Postdoctoral research positions in machine learning and computational biology

Mentor: Dr. William Noble
Department of Genome Sciences
University of Washington, Seattle WA 98109

The Noble lab has several openings for postdoctoral fellows to work on machine learning projects related to genomics and proteomics. An ideal candidate will be motivated by the desire to develop and apply novel machine learning techniques. Familiarity with genomic or proteomic data is not required, but candidates must be prepared to become intimately familiar with these complex data types and the generative processes that underlie them.

Genomics and proteomics of the malaria parasite. We have an ongoing collaboration with the lab of Karine Le Roch to study mechanisms of gene regulation in the malaria parasite, Plasmodium falciparum. This project’s main goal is to characterize the molecular determinants that control chromatin organization and gene regulation in this pathogen. The research continues a longstanding collaboraiton between the Le Roch and Noble labs and builds upon a large body of molecular, cellular, and genome-wide data generated in the Le Roch lab that demonstrate how 3D genome organization and transcription regulate sexual differentiation and parasite development.

3D genome architecture changes in HIV and methamphetamine use. The human genome is hierarchically organized in the nucleus, and this 3D organization critically impacts nuclear processes such as gene expression and DNA replication, as well as HIV integration sites and expression. This project will use genomic technologies to elucidate the role of 3D chromatin architecture in maintaining HIV reservoirs, and how methamphetamine use impacts the reservoir. This is a collaboration with the lab of Jim Mullins, UW Microbiology.

Bioinformatics and cardiac biology. Together with the lab of Chuck Murry, UW Pathology, we have an opening for postdoctoral research for projects involving bioinformatics and cardiac biology. A high priority project involves the characterization of the role of genome architecture dynamics during the differentiation of cardiovascular cells from human pluripotent stem cells. This project is part of an ongoing collaboration funded through the UW Center for Nuclear Organization & Function (http://www.uw-cnof.com). A successful candidate should have strong computational skills and be willing to learn required wet lab skills.

Requirements:

The University of Washington is consistently ranked as one of the top research universities in the country and has more than 25,000 undergraduates and 9,000 others enrolled in its professional and graduate programs. Seattle is considered one of the nation's most beautiful and livable cities, boasting an array of cultural activities, parks, sports teams and restaurants, and serving as the gateway to National Parks and Forests, as well as boating, skiing and hiking areas.

The University of Washington is a culturally diverse community, and we strongly encourage applications from women and minority candidates. The University of Washington is an Affirmative Action/Equal Opportunity Employer.

Applications will be accepted until the position is filled.

Please send a CV and cover letter to

Dr. William Noble
william-noble@u.washington.edu


Postdoctoral research position in cardiac molecular and computational biology

Co-mentors: Dr. Charles Murry and Dr. William Noble
Departments of Pathology and Genome Sciences
University of Washington, Seattle WA 98109

Job Description:

The Murry and Noble labs have an opening for postdoctoral research for projects involving bioinformatics and cardiac biology. A high priority project involves the characterization of the role of genome architecture dynamics during the differentiation of cardiovascular cells from human pluripotent stem cells. This project is part of an ongoing collaboration funded through the UW Center for Nuclear Organization & Function (http://www.uw-cnof.com).

Requirements:

The University of Washington is consistently ranked as one of the top research universities in the country and has more than 25,000 undergraduates and 9,000 others enrolled in its professional and graduate programs. Seattle is considered one of the nation's most beautiful and livable cities, boasting an array of cultural activities, parks, sports teams and restaurants, and serving as the gateway to National Parks and Forests, as well as boating, skiing and hiking areas.

The University of Washington is a culturally diverse community, and we strongly encourage applications from women and minority candidates. The University of Washington is an Affirmative Action/Equal Opportunity Employer.

Applications will be accepted until the position is filled.

Please send a CV and cover letter to:

Dr. Charles Murry
murry@uw.edu

Dr. William Noble
william-noble@u.washington.edu