of the dynactin complex YNR021W Hypothetical ORF YKL148C,SDH1 Yeast succinate dehydrogenase (SDH) is a tetramer of non-equivalent subunits--Sdh1p, Sdh2p, Sdh3p, Sdh4p--that couples the oxidation of succinate to the transfer of electrons to ubiquinone. YDR164C,SEC1 Hydrophilic protein involved at the late stage of secretion YLR224W Hypothetical ORF YCR026C Hypothetical ORF YIL104C,SHQ1 required for SnoRNAs of the box H/ACA Quantitative accumulation YOR279C,RFM1 Repression Factor of MSE YKL216W,URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid YEL016C Hypothetical ORF YNL207W,RIO2 Protein required for cell viability YDL109C Hypothetical ORF YPR084W Hypothetical ORF YLR396C,VPS33,CLS14, MET27, PEP14, SLP1, VAM5, VPL25, VPT33 vacuolar sorting protein essential for vacuolar morphogenesis and function YGL257C,MNT2 MaNnosylTransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans YNL268W,LYP1 lysine permease YDR030C,RAD28 Protein involved in the same pathway as Rad26p, has beta-transducin (WD-40) repeats YJR098C Hypothetical ORF YBL091C,MAP2 methionine aminopeptidase 2 YLL028W,TPO1 plasma membrane-bound exporter, involved in the detoxification of excess spermidine YNL197C,WHI3 Protein involved in regulation of cell size YGL023C,PIB2 Phosphatidylinositol 3-phosphate binding YML061C,PIF1,TST1 involved in repair and recombination of mitochondrial DNA; also plays a role in (nuclear) chromosomal telomere formation and elongation YDL028C,MPS1,RPK1 Required for spindle pole body duplication and a mitotic checkpoint function. YLR002C,NOC3 NucleOlar Complex 2; involved in the nuclear export of pre-ribosomes YOR119C,RIO1,RRP10 Essential in yeast; plays a role in cell cycle progression. YGL221C,NIF3 similar to Listeria monocytogenes major sigma factor (rpoD gene product) YML111W,BUL2 a homologue of BUL1 YDL153C,SAS10,UTP3 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Something About Silencing 10 YKL078W,DHR2 DEAH-box protein involved in ribosome synthesis YLR144C,ACF2,ENG2 glucan-hydrolyzing protein that specifically acts on 1,3-beta linkages, with an endolytic mode of action. necessary for actin polymerization in permeabilized cells. YOR192C Hypothetical ORF YIL072W,HOP1 Meiosis-specific protein involved in homologous chromosome synapsis and chiasmata formation YNL182C Involved in Processing ITS2 YDR221W Hypothetical ORF YMR206W Hypothetical ORF YLR241W Hypothetical ORF YOR322C Hypothetical ORF YJL071W,ARG2,HRB574 First step in ornithine biosynthesis pathway YOL057W Hypothetical ORF YDR376W,ARH1 adrenodoxin oxidoreductase homolog YNL292W,PUS4 catalyzes formation of Psi55 (modified uridine) in mitochondrial and cytoplasmic tRNAs YFL026W,STE2 alpha-factor pheromone receptor; seven-transmembrane domain protein YLR288C,MEC3,PIP3 Involved in checkpoint control and DNA repair YOL065C,INP54 INositol polyphosphate 5-Phosphatase, fourth one identified; has homology to Type I mammalian inositol polyphosphate 5-phosphatases YCR092C,MSH3 acts in mismatch repair in mitosis and meiosis but to a lesser extent than MSH2, required for microsatellite stability YIL092W Hypothetical ORF YLR417W,VPS36,GRD12, VAC3, VPL11 Defective in vacuolar protein sorting YGL228W,SHE10 Mrna (identified by a library screen) that causes growth arrest when overexpressed YLR394W,CST9,ZIP3 Chromosome STability; involved in meiotic chromosome synapsis YOR058C,ASE1,YOR29-09 essential for anaphase spindle elongation YDL122W,UBP1 Ubiquitin-specific protease YJL045W Similar to SDH1 YML115C,VAN1,VRG7, VRG8 vanadate resistance protein. YHR002W,LEU5 mitochondrial carrier protein, involved in the accumulation of CoA in the mitochondrial matrix; homologue of human Graves disease protein; LEU5 does not encode an alpha-IPM synthase, as was first hypothesized. YML043C,RRN11 rDNA transcription factor CF component, which also contains Rrn6p and Rrn7p, which is required for rDNA transcription by RNA polymerase I YOR127W,RGA1,DBM1, THE1 putative GTPase-activating protein for the polarity-establishment protein Cdc42p or Rho1p; activates the pheromone-response pathway YDR129C,SAC6,ABP67 fimbrin homolog (actin-filament bundling protein) YJL073W,JEM1,KAR8 DnaJ-like protein of the endoplasmic reticulum membrane YMR115W Hypothetical ORF YHR098C,SFB3,LST1 binds to Sed5p and Sec23p by distinct domainshirteen YML107C Hypothetical ORF YPL171C,OYE3,ZRG6 Old yellow enzyme YDR419W,RAD30,DBH1 Radiation sensitive. Replication fork is protected from inaccurate synthesis by Pol eta in the absence of DNA damage. YJL139C,YUR1 Probable glycosyltransferase of KRE2/KTR1/YUR1 family; located in the Golgi YMR154C,RIM13,CPL1 Regulator of IME2 (RIM) YFR050C,PRE4 B-type subunit of proteasome, euk. & archae. multicatalytic proteinase complex likelyinvolved in an ATP/ubiquitin-dependent nonlysosomal proteolytic pathway. eukary: the proteasome is composed of ~24 subunits forming a ring-shaped structure YKR004C,ECM9 ExtraCellular Mutant YDL006W,PTC1,CWH47, KCS2, TPD1 serine-threonine protein phosphatase YKL206C Hypothetical ORF YPR027C Hypothetical ORF YPL246C,RBD2 homologous to RBD1 YNL320W Hypothetical ORF YJR111C Hypothetical ORF YHR160C,PEX18 Peroxin; Pex18p and Pex21p are partially functionally redundant. YNR068C Hypothetical ORF YLR404W Hypothetical ORF YFR027W,ECO1,CTF7 Establishment of COhesion YNL289W,PCL1,HCS26 G(sub)1 cyclin that associates with PHO85 YGR066C Hypothetical ORF YNL314W,DAL82 Positive regulator of allophanate inducible genes YPR015C Hypothetical ORF YIL114C,POR2 Mitochondrial porin YOL102C,TPT1 Gene encodes a protein implicated in the last step of tRNA splicing in yeast: transfer of the splice junction 2'-phosphate from ligated tRNA to NAD YHR133C - YGR262C,BUD32 - YML003W Hypothetical ORF YGL005C,COG7,COD5 Complexed with Cog8p YNR040W Hypothetical ORF YER148W,SPT15,BTF1, TBP1, TFIID TATA-binding protein (TBP) YDR304C,CPR5,CYP5 Cyclophilin D, Peptidyl-prolyl cis-trans isomerase D YDR399W,HPT1,BRA6 enzyme involved in de novo purine biosynthesis YJL121C,RPE1,EPI1, POS18 D-ribulose-5-Phosphate 3-epimerase YJR012C Protein required for cell viability YKR045C Hypothetical ORF YMR197C,VTI1 Involved in cis-Golgi membrane traffic YHR127W (H)igh copy (S)uppressor of (N)34 dominant negative allele of SEC4. Suppression is very specific to this allele. It has no affect on the analogous YPT1 allele. No homology or known function. YDR391C Hypothetical ORF YDR003W Hypothetical ORF YIL010W,DOT5,nTPx Derepression Of Telomeric silencing homologous to 4 other S.c. thioredoxin peroxidases YMR202W,ERG2,END11 sterol biosynthesis YNR061C Hypothetical ORF YPL267W Hypothetical ORF YOR367W,SCP1 homolog of chicken calponin, thus the name S. cerevisiae CalPonin YDR302W,GPI11 Glycosylphosphatidylinositol (GPI) assembly YLR118C href="http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?sgdid=S0004484">APT1 YNL306W,MRPS18 - YPL213W,LEA1 Looks Exceptionally like U2A YOL149W,DCP1 Decapping protein involved in mRNA degradation YDL115C Interacts with RNA Polymerase II YDL018C,ERP3 Emp24p/Erv25p related protein 2 YDR013W,PSF1,CDC101 Partner of Sld Five 1 YNR049C,MSO1 multicopy suppressor of sec1; small hydrophilic protein, enriched in microsomal membrane fraction, interacts with Sec1p YPR028W,YOP1,YIP2 Ypt Interacting Protein. Regulates vesicular traffic in stressed cells either to facilitate membrane turnover or to decrease unnecessary secretion. YPR046W,MCM16 Involved in a nonessential role that governs the kinetochore-microtubule mediated process of chromosome segregation YDL046W Niemann Pick Type C Gene corresponding to complementation group 2. Putative yeast homologue of human NPC2/He1 YMR255W,GFD1 Great for FULL DEAD box protein activity YPR067W,ISA2 Iron Sulfur Assembly -- IscA/NifA homolog YLR109W,AHP1,cTPxIII thioredoxin peroxidase YGL231C Hypothetical ORF YDL192W,ARF1 implicated in signal transduction and intracellular protein transport to or within the Golgi apparatus YGL018C,JAC1 may be involved in assembly/maturation of mitochondrial iron-sulfur proteins YDR454C,GUK1,PUR5 guanylate kinase YLR021W Hypothetical ORF YIL161W Hypothetical ORF YJL161W Hypothetical ORF YOL067C,RTG1 Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus YPL010W,RET3 vesicle coat component YPL108W Hypothetical ORF YER150W,SPI1 Stationary Phase Induced; strongly expressed during stationary phase, and trancription is dependent on MSN2/MSN4. YLR008C Protein required for cell viability YCR090C Hypothetical ORF YGR102C Hypothetical ORF YBR137W Hypothetical ORF YNL255C,GIS2 GIG3 suppressor YLR193C Hypothetical ORF YEL039C,CYC7 iso-2-cytochrome c YNR046W Protein required for cell viability YLR110C,CCW12 - YER072W,VTC1,NRF1, PHM4 Null mutant identified in different genetic screens both by its ability to reverse the Cdc42p suppression of a cdc24-4ts mutant and its ability to suppress the vacuolar ATPase null phenotype YPR170C Hypothetical ORF YGL087C,MMS2 Member of error-free postreplication DNA repair pathway YCL002C Hypothetical ORF YLR334C Hypothetical ORF YJL086C Protein required for cell viability YGR236C Hypothetical ORF YOL014W Hypothetical ORF YOR327C,SNC2 mediate the targeting and transport of secretory proteins YLR385C Hypothetical ORF YJL003W,COX16 Cytochrome oxidase assembly YPR200C,ARR2,ACR2 Required for arsenate but not for arsenite resistance YJL190C,RPS22A,RPS24 Homology to rat S15a YDL157C Hypothetical ORF YIL100W Hypothetical ORF YLR445W Hypothetical ORF YOL085C Hypothetical ORF YJR063W,RPA12,RRN4 A12.2 subunit of RNA polymerase I YCR082W Hypothetical ORF YGL088W Hypothetical ORF YJL008C,CCT8 Required for assembly of microtubules and actin in vivo YBR245C,ISW1,SGN2 has strong homology to Drosophila ISWI YPL115C,BEM3 Gtpase-activating protein activity toward the essential bud-site assembly GTPase Cdc42 YBL088C,TEL1 Involved in controlling telomere length; ataxia telangiectasia (ATM) gene homolog YHR056C,RSC30 RSC complex component YKL088W Protein required for cell viability YGR229C,SMI1,KNR4 Protein involved in (1,3)-beta-glucan synthesis, possibly through regulation of cell wall glucan and chitin synthesis; chromatin binding protein YKL124W,SSH4,MLF4 Suppressor of SHR3; confers leflunomide resistance when overexpressed YCR061W Hypothetical ORF YOR217W,RFC1,CDC44 RFC is a DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA YML047C,PRM6 pheromone-regulated membrane protein YNL236W,SIN4,BEL2, GAL22, SDI3, SSF5, SSN4, TSF3, RYE1 involved in positive and negative regualtion of transcription, possibly via changes in chromatin structure; regulation of YGP1 expression YJL129C,TRK1 180 kDa high affinity potassium transporter YKR048C,NAP1 nucleosome assembly protein I YPL242C,IQG1,CYK1 Homolog of the mammalian IQGAP1 and 2 genes; probable regulator of cellular morphogenesis, inducing actin-ring formation in association with cytokinesis YDL017W,CDC7,LSD6, SAS1 Required for mitotic DNA synthesis but dispensable for premeiotic DNA synthesis and spindle pole body duplication; required for synaptonemal complexes, meiotic recombination, spindle pole body separation and spindles YBR063C Hypothetical ORF YML102W,CAC2 Involved in DNA-replication-linked nucleosome assembly; homologous to the p60 subunit of the Human CAF-I YMR153W,NUP53 Component of karyopherin docking complex of the nuclear pore complex YMR280C,CAT8,DIL1, MSP8 CAT8 controls the key enzymes of gluconeogenesis in S. cerevisiae. YKL029C,MAE1 Mitochondrial malic enzyme YDR402C,DIT2,CYP56 Disp. for spores & spore viab. - required for dityrosine biosynth. & dityrosine accumul. in outer spore wall (s.w.); s.w. matur. & resist. to ether & lytic enz. mRNA trans. mid/late during s.w. formation YNL270C,ALP1,APL1 Homologous to permeases Can1p and Lyp1p YHR219W Hypothetical ORF YDL245C,HXT15 High-affinity hexose transporter YLR157C,ASP3-2,ASP3 nitrogen catabolite-regulated cell-wall L-asparaginase II YMR046C TyA Gag protein YJR161C,COS5 Protein with similarity to members of the Ybr302p/Ycr007p/Cos8p/Cos9p family, coded from subtelomeric region YOR388C,FDH1 Protein with similarity to formate dehydrogenases YLR467W,YRF1-5,YRF1 Y'-helicase protein 1 YBR302C,COS2 Protein with similarity to members of the Cos3/Cos5/Cos1/Cos4/Cos8/Cos6/Cos9 family, coded from subtelomeric region YLR160C,ASP3-4,ASP3 nitrogen catabolite-regulated cell-wall L-asparaginase II YGR287C Hypothetical ORF YCR102C Hypothetical ORF YMR173W-A Hypothetical ORF YDR343C,HXT6 Repression of HXT6 expression by glucose requires SNF3 YJR009C,TDH2,GLD2 glyceraldehyde 3-phosphate dehydrogenase YIL172C Hypothetical ORF YDL182W,LYS20 homocitrate synthase, highly homologous to YDL131W YOL157C Hypothetical ORF YOR389W Hypothetical ORF YOR133W,EFT1 translation elongation factor 2 (EF-2) YDR342C,HXT7 Hexose transporter YKR106W Hypothetical ORF YPL279C Hypothetical ORF YHR218W Hypothetical ORF YBR092C,PHO3 Acid phosphatase, constitutive YPL182C Hypothetical ORF YOL037C Hypothetical ORF YOR364W Hypothetical ORF YJR087W Hypothetical ORF YPL035C Hypothetical ORF YEL049W,PAU2 member of the seripauperin protein/gene family (see Gene_class PAU) YCR103C MIPS: ORF destroyed with chrIII seq. update (nt exchange created a stop after aa 45) (09/14/2000) YLR461W,PAU4 member of the seripauperin protein/gene family (see Gene_class PAU) YKL177W Hypothetical ORF YLR156W Note: YLR156W, YLR159W, and YLR161W are identical. YIL059C Hypothetical ORF YIL176C Hypothetical ORF YLR235C Involved in meiotic nuclear division. YNL114C Protein required for cell viability YDL191W,RPL35A,SOS1 Homology to rat L35 YLR161W Note: YLR156W, YLR159W, and YLR161W are identical. YMR052C-A Hypothetical ORF YJR162C Hypothetical ORF YJR022W,LSM8 Like Sm-B protein YCR096C,HMRA2,A2, MATA2 Silenced copy of A2, which encodes a protein of unknown function. YJL067W Hypothetical ORF YPR038W Hypothetical ORF YNL162W,RPL42A Homology to rat L36a and human L36a YNR076W,PAU6 member of the seripauperin protein/gene family YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YER129W,PAK1 high copy suppressor of temperature sensitive cdc17 (DNA polymerase alpha) mutations YOR326W,MYO2,CDC66 Myo2p plays a crucial role in polarized distribution of mitochondria. YLR086W,SMC4 Stable Maintenance of Chromosomes YAL026C,DRS2,FUN38, SWA3 cation transport (E1-E2) ATPase family member YJR151C,DAN4 Delayed Anaerobic Gene YCL019W TyB Gag-Pol protein YOR153W,PDR5,LEM1, YDR1, STS1 multidrug resistance transporter YOR109W,INP53,SJL3, SOP2 Synaptojanin-like protein YML059C Hypothetical ORF YPR026W,ATH1 Null mutant is viable; increased tolerance to dehydration, freezing, and toxic levels of ethanol hydrolyzes trehalose YKL020C,SPT23 Dosage dependent suppressor of Ty-induced promoter mutations. Homolog of Mga2. Spt23p and Mga2p differentially activate and regulate OLE1 transcription. YLR096W,KIN2 Serine/threonine protein kinase YFL036W,RPO41 mitohcondrial RNA polymerase YKR082W,NUP133,RAT3 Nuclear pore complex protein involved in poly(A)+ RNA transport, nuclear pore distribution, and possibly in the biogenesis of functional tRNA YHR186C,KOG1 rowth YLR419W Hypothetical ORF YMR308C,PSE1,KAP121 Functions in nuclear transport of proteins YGR097W,ASK10 transcriptional activator of the SKN7 mediated 'two-component' regulatory system YLL040C,VPS13,SOI1, VPT2 vacuolar Protein Sorting YKL101W,HSL1,NIK1 Histone Synthetic Lethal Negative regulator of Swe1 kinase YLR454W Hypothetical ORF YDR334W DEAH-box protein, putative RNA helicase YML091C,RPM2 involved in processing of mitochondrial precursor tRNAs and protein import YPR036W,VMA13,CLS11 vacuolar ATPase V1 domain subunit H (54 kDa) YLR143W Hypothetical ORF YKL050C Hypothetical ORF YKL133C Hypothetical ORF YAR007C,RFA1,BUF2, FUN3, RPA1 Required for DNA-damage repair, full levels of gene conversion and sporulationRFA1, RFA2, and RFA3 make up RPA YBR227C,MCX1 Mitochondrial ATP-binding protein, similar to ClpX YMR307W,GAS1,CWH52, GGP1 Glycophospholipid-anchored surface protein YDR019C,GCV1,GSD1 Required for metabolizing glycine as a nitrogen source YLL043W,FPS1 Suppressor of tps1/fdp1 and member of the MIP family of transmembrane channels; may be involved in glycerol efflux YMR024W,MRPL3,YML3 Mitochondrial ribosomal protein MRPL3 (YmL3) YLR337C,VRP1,YLR337W, END5, MDP2 Involved in cytoskeletal organization and cellular growth YHR113W Hypothetical ORF YBR114W,RAD16,PSO5 Nucleotide excision repair protein with DNA helicase domain of Snf2p family YBR293W Hypothetical ORF YML048W,GSF2,ECM6 Glucose Signaling Factor YOR308C,SNU66 66kD U4/U6.U5 snRNP associated protein