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Zafer Aydin
Genome Sciences, Box 357456
1705 NE Pacific St.
Seattle, WA 98195-5065

Phone: (206) 616-5021
E-mail: zafer@u.washington.edu
Url: http://noble.gs.washington.edu/~zafer/

 

EDUCATION

Georgia Institute of Technology, Atlanta, GA
Ph.D. in Electrical and Computer Engineering, 2008
Overall GPA: 4.00 / 4.00
Specialized Area:

Computational Biology, Bioinformatics, Machine Learning, Pattern Recognition

Advisor: Prof. Yucel Altunbasak
Co-advisor: Prof. Mark Borodovsky
Relevant Courses: Bioinformatics, Prokaryotic Molecular Genetics, Eukaryotic Molecular Genetics, Advanced Digital Signal Processing, Coding Theory

Bilkent University, Ankara, Turkey
M.S. in Electrical and Electronics Engineering, July 2001
Overall GPA: 3.80 / 4.00
Specialized Area:

DSP, time-frequency signal processing

Thesis Topic: A New Approach to Time-Frequency Localized Signal Design
Relevant Courses: Neural Networks, Detection and Estimation, Random Processes

Bilkent University, Ankara, Turkey
B.Sc. in Electrical and Electronics Engineering, June 1999
Overall GPA: 3.56 / 4.00

 

ACADEMIC
EXPERIENCE

University of Washington, Seattle, WA
Post-Doctoral Fellow,
2008-Present

  • Developing protein secondary structure prediction methods with dynamic Bayesian networks

  • Developing SVM classifiers that find the annotation errors of C.elegans cells during embryonic development

Georgia Institute of Technology, Atlanta, GA
Graduate Research Assistant,
2002-2008

  • Performed statistical analysis to analyze correlations in protein secondary structure.
  • Developed and implemented hidden semi-Markov models for protein secondary structure prediction.
  • Developed training methods to estimate HMM parameters.
  • Derived a global scoring function from 3D structural alignments that jointly captures secondary structure and amino acid similarity.
  • Developed and implemented HMMs for pairwise alignments of amino acid and secondary structure sequences.
  • Developed and implemented N-Best algorithms to compute suboptimal segmentations of protein secondary structure.
  • Developed a Bayesian model for protein β-sheets.
  • Developed and implemented algorithms that find the optimum β-sheet architecture of a protein.

Bilkent University, Ankara, Turkey
Graduate & Undergraduate Teaching Assistant, 1999-2002 & Fall 1998
Homework grading, lab tutoring, exam proctoring

 

INDUSTRIAL EXPERIENCE

Nortel Networks Netas, Istanbul, Turkey
Summer Intern, Summer 1998

Turkish Telecommunication, Ankara, Turkey
Summer Intern, Summer 1997

 

HONORS AND DISTINCIONS

1. MCCL best researcher award, Multimedia Computing and Communications Lab (MCCL), Georgia Institute of Technology, Spring 2007.

1. 2nd place award in EMBS Student Design Competition, 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco CA, Sep 2004.

2. Received a full-time scholarship from the Master's Program of the Electrical and Electronics Engineering Department, Bilkent University, Ankara, Turkey, 1999.

3. Received a merit-based full four-year scholarship from the Electrical and Electronics Engineering Department, Bilkent University, Ankara, Turkey, 1995.

4. Honored as 117th among over 1 million students in Turkish Nationwide University Entrance Examination, 1995.

5. Honored to compete in the finals of Turkish Nationwide Intelligence Games, Turkish National Intelligence Association, Ankara, Turkey, 2000.

6. Ranked 1st in Intelligence Games, Istanbul Ataturk Science High School, which is among the best 3 high schools in Turkey, Istanbul, Turkey, 1993.

7. Ranked 6th among secondary school students in Turkish Nationwide Chess Tournament, Ministry of Education, Turkey, 1992.

 

SKILLS

Computer Skills

1. Proficient in C for more than 5 years. Implemented HMMs, secondary structure prediction, pairwise alignment and numerical analysis algorithms.

2. Competent with C++.

3. Proficient in Matlab for more than 8 years. Implemented several engineering projects and simulation tools.

4. Competent with Python. Implemented several scripts for data formatting.

5. Competent with Perl. Implemented pairwise alignment algorithms, multiple sequence alignment using Gibbs sampling algorithm.

6. Experienced with BLAST. Competent with CLUSTALW. Knowledge of public databases including PDB, NCBI-NR, EMBL, Swiss-Prot, COGs, PFAM, CDD. Competent with bioinformatics software including GeneMark, PSIPRED, Porter, SSpro4, BetaPro, DSSP. 