YOR149C,SMP3,LAS2, SAP2 Involved in glycosyl phosphatidyl inositol synthesis; most likely an alpha 1,2 mannosyltransferase utilized for addition of the fourth, side-branching mannose onto the GPI core structure. YBR095C Hypothetical ORF YCR068W,CVT17,AUT5 Cytoplasm to vacuole targeting mutant. essential for intravacuolar lysis of autophagic bodies. amino terminus is located in cytosol, carboxyl terminus is located inside the ER lumen. YDR218C,SPR28 Septin-related protein expressed during sporulation YJL002C,OST1,NLT1 Oligosaccharyltransferase catalyzes the transfer of oligosaccharide from dolichol-oligosaccharide donor to consensus glycosylation acceptor sites (asparagines) in newly synthesized proteins in ER lumen YAL043C,PTA1,FUN39 pre-tRNA processing YGR124W,ASN2 Asn1p and Asn2p are isozymes YCL014W,BUD3,YCL012W cell cycle regulated protein required for axial bud formation; co-assembles with Bud4p at bud sites YDR499W,LCD1,DDC2, PIE1 required for the DNA integrity checkpoint pathways; S. pombe Rad26 functional homolog (putative) YPL140C,MKK2,LPI6, SSP33 Member of MAP kinase pathway involving PKC1, BCK1, and SLT2. Shows functional redundancy with MKK1 YGR083C,GCD2,GCD12 translation initiation factor eIF2B, 71 kDa (delta) subunit; translational repressor of GCN4 protein YBR138C High-Dosage Reductional segregation defective. Converts reductional segregation to equational when borne on a 2um plasmid. YLR377C,FBP1,ACN8 fructose-1,6-bisphosphatase YDR175C,RSM24 mitochondrial ribosome small subunit component YCL004W,PGS1,YCL003W, PEL1 17 kDa phosphatidylglycerolphosphate synthase YLR442C,SIR3,CMT1, MAR2, STE8 regulator of silencing at HML, HMR, and telomeres YDL188C,PPH22,PPH2 serine-threonine protein phosphatase 2A YPL100W,MAI1 Maturation of pro-AmInopeptidase I (proAPI) defective; protein similar to Aut10p and YGR223Cp with three putative WD repeats YJL172W,CPS1 carboxypeptidase yscS YER075C,PTP3 Protein tyrosine phosphatase YHR096C,HXT5 Member of superfamily of monosaccharide transporters YMR221C Hypothetical ORF YKL213C,DOA1,UFD3, ZZZ4 Required for normal intracellular ubiquitin metabolism and for normal rates of proteolysis of ubiquitin-dependent proteolytic substrates in vivo YPR086W,SUA7,SOH4 transcription factor TFIIB homolog YML069W,POB3 binds to catalytic subunit of DNA polymerase alpha (Pol1p) YHL012W Hypothetical ORF YJL204C,RCY1 ReCYcling 1 YCL054W,SPB1 Suppressor of PaB1 mutant; involved in 60S ribosomal subunit biogenesis YMR034C Hypothetical ORF YDL141W,BPL1,ACC2 Biotin:apoprotein ligase YBR286W,APE3,APY1 Aminopeptidase yscIII YDL080C,THI3,KID1 Positive regulatory factor with thiamin pyrophosphate-binding motif for thiamin metabolism YDL185W,TFP1,CLS8, VMA1 Encodes a protein with three regions (ABC) that is spliced to yield the extein AC & the intein B; AC is a 69K vacuolar (H+)-ATPase & B is a 50K site-specific endonuclease named VDE (PI-SceI) that is homologous to HO YKL090W Hypothetical ORF YJL127C,SPT10,CRE1, SUD1 chromatin maintenance and transcriptional regulation YJL183W,MNN11 member of a cis Golgi complex that is involved in mannan synthesis, other complex members include Mnn10p, Hoc1p, Anp1p, Mnn9p YGR071C Hypothetical ORF YGL035C,MIG1,CAT4, SSN1, TDS22 Transcription factor involved in glucose repression YDR277C,MTH1,BPC1, DGT1, HTR1 Negative regulator of HXT gene expression YMR001C,CDC5,MSD2, PKX2 CDC5 is dispensable for premeiotic DNA synthesis and recombination, but required for tripartite synaptonemal complexes, haploidization, and spores YLR103C,CDC45 Cdc45p assembles into a complex with Cdc46p/Mcm5p YJR053W,BFA1 Byr four alike YJL082W,IML2 Similar to Ykr018p YHR169W,DBP8 Dead-Box Protein 8, ATP-dependent helicase involved in rRNA processing YDR392W,SPT3 Transcription factor YNL274C Putative hydroxyisocaproate dehydrogenase YLR418C,CDC73 accessory factor associated with RNA polymerase II by affinity chromatography YBL015W,ACH1 Mannose-containing glycoprotein which binds concanavalin A YKL194C,MST1 mitochondrial threonine-tRNA synthetase YJL099W,CHS6,CSD3 Involved in chitin biosynthesis and/or its regulation YPR173C,VPS4,CSC1, END13, GRD13, VPL4, VPT10, DID6 Defective in vacuolar protein sorting; homologous to mouse SKD1 and to human hVPS4 YOL095C,HMI1 Helicase in MItochondria YBL042C,FUI1 uridine permease YMR265C Hypothetical ORF YJR129C Hypothetical ORF YGL113W,SLD3 synthetic lethality with dpb11-1; Sld3p interacts with Cdc45 and is required for initiation of DNA replication. YGR216C,GPI1 Participates in synthesis of N-acetylglucoaminylphosphatidylinositol, the first intermediate in synthesis of glycosylphosphatidylinositol (GPI) anchors YPR042C,PUF2 mRNA binding protein YOR195W,SLK19 synthetic lethal KAR3 YOL025W,LAG2,ECM36 affects longevity YLR355C,ILV5 branched-chain amino acid biosynthesis YGL241W,KAP114 KAryoPherin (collective name for homologous family of nuclear transport receptors) of approximately 114kD YHR001W,OSH7 Oxysterol Binding Protein YBL011W,SCT1,GAT2 High copy suppresor of choline-transport mutants YPL105C Hypothetical ORF YPL023C,MET12 Gene encodes mthfr which catalyzes step before methionine synthesis. YMR237W Hypothetical ORF YJL070C Hypothetical ORF YIL019W Protein required for cell viability YCR028C,FEN2 Fenpropimorph resistance gene. Protein shows similarity to Dal5p and members of the allantoate permease family of the major facilitator superfamily (MFS). YBR033W Expression dependent on Slt2 YDR125C,ECM18 ExtraCellular Mutant YNL083W Hypothetical ORF YKL191W,DPH2 Diptheria toxin resistance protein, required for diphthamide biosynthesis YKR036C,CAF4 CCR4 associated factor YDL168W,SFA1,ADH5 Long-chain alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) YBR061C,TRM7 tRNA methyltransferase YHR074W,QNS1 Glutamine-dependent NAD Synthetase YGL130W,CEG1 mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit YDR422C,SIP1 SNF1 protein kinase substrate YNL097C,PHO23 Involved in expression of PHO5 YER113C Hypothetical ORF YOL105C,WSC3 cell wall integrity and stress response component 3 YKL114C,APN1 major apurinic/apyrimidinic endonuclease/3'-repair diesterase YIL156W,UBP7 Ubiquitin-specific protease YFL047W,RGD2 specific GTPase activating protein (RhoGAP) YNL253W,TEX1 transcription export complex component YGL144C,ROG1 Hypothetical ORF YOR154W Hypothetical ORF YMR053C,STB2 binds Sin3p in two-hybrid assay and is part of large protein complex with Sin3p and Stb1p YJL149W Hypothetical ORF; has similarity to F-box proteins YGL236C,MTO1,IPS1 Mitochondrial Translation Optimization; Strong similarity to E. coli GidA YPL123C,RNY1 RiboNuclease from Yeast YGL202W,ARO8 aromatic amino acid aminotransferase YPR070W,MED1 Subunit 1 of the Mediator complex essential for transcriptional regulation YOR209C,NPT1 homology to bacterial nicotinate phosphoribosyl transferase; NAD(+) salvage pathway YKR075C Hypothetical ORF YHL029C Hypothetical ORF YPR178W,PRP4,RNA4 Specific component of the U4/U6 and U4/U6-U5 snRNPs which associates transiently with the spliceosome before the first step of splicing. YCR095C Hypothetical ORF YHR196W,UTP9 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YBR233W,PBP2,HEK1 Overexpression confers resistance to the antimalarial drug mefloquine YMR209C Hypothetical ORF YDR208W,MSS4 Involved in actin cytoskeleton organization; multicopy suppressor of stt4 mutation YMR032W,HOF1,CYK2 SH3 domain containing-protein required for cytokinesis YIL123W,SIM1 (putative) invovled in control of DNA replication YDL015C,TSC13 ER protein involved in very long chain fatty acid synthesis YMR287C,MSU1,DSS1 Protein essential for mitochondrial biogenesis YER078C Hypothetical ORF YMR111C Hypothetical ORF YGR003W Hypothetical ORF YDL073W Hypothetical ORF YOR346W,REV1 Protein required for mutagenesis by physical and chemical agents YER140W Hypothetical ORF YNL016W,PUB1,RNP1 abundant mRNP-component protein hypothesized to bind a pool of non-translatable mRNAs. not reported to associate with polyribosomes. YGR031W Hypothetical ORF YLR003C Hypothetical ORF YDR379W,RGA2 contains a Rho-GAP domain and two LIM domains, similar to Rga1p and all known Rho-GAPs YPR176C,BET2 Geranylgeranyltransferase Type II beta subunit YGL125W,MET13,MET11 converts 5,10-CHfolate. YOL017W,ESC8 Establishes Silent Chromatin 8 YGR093W Hypothetical ORF YGL215W,CLG1 cyclin-like protein that interacts with Pho85p in affinity chromatography YMR108W,ILV2,SMR1, THI1 acetolactate synthase YDL033C Hypothetical ORF YMR235C,RNA1 Protein involved in RNA processing and export from nucleus YER038C,KRE29 Killer toxin REsistant YNL020C,ARK1 actin regulating kinase YGR004W Hypothetical ORF YNL074C,MLF3,YMK1 Protein of unknown function YGR068C Hypothetical ORF YOL104C,NDJ1,TAM1 Involved in meiotic chromosome segregation; may stabilize homologus DNA interactions at telomeres and is required for a telomere activity in distributive segregation; is associated with telomeres YER077C Hypothetical ORF YNR011C,PRP2,RNA2 Dead-box protein required for the first catalytic event of pre-mRNA splicing. YHL036W,MUP3 methionine uptake YNL313C Protein required for cell viability YHL004W,MRP4 Involved in mitochondrial protein synthesis YOR334W,MRS2 mitochondrial magnesium ion transporter similar to bacterial CorA, essential for splicing of group II introns YIL022W,TIM44,ISP45, MIM44, MPI1 48.8 kDa protein involved in mitochondrial protein import YOL115W,TRF4 TRF5 homolog; Involved in mitotic chromsome condensation; associates with Smc1p and Smc2p YHR201C,PPX1 Cytosolic exopolyphosphatase YOR156C,NFI1,SIZ2 Interacts with C-terminus of CDC12. Contains two known protein motifs: SAP (DNA binding) and MIZ-finger YHR111W,UBA4 Ubiquitin activating enzyme YPL119C,DBP1,LPH8 putative ATP-dependent RNA helicase; Dead box protein YJL206C Hypothetical ORF YPR054W,SMK1 SMK1 encodes a mitogen-activated protein kinase required for spore morphogenesis that is expressed as a middle sporulation-specific gene. YAL028W Hypothetical ORF YFR006W Hypothetical ORF YMR224C,MRE11,RAD58, XRS4, NGS1 Disp. for premeiotic DNA synthesis, but required for both double strand break formation & resection, synaptonemal complexes, meiotic recombination & viable spores. Localizes to discrete sites in rad50 mutants YDL025C Hypothetical ORF YLR427W Hypothetical ORF YDR369C,XRS2 classified as an early recombination function, required for DNA repair but dispensable for mitotic recombination (xrs2 is hyper-Rec during vegatative growth), required for double strand breaks, meiotic recombination and spore viability YBR132C,AGP2 The acronym may be misleading. AGP2 has been shown to be a carnitine permease, not a general amino acid permease with broad substrate specificity. YHR124W,NDT80 Meiosis-specific gene; mRNA is sporulation specific; required for exit from pachytene and for full meiotic recombination YNL216W,RAP1,GRF1, TBA1, TUF1 DNA-binding protein involved in either activation or repression of transcription, depending on binding site context. Also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure. YDR251W,PAM1 multicopy suppressor of protein phosphatase 2A YMR183C,SSO2 SSO1 and SSO2 encode syntaxin homologs (post-Golgi t-SNAREs); act in late stages of secretion YGR108W,CLB1,SCB1 Involved in mitotic induction YBR163W,DEM1 weak similarity to Pta1p (pre-tRNA processing protein) YJL083W Hypothetical ORF YOR245C,DGA1 DiacylGlycerol Acyltransferase YDR490C,PKH1 Pkb-activating Kinase Homologue YOR066W Hypothetical ORF YGR258C,RAD2 Incision step of nucleotide excision repair of DNA damaged by UV light; co-purifies with transcription factor, TFIIH mRNA is cell cycle regulated & induced by DNA damage & by meiosis YBR177C,EHT1 alcohol acyl transferase YKR009C,FOX2,POX2 peroxisomal multifunctional beta-oxidation protein YOR303W,CPA1 Carbamoyl phosphate synthetase, arginine specific YFL025C,BST1 Negatively regulates COPII vesicle formation YPR019W,CDC54,HCD21, MCM4 essential for initiation of DNA replication; homolog of S. pombe CDC21 YJR119C Hypothetical ORF YOR208W,PTP2 protein tyrosine phosphatase YBR176W,ECM31 ExtraCellular Mutant YDL222C Cell cortex protein YGR277C Homolog to human PPAT YER133W,GLC7,CID1, DIS2, PP1 Glycogen accumulation. Gip1p-Glc7p phosphatase complex is required for proper septin organization and initiation of spore wall formation during sporulation. YOR261C,RPN8 Regulatory Particle Non-ATPase, homolog of mammalian proteasomal subunit S12/p40 YLR426W Hypothetical ORF YCR069W,CPR4,YCR070W, CYP4, SCC3 cyclophilin homolog YJR095W,SFC1,ACR1 succinate-fumarate carrier YOR288C,MPD1 Disulfide isomerase related protein YHR142W,CHS7 The seventh gene identified that is involved in chitin synthesis; involved in Chs3p export from the ER YPL007C,TFC8 Transcription factor for RNA polymerase III YGR062C,COX18 Mitochondrial inner membrane protein, required for export of the Cox2p C terminus from the mitochondrial matrix to the intermembrane space YOR130C,ORT1,ARG11 Mitochondrial integral membrane protein, ornithine transporter YBR165W,UBS1 General positive regulator of CDC34; Suppress some cdc34 mutations when over-expressed YNL002C,RLP7,RPL7 Significant sequence similarity to RPL7B, but neither can functionally replace the other. Does not correspond to any ribosomal component identified so far, based on its biochemical features YJL185C Hypothetical ORF YPL157W,TGS1 TrimethylGuanosine Synthase YCL050C,APA1,DTP1 diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase I YEL029C,BUD16 - YLR271W Hypothetical ORF YDL236W,PHO13 p-nitrophenyl phosphatase YOL032W Hypothetical ORF YGL224C,SDT1,SSM1 suppressor of deletion of TFIIS YLR052W Hypothetical ORF YKL099C,UTP11 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YHR134W,WSS1 weak suppressor of smt3 YDR476C Hypothetical ORF YCL010C,SGF29 SaGa associated Factor 29kDa YKR043C Hypothetical ORF YBL041W,PRE7 proteasome subunit YCL005W Hypothetical ORF YNR057C,BIO4 dethiobiotin synthetase YOL146W,PSF3 Partner of sld Five 3 YEL019C,MMS21 Protein involved in DNA repair YDR179W-A Hypothetical ORF YKL023W Hypothetical ORF YER026C,CHO1,PSS1 phosphatidylserine synthase YHR049W - YPL241C,CIN2 involvement in microtubule function YGR026W Hypothetical ORF YBL064C,PRX1 also called mTPx I, a mitochondrial isoform of thioredoxin peroxidase (EC 1.11.1.-) YGR024C Protein required for cell viability YNL210W,MER1 Disp. for axial elements in meiosis but required for full chr. pairing & chr. condensation seen by in situ hybridization, wt level of synaptonemal complexes, heteroduplex DNA, gene conversion & reciprocal recombination & spore viability YCR059C,YIH1 piecemeal microautophagy of the nucleus (PMN) YIL064W Hypothetical ORF YPL178W,CBC2,MUD13, SAE1, CBP20 cap binding complex YNL190W Hypothetical ORF YLR363C,NMD4 putative Upf1p-interacting protein YDR253C,MET32 Involved in methionine metabolism YDR367W Protein required for cell viability YLR199C Hypothetical ORF YHR181W Sed5-Vesicle Protein of 26 kDa YDL213C Hypothetical ORF YHR041C,SRB2,HRS2 RNA polymerase II holoenzyme/mediator subunit YPL257W Hypothetical ORF YJL038C Hypothetical ORF YMR184W Hypothetical ORF YOR283W Hypothetical ORF YGL045W,RIM8,YGL046W, PAL3 Regulator of IME2 (RIM) Involved in proteolytic processing of Rim1p YJL158C,CIS3,CCW11 cik1 suppressor YER183C,FAU1 Folinic Acid Utilization YGL147C,RPL9A Homology to rat L9 YJL030W,MAD2 spindle checkpoint complex subunit YBR066C,NRG2 homologue of NRG1 YNL110C,NOP15 Nucleolar protein 15 YML106W,URA5,PYR5 Fifth step in pyrimidine biosynthesis pathway YDR041W,RSM10 mitochondrial ribosome small subunit component YKL001C,MET14 adenylylsulfate kinase YKL069W Hypothetical ORF YGL230C Hypothetical ORF YIL016W,SNL1 Suppressor of nup116-C lethal. Snl1p is the first Bag domain protein identified in S. cerevisiae. YLR068W,FYV7 Function required for Yeast Viability on toxin exposure YMR022W,QRI8,UBC7 part of the HRDDER pathway of ER-associated protein degradation YDR260C,SWM1 Spore Wall Maturation 1 YDR201W,SPC19 Spindle Pole Component of molecular weight 23kDa YDL008W,APC11 subunit of the Anaphase Promoting Complex; all known APC subunits co-immunoprecipitate with epitope-tagged Apc11p YGR085C,RPL11B Homology to rat L11 and E. coli L5; involved in protein synthesis YOR044W Hypothetical ORF YNL052W,COX5A One of two genes (COX5A and COX5B, both nuclear-encoded) coding for subunit V of cytochrome c oxidase; COX5A gene product is the predominantform of subunit V found in holocytochrome c oxidase under normal growth conditions YPR168W,NUT2,MED10 Negative regulator of URS2 of the HO promoter YJR025C,BNA1,HAD1 biosynthesis of nicotinic acid YPR073C,LTP1 Homologous to mammalian phosphotyrosine phosphatase YPR101W,SNT309 Synergistic to prp19 (NineTeen) mutation. Essential for mRNA splicing. YMR260C,TIF11 Translation initiation factor eIF1A YBR135W,CKS1 subunit of the Cdc28 protein kinase YKR020W,VPS67,WHI6, API3, VPS51 whiskey (whi) mutant; forms a tetramer with VPS52, VPS53, and VPS54 YMR009W Hypothetical ORF YCR006C Hypothetical ORF YIL057C Hypothetical ORF YPR188C Mlc2p is likely the regulatory light chain for the type II myosin, Myo1p. Mlc2p binds to an IQ motif of Myo1p. Mlc2p localization to the bud neck depends on Myo1p. YPL200W,CSM4 Chromosome segregation in meiosis YER030W Hypothetical ORF YKL084W Hypothetical ORF YFR036W,CDC26,HIT3, SCD26 component of anaphase-promoting complex; required for ubiquitination of Clb2p and Clb3p, is a nuclear protein, and is induced by heat shock YPL013C,MRPS16 - YNL303W Hypothetical ORF YAL046C Hypothetical ORF YOR235W Hypothetical ORF YCR071C,IMG2 required for integrity of mitochondrial genome YIL165C Hypothetical ORF YJR086W,STE18 gamma subunit of G protein coupled to mating factor receptors YCR022C Hypothetical ORF YJR085C Hypothetical ORF YGR182C Hypothetical ORF YIR009W,MSL1 involved in splicing YLR012C Hypothetical ORF YDR493W Hypothetical ORF YMR230W,RPS10B Homology to rat S10 YCL035C,GRX1 Glutaredoxin YPR166C,MRP2 14 kDa mitochondrial ribosomal protein; homologous to E. coli S14 protein YJR034W,PET191 Required for assembly of active cytochrome c oxidase YMR107W Hypothetical ORF YOR015W Hypothetical ORF YHR130C Hypothetical ORF YPL186C,UIP4 Ulp1 Interacting Protein 4 YNL099C,OCA1 Oxidant-induced Cell-cycle Arrest 1 YJL203W,PRP21,SPP91 RNA splicing factor YLR457C,NBP1 Nap1p Binding Protein YJL210W,PEX2,CRT1, PAS5 Pex2p, Pex10p, and Pex12p together make up the RING finger complex of the peroxisomal import machinery. YDL173W Hypothetical ORF YKL198C,PTK1,YKL199C, KKT8, STK1, YKT9, POT1 Putative serine/threonine protein kinase YBR175W,SWD3,CPS30, SAF35 likely involved in chromatin remodelingmember of Set1p complex YBR267W Hypothetical ORF YGR010W,NMA2 NAD(+) salvage pathway YOR104W,PIN2 [PSI+] induction YGR136W,LSB1 LAs17 Binding protein YKL082C Required for normal pre-rRNA Processing YOR239W,ABP140,YOR240W actin filament binding protein YNR041C,COQ2 transfers polyprenyl group to p-hydroxybenzoic acid (the aromatic ring precursor of CoQ) YKL112W,ABF1,BAF1, OBF1, REB2, SBF1 transcriptional activator and ARS1 binding protein YNL265C,IST1 Similar to Nuf1p (spindle pole body component) YJR113C,RSM7 mitochondrial ribosome small subunit component YDL150W,RPC53,RPC4 RNA polymerase III (C) subunit, homologus to human BN51 protein YLR332W,MID2,KAI1 Protein required for mating YPR088C,SRP54,SRH1 Signal recognition particle subunit (homolog of mammalian SRP54) YGR220C,MRPL9,YML9 Mitochondrial ribosomal protein MRPL9 (YmL9) (E. coli L3) (human MRL3) YOR083W,WHI5 whiskey (whi) mutant YMR135W-A Hypothetical ORF YOR390W Hypothetical ORF YMR169C,ALD3 Expression induced in response to heat shock, oxidative and osmotic stress. NAD+ is preferred coenzyme. YNL139C,RLR1,THO2, ZRG13 Required for LacZ RNA expression from certain plasmids; suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O); plays a role in transcription elongation by RNA polymerase II YGR214W,RPS0A,NAB1, NAB1A, YST1 Homology to rat Sa YPL090C,RPS6A Homology to rat, mouse, and human S6 YGL258W Increased in velum formation in flor strain YJR160C,MPH3 Maltose Permease Homologue. Maltose transporter family member, able to transport hexoses. Capable of transporting maltose, maltotriose, alpha-methylglucoside and turanose. YNR072W,HXT17 Hexose transporter YHR203C,RPS4B Homology to rat S4 and human S4 YFL035C - YBR181C,RPS6B,LPG18, RPS101, RPS102 Homology to rat, human, and mouse S6 YER102W,RPS8B Homology to mammalian S8 YJR159W,SOR1,SDH1 sorbitol-induced sorbitol dehydrogenase YHL049C Hypothetical ORF YEL076C Hypothetical ORF YOR391C Hypothetical ORF YNL335W Hypothetical ORF YJR026W Ty ORF YLL067C Hypothetical ORF YLR338W Hypothetical ORF YGL051W Multicopy suppressor of Sec Twenty one of 27 kDa YLR029C,RPL15A,RPL10A Homology to rat L15 YCR013C Protein required for cell viability YDL016C Protein required for cell viability YGR022C Hypothetical ORF YOR379C Hypothetical ORF YLR333C,RPS25B Homology to rat S25; belongs to the S25E family of ribosomal proteins YOR293W,RPS10A Homology to rat S10 YLR101C Protein required for cell viability YLR415C Hypothetical ORF YOR277C Hypothetical ORF YOR248W Hypothetical ORF YMR158W-A - YCR050C Hypothetical ORF YMR244C-A Hypothetical ORF YPR203W Hypothetical ORF YJL188C,BUD19 - YJL022W Hypothetical ORF YDL032W Hypothetical ORF YOL106W Hypothetical ORF YMR316C-A Hypothetical ORF YGL132W Hypothetical ORF YOR225W Hypothetical ORF YMR194W,RPL36A,RPL39B Homology to rat L36 YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YMR076C,PDS5 Precocious Dissociation of Sister chromatids YGR281W,YOR1,YRS1 multispecific organic anion transporter important for tolerance against toxic environmental organic anions YBL005W-B TyB Gag-Pol protein YOR336W,KRE5 appears to function early in (1,6)-beta-D-glucan synthesis pathway YOL145C,CTR9,CDP1 CTR9 is required for normal CLN1 and CLN2 G1 cyclin expression YDL145C,COP1,SEC33, RET1 alpha subunit of the coatamer complex; gamma-alpha-COP YDL171C,GLT1 Glutamate synthase (NADH) YMR045C TyB Gag-Pol protein YMR176W,ECM5 ExtraCellular Mutant YOR291W Hypothetical ORF YBR136W,MEC1,ESR1, SAD3 Required for mitotic growth, DNA repair and mitotic recombination, regulates phosporylation of Rad53p, required for dmc1 arrest and meiotic recombination YHR023W,MYO1 myosin class II YPL058C,PDR12 similar to Pdr5p YKR096W Hypothetical ORF YLR189C,UGT51 Udp-glycosyltransferase YEL077C Hypothetical ORF YHR155W Hypothetical ORF YMR162C,DNF3 Drs2 Neo1 Family YDR039C,ENA2 plasma membrane protein; putative Na+ pump; P-type ATPase YMR304W,UBP15 putative deubiquitinating enzyme YLR305C,STT4,BLM1 functions in the PKC1 protein kinase pathway, in a pathway with STT1 and MSS4 YGR070W,ROM1,SKC1 Gdp-GTP Exchange Protein (GEP) for the Rho1p Small GTP-binding Protein YHR020W Protein required for cell viability YNL053W,MSG5 Tyrosine protein phosphatase involved in adaptation response to pheromone YJR001W,AVT1 related to the neuronal gamma -ransporters YJR147W,HMS2 High-copy mep2 suppressor YIL047C,SYG1 Protein for which truncation and overexpression can suppress lethality of G-alpha protein deficiency YMR177W,MMT1 Protein involved in mitochondrial iron accumulation YLL034C Protein required for cell viability YPR145W,ASN1 Asn1p and Asn2p are isozymes YLR381W,CTF3,CHL3 kinetochore-related protein YKL027W Hypothetical ORF YOL002C - YNL264C,PDR17,ISS1, SFH4 involved in pleiotropic drug resistance by controlling lipids in various cellular compartments; putative phosphatidylinositol transfer protein. YBR272C,HSM3 Involved in DNA mismatch repair pathways YBR287W Hypothetical ORF YPL057C,SUR1,BCL21, CSG1, LPE15 Involved in maintenance of phospholipid levels YLR131C,ACE2 involved in transcriptional regulation of CUP1. enters nucleus only at the end of mitosis. YOR049C,RSB1 Resistance to Sphingoid long-chain Base. Putative transporter or flippase that translocates LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane. YPL146C Protein required for cell viability YLL011W,SOF1 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); 56 kDa nucleolar snRNP protein that shows homology to beta subunits of G-proteins and the splicing factor Prp4 YDL211C Hypothetical ORF YNL243W,SLA2,END4, MOP2 Protein involved in membrane cytoskeleton assembly, required for cell polarization and endocytosis YDL233W Hypothetical ORF YDR037W,KRS1,GCD5 lysyl-tRNA synthetase YER061C,CEM1 homology with beta-keto-acyl synthases YNL065W,AQR1 A(acids, azoles) Q(quinidine, quinine) Resistance YPR085C Protein required for cell viability YBR255W Hypothetical ORF YBR221C,PDB1 beta subunit of pyruvate dehydrogenase (E1 beta) YEL062W,NPR2 Putative post-transcriptional regulator of nitrogen permeases YGR289C,MAL11,AGT1 Part of MAL1 complex locus; encodes funct. maltose permease in all strains, exhibits sign. seq. variability; shows homol. to functional maltose permease from S. carlsbergenesis; member of the 12 tm domain superfamily of sugar transporters YCL017C,NFS1,SPL1 NifS-like protein YBR131W,CCZ1,CVT16 Calcium Caffeine Zinc sensitivity YDR266C Hypothetical ORF YDL030W,PRP9 involved in pre-spliceosome assembly, important for U2 snRNP addition YGR056W,RSC1 RSC1 is a member of RSC complex, which remodels the structure of chromatin YLR176C,RFX1,CRT1 DNA binding protein, homologous to a family of mammalian RFX1-4 proteins which have a novel highly conserved DNA binding domain YDR257C,RMS1 Transcription regulator YDL055C,PSA1,MPG1, VIG9, SRB1 synthesizes GDP-mannose from GTP and mannose-1-phosphate. YHR108W,GGA2 Golgi-localized, gamma-adaptin homology, Arf-binding. Interacts with Arf1p and Arf2p in a GTP-dependent manner. Effector of Arf that facilitates traffic through the late Golgi. YGR112W,SHY1 involved in respiration YJL212C,OPT1,HGT1 Oligopeptide transporter; Opt1p transports tetra- and pentapeptides, including the endogenous opioid pentapeptide leucine enkephalin. YMR088C Hypothetical ORF YGR144W,THI4,ESP35, MOL1 Protein highly expressed in early stationary phase during growth on molasses YDL164C,CDC9,MMS8 essential for mitosis and meiosis, dispensable for intragenic recombination, but required for haploidization and spores YKL184W,SPE1,ORD1, SPE10 Rate limiting step of polyamine biosynthesis pathway YHR035W Hypothetical ORF YBR085W,AAC3,ANC3 highly homologous to PET9 (AAC2) and AAC1; expression occurs only under anaerobic conditions YNL221C,POP1 Required for processing of pre-tRNAs and the 5.8S rRNA precursor YMR268C,PRP24 U4/U6 snRNA-associated splicing factor YHL047C,ARN2,TAF1 Siderophore transporter for triacetylfusarinine C YGR012W Hypothetical ORF YDL133W Hypothetical ORF YDR398W,UTP5 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YPL260W Hypothetical ORF YMR299C Hypothetical ORF YKR039W,GAP1 general amino acid permease YIL017C,VID28,GID5 Vacuole import and degradation YFL013C Hypothetical ORF YIL153W,RRD1,YPA1 Resistant to Rapamycin Deletion YDR089W Hypothetical ORF YOR165W,SEY1 Synthetic Enhancement with YOP1 YML126C,ERG13,HMGS involved in mevalonate synthesis YGR099W,TEL2 Involved in controlling telomere length YJL186W,MNN5 mannan synthesis YER015W,FAA2,FAM1 acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatty acid activator 2), activates endogenous but not imported fatty acids and provides substrates for N-myristoylation YOR380W,RDR1 Repressor of drug resistance YMR155W Hypothetical ORF YLR300W,EXG1,BGL1 Has a broad specificity for beta-1,3-linkages as well as beta-1,6-linkages, and also for other beta-glucosidic linked substrates, such as cellobiose. YGR223C Hypothetical ORF YCL030C,HIS4 histidinol dehydrogenase YMR163C Hypothetical ORF YER145C,FTR1 high-affinity iron transporter, primarily expressed under oxygenated conditions. YNL027W,CRZ1,HAL8, TCN1 inc-finger YJR076C,CDC11,PSL9 involved in proper bud growth YDR212W,TCP1,CCT1 tailless complex polypeptide 1 YNL095C Hypothetical ORF YGR101W,PCP1,MDM37, RBD1 processing of cytochrome c peroxidase YNL298W,CLA4,ERC10 Involved in localizing cell growth with respect to the septin ring YLR007W,NSE1 lement 1. essential for cell proliferation. YPR079W,MRL1 Mannose 6-phosphate Receptor Like YGL090W,LIF1 Ligase Interacting Factor 1; physically interacts with DNA ligase 4 protein (Lig4p) YOR244W,ESA1,TAS1 contains amino-terminal chromodomains; Essential SAS family Acetyltransferase sharing homology with acetyltransferases from many different organisms YGR204W,ADE3 Required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and formylmethionyl-tRNA YOL054W istone associated YPR190C,RPC82,RPC3 82-kDa subunit of RNA polymerase III (C) YGR019W,UGA1 gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) YPR179C Ploidy-related. Nuclear protein YHL027W,RIM101,RIM1 Regulator of IME2 (RIM)Rim101p is similar to the Aspergillus Phenotype-response regulator PacC and the Yarrowia proteinase YlRim1010p; transcriptional activator required for entry into meiosis YPL133C,RDS2 Regulator of drug sensitivity YML052W,SUR7 Multicopy suppressor of rvs167 mutation YBL037W,APL3 clathrin Associated Protein complex Large subunit YDR282C Hypothetical ORF YMR044W,IOC4 Iswi One Complex YHR065C,RRP3 Required for maturation of the 35S primary transcript of pre-rRNA and is required for cleavages leading to mature 18S RNA YEL047C Fumurate ReDuctase Soluble YOR113W,AZF1 probable transcription factor, asparagine-rich zinc-finger protein, suppressor of mutation in the nuclear gene for the core subunit of mitochondrial RNA polymerase YIL160C,POT1,FOX3, POX3 peroxisomal 3-oxoacyl CoA thiolase YER073W,ALD5 Utilizes NADP+ as the preferred coenzyme. Activated by K+. YMR272C,SCS7,FAH1 Required for the hydroxylation of the very long chain fatty acid (VLCFA), located in the endoplasmic reticulum YJL132W Hypothetical ORF YER107C,GLE2,RAE1 Nuclear pore protein required for poly(A)+ RNA export, has beta-transducin (WD-40) repeats YPL138C,SPP1,CPS40, SAF41 likely involved in chromatin remodelingmember of Set1p complex YJL094C,KHA1 putative K+/H+ antiporter YGR058W Hypothetical ORF YOL052C,SPE2 S-adenosylmethionine decarboxylase YML118W,NGL3 DNase/RNase (putative); CCR4 C-terminal homolog; displays homology to drosophila Angel gene; homolog to ngl1 and ngl2 YPR201W,ARR3,ACR3 Putative membrane protein involved in arsenite transport YKL195W Protein required for cell viability YOR108W,LEU9 gene product responsible for alpha-isopropylmalate synthase II activity YMR089C,YTA12,RCA1 Mitochondrial ATPase (similar to E. coli FtsH protein) that resides in the innner mitochondrial membrane YHR063C,PAN5 ketopantoate reductase YBR289W,SNF5,HAF4, SWI10, TYE4 Involved in global regulation of transcription YML021C,UNG1 uracil DNA glycosylase YHR025W,THR1 homoserine kinase YPR128C,ANT1 adenine nucleotide transporter YIL108W Hypothetical ORF YPL210C,SRP72 part of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane YJR065C,ARP3,ACT4 actin-related gene YPL008W,CHL1,CTF1, LPA9 Required for mitotic chromosome segregation, needed for wild-type levels of meiotic recombination and spore viability YJL102W,MEF2 mitochondrial elongation factor G-like protein YBR214W,SDS24 Similar to S. pombe SDS23, suppresses DIS2, localized to the nucleus YJR122W,CAF17 CCR4 associated factor YDR047W,HEM12,HEM6 fifth enzyme in the heme biosynthetic pathway YKL028W,TFA1 Large subunit of transcription factor tfIIE YKL100C Hypothetical ORF YDL193W Protein required for cell viability YLL061W,MMP1 S-MethylMethionine Permease YLR055C,SPT8 transcription factor, probable member of histone acetyltransferase SAGA complex YBL097W,BRN1 BaRreN, a gene with sequence similarity to Drosophila barren and Xenopus XCAP-H, and a functional homolog of human BRRN1 YKR022C Protein required for cell viability YDR322W,MRPL35 Mitochondrial ribosomal protein MRPL35 (YmL35) YLR431C Hypothetical ORF YDR197W,CBS2,CBP7 Translational activator of COB mRNA; soluble protein YMR257C,PET111 translational activator of cytochrome c oxidase subunit II YBR043C A(acid, azole) Q(quinidine) Resistance YAL042W,ERV46,FUN9 ER vesicle protein of 46 kDa YJL085W,EXO70 70 kDa exocyst component protein; the exocyst proteins are required for exocytosis late in the secretory pathway YOR321W,PMT3 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway YLR108C Hypothetical ORF YDL107W,MSS2 cox1 pre-mRNA splicing factor YKL173W,SNU114,GIN10 involved in splicing YDL090C,RAM1,DPR1, FUS8, SCG2, SGP2, STE16 essential for processing of ras proteins YPL249C,GYP5 GAP for Ypt protein YNL101W,AVT4 related to the neuronal gamma -ransporters YDR240C,SNU56,MUD10 Snurp = Small nuclear ribonucleoprotein particle of MW 56 kDa. Associated with the U1 snRNP; no counterpart in mammalian U1 snRNP. Serine-rich. YLR054C Outer Spore Wall YDR158W,HOM2 threonine and methionine pathway YLR117C,CLF1,SYF3 SYnthetic lethal with cdcForty; Crooked neck Like Factor, an ortholog of the Drosophila crooked neck gene, crn YBR211C,AME1,ARP100 associated with microtubules and essential YPL063W,TIM50 Protein of the inner mitochondrial membrane, required for import of mitochondrial matrix proteins YFR009W,GCN20 Positive effector of the