7. Experienced in web design.

8. Proficient with Microsoft Word, Excel, Outlook, Powerpoint, Frontpage. Competent with ACT, Goldmine, and SQL.

9. Comfortable with Linux, UNIX, and Windows environments.

 

PUBLICATIONS 

Journal Publications

1. Zafer Aydin, Yucel Altunbasak and Hakan Erdogan, "Bayesian models and algorithms for protein beta-sheet prediction," to appear in IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2009. [pdf]

2. Zafer Aydin, Yucel Altunbasak and Hakan Erdogan, "Bayesian protein secondary structure prediction with near-optimal segmentations," IEEE Transactions on Signal Processing, vol. 55, no. 7, 2007. [pdf]

3. Zafer Aydin and Yucel Altunbasak, "A signal processing application in genomic research: protein secondary structure prediction," IEEE Signal Processing Magazine, vol: 23 Issue: 4, page(s): 128-131, 2006. [pdf] [pdf: extended version titled "dsp applications in genomics"]

4. Zafer Aydin, Yucel Altunbasak and Mark Borodovsky, "Protein secondary structure prediction for a single-sequence using hidden semi-Markov models," BMC Bioinformatics, vol. 7, no. 178, 2006. [pdf] [IPSSP web-server]

Conference Publications

1. Eser Aygun, Caner Komurlu, Zafer Aydin and Zehra Cataltepe, "Protein function prediction with amino acid and sequence and secondary structure alignment scores," International Symposium on Health Informatics and Bioinformatics (HIBIT'08), May 2008. [doc]

2. Zafer Aydin, Isa Kemal Pakatci, Hakan Erdogan and Yucel Altunbasak, "Training set reduction methods for protein secondary structure prediction in single-sequence condition," in Proceedings of the 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS'07), page(s) 5025-5028, Aug 2007. [pdf]

3. Zafer Aydin, Hakan Erdogan and Yucel Altunbasak, "Protein fold recognition using residue-based alignments of sequence and secondary structure," in Proceedings of the IEEE International Conference on Acoustics Speech and Signal Processing (ICASSP '07), vol. 1, page(s): I349-I352, April 2007. [pdf]

4. Isa Kemal Pakatci, Zafer Aydin, Hakan Erdogan and Yucel Altunbasak, "Training set reduction methods for single-sequence protein secondary structure prediction," IEEE Signal Processing and Communication Applications Conference (SUI'2007). [doc]

5. Zafer Aydin, Toygar Akgun and Yucel Altunbasak, "A Modified Stack Decoder for Protein Secondary Structure Prediction," in Proceedings of the IEEE Int. Conf. on Acoustics Speech and Signal Processing (ICASSP '05), vol. 4, Page(s): iv/737-iv/740, March 2005. [pdf]

6. Zafer Aydin, Yucel Altunbasak and Mark Borodovsky, "Protein secondary structure prediction with semi Markov HMMs," in Proceedings of the 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '04), vol. 2, Page(s): 2964-2967, Sep 2004. [pdf]

7. Zafer Aydin, Yucel Altunbasak and Mark Borodovsky, "Protein secondary structure prediction with semi Markov HMMs," in Proceedings of the IEEE Int. Conf. on Acoustics Speech and Signal Processing (ICASSP '04), vol. 5, Page(s): V - 577-580, May 17-21, 2004. [pdf]

8. Ahmet Kemal Ozdemir, Zafer Aydin and Orhan Arikan, "A New approach to time-frequency localized signal design," in Proceedings of the IEEE Int. Conf. on Acoustics Speech and Signal Processing (ICASSP '02), vol. 2, Page(s): 1229-1232, May 13-17, 2002. [pdf]

 

 

GRANT PROPOSALS

1. "Understanding the Book of Life: Non-Local Interaction Modeling for Protein Beta-Sheets and Its Integration to Protein Structure Prediction," funded by National Science Foundation (NSF) for three years, PI:Yucel Altunbasak, 2007.

2. "Understanding the Book of Life: Bayesian Protein Secondary Structure Analysis and Its Application to Protein Function Prediction," funded by National Science Foundation (NSF) for three years, PI:Yucel Altunbasak, 2005.

 

POSTER SESSIONS

1. Zafer Aydin, Yucel Altunbasak and Mark Borodovsky, "Protein secondary structure prediction with semi Markov HMMs," The Fourth Georgia Tech and University of Georgia International Conference on Bioinformatics, Nov 13-16, 2003.

 

SELECTED TALKS

1. "Genomics from an Engineering Perspective," Sabanci University, Istanbul, Turkey, 2003.

2. "Bayesian Protein Secondary Structure Prediction and Homology Detection with Residue-Based Alignments of Sequence and Secondary Structure," Arizona State University, Arizona, 2006.

 

REFERENCES

Available upon request

 

 


 

 

 

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This site was last updated 12/26/08