EIF-2-alpha kinase activity of GCN2; component of a heteromeric complex that includes GCN1 and GCN20 YML085C,TUB1 alpha-tubulin YFR046C Hypothetical ORF YMR041C Hypothetical ORF YCR094W,CDC50 cell division cycle mutant YNL176C Hypothetical ORF YKL189W,HYM1 Cbk1p and Hym1p regulate two distinct cell morphogenesis pathways: an ACE2-indep. pathway req'd for efficient apical growth and mating projection formation, and an ACE2-dep. pathway req'd for efficient cell separation following cytokinesis. YBR239C Hypothetical ORF YHR171W,APG7,CVT2 autophagy YNL004W,HRB1,TOM34 an ORF of unknown function located in a centromeric region duplicated between chromosomes III and XIV YDR176W,NGG1,ADA3, SWI7 Involved in glucose repression of GAL4p-regulated transcription YNL021W,HDA1 component of histone deacetylase A YLR153C,ACS2 one of 2 acetyl-coA synthetases in yeast YCL063W,VAC17 vacuole inheritance YIR010W,DSN1 Dosage Suppressor of NNF1 YNL290W,RFC3 RFC is a DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA YNL047C Hypothetical ORF YMR037C,MSN2 Transcription factor. Multicopy suppressor of snf1 mutation. Key regulator of stress-responsive gene expression. YDL175C,AIR2 ING finger protein YJR049C,UTR1 associated with ferric reductase YOR008C,SLG1,HCS77, WSC1 cell wall integrity and stress response component 1 YFL029C,CAK1,CIV1 binds and phosphorylates Cdc28p YNL258C,DSL1 dsl1 mutations are suppressed by a dominant allele of SLY1, called sly1-20 YNR030W,ECM39,ALG12 mannosyltransferase YDR186C Hypothetical ORF YLL035W,GRC3 Product of gene unknown YOR099W,KTR1 mannosyltransferase involved in O- and N-linked glycosylation YNR047W Hypothetical ORF YGR127W Hypothetical ORF YKL094W,YJU3 Product of gene unknown YNR007C,AUT1,APG3 Protein involved in autophagocytosis during starvation YOR125C,CAT5,COQ7 may encode a protein involved in one or more monoxygenase or hydroxylase steps of ubiquinone biosynthesis YGL254W,FZF1,NRC299, RSU1, SUL1 involved in sulfite resistance YIL044C,AGE2,SAT2 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector YMR267W,PPA2,IPP2 mitochondrial inorganic pyrophosphatase YBR251W,MRPS5 Probable mitochondrial ribosomal protein S5 YER083C Required for Meiotic nuclear Division YDR472W,TRS31 targeting complex (TRAPP) component involved in ER to Golgi membrane traffic YGL162W,SUT1 Involved in sterol uptake YIL117C,PRM5 pheromone-regulated membrane protein YOL093W,TRM10 responsible for most, if not all, m(1)G(9) modification of tRNAs. YLR208W,SEC13,ANU3 cytoplasmic protein involved in release of transport vesicles from the ER YJL079C,PRY1 Pathogen Related in Sc, contains homology to the plant PR-1 class of pathogen related proteins. The protein sequence is over 60% identical with the Pry2p & Pry3p over 145 resid. PRY1 is >35% identical (50% similar) to tobacco PR-1c protein. YPL173W,MRPL40 Mitochondrial ribosomal protein MRPL40 (YmL40) YDR287W onophosphatase YJR077C,MIR1 Product of gene unknown YBR040W,FIG1 Factor-Induced Gene 1: expression is induced by the mating pheromones, a and alpha factor; required for efficient mating YBR037C,SCO1,PET161 inner mitochondrial membrane protein YLL056C Hypothetical ORF YFR041C Hypothetical ORF YNR028W,CPR8 Shows similarity to the secretory pathway cyclophilin Cpr4 YHR167W,THP2 affects transcription elongation YAL009W,SPO7 dispensable for mitosis, but required for a normal mutation rate, required for premeiotic DNA synthesis, recombination, meiosis I, meiosis II, glycogen degradation and spores YKL207W Hypothetical ORF YOL147C,PEX11,PMP24, PMP27 May promote peroxisomal proliferation by participating in peroxisomal elongation or fission or segregation of peroxisomes to daughter cells YIR035C Hypothetical ORF YNR020C Hypothetical ORF YIL093C,RSM25 mitochondrial ribosome small subunit component YLR411W,CTR3 integral membrane protein that functions in high affinity copper transport YLR323C,CWC24 Complexed with Cef1p YDR305C,HNT2,APH1 Fhit homolog, member of the histidine triad superfamily of nucleotide binding-proteins YER182W Hypothetical ORF YOL154W Zinc and pH regulated Surface protein. Similar to Candida albicans protein Pra1, a pH-regulated cell surface glycoprotein with weak similarity to zinc metalloproteinases. YNL024C Hypothetical ORF YMR038C,LYS7,CCS Involved in lysine biosynthesis, oxidative stress protection YEL038W,UTR4 Product of gene unknown YIL106W,MOB1 Mps One Binder YER004W Hypothetical ORF YCR076C Hypothetical ORF YIR018W,YAP5 bZIP protein; transcription factor YBR154C,RPB5 25-kDa RNA polymerase subunit (common to polymerases I, II and III) YER062C,HOR2,GPP2 RHR2 (GPP1) encodes another DL-glycerol-3-phosphatase YOR004W Protein required for cell viability YGR033C Hypothetical ORF YER050C,RSM18 protein similar to bacterial ribosomal subunit S18 YPR113W,PIS1 phosphatidylinositol synthase YNL214W,PEX17,PAS9 23 kDa peroxisome associated protein, binds Pex14p YER128W Hypothetical ORF YBR052C Hypothetical ORF YML028W,TSA1,ZRG14, TPX1, cTPxI antioxidant enzyme that provides protection against oxidation systems capable of generating reactive oxygen and sulfur species YML095C,RAD10 endonuclease (with Rad1p) that degrades single-stranded DNA for repair YNL093W,YPT53 Involved in vacuolar protein sorting and endocytosis YPL041C Hypothetical ORF YJR057W,CDC8 essential for mitotic DNA synthesis. Required for premeiotic DNA synthesis, synaptonemal complexes, recombination, meiosis I, meiosis II, and spores YNL282W,POP3 RNase P and RNase MRP subunit YMR072W,ABF2 HMG-1 homolog, mitochondrial YHR105W Hypothetical ORF YCR020C,PET18,HIT2 Transcription regulator YGR146C Hypothetical ORF YOR215C Hypothetical ORF YPL229W Hypothetical ORF YGR078C,PAC10,GIM2, PFD3, RKS2 Polypeptide 3 of a Yeast Non-native Actin Binding Complex, homolog of a component of the bovine NABC complex YNR014W Hypothetical ORF YLR016C Hypothetical ORF YBR005W Hypothetical ORF YOL162W Hypothetical ORF, member of the Dal5p subfamily of the major facilitator family YFL046W Hypothetical ORF YER042W,MXR1,MSRA peptide Methionine sulfoXide Reductase 1 YBR077C Hypothetical ORF YKL160W - YPL135W,ISU1,NUA1 Iron-sulfur cluster nifU-like protein YKL066W Hypothetical ORF YBR285W Hypothetical ORF YCR025C Hypothetical ORF YIR022W,SEC11 signal peptidase subunit YOR369C,RPS12 Homology to rat S12 YJL143W,TIM17,MIM17, MPI2, SMS1 Mitochondrial inner membrane protein involved in protein import YLR218C Hypothetical ORF YIL029C Hypothetical ORF YOR257W,CDC31,DSK1 Required for spindle pole body duplication and mitosis in meiosis II; calcium-binding protein component of spindle pole bodies, localizes to half-bridges and interacts with KAR1 YPR193C,HPA2 Histone and other Protein Acetyltransferase; Has sequence homology to known HATs and NATs YBL021C,HAP3 Regulates respiratory functions; encodes divergent overlapping transcripts YPR153W Hypothetical ORF YIR005W,IST3,SNU17 U2 snRNP associated protein YPL037C,EGD1 beta subunit of the nascent-polypeptide-associated complex (NAC); homologous to human BTF3b; GAL4 enhancer protein YBR244W,GPX2,AMI1 Glutathione peroxidase paralogue YEL034W,HYP2,TIF51A Translation initiation factor eIF-5A YGR272C Hypothetical ORF YOR224C,RPB8 16-kDa RNA polymerase subunit (common to polymerases I, II and III) YER159C,BUR6,NCB1 Homolog of DRAP1 (NC2alpha) YPR020W,ATP20 Protein associated with mitochondrial ATP Synthase; essential for dimeric state of ATP synthase YGR269W Hypothetical ORF YJR082C Esa1p-Associated Factor-6 YDR525W,API2 cal 2 YBR268W,MRPL37,YML37 Probable mitochondrial protein L37 YOR318C Hypothetical ORF YGR051C Hypothetical ORF YLR154C subunit 3 of RNase H2 YOR314W Hypothetical ORF YPR195C Hypothetical ORF YCL006C MIPS: ORF destroyed with chrIII seq. update (09/14/2000) YBR157C,ICS2 Increased Copper Sensitivity YMR086C-A Hypothetical ORF YBL025W,RRN10 subunit of UAF (upstream activation factor); involved in promoting high level transcription of rDNA YDR010C Hypothetical ORF YDR322C-A,TIM11,ATP21 Protein associated with mitochondrial ATP synthase; essential for dimeric state of ATP synthase. YJL135W Hypothetical ORF YAR047C Hypothetical ORF YBR062C Hypothetical ORF YIL102C Hypothetical ORF YEL059W Hypothetical ORF YJL028W Hypothetical ORF YOR183W,FYV12 Function required for Yeast Viability on toxin exposure YGR027C,RPS25A,RPS31A Homology to rat S25 YDL051W,LHP1,LAH1, YLA1 Protein homologous to human La (SS-B) autoantigen YJL118W Hypothetical ORF YNR024W Hypothetical ORF YGL052W Hypothetical ORF YPR196W nuclear protein (putative) YOL080C,REX4 RNA EXonuclease; member of 3'->5' exonuclease family. See Moser et al. 1997 Nucleic acids Res. 25:5110-5118 YLR295C,ATP14 ATP synthase subunit h YJL150W Hypothetical ORF YKL152C,GPM1 converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis YPL185W Hypothetical ORF YJR038C Hypothetical ORF YLR251W stress-induced yeast MPV17 homolog YLR229C,CDC42 cell division cycle blocked at 36 degree C YLR104W Hypothetical ORF YER066C-A Hypothetical ORF YMR304C-A Hypothetical ORF YKR105C Hypothetical ORF YER119C-A Hypothetical ORF YBR134W Hypothetical ORF YEL074W Hypothetical ORF YOR203W Protein required for cell viability YML090W Hypothetical ORF YDR413C Protein required for cell viability YEL076W-C - YNL096C,RPS7B Homology to human S7 and Xenopus S8 YDL172C Hypothetical ORF YDR433W Hypothetical ORF YGL214W Hypothetical ORF YHR214W putative membrane protein YNL109W Hypothetical ORF YHR214W-A Hypothetical ORF YOR394W Hypothetical ORF YAR062W Hypothetical ORF YKL083W Protein required for cell viability YKL153W Protein required for cell viability YBR191W,RPL21A,URP1 Homology to rat L21 YCR087W Hypothetical ORF YHL001W,RPL14B Homology to mammalian L14 YHR213W Hypothetical ORF YCL068C Hypothetical ORF YBR300C Hypothetical ORF YPR136C Hypothetical ORF YNL105W Hypothetical ORF YFL068W Hypothetical ORF YKL156W,RPS27A Homology to mammalian S27 YPL271W,ATP15,ATPEPSILON nuclear gene for ATP synthase epsilon subunit YLR262C-A Similar to C. elegans protein YGL188C Hypothetical ORF YER177W,BMH1,APR6 Brain Modulosignalin Homolog YDR086C,SSS1 Subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p), involved in transfer of secretory precursors through the endoplasmic reticulum membrane YGR291C Hypothetical ORF YBR162W-A,YSY6 Protein that participates in secretory pathway YKL162C-A Similar to PIR1, PIR2 and PIR3 proteins YIL080W TyB Gag-Pol protein YNL259C,ATX1 antioxidant protein and metal homeostasis factor, protects against oxygen toxicity YOR031W,CRS5 Metallothionein-like protein YJL206C-A - YDR199W Hypothetical ORF YBR144C Hypothetical ORF YML129C,COX14 Mitochondrial membrane protein, required for assembly of cytochrome c oxidase YFR032C-A,RPL29 Homology to rat L29 YCR024C-A,PMP1 May regulate plasma membrane H(+)-ATPase YJR079W Hypothetical ORF YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YBR295W,PCA1,CAD2, PAY2 thought to play a role in resistance to copper ion toxicity YMR196W Hypothetical ORF YKL092C,BUD2,CLA2, ERC25 GTPase-activating protein (GAP) for Rsr1p/Bud1p YJL074C,SMC3 involved in sister chromatid cohesion YNR070W pleiotropic drug resistance YDR135C,YCF1 Metal resistance protein with similarity to human cystic fibrosis protein CFTR and multidrug resistance proteins YJR090C,GRR1,CAT80, COT2, SSU2 F box protein with several leucine rich repeats YER093C,TSC11,AVO3 Binding Protein of TOR YKL014C Protein required for cell viability YNL163C,RIA1,EFL1 RIbosome Assembly; Elongation Factor Like YGR170W,PSD2 converts phosphatidylserine to phosphatidylethanolamine YJL197W,UBP12 ubiquitin carboxyl-terminal hydrolase YKR028W,SAP190 190 kDa protein that associates with the SIT4 phosphatase in a cell cycle dependent manner YER013W,PRP22 helicase-like protein YGR233C,PHO81 Positive regulatory protein of phosphate pathway YBR097W,VPS15,GRD8, VAC4, VPL19 myristoylated protein kinase involved in vacuolar protein sorting YBL004W U3 protein YIL149C,MLP2 involved in translocation of macromolecules between the nucleoplasm and the NPC YML045W TyB Gag-Pol protein YMR128W,ECM16,DHR1 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); ExtraCellular Mutant DEAH-box protein involved in ribosome synthesis YNL273W,TOF1 topoisomerase I interacting factor 1 YKL209C,STE6 ABC transporter, glycoprotein, component of a-factor secretory pathway YHL022C,SPO11 Dispensable for mitosis, premeiotic DNA synthesis, spindle pole body duplication, meiosis I, meiosis II & spores. Required for chromosome pairing seen by in situ hybridization, double strand breaks, synaptonemal complexes. YFR019W,FAB1,SVL7 May regulate vacuole homeostasis. Catalyzes formation of phosphatidylinositol-3,5-bisphosphate via phosphorylation of phosphatidylinositol-3-phosphate. YEL071W,DLD3 D-lactate dehydrogenase YAL011W Hypothetical ORF YOR329C,SCD5,FTB1 Multicopy suppressor of clathrin deficiency and of ts mutants of IPL1 YKL064W,MNR2 Product of gene unknown YLR210W,CLB4 Involved in mitotic induction YJR148W,BAT2,TWT2, ECA40 BAT1 highly expressed during logarithmic phase and is repressed during stationary phase, whereas BAT2 has the opposite pattern of expression. YKL222C Hypothetical ORF YCL059C,KRR1 Involved in cell division and spore germination YDR014W Affects radiation sensitivity YLR195C,NMT1,CDC72 N-myristoyl transferase YNR071C Hypothetical ORF YMR220W,ERG8 Involved in isoprene and ergosterol biosynthesis pathways YOR384W,FRE5 similar to FRE2 YDR403W,DIT1 Disp. for spores & spore viability - required for dityrosine accumul. in the outer spore wall (s.w.), s.w. maturation & resist. to ether & lytic enzymes. Spore-autonomous function in heterozygotes. mRNA is trans. mid/late in s.w. formation YGL181W,GTS1,FHT1 Putative zinc-finger transcription factor YMR301C,ATM1 transporter of the inner mitochondrial membrane oriented with a probable ATP-binding site in the matrix, so that it could function to export substrates from the matrix to the cytoplasm YBL056W,PTC3 protein phosphatase type 2C YPL244C,HUT1 similar to UDP-galactose transporter YLL029W Hypothetical ORF YEL043W Hypothetical ORF YOL148C,SPT20,ADA5 Transcription factor YDR338C Hypothetical ORF YJR003C Hypothetical ORF YKR078W Hypothetical ORF YMR214W,SCJ1 dnaJ homolog YMR250W,GAD1 glutamate decarboxylase YPL177C,CUP9 homeobox domain similar human proto-oncogene PBX1 YKL134C,OCT1 mitochondrial protein import machinery component involved in the biogenesis of the oxidative phosphorylation system YNL272C,SEC2 Protein with coiled-coil domain essential for vesicular transport YPL274W,SAM3 S-adenosylMethionine Permease YBL099W,ATP1 mitochondrial F1F0-ATPase alpha subunit YPR032W,SRO7,SNI1, SOP1 Suppressor of rho3 YLR069C,MEF1 mitochondrial elongation factor G-like protein YOR003W,YSP3 subtilisin-like protease III YDL014W,NOP1,LOT3 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA. Low Temperature-responsive. YDR046C,BAP3 branched-chain amino acid permease YHL003C,LAG1 YKL008C YHR030C,SLT2,BYC2, MPK1, SLK2 Suppressor of lyt2 YMR078C,CTF18,CHL12 Chromosome transmission YDL132W,CDC53 acts together with Cdc4p and Cdc34p to control the G1-S phase transition, assists in mediating the proteolysis of the Cdk inhibitor Sic1p in late G1 YDR348C Hypothetical ORF YGL003C,CDH1,HCT1 CDC20 homolog 1 YPL172C,COX10 Required for an essential posttranslational stage in assembly of cytochrome oxidase YLR044C,PDC1 pyruvate decarboxylase YGR211W,ZPR1 Involved in nucleolar function; similar to murine ZPR1 protein YDL225W,SHS1,SEP7 Interacts with Spa2p and plays a role in cytokinesis YPL214C,THI6 thiamin biosynthetic bifunctional enzyme YDR289C,RTT103 Regulator of Ty1 Transposition YLR360W,VPS38,VPL17 involved in vacuolar protein targeting YIL094C,LYS12,LYS10, LYS11 homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate. YDR214W,AHA1 Activator of Heat Shock Protein 90 ATPase YDL108W,KIN28 serine-threonine kinase, subunit of transcription factor TFIIK, a subcomplex of TFIIH YER165W,PAB1 Poly(A) binding protein, cytoplasmic and nuclear YBR297W,MAL33,MAL3R Part of complex locus MAL3; nonfunctional in S288C, shows homology to both functional & nonfunctional MAL-activator proteins in other Sc strains & to other nonfunctional MAL-activator sequences from S288C (i.e. MAL33, YPR196W, & YFL052W) YNL064C,YDJ1,MAS5 yeast dnaJ homolog (nuclear envelope protein); heat shock protein YJR084W,CSN12 subunit of COP9 signalosome (CSN) YFL054C Hypothetical ORF YDR295C Ploidy-related. Shares homology with PLO1 YHR086W,NAM8,MRE2, MUD15 May be non-essent. part of mito. splicing. Assoc. with spliceosomal snRNPs. Disp. for mitosis & premeiotic DNA synth. Required in meiosis-specific splicing of MER2 & MER3, double strand breaks, synaptonemal complexes YDR263C,DIN7,DIN3 DNA-damage inducible gene YOL086C,ADH1,ADC1 Adh protein catalyzes activities for the production of certain carboxylate esters. YKR081C,RPF2 - YIR008C,PRI1 p48 polypeptide of DNA primase YJL155C,FBP26 fructose-2,6-bisphosphatase YHR198C Hypothetical ORF YIR026C,YVH1 nitrogen starvation-induced protein phosphatase YDR126W Spore Wall Formation YDL097C,RPN6,NAS4 Regulatory Particle Non-ATPase, homolog of mammalian proteasomal subunit S9/p44.5. YJL162C Hypothetical ORF YPR155C,NCA2 Regulates proper expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase YPL019C,VTC3,PHM2 Phosphate metabolism; transcription is regulated by PHO system YJR021C,REC107,MER2 meiotic recombination protein YEL006W Hypothetical ORF YDL174C,DLD1 mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase YKR086W,PRP16 putative ATP-binding protein YDR232W,HEM1 First enzyme in heme biosynthetic pathway YPR162C,ORC4 Part of complex that binds to origins of replication and thereby directs DNA replication and is also involved in transcriptional silencing YLR212C,TUB4 spindle pole body component that organizes both cytoplasmic and nuclear microtubule arrays YGL110C Hypothetical ORF YDR438W Hypothetical ORF YLR420W,URA4 Third step in pyrimidine biosynthesis pathway YGL186C,TPN1 transport of pyridoxine YAL035W,FUN12,yIF2 Functions in general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining. Also known as eIF5B. YMR185W Protein required for cell viability YGR285C,ZUO1 Zuotin has region of DnaJ homology YDR530C,APA2 5',5'''-P-1,P-4-tetraphosphate phosphorylase II YMR285C,NGL2 correct 3'-end formation of 5.8S rRNA at site E is strictly dependent on Ngl2p. YGR180C,RNR4,CRT3 ribonucleotide reductase, small subunit (alt) YBR108W Hypothetical ORF YPL042C,SSN3,GIG2, NUT7, SRB10, UME5, RYE5 Component of RNA polymerase II holoenzyme, involved in RNA pol II carboxy-terminal domain phosphorylation. Activity of the kinase (SSN3)/cyclin (SSN8) pair required, along with SSN6 & TUP1, for transcriptional repression of a-specific genes YHR188C,GPI16 Glycosyl Phosphatidyl Inositol 16 YPL028W,ERG10,LPB3, TSM0115 induced under stress conditions YNR058W,BIO3 biotin biosynthesis YMR187C Hypothetical ORF YLR033W,RSC58 Remodels the structure of chromatin complex 58KDa subunit YPR007C,SPO69,REC8 Required for sporulation; highly induced during sporulation. YHR204W,MNL1,HTM1 mannosidase like YCR024C Hypothetical ORF YOR172W transcription factor YML080W,DUS1 tRNA dihydrouridine synthase YCR008W,SAT4,HAL4 Protein with similarity to Npr1p protein kinase YIR012W,SQT1 Involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p YDL189W RNA-Binding Suppressor of PAS kinase YPR072W,NOT5 member of the NOT complex, a global negative regulator of transcription YOL007C Appears to be a structural component of the chitin synthase 3 complex YDR238C,SEC26 Involved in endoplasmic-to-Golgi protein trafficking YGR239C,PEX21 Peroxin; Pex18p and Pex21p are partially functionally redundant. YDR371W chitinase YPL074W,YTA6 Member of CDC48/PAS1/SEC18 family of ATPases YMR238W,DFG5 Protein required for filamentous growth, cell polarity, and cellular elongation YEL030W,ECM10 ExtraCellular Mutant YNL152W Protein required for cell viability YGL129C,RSM23 mitochondrial ribosome small subunit component YPL003W,ULA1,ENR2 Required for activation of RUB1 (ubiquitin-like protein) together with UBA3. Related to AOS1 and to N-terminus of UBA1. Collaborates with UBC12 in conjugation of RUB1 to other proteins. Required for modification of CDC53/cullin with RUB1 YDR517W Yeast (GR)ASP65 (H)omologue YNL177C,MRPL22 Hypothetical ORF YOR110W,TFC7 Transcription factor for RNA polymerase III YGR162W,TIF4631 also called eIF4 (eIF-4) gamma YBR168W Hypothetical ORF YGL238W,CSE1,KAP109 homologue of human CAS; specific exportin for Srp1p; required for accurate mitotic chromosome segregation. YPL221W bypass of PAM1 YGR044C,RME1,CSP1 mediates cell type control of sporulation; negatively regulates IME1 and sporulation YOR250C,CLP1 cleavage/polyadenylation factor IA subunit; interacts with Pcf11p in the 2-hybrid system YGR244C,LSC2 beta subunit of succinyl-CoA ligase (synthetase; ATP-forming), a mitochondrial enzyme of the TCA cycle YCL029C,BIK1,ARM5, PAC14 Microtubule-associated protein required for microtubule function during mating and mitosis YHR150W,PEX28 Similar to PEX24 in Yarrowia lipoytica YPR035W,GLN1 glutamine synthetase YAL032C,PRP45,FUN20 protein required for pre-mRNA splicing in vivo and in vitro, associated with the spliceosome, weakly associated with U2, U5 and U6 snRNPs YHR088W,RPF1 protein that localizes to the nucleolus YDL040C,NAT1,AAA1 Required for entry into stationary phase, heat shock-resistance, a mating-type functions, and sporulation; forms a complex with Ard1p YIL097W,FYV10,GID9 Function required for Yeast Viability on toxin exposure YAL025C,MAK16 putative nuclear protein YPL015C,HST2 Homolog of SIR2 YGR173W Genetically interacts with ribosomal genes YPL165C,SET6 - YER101C,AST2 Protein involved in targeting of plasma membrane [H+]ATPase YOL089C,HAL9 involved in salt tolerance YDL226C,GCS1 Zn-finger-containing protein that functions as ADP-ribosylation factor GTPase-activating protein and is involved in regulating vesicle transport YPL089C,RLM1 serum response factor-like protein that may function downstream of MPK1 (SLT2) MAP-kinase pathway YIR014W Hypothetical ORF YPL243W,SRP68 part of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane YER168C,CCA1,TNT1 tRNA nucleotidyltransferase (tRNA CCA-pyrophosphorylase) YOR056C,NOB1,YOR29-07 Nin1 (One) Binding protein YDR409W,SIZ1,ULL1 Sap and mIZ. Contains two known protein motifs: SAP (DNA binding) and MIZ-finger; ubiquitin-like protein ligase 1 YPL203W,TPK2,PKA2, YKR1, PKA3 Involved in nutrient control of cell growth and division YJL200C Hypothetical ORF YBR011C,IPP1,PPA1 pyrophosphate phosphohydrolase, EC 3.6.1.1; catalyzes the rapid exchange of oxygens of Pi with water. YGL225W,VRG4,VAN2, GOG5, LDB3 May regulate Golgi function and glycosylation in Golgi YOR173W Similar to mRNA decapping enzyme, HIT superfamily. YDR440W,DOT1,PCH1 involved in meiosis and transcriptional silencing YBR207W,FTH1 FTS3 Homolog 1 YKL168C,KKQ8 Serine/threonine protein kinase of unknown function YBR045C,GIP1 Developmentally-regulated protein phosphatase 1 (Glc7) interacting protein which is required for spore formation. YGR154C Hypothetical ORF YOR219C,STE13,YCI1 dipeptidyl aminopeptidase YDR531W Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33) catalyzes the first committed step in the universal biosynthetic pathway leading to CoA. YDR166C,SEC5 107 kDa component of the Exocyst complex; required for exocytosis. YIL109C,SEC24,ANU1 The Sec23p-Sec24p complex is one of three cytoplamic COPII factors involved in ER to Golgi transport YOL141W,PPM2 carboxy methyl transferase; homolog of PPM1 YJL115W,ASF1 anti-silencing protein that causes depression of silent loci when overexpressed YPL189W,GUP2 Involved in active glycerol uptake YDR390C,UBA2,UAL1 Protein with homology to mammalian ubiquitin activating (E1) enzyme YKL011C,CCE1,MGT1 cruciform cutting endonuclease YOR184W,SER1,ADE9 phosphoserine transaminase YDR148C,KGD2 dihydrolipoyl transsuccinylase component of alpha-ketoglutarate dehydrogenase complex in mitochondria YKL025C,PAN3,ECM35 Dun1 and Pan2-Pan3 cooperate to regulate the stoichiometry and activity of postreplication repair complexes. YPR068C,HOS1 Protein with similarity to Hda1p, Rpd3p, Hos2p, and Hos3p YDR423C,CAD1,YAP2 Transcriptional activator involved in resistance to 1,10-phenanthroline; member of yeast Jun-family of transcription factors related to mammalian c-jun YKR099W,BAS1 Transcription factor regulating basal and induced activity of histidine and adenine biosynthesis genes YOR275C,RIM20 Regulator of IME2 YDR292C,SRP101 signal recognition particle receptor - alpha subunit YKL120W,OAC1 oxaloacetate carrier YPR137W,RRP9 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Rrp9p is an ortholog of the human U3-55k protein; the human cDNA partially complements a yeast rrp9 null mutant. (Pluk et al. (1998) Mol. Cell. Biol. 18, 488-498.) YER006W,NUG1 NUclear GTPase YML097C,VPS9,VPL31, VPT9 Required for Golgi to vacuole trafficking, shares similarity to mammalian ras inhibitors YOR386W,PHR1 photolyase YKR062W,TFA2 Small subunit of TFIIE transcription factor YBL023C,MCM2 Member of complex that acts at ARS's to initiate replication YKR026C,GCN3,AAS2 34 KD alpha subunit of eIF2B YOR114W Hypothetical ORF YHR067W Required for Meiotic nuclear Division YDR262W Hypothetical ORF YOR060C Protein required for cell viability YDL201W,TRM8 Transfer RNA methyltransferase YPL117C,IDI1,BOT2, LPH10 catalyzes activation step in isoprenoid biosynthetic pathway YDL049C,KNH1 46% identical at amino acid level to Kre9p; located extracellularly YPL131W,RPL5,LPI14, RPL1 Homology to rat ribosomal protein L5; required for assembly of stable 60S ribosomal subunits YGR147C,NAT2 Transfers acetyl group from acetyl coenzyme A to the N-termini of proteins beginning with methionine YDR315C,IPK1,GSL1 inositol polyphosphate kinase YOR344C,TYE7,SGC1 may be involved in glycolytic gene expression YKR030W gea1-6 membrane-associated high-copy suppressor Multicopy suppressor of gea1-6 YOR228C Hypothetical ORF YOR278W,HEM4,SLU2 catalyzes the fourth step in the heme biosynthesis pathway YDR106W,ARP10 actin-related protein YHR128W,FUR1 Regulation of the pyrimidine salvage pathway YBR213W,MET8 Protein involved in the expression of PAPS reductase and sulfite reductase. Also executes last 2 steps in the biosynthesis of sirohaem. YNL305C Hypothetical ORF YMR099C Hypothetical ORF YER185W Hypothetical ORF YDR272W,GLO2 Cytoplasmic glyoxylase-II YER039C,HVG1,YEM9 Homologous to VRG4 YMR025W,CSI1 COP9 signalosome interactor YBL036C Hypothetical ORF YPL129W,TAF14,SWP29, TAF30, TFG3, ANC1 Protein required for actin cytoskeleton assembly or function YKL041W,VPS24,DID3 involved in secretion YOR289W Hypothetical ORF YOR185C,GSP2,CNR2 maintenance of nuclear organization; homologous to mammalian Ran, a small nuclear GTPase of the ras superfamily YDR020C Hypothetical ORF YER188W Hypothetical ORF YLR022C Protein required for cell viability YDR410C,STE14 farnesyl cysteine-carboxyl methyltransferase YDR381W,YRA1,SHE11 Yeast RNA Annealing Protein YDR226W,ADK1,AKY1, AKY2 adenylate kinase YMR233W Interacts with Top1p in 2-hybrid assay. YGL250W Hypothetical ORF YGR195W,SKI6,ECM20, RRP41 superkiller; ExtraCellular Mutant; Ribosomal RNA Processing YNL200C Hypothetical ORF; similarity to human TGR-CL10C, thyroidal receptor for N-acetylglucosamine YOL135C,MED7 Member of RNA Polymerase II transcriptional regulation mediator YOR214C Hypothetical ORF YLR350W,ORM2 Homologous to ORM1. YJL043W Hypothetical ORF YMR134W Protein required for cell viability YGR038W,ORM1 Product of gene unknown YDL139C Suppressor of chromosome missegregation YKL009W,MRT4 mRna turnover 4 YGR016W Hypothetical ORF YLR329W,REC102 Dispensable for mitotic recombination, DNA damage repair, axial elements & meiotic chromosome condensation; required for wild-type level of chromosome pairing seen by in situ hybridization, tripartite synaptonemal complexes YGL200C,EMP24,BST2 type I transmembrane protein, component of COPII-coated, ER-derived transport vesicles YER115C,SPR6 sporulation-specific protein YOR179C Hypothetical ORF YKL190W,CNB1,CRV1, YCN2 Type 2B protein phosphatase; regulatory B subunit of calcineurin YAL044C,GCV3 H-protein subunit of the glycine cleavage system YNL079C,TPM1 tropomyosin I YKL141W,SDH3,CYB3, YKL4 Yeast succinate dehydrogenase (SDH) is a tetramer of non-equivalent subunits--Sdh1p, Sdh2p, Sdh3p, Sdh4p--that couples the oxidation of succinate to the transfer of electrons to ubiquinone. YDR073W,SNF11 component of SWI/SNF global transcription activator complex YBL059W Hypothetical ORF YMR003W Hypothetical ORF YIL158W Hypothetical ORF YOR387C Hypothetical ORF YNL260C Protein required for cell viability YER029C,SMB1,SMB associated with U1, U2, U4, and U5 snRNPs as part of the Sm-core that is common to all spliceosomal snRNPs YLR292C,SEC72,SEC67, SIM2 protein involved in membrane protein insertion into the ER YFR045W Hypothetical ORF YGR251W Protein required for cell viability YOL143C,RIB4 catalyzes synthesis of immediate precursor to riboflavin, also known as Lumazine Synthase YOL114C Hypothetical ORF YBR217W,APG12 autophagy YDR042C Hypothetical ORF YLR306W,UBC12 Required for conjugation of RUB1 (ubiquitin-like protein) to other proteins. Collaborates with ULA1/UBA3 RUB1-activating enzyme. Related to ubiquitin-conjugating enzymes (UBC1-8, UBC10-11, UBC13). Related to SMT3-conjugating enzyme UBC9 YOR052C Hypothetical ORF YOL040C,RPS15,RPS21 Homology to rat S15 and E. coli S19 YOR286W Hypothetical ORF YDR344C Hypothetical ORF YLR302C Hypothetical ORF YER046W,SPO73 Sporulation YLL052C,AQY2 aquaporin water channel in yeast YBR016W Hypothetical ORF YJL077C,ICS3 Increased Copper Sensitivity YOR285W Hypothetical ORF YNL131W,TOM22,MAS17, MAS22, MOM22 Translocase of Outer Mitochondrial membrane YBL006C Low Dye Binding. The deletion strain shows a reduced affinity by the alcian blue dye, which suggests a reduction in the net negative charge of the cell surface YLR125W Hypothetical ORF YDR215C Hypothetical ORF YKL097C Hypothetical ORF YGL127C,SOH1 Soh1p has limited sequence similarity to RNA polymerases and interacts with a DNA repair protein, Rad5p, in a two-hybrid system assay; may provide a link between recombination in direct repeats and transcription YBR230C Hypothetical ORF YCR028C-A,RIM1 Replication In Mitochondria YBR167C,POP7,RPP2 Processing of Precursors YCL075W Psuedogene: encodes fragment of Ty Pol protein YOL012C,HTZ1,HTA3 Histone-related protein that can suppress histone H4 point mutation YKL003C,MRP17 Mitochondrial ribosomal protein MRP17 YOR234C,RPL33B Homology to rat L35a YOR265W,RBL2 binds to beta-tubulin and may participate in microtubule morphogenesis YGR025W Hypothetical ORF YHR005C-A,MRS11,TIM10 May act cooperatively with Mrs5p in mitochondrial protein import or other related essential mitochondrial processes YJR010C-A,SPC1 Homolog of the SPC12 subunit of mammalian signal peptidase complex. Protein is important for efficient signal peptidase activity. YGL226C-A,OST5 Oligosaccharyltransferase catalyzes the transfer of oligosaccharide from a dolichol-oligosaccharide donor to consensus glycosylation acceptor sites (asparagines) in newly synthesized proteins in ER lumen YBL001C,ECM15 ExtraCellular Mutant YDR016C,DAD1 Duo1 And Dam1 interacting; localized to intranuclear spindles and spindle pole bodies YGL193C Hypothetical ORF YHL005C Hypothetical ORF YDR070C Hypothetical ORF YFL017W-A,SMX2,YFL018W-A, SNP2 snRNP G protein (the homologue of the human Sm-G) YGR209C,TRX2,LMA1 thioredoxin YLR043C,TRX1,LMA1 thioredoxin YBR032W Hypothetical ORF YDR500C,RPL37B Homology to rat L37 YDR250C Hypothetical ORF YBL026W,LSM2,SMX5, SNP3 Like Sm-D1 protein YLR366W Hypothetical ORF YPR096C Hypothetical ORF YMR225C,MRPL44,YMR44 Mitochondrial ribosomal protein MRPL44 (YmL44) YEL010W Hypothetical ORF YDR139C,RUB1 Related to ubiquitin (53% identical). Homolog of mammalian ubiquitin-like protein NEDD8. Matures by proteolytic removal of C-terminal asparagine (ASN) residue. Requires the proteins ULA1 & UBA3 for activation YLR349W Hypothetical ORF YLR167W,RPS31,RPS37, UBI3, UB13 Homology to rat S27a YDR538W,PAD1,POF1 Phenylacrylic acid decarboxylase YJL211C Hypothetical ORF YGR190C Protein required for cell viability YDL062W Hypothetical ORF YDR155C,CPR1,CYP1, CPH1 cyclophilin peptidyl-prolyl cis-trans isomerase YBR099C Hypothetical ORF YGL068W Protein required for cell viability YML095C-A - YDR154C Hypothetical ORF YGL072C Hypothetical ORF YOR282W Protein required for cell viability YGL165C Hypothetical ORF YDR382W,RPP2B,RPL45, YPA1 Homology to rat P2, human P2, and E.coli L12eIA YLR236C Hypothetical ORF YPR151C - YER060W-A,FCY22 identical to FCY2 YBR088C,POL30,PCNA Accessory factor for DNA polymerase delta, mRNA increases in G1, peaks in S in mitosis, & increases prior to DNA synthesis in meiosis; required for DNA replication & repair, required for viability in cdc44, rad50, rad52 or rad57 backgrounds YJL182C Hypothetical ORF YLL046C,RNP1 ribonucleoprotein 1 YGR114C Protein required for cell viability YBL077W Protein required for cell viability YGR148C,RPL24B,RPL30B Homology to rat L24 YNL302C,RPS19B,RP55B Homology to rat S19 YOR103C,OST2 Oligosaccharyltransferase catalyzes the transfer of oligosaccharide from dolichol-oligosaccharide donor to consensus glycosylation acceptor sites (asparagines) in newly synthesized proteins in ER lumen YKL224C Hypothetical ORF YDR447C,RPS17B,RP51B, RPL51B Homology to rat ribosomal protein S17 YBL062W Hypothetical ORF YNL170W Sporulation YBR064W Hypothetical ORF YPR050C Hypothetical ORF YOR218C Protein required for cell viability YML024W,RPS17A,RP51A, RPL51A Homology to rat S17 YOR263C Hypothetical ORF YGL199C Hypothetical ORF YNR042W Hypothetical ORF YPL238C Protein required for cell viability YOR333C Spore Wall Formation YAL064W-B Hypothetical ORF YER189W Hypothetical ORF YJL075C - YDR397C,NCB2,YDR1 Negative Cofactor B2 is the beta subunit of a negative regulator of RNA polymerase II holoenzyme. It is homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2) YML026C,RPS18B Homology to rat S18 and E. coli S13 YBL003C,HTA2,H2A2 Histone H2A (HTA1 and HTA2 code for nearly identical proteins) YNL324W Hypothetical ORF YIR041W Hypothetical ORF YOR146W Protein required for cell viability YML048W-A - YPR002C-A Similar to probable membrane protein YLR334C and ORF YOL106W YMR046W-A Similar to probable membrane protein YLR334C and ORF YOL106W YOL053C-A - YLR122C Hypothetical ORF YCR018C-A Similar to probable membrane protein YLR334C and ORF YOL106W YAR029W Hypothetical ORF YER138W-A Similar to TyB and TyA YBL012C Hypothetical ORF YLR339C Protein required for cell viability YDR355C Protein required for cell viability YPR087W,VPS69 - YOR182C,RPS30B Homology to mammalian S30 YDL133C-A,RPL41B,RPL47B Homology to human L41 YCR107W,AAD3 high degree of similarity with the AAD of P. chrysosporium YCL022C Hypothetical ORF YJR023C Protein required for cell viability YJL136C,RPS21B Homology to rat S21 YAR020C,PAU7 similar to Pau3, member of Pau1 family YDR509W Hypothetical ORF YKL164C,PIR1,CCW6 Protein containing tandem internal repeats YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YNR067C,DSE4,ENG1 Daughter Specific Expression 4 YER008C,SEC3,PSL1 Profilin synthetic lethal protein, has region of coiled-coil structure; subunit of the Exocyst complex--the Exocyst complex contains the gene products encoded by SEC3, SEC5, SEC6, SEC8, SEC10, SEC15 and EXO70 and is required for exocytosis YLR084C,RAX2 Involved in the maintenance of bipolar pattern YKL215C Hypothetical ORF YBL079W,NUP170,NLE3 Component of yeast nuclear pore complex; may play a role in localizing specific nucleoporins to nuclear pore complex; High identity with Sc nucleoporin NUP157 & to mammalian nucleoporin Nup155p. Complemented with Nup155p YOL034W,SMC5 Structural maintenance of chromosomes (SMC) protein YOR093C Hypothetical ORF YOL100W,PKH2 Pkb-activating Kinase Homologue YPL216W Hypothetical ORF YEL031W,SPF1,COD1, PIO1, PER9 Sensitivity to a killer toxin (SMK toxin) produced by Pichia Farinosa YPL231W,FAS2 Trifunctional enzyme YIR006C,PAN1,MDP3, MIP3, DIM2 Involved in actin organization and endocytosis YPR115W Hypothetical ORF YPL167C,REV3,PSO1 DNA polymerase zeta, which is unique in its ability to bypass thymine dimers during replication, is composed of Rev3p and Rev7p. YNL271C,BNI1,PPF3, SHE5 Protein involved in cytoskeletal control and required for proper bipolar budding pattern; interacts with Rho1p YOR207C,RET1,PDS2, RPC2, RPC128 second-largest subunit of RNA polymerase III YNL297C,MON2,YSL2 protein with similarity to N-terminal region of the human protein BIG1 YPL016W,SWI1,ADR6, GAM3, LPA1 Global transcription activator that acts in complex with Snf2p, Snf5p, Snf6p, and Swi3p to assist gene-specific activators; involved in the regulation of expression of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2 YJL095W,BCK1,LAS3, SAP3, SLK1, SSP31 bypass requirement for protein kinase C homolog YPL110C Hypothetical ORF YBR023C,CHS3,CSD2, DIT101, KTI2, CAL1 Required for chitin synthesis. Enzyme responsible for the hyperaccumulation of chitin in response to cell wall stress. YBL034C,STU1 Suppressor of cold-sensitive tub2 mutation. Stu1p binds to interpolar microtubules of the mitotic spindle and plays an essential role in their ability to provide an outward force on the spindle poles. YPR030W,CSR2,MRG19 chs5 spa2 rescue; overexpression rescues the lethality of chs5 spa2 at 37 degrees YDR326C Hypothetical ORF YPR159W,KRE6,CWH48 cell wall beta-glucan assembly YMR284W,YKU70,HDF1, NES24 Shows homology to 70-kDa subunit of mammalian Ku protein, the regulatory subunit of the DNA-dependent protein kinase YLR094C,GIS3 GIG3 suppressor YFR022W Hypothetical ORF YPL018W,CTF19,MCM18 Chromosome Transmission Fidelity YDR470C,UGO1 outer membrane protein required for for mitochondrial fusion YFL004W,VTC2,PHM1 Phosphate metabolism; transcription is regulated by PHO system YOR316C,COT1 Protein involved in cobalt accumulation; dosage dependent suppressor of cobalt toxicity YPL040C,ISM1 nuclear encoded mitochondrial isoleucyl-tRNA synthetase YOR372C,NDD1 Nuclear Division Defective 1 YDR359C Vacuolar import degradation YGL071W,RCS1,AFT1 Involved in iron homeostasis and affects cell size regulation. Activates the expression of its target genes in response to low-iron conditions. YGL056C,SDS23 homolog of pombe SDS23; localizes to spindle pole body YDL065C,PEX19,PAS12 40 kDa farnesylated protein associated with peroxisomes YDR356W,SPC110,XCM1, NUF1 may be involved in connecting nuclear microtubules to the spindle pole body YGL124C,MON1 Product of gene unknown YNL284C,MRPL10 Mitochondrial ribosomal protein MRPL10 (YmL10) YKL103C,LAP4,APE1, YSC1, API vacuolar aminopeptidase ysc1 YIL085C,KTR7 Putative mannosyltransferase of the KRE2 family YFL021W,GAT1,NIL1, MEP80 activator of transcription of nitrogen-regulated genes; inactivated by increases in intracellular glutamate levels YFR018C Hypothetical ORF YGR255C,COQ6 Involved in ubiquinone biosynthesis YDR439W,LRS4 Loss of rDNA silencing YMR192W Hypothetical ORF YOR306C,MCH5 monocarboxylate permease homologue YGR241C,YAP1802 Yeast Assembly Polypeptide, member of AP180 protein family, binds Pan1p and clathrin YDR528W,HLR1 LRE1 homolog YMR030W Hypothetical ORF YJR094C,IME1 Transcriptional activator of meiotic gene expression. YNL287W,SEC21 non-clathrin coat protein involved in transport between ER and Golgi YPR144C,NOC4 U3 protein, localized to the nucleolus YNL316C,PHA2 prephenate dehydratase YHR182W Hypothetical ORF YMR243C,ZRC1,OSR1 Zinc- and cadmium-resistance protein YKL074C,MUD2 Involved in early pre-mRNA splicing YOR026W,BUB3 Protein required for cell cycle arrest in response to loss of microtubule function YGR221C Target of SBF YOR048C,RAT1,HKE1, TAP1, XRN2 RNA trafficking protein; transcription activator YNL189W,SRP1,KAP60, SCM1 karyopherin alpha homolog of 60 kDa YOR197W,MCA1,YCA1 metacaspase YLR313C,SPH1 SPa2-Homolog; protein involved in shmoo formation and required for bipolar bud site selection (GB:AF008236). YPL253C,VIK1 ar3p YLL010C,PSR1 Plasma membrane Sodium Response 1 YOR107W,RGS2 Regulator of G-protein Signalling for gpa2; belongs to the RGS protein family and acts on Gpa2 YOR338W Hypothetical ORF YAL062W,GDH3,FUN51 Involved in glutamate biosynthesis YMR110C Hypothetical ORF YJR132W,NMD5,KAP119 Involved in nuclear import YER178W,PDA1 alpha subunit of pyruvate dehydrogenase (E1 alpha) YBL075C,SSA3,HSP70 heat-inducible cytosolic member of the 70 kDa heat shock protein family YOR017W,PET127 May be component of mitochondrial translation system with role in promoting accuracy of translational initiation or may play a role in RNA surveillance or RNA processing in mitochondria YLR387C Hypothetical ORF YJL112W,MDV1,NET2, FIS2, GAG3 WD repeat protein that regulates steps in the Dnm1p-dependent process of mitochondrial fission. YLR121C,YPS3,YPS4 Gpi-anchored aspartic protease (Yapsin 3) YGL175C,SAE2,COM1 Involved in meiotic recombination and chromosome metabolism YCL055W,KAR4 May assist Ste12p in pheromone-dependent expression of KAR3 and CIK1 YPL141C Hypothetical ORF YNL045W Similar to human LTA4 hydrolase but in vivo substrates not yet defined. YKR038C Kinase-Associated Endopeptidase 1 YLR174W,IDP2 concerts isocitrate and NADP+ to 2-oxoglutarate, CO2, and NADPH YGR227W,DIE2,ALG10 De-repression of ITR1 Expression YDR508C,GNP1 high-affinity glutamine permease YBR025C Hypothetical ORF YPL245W Hypothetical ORF YOL082W,CVT19 Cytoplasm to Vacuole Targeting; Mutant is defective in import of aminopeptidase I through the cytoplasm to vacuole targeting pathway YML031W,NDC1 dispensable for mitotic spindle pole body duplication, but required for insertion of nascent spindle pole bodies into the nuclear envelope. ndc1 parental spindle pole bodies form monopolar spindles in mitosis. Required for meiosis II. YGR240C,PFK1 phosphofructokinase alpha subunit YER162C,RAD4 Nucleotide excision repair protein YDR518W,EUG1 ER protein functionally likely involved in interacting with nascent polypeptides in the ER YAL060W,BDH1 (2R,3R)-2,3-butanediol dehydrogenase YPL048W,CAM1,TEF3 Calcium and phospholipid binding protein homologous to translation elongation factor 1-gamma (EF-1gamma) YBR195C,MSI1,CAC3 chromatin assembly complex, subunit 3: Encodes the smallest (p50) subunit of the yeast Chromatin Assembly Factor-I (CAF-I) involved in DNA-replication-linked nucleosome assembly. Homologous to the small subunit of the Human CAF-I. YIL096C Hypothetical ORF YBL055C Hypothetical ORF YMR060C,TOM37,MAS37, PET3027 Translocase of the Outer Mitochondrial membrane YDL149W,APG9,AUT9, CVT7 Integral membrane protein YJL125C,GCD14 General Control Derepression YBR296C,PHO89,ITN1 Probable Na+/Pi symporter YJR042W,NUP85,RAT9 Protein in nuclear pore complex; may function in nuclear envelope integrity; may also be involved in tRNA biogenesis YDL079C,MRK1 putative protein kinase with similarity to mammalian glycogen synthase kinase-3 and Drosophila Zeste-White3/Shaggy YNL138W,SRV2,CAP N-terminal domain appears to be involved in cellular responsiveness to RAS. YDR172W,SUP35,GST1, PNM2, SAL3, SUF12, SUP2, SUP36, [PSI], [PSI altered form creates [PSI] prion YKR053C,YSR3,LBP2 Yeast Sphingolipid Resistance Gene YDR427W,RPN9 Regulatory Particle Non-ATPase YKR019C,IRS4 Increased rDNA silencing YGL064C,MRH4 mitochondrial RNA helicase YNL288W,CAF40 CCR4 Associated Factor 40 kDa YDR330W Hypothetical ORF YML020W Hypothetical ORF YEL060C,PRB1,CVT1, yscB dispensable for haploidization and sporulation, but needed for full protein degradation during sporulation, and proper spore morphology YMR232W,FUS2 Involved in cell fusion during mating, also required for the alignment of parental nuclei before nuclear fusion YGR123C,PPT1 serine/threonine phosphatase YPL009C Hypothetical ORF YGL107C Required for Meiotic nuclear Division YGR089W putative partner of Rpb8p YPR033C,HTS1,TSM4572 Nuclear gene that specifies two messages for cytoplasmic and mitochondrial forms YOR212W,STE4,HMD2 beta subunit of G protein coupled to mating factor receptor YJL180C,ATP12 essential for assembly of a functional F1-ATPase; binds the alpha subunit of F1-ATPase. YDR323C,PEP7,VAC1, VPL21, VPS19, VPT19 vacuolar segregation protein required for vacuole inheritance and vacuole protein sorting YMR098C Hypothetical ORF YIL131C,FKH1 forkhead protein YBR073W,RDH54,TID1 genetic interaction with DMC1 YPL112C,PEX25 required for regulation of peroxisome size and maintenance YLR452C,SST2 Protein involved in desensitization to alpha-factor pheromone YER089C,PTC2 Protein phosphatase type 2C YMR171C Hypothetical ORF YJR005W,APL1,YAP80 beta-adaptin, large subunit of the clathrin-associated protein complex YDL045C,FAD1 Flavin adenine dinucleotide (FAD) synthetase, which performs second step in synthesis of FAD from riboflavin YCR052W,RSC6 a subunit of RSC, a fifteen-protein chromatin remodeling complex and related to the swi/snf complex. YMR282C,AEP2,ATP13 Required for the translation of OLI1 mRNA. YGL190C,CDC55 Involved in cellular morphogenesis YNL224C Hypothetical ORF YLR081W,GAL2 Galactose transport, also able to transport hexoses YGR119C,NUP57 Forms complex with Nsp1p, Nup49p, and Nic96p at nuclear pore; this complex participates in nucleocytoplasmic transport; in vitro, Nsp1p, Nup49p and Nup57p form a 1:1:1 stoichiometric complex to which Nic96p can also bind YDL207W,GLE1,BRR3, RSS1 Polyadenylated-RNA-export factor; the HIV Rev protein may mimic function of Gle1 YNL295W Hypothetical ORF YHR205W,SCH9,KOM1 protein kinase involved in growth control, may be redundant with cAMP pathway YOR005C,DNL4,LIG4 DNA ligase IV homolog YLR453C,RIF2 Rap1p-Interacting Factor 2; interacts with the c-terminus of Rap1p and with Rif1p; has functional similarities with Rif1p; Rif2p and Rif1p have synergistic effects on telomere length and chromosome loss YDR435C,PPM1 carboxy methyl transferase for protein phosphatase 2A catalytic subunit YMR166C Hypothetical ORF YDR389W,SAC7 Suppressor of actin mutation YNL130C,CPT1 Phospholipid biosynthesis YCR038C,BUD5 GTP/GDP exchange factor for Rsr1 protein YMR146C,TIF34 p39 subunit of translation initiation factor eIF3 YGL086W,MAD1 coiled-coil protein involved in spindle-assembly checkpoint YNL037C,IDH1 alpha-4-beta-4 subunit of mitochondrial isocitrate dehydrogenase 1 YGL163C,RAD54,XRS1 Required for X-ray damage repair, mitotic recombination, and full meiotic recombination. mRNA increases in meiosis. YNR023W,SNF12,SWP73 73 kDa subunit of the SWI/SNF transcription activation complex, homolog of Rsc6p subunit of the RSC chromatin remodeling complex YDL047W,SIT4,LGN4 SIT4 suppress mutations in DBF2 YNL279W,PRM1 pheromone-regulated membrane protein YGL216W,KIP3 Kinesin-related protein YOL042W,NGL1 DNase/RNase (putative); CCR4 C-terminal homolog, homology to drosophila Angel gene YGR256W,GND2 6-phosphogluconate dehydrogenase, decarboxylating; converts 6-phosphogluconate + NADP to ribulose-5-phosphate + NADPH + CO2 YDL147W,RPN5,NAS5 Regulatory Particle Non-ATPase, homolog of mammalian proteasomal subunit p55 YOR051C Hypothetical ORF YGR103W,NOP7,YPH1 Nucleolar protein present in purified ribosome assembly intermediates. Required for rRNA processing; required for essential steps leading to synthesis of 60S ribosomal subunits. YOR198C,BFR1 Multicopy suppressor of BFA (Brefeldin A)-induced lethality; implicated in secretion and nuclear segregation YJL147C Hypothetical ORF YOR129C Hypothetical ORF YDR375C,BCS1 Mitochondrial protein of the CDC48/PAS1/SEC18 ATPase family, required for expression of functional Rieske iron-sulfur protein YGL244W,RTF1,CSL3 Directly or indirectly regulates DNA-binding properties of Spt15p, TATA box-binding protein, and relative activities of different TATA elements. Member of RNA polymerase II-associated Paf1 complex. YNL049C,SFB2 binds to Sed5p and Sec23p by distinct domains YGL179C Hypothetical ORF YPL224C,MMT2,MFT2 Protein involved in mitochondrial iron accumulation YHR015W,MIP6 RNA-binding protein, interacts with MEX67 YNL237W,YTP1 Yeast putative Transmembrane Protein YGR145W Essential Nucleolar Protein 2 YNL322C,KRE1 cell wall beta-glucan assembly YJL106W,IME2,SME1 Positive regulator of meiosis, dispensable for mitosis, stimulates early, middle and late gene expression and negatively regulates IME1 YPR093C Hypothetical ORF YIL046W,MET30,ZRG11 F-box protein involved in sulfur metabolism and protein ubiquitination YNR054C Protein required for cell viability YHR006W,STP2 Involved in pre-tRNA splicing and in uptake of branched-chain amino acids YNL330C,RPD3,REC3, SDI2, SDS6, MOF6 Transcription modifier; required for vegetative repression of early meiosis-specific as well as non-meiotic genes; required for mitotic intragenic and intergenic recombination and for sporulation YKL072W,STB6 binds Sin3p in two-hybrid assay YAL048C - YIL143C,SSL2,LOM3, RAD25 DNA helicase homolog; homolog of human XPBC, ERCC3 YOL027C,MDM38 Mitochondrial Distribution and Morphology YIL034C,CAP2 capping - addition of actin subunits YOL103W,ITR2,HRB612 member of sugar transporter superfamily YKR066C,CCP1 Cytochrome-c peroxidase YBR034C,HMT1,HCP1, ODP1, RMT1 hnRNP methyltransferase YJL058C Binding Protein of Tor2 YOR178C,GAC1 Regulatory subunit for phosphoprotein phosphatase type 1 (PP-1), also known as Glc7p, which regulates glycogen synthase-2 YOR071C Hypothetical ORF YDR333C Hypothetical ORF YLR120C,YPS1,YAP3 Gpi-anchored aspartic protease (Yapsin 1) YPL001W,HAT1 histone acetyltransferase YIL055C Hypothetical ORF YOR342C Hypothetical ORF YFR004W,RPN11,MPR1 Suppressor of mutant (ts on glycerol) tRNA gene deficient in the processing of its 3'-end; homologous to S. pombe PAD1 gene - global positive regulator of nuclear transcription and is involved in maintenance of chromatin structure YLR369W,SSQ1,SSC2 Stress seventy Q. involved in the synthesis and assembly of iron/sulfur clusters into proteins. YPL152W,RRD2,YPA2 Resistant to Rapamycin Deletion 2 YIL110W Hypothetical ORF YOR273C,TPO4 Polyamine transport protein YPL193W,RSA1 RiboSome Assembly YGL027C,CWH41,GLS1 Glucosidase I, involved in assembly of cell wall beta 1,6 glucan; an ER type II integral membrane N-glycoprotein YMR004W,MVP1 Protein required for sorting proteins to the vacuole YBL009W haspin YLR047C Hypothetical ORF YBR074W Hypothetical ORF YBL085W,BOI1,GIN7, BOB1 Involved in bud growth YHR097C Hypothetical ORF YMR068W,AVO2 Adheres VOraciously (to TOR2) YBR228W,SLX1 - YML015C,TAF11,TAF40 TFIID subunit (TBP-associated factor) with predicted molecular weight of 40 kD. YDL223C,HBT1 Hub1 target YEL009C,GCN4,AAS3, ARG9 transcriptional activator of amino acid biosynthetic genes YBR231C Actin Overexpression Resistant YKR087C Hypothetical ORF YDL179W,PCL9 PHO85 cyclin YOR194C,TOA1 Transcription factor IIA, large chain YBR185C,MBA1 involved in assembly of mitochondrial respiratory complexes YMR130W Hypothetical ORF YBR101C,FES1 facteur d'Echange pour ssa1p (French for "Ssa1p Exchange Factor") YKL107W Hypothetical ORF YER055C,HIS1 involved in the first step of histidine biosynthesis YKR055W,RHO4 ras homolog--GTP binding protein YMR039C,SUB1,TSP1 Suppressor of TFIIB mutations YPR069C,SPE3 biosynthesis of spermidine YGL232W Hypothetical ORF YDL124W Hypothetical ORF YOL077C,BRX1 Essential nucleolar protein required for biogenesis of the 60S ribosomal subunit YGR205W Hypothetical ORF YDR280W,RRP45 Ribosomal RNA Processing YKL091C Sec14p homolog YHR144C,DCD1 dCMP deaminase YOR065W,CYT1,CTC1, YOR29-16 Cytochrome c1 YIL050W,PCL7 PHO85 cyclin YLR150W,STM1,MPT4 Multicopy suppressor of tom1 and pop2 mutations. Genetically interacts with CDC13 to maintain telomere structure. YER163C Hypothetical ORF YMR084W Hypothetical ORF YNL168C Hypothetical ORF YJL055W Hypothetical ORF YAL027W Hypothetical ORF YLR186W,EMG1,NEP1 Essential for Mitotic Growth YAL037W Hypothetical ORF YKL071W Hypothetical ORF YIL020C,HIS6 phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase YOR126C,IAH1 isoamyl acetate-hydrolyzing esterase YIL049W,DFG10 Protein required for filamentous growth, cell polarity, and cellular elongation YDR383C,NKP1 Non-essential kinetochore protein YNL100W Hypothetical ORF YBR096W Hypothetical ORF YCR004C,YCP4 Protein with similarity to S. pombe brefeldin A resistance protein obr1 and E. coli WrbA protein which stimulates binding of Trp repressor to DNA YAR042W,SWH1 Similar to mammalian oxysterol-binding protein YLR201C Hypothetical ORF YPL077C Hypothetical ORF YLL041C,SDH2,ACN17 Yeast succinate dehydrogenase (SDH) is a tetramer of non-equivalent subunits--Sdh1p, Sdh2p, Sdh3p, Sdh4p--that couples the oxidation of succinate to the transfer of electrons to ubiquinone. YGR106C Hypothetical ORF YGR253C,PUP2,DOA5 Proteasome subunit YDR486C,VPS60,MOS10 vacuolar protein sorting (putative) YER153C,PET122 translational activator of cytochrome c oxidase subunit III YKL087C,CYT2 links heme covalently to apocytochrome c1 YML012W,ERV25 COPII coat component of certain ER-derived vesicles YPR107C,YTH1 Yeast 30kDa Homologue YEL012W,UBC8,GID3 Ubiquitin-conjugating enzyme that is able to ubiquitinate histones in vitro YOR078W,BUD21,UTP16, YOR29-29 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); YDR248C Hypothetical ORF YPL021W,ECM23,SRD2 ExtraCellular Mutant; similar to SRD1. Negative regulator of pseudohyphal growth. YPR174C Hypothetical ORF YBR067C,TIP1 cold- and heat-shock induced protein of the Srp1p/Tip1p family of serine-alanine-rich proteins YDL137W,ARF2 ADP-ribosylation factor 2 YOL111C Hypothetical ORF YBL107C Hypothetical ORF YCR027C,RHB1 rheb homologue YKL119C,VPH2,CLS10, VMA12 Required for the biogenesis of a functional vacuolar ATPase (V-ATPase), but not part of the final enzyme complex. YEL024W,RIP1 oxidizes ubiquinol at center P in the protonmotive Q cycle mechanism, transferring one electron to cytochrome c1 and generating a low-potential ubisemiquinone anion which reduces the low-potential cytochrome b-566 heme group YJR133W,XPT1 Xanthine Phosphoribosyl Transferase YDL135C,RDI1 Rho GDP dissociation inhibitor with activity toward Rho1p YKR065C Hypothetical ORF YHR189W,PTH1,PTH peptidyl-tRNA hydrolase YLR221C RiboSome Assembly YER104W,RTT105 same phenotype as RTT101, 102, 103, 104 YMR242C,RPL20A,RPL18A2 Homology to rat L18a YJR069C,HAM1 Product of gene unknown YOR297C,TIM18 mitochondrial inner membrane translocase YDR063W Hypothetical ORF YHR051W,COX6 subunit VI of cytochrome c oxidase YPR187W,RPO26,RPB6 subunit common to RNA polymerases I, II, and III YIL027C,KRE27 Killer toxin REsistant YHR116W Hypothetical ORF YKL002W,DID4,VPS2, GRD7, REN1, VPL2, VPT14 - YJR047C,ANB1,HYP1, TIF51B hypusine containg protein; ANB1 is expressed under anaerobic conditions and repressed under aerobic conditions whereas its homolog HYP2 is inversely regulated YML077W,BET5 Bet5p/18kD component of TRAPP YBR188C,NTC20 Prp19p (NineTeen)-associated Complex protein YIL062C,ARC15 Arp complex subunit YIL040W - YDR482C,CWC21 Complexed With Cef1p YNR004W Hypothetical ORF YER137C Hypothetical ORF YDR209C Hypothetical ORF YIL087C Hypothetical ORF YER071C Hypothetical ORF YHR126C Hypothetical ORF YEL048C Hypothetical ORF YDR024W,FYV1 Function required for Yeast Viability on toxin exposure YOR186W Hypothetical ORF YMR002W Hypothetical ORF YHL042W Hypothetical ORF YKR073C Hypothetical ORF YLR390W,ECM19 ExtraCellular Mutant YOL166C Hypothetical ORF YOR343C Hypothetical ORF YLL017W,SDC25 homologous to cdc25 YMR031W-A Hypothetical ORF YNL122C Hypothetical ORF YDL081C,RPP1A,RPLA1 Homology to rat P1, human P1, and E.coli L12eIIA YHR173C Hypothetical ORF YGL041C Hypothetical ORF YAL066W Hypothetical ORF YBL091C-A SCS2 homologue YKL044W Hypothetical ORF YLR053C Hypothetical ORF YDR281C,PHM6 Phosphate metabolism; transcription is regulated by PHO system YJL144W Hypothetical ORF YBR262C Hypothetical ORF YDR079W,PET100 cytochrome c oxidase-specific assembly factor YEL068C Hypothetical ORF YOR029W Hypothetical ORF YPR094W,RDS3 Protein required for cell viability YGL149W Hypothetical ORF YNL147W,LSM7 Like Sm-G protein YOR226C,ISU2,NUA2 Iron-sulfur cluster nifU-like protein YDR231C,COX20 COX: cytochrome oxidase, 20: 20th gene involved in cytochrome oxidase activity YCL041C Protein required for cell viability YMR246W,FAA4 acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatty acid activator 2), activates imported fatty acids and provides substrates for N-myristoylation YDR115W Hypothetical ORF YAL035C-A - YKR041W Hypothetical ORF YPL187W,MF mating factor alpha YJR017C,ESS1,PTF1, PIN1 Mitotic regulator; structurally and functionally homologous to human PIN1 YKR012C Hypothetical ORF YLR249W,YEF3,TEF3 contains two ABC cassettes, and binds and hydrolyses ATP YCL042W Hypothetical ORF YHR021W-A,ECM12 ExtraCellular Mutant YML089C Hypothetical ORF YOL151W,GRE2 induced by osmotic stress; similar to dihydroflavonol 4-reductase from plants YFL043C - YPL034W Hypothetical ORF YNL202W,SPS19,SPX19 late sporulation specific gene which may function during spore wall formation YFL013W-A - YBR266C Hypothetical ORF YGL108C Hypothetical ORF YOR012W Hypothetical ORF YGL198W,YIP4 rotein 4 YDL228C Hypothetical ORF YBR189W,RPS9B,RPS13A, SUP46 Homology to rat S9 and E. coli S4 YDR401W Hypothetical ORF YDR396W Protein required for cell viability YML010W-A - YFL057C,AAD16 Hypothetical ORF YNL090W,RHO2 Gtp-binding protein of the rho subfamily of ras-like proteins YJL175W Hypothetical ORF YLR448W,RPL6B Homology to rat and human L6; involved initiation of protein synthesis YPR102C,RPL11A Homology to rat L11 and E. coli L5 YNL089C Hypothetical ORF YLR170C,APS1,YAP19 Involved in a subset of clathrin functions at the Golgi YKR035C Hypothetical ORF YPL081W,RPS9A Homology to rat S9 and E.coli S4 YGL069C Protein required for cell viability YMR143W,RPS16A Homology to rat S16 YKR033C Hypothetical ORF YDL082W,RPL13A Homology to rat L13 YNL174W Hypothetical ORF YFL064C Hypothetical ORF YCL066W,HMLALPHA1,ALPHA1, MATALPHA1 transcription factor involved in the regulation of alpha-specific genes YDR418W,RPL12B Homology to rat L12(a) and E. coli L11 YNL319W Hypothetical ORF YLR325C,RPL38 Homology to rat L38 YHR143W-A,RPC10,RPB12 subunit of RNA polymerase II YOR298C-A,MBF1,SUF13 bridges the DNA-binding region of GCN4 and TBP; similar to multiprotein bridging factor 1 of Bombyx mori YNL145W,MFA2 lipopeptide mating pheromone YER091C-A Hypothetical ORF YKL033W-A Similar to S. pombe hypothetical proteins YDL232W,OST4 subunit or accessory component of oligosaccharyltransferase YOR008C-A diepoxybutane and mitomycin C resistance YML081C-A,ATP18 Subunit i/j of mitochondrial ATP synthase. Similar to S. pombe hypothetical protein YPR133W-A,TOM5,MOM8A Translocase of the Outer Mitochondrial membrane YOR304C-A Hypothetical ORF YMR174C,PAI3 Cytoplasmic inhibitor of proteinase Pep4p YDL067C,COX9 Plays role in cytochrome c oxidase holoenzyme assembly or stability YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL - YKR031C,SPO14,PLD1 Catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid. Dispensable for mitosis, premeiotic DNA synthesis, recombination, meiosis I. Required for commitment to meiosis, meiosis II and sporulation. YLR398C,SKI2 blocks translation of non-poly(A) mRNAs YFL034W Hypothetical ORF YJL050W,MTR4,DOB1 Dead-box family helicase required for mRNA export from nucleus YJL113W TyB Gag-Pol protein YMR218C,TRS130 targeting complex (TRAPP) component involved in ER to Golgi membrane traffic; 130 kD subunit YNL091W,NST1 olerance YGR098C,ESP1 Esp1 promotes sister chromatid separation by mediating dissociation from the chromatin of the cohesin Scc1. The anaphase-promoting complex promotes anaphase by mediating destruction of Pds1 which binds to Esp1 and inhibits its activity YOR191W,RIS1,DIS1 Role in silencing YLR087C,CSF1 Cold Sensitive for Fermentation in cs mutants, fermentation capacity is almost none at 5 deg C, but restored to wild type at 25 deg C YBR115C,LYS2 A key step in fungal biosynthesis of lysine, enzymatic reduction of alpha-aminoadipate at C6 to the semialdehyde is catalyzed by holo-Lys2p, which is generated from apo-Lys2p by addition of phosphopantetheine by Lys5p. YML072C Hypothetical ORF YOR116C,RPO31,RPC1, RPC160 RNA polymerase III large subunit YBL105C,PKC1,CLY15, HPO2, STT1 Protein Kinase C YDR406W,PDR15 similar to Pdr5p and Pdr10p YNL088W,TOP2,TOR3, TRF3 dispensable for premeiotic DNA synthesis and recombination, but required for meiosis I YPR049C,CVT9 Oligomeric, coiled-coil, peripheral membrane protein YDL019C,OSH2 Oxysterol Binding Protein YCR042C,TAF2,TAF150, TSM1 TATA binding protein-associated factor (TAF) YIL147C,SLN1,YPD2 Synthetic lethal of N-end rule YJL222W,VTH2 vps ten homolog YNL172W,APC1 anaphase-promoting complex component YLR410W,VIP1 Homologous to S. pombe asp1+ YPL226W,NEW1 This gene encodes a protein with an Q/N-rich amino terminal domain that acts as a prion, termed [NU]+. YGR238C,KEL2 protein containing six kelch repeats suspected of mediating binding interactions with actin; similar to KEL1 and KEL3. YLL003W,SFI1 Product of gene unknown YPR055W,SEC8 121 kDa component of the Exocyst complex, which is required for exocytosis, and which also contains the gene products encoded by SEC3, SEC5, SEC6, SEC10, SEC15, and EXO70 YIL036W,CST6,ACA2, SHF1 Chromosome STability; contains an ATF/CREB-like bZIP domain; transcriptional activator; interacts with the STB locus on 2-micron plasmid YMR027W High level expression reduced Ty3 Transposition YER173W,RAD24,RS1 checkpoint protein YLR020C Hypothetical ORF YDR495C,VPS3,PEP6, VPL3, VPT17 vacuolar sorting protein YKL098W Hypothetical ORF YOR092W,ECM3,YOR3165W ExtraCellular Mutant YGL066W,SGF73 SaGa associated Factor 73kDa YOL043C,NTG2,SCR2 Endonuclease III-like glycosylase YNL233W,BNI4 bud neck involved YGL223C,COG1,COD3 Complexed with Cog8p; interacts with Cog2p YKR092C,SRP40 Suppressor of mutant AC40 subunit of RNA polymerase I and III (high serine) YBL067C,UBP13 similar to Ubp9p YHR177W Hypothetical ORF YOR354C,MSC6 Meiotic Sister-Chromatid recombination YOR007C,SGT2 small glutamine-rich tetratricopeptide repeat containing protein YIL023C Hypothetical ORF YNL141W,AAH1 adenine aminohydrolase (adenine deaminase) YCR030C,SYP1,YCR029C-A rofilin deletion YLR056W,ERG3,SYR1, PSO6 C-5 sterol desaturase YML131W Hypothetical ORF YLR424W Protein required for cell viability YDL116W,NUP84 component of nuclear pores; Part of complex with Nup120p, Nup85p, Sec13p, and a Sec13p homolog YDL240W,LRG1 Expressed most highly in sporulating cells; may also play a role during mating YIL037C,PRM2 pheromone-regulated membrane protein YJL137C,GLG2 self-glucosylating initiator of glycogen synthesis; similar to mammalian glycogenin YOR361C,PRT1,CDC63, DNA26 translation initiation factor eIF3 subunit YNR013C,PHO91 Low-affinity phosphate transporter YGR121C,MEP1,AMT1 belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH(4)(+) + NH(3)). YFL018C,LPD1,HPD1 an FAD flavoprotein which contains a pair of redox-active cysteines involved in the transfer of reducing equivalents from the FAD cofactor to the substrate YIL125W,KGD1,OGD1 alpha-ketoglutarate dehydrogenase YLR299W,ECM38,CIS2 ExtraCellular Mutant; cik1 suppressor YBR274W,CHK1 checkpoint kinase 1; homolog of the S. pombe and mammalian Chk1 checkpoint kinases YBR143C,SUP45,SAL4, SUP1, SUP47, eRF1 Recessive omnipotent suppressor. The wild-type gene functions in termination of translation. YHR048W Hypothetical ORF YJR046W,TAH11,SID2, CDT1 Essential protein. YMR058W,FET3 FET3 encodes a ferro-O2-oxidoreductase that is part of the high-affinity iron transport system YDR077W,SED1 putative cell surface glycoprotein YER041W,YEN1 - YJL103C Hypothetical ORF YJL164C,TPK1,PKA1, SRA3 putative catalytic subunit of cAMP-dependent protein kinase YLR343W Hypothetical ORF YOL003C DHHC-CRD protein YER060W,FCY21 identical to FCY2 YML029W,USA1 Identified by its interaction with the U1 snRNP-specific protein, Snp1p. YKL181W,PRS1,PRP1 ribose-phosphate pyrophosphokinase YLL018C,DPS1 Aspartyl-tRNA synthetase, cytosolic YJL117W,PHO86 May collaborate with Pho87p and Pho84p in phosphate uptake YGR194C,XKS1 third enzyme in the xylose pathway YBL031W,SHE1 Product of gene unknown YMR070W,MOT3,ROX7 High Copy Suppressor of MOT1-SPT3 synthetic lethality. May have a role in the regulation of membrane-related genes. YML004C,GLO1 Regulated by HOG (high osmolarity glycerol)-MAP (mitogen-activated protein) kinase pathway in osmotic stress response YNL059C,ARP5 Actin-related protein. Part of the carboxypeptidase Y pathway. YJR105W,ADO1 adenosine kinase YIL128W,MET18,MMS19 Involved in nucleotide excision repair and regulation of TFIIH YBR273C Hypothetical ORF YNL142W,MEP2 belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH(4)(+) + NH(3)). YMR227C,TAF7,TAF67 TFIID subunit (TBP-associated factor) with predicted molecular weight of 67 kD YOR246C Hypothetical ORF YMR191W Hypothetical ORF YKR003W,OSH6 Oxysterol Binding Protein YGL014W,PUF4,YGL023 member of the PUF protein family YBR203W,COS111 Ciclopirox olamine sensitive, COS111 is not part of the gene family containing genes COS1-COS10, COS12, and COS16. YOR112W Hypothetical ORF YDL048C,STP4 Involved in pre-tRNA splicing and in uptake of branched-chain amino acids YNL103W,MET4 main transcriptional activator of the sulfate assimilation pathway YNR069C,BSC5 Bypass of Stop Codon transcript encoded by this ORF shows a high level of stop codon bypass YJR106W,ECM27 ExtraCellular Mutant YGL105W,ARC1 associated with tRNA and amino acyl-tRNA synthetases; has affinity for quadruplex nucleic acids YNL238W,KEX2,QDS1, VMA45, SRB1 prohormone processing; golgi localization marker, dispensable for meiotic recombination but partially required for meiosis I and/or meiosis II YLR330W,CHS5,CAL3 Involved in chitin synthase III activity, also required for homozygosis in the first stages of mating YDR109C Hypothetical ORF YOL084W,PHM7 - YML066C,SMA2 Spore Membrane Assembly YGL172W,NUP49,NSP49 localizes to discrete spots in the nuclear envelope YOL113W,SKM1 Serine/threonine protein kinase with similarity to Ste20p and Cla4p YLR409C Protein required for cell viability YDR147W,EKI1 Ethanolamine Kinase 1 YPL097W,MSY1 Tyrosyl-tRNA synthetase YOR231W,MKK1,SSP32 Mitogen-activated kinase-kinase involved in protein kinase C pathway YGL246C,RAI1 Product of gene unknown YOR340C,RPA43 DNA-dependent RNA polymerase I subunit A43 YNL094W Actin Patch Protein YDR242W,AMD2 putative amidase YBL024W,NCL1,TRM4 Nuclear protein 1, similar to NOP2 and human proliferation associated nucleolar protein p120 YBR240C,THI2,PHO6 Transcriptional activator of thiamine biosynthetic genes YHR143W,DSE2 Daugher Specific Expression 2 YOR374W,ALD4,ALD7 Glucose repressed. Utilizes NADP+ or NAD+ as a coenzyme equally well. (sold by SIGMA under the catalogue number A5550, according to A. Blomberg). YOR035C,SHE4,DIM1 Required for mother cell-specific HO expression YDR539W Hypothetical ORF YER007W,PAC2 Required for viability in the absence of the kinesin-related mitotic motor Cin8p; required for normal microtubule stability YLR238W,FAR10 Pheromone Arrest YGR263C presents weak similarity to a putative protein defined as a lipase-like enzyme YER090W,TRP2 anthranilate synthase Component I YBR294W,SUL1 sulfate uptake is mediated by specific sulfate transporters SUL1 and SUL2, which control the concentration of endogenous activated sulfate intermediates. YNL007C,SIS1 HSP40 family chaperone YGL159W Hypothetical ORF YML060W,OGG1 Excises 7,8-dihydro-8-oxoguanine (8-OxoG) when 8-OxoG is oppposite cytosine or thymine (but not adenine) YHR085W Involved in Processing ITS2 YGL251C,HFM1,MER3 DNA helicase that functions in meiotic crossing over YDL190C,UFD2 Ubiquitin fusion degradation protein YNL294C,RIM21,PAL2 Regulator of IME2 YGR092W,DBF2 Kinase required for late nuclear division. Cdc15 promotes the exit from mitosis by directly switching on the kinase activity of Dbf2. YMR309C,NIP1 Protein required for nuclear import with some similarity to Nsr1p, another protein involved in nuclear transport YLR001C Hypothetical ORF YHR154W,RTT107,ESC4 Regulator of Ty1 Transposition; Establishes Silent Chromatin YGR009C,SEC9,HSS7 Putative t-SNARE of the plasma membrane YPL204W,HRR25 Similar to YCK1 and YCK2, two other casein kinase I isoforms; found primarily in nucleus; may be involved in DNA-damage repair YGR224W,AZR1 MFS-MDR YNL326C likely functions in pathway(s) outside Ras; not essential for vegetive growth YLR227C,ADY4 Accumulation of dyads YJR054W Hypothetical ORF YIL071C,PCI8,YIH1, CSN11 subunit of COP9 signalosome (CSN); Proteasome-COP9 signalosome-eukarytotic Initiation factor 3 (PCI) domain-containing protein YBR112C,CYC8,CRT8, SSN6 General repressor of transcription (with Tup1p); mediates glucose repression YIL107C,PFK26 6-Phosphofructose-2-kinase YBR162C Target of SBF YLL013C,PUF3 member of the PUF protein family, which is named for the founding members, PUmilio and Fbf YDL194W,SNF3 glucose sensor YJL060W,BNA3 Biosynthesis of Nicotinic Acid YBR126C,TPS1,BYP1, CIF1, FDP1, GGS1, GLC6, TSS1 Probable regulator of glucose influx into the cell & into glycolytic pathway, indirectly regulating glucose-induced signalling (activation & inactivation) & initial step(s) of glucose metabolism. Homologue of E. coli otsA protein YKL161C Mpk1-like protein kinase; associates with Rlm1p YDR081C,PDC2 Regulates transcription of PDC1 and PDC5, which encode pyruvate decarboxylase YLR372W,SUR4,ELO3, SRE1, VBM1 Required for conversion of 24-carbon fatty acids to 26-carbon species YKL033W Protein required for cell viability YCL009C,ILV6 acetolactate synthase regulatory subunit YML120C,NDI1 NADH dehydrogenase (ubiquinone) YDR142C,PEX7,PAS7, PEB1 May serve as intraperoxisomal receptor for type 2 peroxisomal proteins (such as thiolase) YNL039W,BDP1,TFC5 RNA polymerase III Transcription factor TFIIIB (90 kDa subunit; also called TFIIIB90 or B'' or B''90 component) YDR363W,ESC2 Establishes Silent Chromatin YLR005W,SSL1 Component of RNA polymerase transcription factor TFIIH YDL029W,ARP2,ACT2 Involved in endocytosis and membrane growth and polarity YMR136W,GAT2 Similar to GATA-family of DNA binding proteins YER142C,MAG1,MMS5 3-methyladenine DNA glycosylase YNL225C,CNM67 chaotic nuclear migration; predicted mass is 67kDa YMR036C,MIH1 S. pombe cdc25+ homolog YDL180W Hypothetical ORF YCR011C,ADP1 Shows homology to ATP-dependent permeases YKR098C,UBP11 Ubiquitin-specific protease YBR103W,SIF2,EMB1 Sir4p-Interacting Factor YHR197W Involved in Processing ITS2 YPL158C Hypothetical ORF YGL099W,LSG1,KRE35 Killer toxin REsistant YDR082W,STN1 involved in telomere length regulation, function in telomere metabolism during late S phase YLR098C,CHA4,SIL2, SIL3 Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain YCR035C,RRP43 Ribosomal RNA Processing YKL047W Hypothetical ORF YPR057W,BRR1 Protein involved in snRNP biogenesis YFL037W,TUB2,ARM10, SHE8 beta subunit of tubulin monomer; involved in chromosome segregation and nuclear migration YMR278W Hypothetical ORF YDL117W,CYK3 involved in CYtoKinesis YLR114C PHO85 Requiring YAL031C,FUN21 Function unknown now YHL008C Hypothetical ORF YGL180W,APG1,AUT3 Required for autophagy YNR045W,PET494 translational activator of cytochrome c oxidase YBR139W Hypothetical ORF YHR137W,ARO9 aromatic amino acid aminotransferase II YGL205W,POX1,FOX1 fatty-acyl coenzyme A oxidase YMR215W,GAS3 Hypothetical ORF YPL153C,RAD53,LSD1, MEC2, SPK1 Required for DNA damage-induced checkpoint arest in G1, S/M, and G2/M in mitosis, dispensable for sporulation but required for wild-type spore viability; Mec1p and Tel1p regulate rad53p phosphorylation YGL082W Hypothetical ORF YLR039C,RIC1 Ric1p binds to Rgp1p, on the Golgi, and the complex catalyses nucleotide exchange on Ypt6p. YBR028C Hypothetical ORF YGR084C,MRP13 35 kDa mitochondrial ribosomal small subunit protein YNL092W Hypothetical ORF YPR005C,HAL1 Protein induced by NaCl, KCl, or sorbitol; involved in halotolerance (tolerance to salt) YGR169C,PUS6 RNA:Psi-synthase YMR056C,AAC1 minor species of mitochondrial ADP/ATP translocator, highly homologous to PET9 (AAC2) and AAC3 YBR170C,NPL4,HRD4 Nuclear pore or nuclear pore-associated protein required for nuclear membrane integrity and nuclear transport YGR283C Hypothetical ORF YNL173C,MDG1 multicopy suppressor of bem1 mutation, may be involved in G-protein mediated signal transduction; binds cruciform DNA YBR128C,APG14 Required for autophagy YHR104W,GRE3 Induced by osmotic stress; similar to xylose reductase from other fungi. Reduces xylose to xylitol. YNL239W,LAP3,BLH1, GAL6, YCP1 AKA bleomycin hydrolase. This protein may represent the first example of a eukaryotic DNA-binding protease. YCL038C,AUT4 Autophagy gene essential for breakdown of autophagic vesicles in the vacuole YIL083C Homolog to human PPCS YNL307C,MCK1,YPK1 Disp. for mitosis, required for chr. segregation, benomyl resist., basal IME1 transcript. in mitosis, IME1 induction in meiosis & ascus mat. independ. of IME1; maybe in mitotic chr. segregation specific to CDEIII YCL074W Psuedogene: encodes fragment of Ty Pol protein YIL084C,SDS3 Suppressor of Defective Silencing 3Functions are similar to those of SIN3 and RPD3 YOR030W,DFG16,ECM41, ZRG11 Involved in cell wall maintenance, filamentous growth YDL237W Hypothetical ORF YOR039W,CKB2 protein kinase CK2, beta' subunit YPL149W,APG5 Involved in autophagy YHR058C,MED6 RNA polymerase II transcriptional regulation mediator YHR163W,SOL3 weak multicopy suppressor of los1-1 YLR030W Hypothetical ORF YHL034C,SBP1,SSBR1, SSB1 single stranded nucleic acid binding protein YKR104W New Full-length MRP-type Transporter ORFs YKR103W and YKR104W are merged in different strain backgrounds. YPL068C Hypothetical ORF YCL031C,RRP7 involved in rRNA processing YBR119W,MUD1 U1 snRNP A protein YMR149W,SWP1 oligosaccharyl transferase glycoprotein complex, delta subunit YNL196C Sporulation-specific protein with a leucine zipper motif YPL031C,PHO85 involved in phosphate and glycogen metabolism and cell cycle progression YDL198C,YHM1 high copy suppressor of abf2 lacking the HMG1-like mitochondrial HM protein; putative mitochondrial carrier protein YDL076C Hypothetical ORF YLR393W,ATP10 essential for assembly of a functional mitochondrial ATPase complex YGL050W Hypothetical ORF YGR053C Hypothetical ORF YPR116W Hypothetical ORF YAL039C,CYC3 cytochrome c heme lyase (CCHL) YIL070C,MAM33 33-kDa mitochondrial acidic matrix protein YER053C sequence similarity to mitochondrial phosphate transporters YNL155W Hypothetical ORF YEL051W,VMA8 vacuolar ATPase V1 domain subunit D YOL028C,YAP7 basic leucine zipper (bZIP) transcription factor YER010C Hypothetical ORF YHR122W Protein required for cell viability YAR027W,UIP3 Ulp1 Interacting Protein 3 YBL057C,PTH2 peptidyl-tRNA hydrolase YOR305W Hypothetical ORF YPR158W Hypothetical ORF YLR126C Hypothetical ORF YJL063C,MRPL8,HRD238, YML8 Mitochondrial ribosomal protein MRPL8 (YmL8) (E. coli L17) YGR036C,CAX4,CWH8 CAX4p contains 3 short stretches of amino acids that are characteristic for a wide variety of phosphatases, including lipid phosphatases and a protein phosphatase. YGL079W Hypothetical ORF YFL006W Hypothetical ORF YDR174W,HMO1,HSM2 one of seven HMG-box proteins of Saccharomyces cerevisiae. YBR193C,MED8 Member of RNA Polymerase II transcriptional regulation mediator YNL178W,RPS3,SUF14 Homology to mammalian S3. The AP endonuclease activity of Rps3p is affected by pH, KCl, and beta-mercaptoethanol, but not Triton X-100 or EDTA. YHL031C,GOS1 SNARE protein with a C-terminal membrane anchornare YDR043C,NRG1 involved in regulation of glucose repression YMR271C,URA10 Fifth step in pyrimidine bio5 YLL038C,ENT4 epsin N-terminal homology-containing protein YML064C,TEM1 Gtp-binding protein of the ras superfamily involved in termination of M-phase YML113W,DAT1 datin, an oligo(dA).oligo(dT)-binding protein YLR268W,SEC22,SLY2, TSL26 Synaptobrevin (v-SNARE) homolog present on ER to Golgi vesicles YKR085C,MRPL20,YML20 22.3 kDa mitochondrial ribosomal large subunit protein YmL20; homologous to L17 of E. coli YFR001W,LOC1 Localization of mRNA YDR022C,CIS1 Involved in microtubule assembly YFR042W Protein required for cell viability YDL165W,CDC36,DNA19, NOT2 Required for Start B in mitosis and for meiosis I spindle pole body separation YDL098C,SNU23 23 kD U4/U6.U5 snRNP associated protein YHR157W,REC104 meiosis-specific recombination gene, dispensable for mitotic recombination and axial elements in meiosis, required for tripartite synaptonemal complexes, meiotic recombination and spore viability; classified as an early recombination gene YLR009W,RLP24 Ribosomal Like Protein 24 YLR036C Hypothetical ORF YJL170C,ASG7 an a-specific gene that is induced to a higher expression level by alpha factor YJL024C,APS3,YKS7 sigma3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function YGL242C Hypothetical ORF YKR068C,BET3 Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles YAR023C Hypothetical ORF YOL129W,VPS68 - YJL217W Hypothetical ORF YNL069C,RPL16B,RP23 Homology to rat ribosomal protein L13a YOR096W,RPS7A,RPS30 Homology to human S7 and Xenopus S8 YIL127C Hypothetical ORF YIL157C Hypothetical ORF YDL053C Hypothetical ORF YDR478W,SNM1 Has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. YGR275W,RTT102 Regulator of Ty1 Transposition YHR060W,VMA22,CEV1, VPH6 Required for V-ATPase activity. Required for the biogenesis of a functional vacuolar ATPase (V-ATPase), but not part of the final enzyme complex. YDR059C,UBC5 ubiquitin-conjugating enzyme YGR107W Hypothetical ORF YCR043C Hypothetical ORF YNL081C sick with securin disruption YKL167C,MRP49 16 kDa mitochondrial ribosomal large subunit protein YIL163C Hypothetical ORF YPL059W,GRX5 Member of glutaredoxin subfamily together w/GRX3, GRX4. Significant sequence diff. from other glutaredoxin subfamily, GRX1 & GRX2. Part of mt machinery involved in synthesis/assembly of iron/sulfur centers. YPR082C,DIB1 Homolog of S. pombe dim1+ YGR203W Similar to Hs CDC25 and Sc ACR2 YBL049W Hypothetical ORF YLR344W,RPL26A Homology to rat L26 YLR112W Hypothetical ORF YMR112C,MED11 14 Kd mediator subunit of RNA polymerase II holoenzyme YOL127W,RPL25 Homology to E. coli L23 and rat L23a YLR211C Hypothetical ORF YMR252C Hypothetical ORF YAL030W,SNC1 Involved in mediating targeting and transport of secretory proteins; forms a complex with Snc2p and Sec9p YER093C-A Hypothetical ORF YFR057W Hypothetical ORF YER187W Hypothetical ORF YJL027C Hypothetical ORF YDR471W,RPL27B Homology to mammalian L27 YPR017C,DSS4 dominant suppressor of sec4 YDR308C,SRB7 Suppressor of RNA polymerase II, possible component of the holoenzyme YBL071C Hypothetical ORF YDR424C,DYN2,SLC1 putative light chain of dynein YPL261C Hypothetical ORF YMR286W,MRPL33,YML33 essential for mitochondrial function YMR175W,SIP18 Salt-Induced Protein YGL030W,RPL30 Homology to rat and mouse L30 YDL045W-A,MRP10 Involved in mitochondrial translation YLL018C-A,COX19 cytochrome oxidase gene 19. Clone containing this region complements respiratory deficient mutants of group G188 (Dr. A. Tzagoloff). Defect affects specifically cytochrome oxidase activity in mitochondria. YCR020W-B,HTL1 High-Temperature Lethal YPR012W Hypothetical ORF YER039C-A Hypothetical ORF YOR072W Hypothetical ORF YGL204C Hypothetical ORF YKL086W Hypothetical ORF YGR037C,ACB1 Involved in transport of newly synthesized acyl-CoA esters from the fatty acid synthetase to acyl-CoA-consuming processes YPL205C Hypothetical ORF YNL086W Hypothetical ORF YLR437C Hypothetical ORF YAR070C Hypothetical ORF YLR185W,RPL37A Homology to rat L37 YER019C-A,SBH2,SEB2 Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum YGR105W,VMA21 Protein involved in vacuolar H-ATPase assembly or function. Required for the biogenesis of a functional vacuolar ATPase (V-ATPase), but not part of the final enzyme complex. YPR142C Protein required for cell viability YJL018W - YML100W-A - YLL020C Hypothetical ORF YJL065C Hypothetical ORF YHR145C Hypothetical ORF YMR119W-A Hypothetical ORF YIL141W Hypothetical ORF YGR138C,TPO2 Polyamine transport protein YOL133W,HRT1,RBX1, ROC1, HRT2 High level expression Reduces Ty3 Transposition YNL028W Hypothetical ORF YML032C-A deleted (8/23/1999) YPR058W,YMC1 putative mitochondrial carrier protein YLR202C Hypothetical ORF YKL037W Hypothetical ORF YML058C-A - YOR013W Hypothetical ORF YLR374C Hypothetical ORF YLR169W Hypothetical ORF YGR064W Hypothetical ORF YGR242W Hypothetical ORF YCR062W - YDL131W,LYS21 homocitrate synthase, highly homologous to YDL182W YKL006W,RPL14A Homology to mammalian L14 YKR094C,RPL40B,UBI2, CEP52B, UB12 Homology to rat L40 YNL031C,HHT2 Histone H3 (HHT1 and HHT2 code for identical proteins) YNL013C Hypothetical ORF YNL276C Hypothetical ORF YKL136W Hypothetical ORF YPL197C Hypothetical ORF YOR041C Hypothetical ORF YPL114W Hypothetical ORF YBL083C Hypothetical ORF YCR104W,PAU3 member of the seripauperin protein/gene family (see Gene_class PAU) YAL043C-A - YDL118W Hypothetical ORF YLR076C Protein required for cell viability YAL065C Hypothetical ORF YDR134C Hypothetical ORF YGR265W Protein required for cell viability YNR005C Hypothetical ORF YLR317W Hypothetical ORF YDR053W Protein required for cell viability YOL165C,AAD15 high degree of similarity with the AAD of P. chrysosporium YPR077C Hypothetical ORF YAL064C-A Hypothetical ORF YBR218C,PYC2 converts pyruvate to oxaloacetate YOL035C Hypothetical ORF YHR053C,CUP1-1,CUP1 required for cell growth at high copper concentrations. YDR327W Protein required for cell viability YGR290W Hypothetical ORF YNL150W Protein required for cell viability YDR543C Hypothetical ORF YNR077C Hypothetical ORF YMR251W-A,HOR7 hyperosmolarity-responsive gene YER067W Hypothetical ORF YOR276W,CAF20,CAF2, CAP20 binds to eIF-4E, the mRNA cap-binding protein, and represses cap-dependent translation initiation by interfering with the interaction of eIF4E and eIF4G YOR382W,FIT2 FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylphosphatidylinositol anchors. YKL123W Hypothetical ORF YLR230W Protein required for cell viability YJL189W,RPL39,PUB2, RPL46, SPB2 Homology to rat L39 YGR063C,SPT4 Zn-finger protein, transcriptional regulator YNL113W,RPC19 subunit common to RNA polymerases I (A) and III (C) YDL158C Hypothetical ORF YDR210W Hypothetical ORF YDR034C-A Similar to probable membrane protein YLR334C and ORF YOL106W YKL163W,PIR3,CCW8 Protein containing tandem internal repeats YGR137W Hypothetical ORF YBR051W Hypothetical ORF YEAST_CONTROL - HUMAN_CONTROL - E._COLI_CONTROL - LAMBDA_CONTROL - PHI174_CONTROL -